Risk-Group Classification of Patients With Newly Diagnosed Acute Lymphoblastic Leukemia



Status:Completed
Conditions:Blood Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:1 - 30
Updated:4/21/2016
Start Date:December 2003

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Classification Of Acute Lymphoblastic Leukemia

This clinical trial is studying risk-group classification of patients with newly diagnosed
acute lymphoblastic leukemia. Developing a risk-group classification guide may help doctors
assign patients with newly diagnosed acute lymphoblastic leukemia to treatment clinical
trials.

OBJECTIVES:

I. Provide a classification guide that will organize the clinical and laboratory data
necessary for assigning each patient with newly diagnosed acute lymphoblastic leukemia (ALL)
to a specific treatment clinical trial.

II. Provide an administrative base to capture classification data for correlative studies
accompanying current Children's Oncology Group (COG) ALL treatment clinical trials.

III. Provide a central reference guide for all required and research only ALL studies that
will be conducted at local and reference laboratories.

IV. Provide a mechanism for optional banking of leukemia and germline specimens for current
and future research.

OUTLINE:

Patients undergo blood collection and bone marrow biopsies at baseline and at the end of
induction therapy for immunophenotyping for marker identification; molecular testing for
translocations; trisomy analysis by fluorescence in situ hybridization (FISH); and DNA
ploidy. Immunophenotype results obtained on this study are used to determine the patient's
assignment to specific treatment clinical trials (consistent with acute lymphoblastic
leukemia).

After completion of induction therapy, patients are followed once or twice annually.

Inclusion Criteria:

- Newly diagnosed acute lymphoblastic leukemia, defined by any of the following:

- At least 25% blasts in the bone marrow

- Absolute blast count at least 10,000/mm^3, if bone marrow aspiration is not
performed

- No prior registration on this study
We found this trial at
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2801 Atlantic Ave
Long Beach, California 90806
(562) 933-5437
Miller Children's Hospital Miller Children
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1201 Camino de Salud Northeast
Albuquerque, New Mexico 87131
(505) 272-4946
University of New Mexico Cancer Center It’s been 40 years since the New Mexico State...
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4900 Mueller Boulevard
Austin, Texas 78723
(512) 324-0000
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3400 N Charles St
Baltimore, Maryland 21205
410-516-8000
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2545 Schoenersville Rd
Bethlehem, Pennsylvania 18017
(484) 884-2200
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1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
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3550 Jerome Avenue
Bronx, New York 10467
(718) 920-4321
Montefiore Medical Center As the academic medical center and University Hospital for Albert Einstein College...
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666 Elm Street
Buffalo, New York 14263
(716) 845-2300
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85 S Prospect St
Burlington, Vermont 5405
(802) 656-3131
University of Vermont The University of Vermont combines faculty-student relationships most commonly found in a...
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1000 Blythe Blvd
Charlotte, North Carolina 28203
(704) 355-2000
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5801 South Ellis Avenue
Chicago, Illinois 60637
 773.702.1234
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3333 Burnet Avenue # Mlc3008
Cincinnati, Ohio 45229
 1-513-636-4200 
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11100 Euclid Avenue
Cleveland, Ohio 44106
(216) 844-1000
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700 Childrens Drive
Columbus, Ohio 43205
(616) 722-2000
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3533 South Alameda Street
Corpus Christi, Texas 78411
(361) 694-5000
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7777 Forest Ln # C840
Dallas, Texas 75230
(972) 566-7000
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Des Moines, Iowa 50309
(515) 241-KIDS
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3300 Gallows Road
Falls Church, Virginia 22042
(703) 776-4001
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1 Hurley Plaza
Flint, Michigan 48503
(810) 262-9000
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9981 S Healthpark Dr # 465
Fort Myers, Florida 33908
239-343-5000
Lee Memorial Health System Our origins can be traced to the Fall of 1916 when...
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Gainesville, Florida 32610
(352) 392-3261
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100 Michigan Street Northeast
Grand Rapids, Michigan 49503
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Hartford, Connecticut 06106
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2500 Campus Rd
Honolulu, Hawaii 96822
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1200 Moursund Street
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2500 N State St
Jackson, Mississippi 39216
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2401 Gillham Rd
Kansas City, Missouri 64108
(816) 234-3000
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529 West Markham Street
Little Rock, Arkansas 72205
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8700 Beverly Blvd # 8211
Los Angeles, California 90048
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4650 Sunset Blvd
Los Angeles, California 90027
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231 E Chestnut St
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4015 22nd Place
Lubbock, Texas 79410
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Miami, Florida 33155
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Nashville, Tennessee 37232
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1 Gustave L Levy Pl # 271
New York, New York 10029
 (212) 241-6500
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601 Children's Lane
Norfolk, Virginia 23507
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1717 South Orange Avenue # 100
Orlando, Florida 32806
(407) 650-7000
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5153 North 9th Avenue
Pensacola, Florida 32504
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530 Northeast Glen Oak Avenue
Peoria, Illinois 61603
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South 34th Street
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Portland, Oregon 97239
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620 John Paul Jones Cir
Portsmouth, Virginia 23708
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593 Eddy Street
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60 Crittenden Blvd # 70
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7700 Floyd Curl Dr
San Antonio, Texas 78229
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3020 Childrens way
San Diego, California 92123
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1600 Rockland Road
Wilmington, Delaware 19803
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1540 East Hospital Drive
Ann Arbor, Michigan 48109
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509 Biltmore Ave
Asheville, North Carolina 28801
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1120 15th Street
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13123 E 16th Ave
Aurora, Colorado 80045
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Baltimore, Maryland 21215
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22 South Greene Street
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489 State St
Bangor, Maine 04401
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8901 Rockville Pike
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Boise, Idaho 83712
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Boston, Massachusetts 02114
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5 Richland Medical Park Dr
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Danville, Pennsylvania 17822
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Detroit, Michigan 48201
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Downey, California 90027
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801 Broadway
Fargo, North Dakota 58102
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1600 S Andrews Ave
Fort Lauderdale, Florida 33316
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801 7th Avenue
Fort Worth, Texas 76104
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Green Bay, Wisconsin 54301
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1001 E 5th St
Greenville, North Carolina 27858
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Hershey, Pennsylvania 17033
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Hollywood, Florida 33021
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1 Jarrett White Rd
Honolulu, Hawaii 96859
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Indianapolis, Indiana 46201
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2001 W 86th St
Indianapolis, Indiana 46260
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200 Hawkins Dr,
Iowa City, Iowa 52242
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