Children's Hospital of Philadelphia
South 34th Street
Philadelphia, Pennsylvania 19104
 215-590-1000 http://www.chop.edu/

Use our guide to learn which trials are right for you!

Since its start in 1855 as the nation's first hospital devoted exclusively to caring for children, The Children's Hospital of Philadelphia has been the birthplace for many dramatic firsts in pediatric medicine. The Hospital has fostered medical discoveries and innovations that have improved pediatric healthcare and saved countless children’s lives. Over 150 years of innovation and service to our patients, their families and our community, reflect an ongoing commitment to exceptional patient care.

We've found
375 trials
at this facility
Brain and Central Nervous System Tumors Clinical Trial
Low-Dose Radiation Therapy and Combination Chemotherapy Following Surgery in Treating Children With Newly Diagnosed Primitive Neuroectodermal Tumor or Medulloblastoma
Status: Enrolling, Phase II
Updated: 11/10/2011
mi
from
Philadelphia, PA
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Biliary Atresia Clinical Trial
Biliary Atresia Study in Infants and Children
Status: Enrolling
Updated: 8/27/2015
mi
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Philadelphia, PA
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Oncology Clinical Trial
Combination Chemotherapy With or Without Lestaurtinib in Treating Infants With Newly Diagnosed Acute Lymphoblastic Leukemia
Status: Enrolling, Phase III
Updated: 2/5/2014
mi
from
Philadelphia, PA
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Endocrinology Clinical Trial
PKUDOS: Phenylketonuria (PKU) Demographic, Outcomes, and Safety Registry
Status: Enrolling
Updated: 12/7/2015
mi
from
Philadelphia, PA
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Nephrology / Urology Clinical Trial
Nephrotic Syndrome Study Network
Status: Enrolling
Updated: 12/1/2015
mi
from
Philadelphia, PA
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Oncology Clinical Trial
Collecting and Storing Biological Samples From Patients With Ewing Sarcoma
Status: Enrolling
Updated: 11/12/2015
mi
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Philadelphia, PA
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Hematology, Oncology Clinical Trial
Collecting and Storing Tissue Samples From Patients With Rare or Cutaneous Non-Hodgkin Lymphoma
Status: Enrolling
Updated: 11/16/2015
mi
from
Philadelphia, PA
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Oncology Clinical Trial
Collecting and Storing Samples of Bone Marrow and Blood From Patients With Relapsed Acute Lymphoblastic Leukemia or Non-Hodgkin Lymphoma
Status: Enrolling
Updated: 9/28/2015
mi
from
Philadelphia, PA
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Hematology, Oncology Clinical Trial
Collecting and Storing Malignant, Borderline Malignant Neoplasms, and Related Samples From Young Patients With Cancer
Status: Enrolling
Updated: 11/12/2015
mi
from
Philadelphia, PA
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Sarcoma Clinical Trial
Collecting and Storing Samples of Blood and Tumor Tissue From Patients With Osteosarcoma
Status: Enrolling
Updated: 9/28/2015
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Philadelphia, PA
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Cardiology / Vascular Diseases, Neurology Clinical Trial
Randomized Control Trial of Fluid Therapy for Pediatric Diabetic Ketoacidosis
Status: Enrolling, Phase III
Updated: 6/1/2015
mi
from
Philadelphia, PA
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Charcot Marie Tooth Disease Clinical Trial
Natural History Evaluation of Charcot Marie Tooth Disease (CMT) Types CMT1B, CMT2A, CMT4A, CMT4C, and Others
Status: Enrolling
Updated: 5/14/2015
mi
from
Philadelphia, PA
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Hematology, Immunology / Infectious Diseases Clinical Trial
Reduced Intensity Conditioning (RIC) Regimen for Patients With Non-malignant Disorders
Status: Enrolling, Phase II
Updated: 12/17/2015
mi
from
Philadelphia, PA
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Oncology Clinical Trial
Temozolomide, Cixutumumab, and Combination Chemotherapy in Treating Patients With Metastatic Rhabdomyosarcoma
Status: Enrolling
Updated: 7/22/2013
mi
from
Philadelphia, PA
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Chronic Hepatitis B Virus, Pediatric Clinical Trial
A Phase III Study of the Safety and Efficacy of Entecavir in Pediatric Patients With Chronic HBV-Infection
Status: Enrolling
Updated: 3/28/2013
mi
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Philadelphia, PA
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Nephrology / Urology Clinical Trial
Intervention to Improve Adherence in Teen Kidney Transplant
Status: Enrolling, Phase III
Updated: 9/2/2014
mi
from
Philadelphia, PA
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Oncology Clinical Trial
PNOC 001: Phase II Study of Everolimus for Recurrent or Progressive Low-grade Gliomas in Children
Status: Enrolling, Phase II
Updated: 5/20/2015
mi
from
Philadelphia, PA
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Pediatric RecurrentRefractory BRAFV600E-mutant Gliomas Clinical Trial
Vemurafenib in Children With Recurrent/Refractory BRAFV600E-mutant Gliomas
Status: Enrolling, Phase
Updated: 11/30/2015
mi
from
Philadelphia, PA
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Latent Autoimmune Diabetes in Adult Clinical Trial
Genetics of Latent Autoimmune Diabetes in Adults
Status: Enrolling
Updated: 10/8/2015
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Philadelphia, PA
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Oncology Clinical Trial
A Pilot Study of Decitabine and Vorinostat With Chemotherapy for Relapsed ALL
Status: Enrolling, Phase I, II
Updated: 12/3/2014
mi
from
Philadelphia, PA
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Gastroenterology Clinical Trial
Improving Medication Adherence in Pediatric Inflammatory Bowel Disease
Status: Enrolling, Phase III
Updated: 10/28/2015
mi
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Philadelphia, PA
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Oncology Clinical Trial
Combination Chemotherapy With or Without Rituximab in Treating Younger Patients With Stage III-IV Non-Hodgkin Lymphoma or B-Cell Acute Leukemia
Status: Enrolling, Phase II, III
Updated: 7/28/2015
mi
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Philadelphia, PA
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Neurology, Oncology Clinical Trial
Chemotherapy Followed by Radiation Therapy in Treating Younger Patients With Newly Diagnosed Localized Central Nervous System Germ Cell Tumors
Status: Enrolling, Phase II
Updated: 10/20/2015
mi
from
Philadelphia, PA
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Oncology Clinical Trial
Cixutumumab and Temsirolimus in Treating Younger Patients With Recurrent or Refractory Sarcoma
Status: Enrolling
Updated: 11/15/2012
mi
from
Philadelphia, PA
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Gastroenterology, Reproductive Clinical Trial
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)
Status: Enrolling
Updated: 5/6/2015
mi
from
Philadelphia, PA
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Thalassemia Major With Severe Transfusional Iron Overload Clinical Trial
Combination Deferasirox and Deferiprone for Severe Iron Overload in Thalassemia
Status: Enrolling, Phase I, II
Updated: 3/19/2015
mi
from
Philadelphia, PA
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Anemia Clinical Trial
Age of Blood in Children in Pediatric Intensive Care Units
Status: Enrolling, Phase III
Updated: 11/23/2015
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Philadelphia, PA
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Injury of Anterior Cruciate Ligament Clinical Trial
Opioid Use in Single Shot Nerve Block vs Continuous Peripheral Nerve Infusion in Anterior Cruciate Ligament (ACL) Repair
Status: Enrolling, Phase III
Updated: 7/30/2014
mi
from
Philadelphia, PA
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Endocrinology, Pharmacology / Toxicology Clinical Trial
Mucopolysaccharidosis (MPS) I, II, and VI Screening in a High-Risk Population With Previous Surgical Repair or Presence of Inguinal and/or Umbilical Hernia in Combination With Pediatric ENT Surgery (The HATT Project)
Status: Enrolling
Updated: 4/13/2015
mi
from
Philadelphia, PA
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Cystic Fibrosis Clinical Trial
Study of Ataluren in Nonsense Mutation Cystic Fibrosis (ACT CF)
Status: Enrolling, Phase III
Updated: 10/13/2015
mi
from
Philadelphia, PA
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Obstructive Sleep Apnea Syndrome Clinical Trial
Steroids for Pediatric Apnea Research in Kids
Status: Enrolling, Phase III
Updated: 10/5/2015
mi
from
Philadelphia, PA
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Cardiology / Vascular Diseases, Pulmonary / Respiratory Diseases Clinical Trial
Coagulation and Fibrinolysis in Pediatric Insulin Titration Trial (CAF-PINT)
Status: Enrolling
Updated: 12/22/2015
mi
from
Philadelphia, PA
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Hemophilia B Clinical Trial
Hemophilia B Gene Therapy - Spark
Status: Enrolling, Phase I, II
Updated: 10/31/2014
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Philadelphia, PA
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Hodgkin Lymphoma Clinical Trial
Pilot Study of Non-Viral, RNA-Redirected Autologous T Cells in Patients With Refractory or Relapsed Hodgkin Lymphoma
Status: Enrolling, Phase
Updated: 12/7/2015
mi
from
Philadelphia, PA
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Clinical Trial
Safety and Dose Escalation Study of AAV2-hCHM in Subjects With CHM (Choroideremia) Gene Mutations
Status: Enrolling, Phase I, II
Updated: 12/6/2015
mi
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Philadelphia, PA
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Cystic Fibrosis Clinical Trial
A Two-Part Multicenter Prospective Longitudinal Study of CFTR-dependent Disease Profiling in Cystic Fibrosis (PROSPECT)
Status: Enrolling
Updated: 11/30/2015
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Philadelphia, PA
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Narcolepsy With Cataplexy Clinical Trial
A Multicenter Study of the Efficacy and Safety of Xyrem With an Open- Label Pharmacokinetic Evaluation and Safety Extension in Pediatric Subjects With Narcolepsy With Cataplexy
Status: Enrolling, Phase III
Updated: 11/12/2015
mi
from
Philadelphia, PA
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Retinopathy of Prematurity Clinical Trial
Telemedicine Approaches to Evaluating Acute-Phase ROP eROP Implementation Project
Status: Enrolling
Updated: 4/2/2015
mi
from
Philadelphia, PA
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Refractory or Recurrent Solid Tumors, Excluding CNS Tumors Clinical Trial
VEGF Receptor Tyrosine Kinase Inhibitor Axitinib in Children With Recurrent or Refractory Solid Tumors
Status: Enrolling, Phase I
Updated: 1/14/2016
mi
from
Philadelphia, PA
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Alagille Syndrome Clinical Trial
An Extension Study to Evaluate the Long-Term Safety and Durability of Effect of LUM001 in the Treatment of Cholestatic Liver Disease in Subjects With Alagille Syndrome
Status: Enrolling, Phase II
Updated: 1/15/2016
mi
from
Philadelphia, PA
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Sickle Cell Anemia Clinical Trial
Evaluation of the AMICUS RBCx System in Sickle Cell Patients
Status: Enrolling
Updated: 1/22/2016
mi
from
Philadelphia, PA
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Oncology Clinical Trial
Study of Efficacy and Safety of CTL019 in Pediatric ALL Patients
Status: Enrolling, Phase II
Updated: 1/29/2016
mi
from
Philadelphia, PA
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Cardiology / Vascular Diseases, Other Clinical Trial
Hypothermia's Impact on Pharmacology
Status: Enrolling
Updated: 1/29/2016
mi
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Philadelphia, PA
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Hypoplastic Left Heart Syndrome Clinical Trial
SVRII Family Factors Study
Status: Enrolling
Updated: 2/1/2016
mi
from
Philadelphia, PA
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Brain Concussion Clinical Trial
BCAA's in Sports-related Concussion
Status: Enrolling, Phase II
Updated: 2/5/2016
mi
from
Philadelphia, PA
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Solid Tumors Clinical Trial
Study of Selinexor in Pediatric Solid Tumors
Status: Enrolling, Phase I
Updated: 2/5/2016
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Philadelphia, PA
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Otolaryngology, Pulmonary / Respiratory Diseases Clinical Trial
Efficacy of Antibiotics in Children With Acute Sinusitis: Which Subgroups Benefit?
Status: Enrolling, Phase III
Updated: 2/10/2016
mi
from
Philadelphia, PA
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Hematology, Immunology / Infectious Diseases, Oncology, Reproductive Clinical Trial
Caspofungin Acetate or Fluconazole in Preventing Invasive Fungal Infections in Patients With Acute Myeloid Leukemia Who Are Undergoing Chemotherapy
Status: Enrolling, Phase III
Updated: 2/22/2016
mi
from
Philadelphia, PA
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Neurology, Oncology, Other Clinical Trial
Phase 2 Study of Bevacizumab in Children and Young Adults With NF 2 and Progressive Vestibular Schwannomas
Status: Enrolling, Phase II
Updated: 2/24/2016
mi
from
Philadelphia, PA
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Hospitalized Neonates and Infants, Expected to Require Parenteral Nutrition for 28 Days Clinical Trial
Phase 3 Study to Compare Safety and Efficacy of Smoflipid 20% to Intralipid 20% in Hospitalized Neonates and Infants
Status: Enrolling, Phase III
Updated: 3/3/2016
mi
from
Philadelphia, PA
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Cardiology / Vascular Diseases Clinical Trial
Randomized Trial of Maternal Progesterone Therapy
Status: Enrolling, Phase II
Updated: 3/4/2016
mi
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Philadelphia, PA
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Congenital Hyperinsulinism Clinical Trial
Effect of Exendin-(9-39) On Glucose Requirements To Maintain Euglycemia
Status: Enrolling, Phase I, II
Updated: 3/7/2016
mi
from
Philadelphia, PA
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Oncology, Other Clinical Trial
Cabozantinib for Plexiform Neurofibromas (PN) in Subjects With NF1 (16 Years +)
Status: Enrolling, Phase II
Updated: 3/8/2016
mi
from
Philadelphia, PA
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Neurology Clinical Trial
A Trial of Two Fixed Doses of ZX008 (Fenfluramine HCL) in Children and Young Adults With Dravet Syndrome
Status: Enrolling, Phase III
Updated: 3/8/2016
mi
from
Philadelphia, PA
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Obesity Clinical Trial
Home Plate: A Trial to Improve Home Food Preparation Practices Among Parents of Toddlers
Status: Enrolling
Updated: 3/9/2016
mi
from
Philadelphia, PA
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Bronchopulmonary Dysplasia Clinical Trial
Transpyloric Feeding in Severe Bronchopulmonary Dysplasia
Status: Enrolling
Updated: 3/15/2016
mi
from
Philadelphia, PA
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Immunology / Infectious Diseases, Ophthalmology, Other, Reproductive Clinical Trial
Natural History Study of SCID Disorders
Status: Enrolling
Updated: 3/16/2016
mi
from
Philadelphia, PA
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Gastroenterology Clinical Trial
Fetoscopic Endoluminal Tracheal Occlusion in Severe Left Congenital Diaphragmatic Hernia
Status: Enrolling
Updated: 3/16/2016
mi
from
Philadelphia, PA
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Endocrinology, Hematology, Immunology / Infectious Diseases, Oncology, Pharmacology / Toxicology, Reproductive Clinical Trial
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)
Status: Enrolling
Updated: 3/22/2016
mi
from
Philadelphia, PA
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Seizures Clinical Trial
Cannabidiol Oral Solution in Pediatric Subjects With Treatment- Resistant Seizure Disorders
Status: Enrolling, Phase I, II
Updated: 3/28/2016
mi
from
Philadelphia, PA
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Seizures Clinical Trial
Cannabidiol Oral Solution as an Adjunctive Treatment for Treatment-resistant Seizure Disorder
Status: Enrolling, Phase III
Updated: 3/28/2016
mi
from
Philadelphia, PA
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Acute Arterial Ischemic Stroke Clinical Trial
Optical Measurement of Cerebral Hemodynamics in Children With Acute Arterial Ischemic Stroke
Status: Enrolling
Updated: 3/30/2016
mi
from
Philadelphia, PA
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Oncology, Other Clinical Trial
Low-Dose or High-Dose Lenalidomide in Treating Younger Patients With Recurrent, Refractory, or Progressive Pilocytic Astrocytoma or Optic Pathway Glioma
Status: Enrolling, Phase II
Updated: 4/4/2016
mi
from
Philadelphia, PA
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Duchenne Muscular Dystrophy (DMD) Clinical Trial
Confirmatory Study of Eteplirsen in DMD Patients
Status: Enrolling, Phase III
Updated: 4/5/2016
mi
from
Philadelphia, PA
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Cystic Fibrosis Clinical Trial
Study of N91115 in Patients With CF Homozygous for the F508del-CFTR Mutation
Status: Enrolling, Phase II
Updated: 4/5/2016
mi
from
Philadelphia, PA
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Diabetes Mellitus, Type 1 Clinical Trial
A Research Trial of Aralast in New Onset Diabetes (RETAIN) - Part I
Status: Enrolling, Phase II
Updated: 10/24/2013
mi
from
Philadelphia, PA
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Charcot Marie Tooth Disease Clinical Trial
Development of Charcot Marie Tooth Disease (CMT) Pediatric Scale for Children With CMT
Status: Enrolling
Updated: 5/14/2015
mi
from
Philadelphia, PA
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Brain and Central Nervous System Tumors Clinical Trial
Biomarkers in Blood Samples From Young Patients With Newly Diagnosed Brain Tumors Undergoing Standard Radiation Therapy and Chemotherapy
Status: Enrolling
Updated: 1/7/2011
mi
from
Philadelphia, PA
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Adenovirus Disease Clinical Trial
The Adv Halt Trial
Status: Enrolling
Updated: 11/14/2012
mi
from
Philadelphia, PA
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Brain and Central Nervous System Tumors Clinical Trial
ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors
Status: Enrolling
Updated: 6/22/2011
mi
from
Philadelphia, PA
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Endocrinology, Other Clinical Trial
Improving Blood Glucose Control With a Computerized Decision Support Tool: Phase 1
Status: Enrolling, Phase II
Updated: 2/24/2015
mi
from
Philadelphia, PA
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Gastroenterology Clinical Trial
Evaluating the Genetic Causes and Progression of Cholestatic Liver Diseases (LOGIC)
Status: Enrolling
Updated: 4/15/2015
mi
from
Philadelphia, PA
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Gastroenterology Clinical Trial
Biliary Atresia Research Consortium
Status: Enrolling
Updated: 9/15/2014
mi
from
Philadelphia, PA
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Atopic Dermatitis Clinical Trial
A Pediatric Longitudinal Evaluation to Assess the Long-Term Safety of Protopic for the Treatment of Atopic Dermatitis
Status: Enrolling
Updated: 6/28/2012
mi
from
Philadelphia, PA
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Lymphoma Clinical Trial
Collecting and Storing Biological Samples From Young Patients With Hodgkin's Lymphoma
Status: Enrolling
Updated: 8/5/2014
mi
from
Philadelphia, PA
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Transplantation, Liver Clinical Trial
Immunosuppression Withdrawal for Stable Pediatric Liver Transplant Recipients
Status: Enrolling, Phase II
Updated: 12/3/2013
mi
from
Philadelphia, PA
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Behavior and Behavior Mechanisms Clinical Trial
Peers for Promoting Adolescent Transplant Health
Status: Enrolling, Phase II
Updated: 12/15/2014
mi
from
Philadelphia, PA
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Hematology, Oncology Clinical Trial
Treosulfan/Fludarabine/Low Dose TBI as a Preparative Regimen for Children With AML/MDS Undergoing Allo HCT
Status: Enrolling, Phase II
Updated: 2/25/2014
mi
from
Philadelphia, PA
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Neuroblastoma Clinical Trial
Neuroblastoma Biology Study
Status: Enrolling
Updated: 12/11/2015
mi
from
Philadelphia, PA
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Hematology, Neurology Clinical Trial
Hydroxyurea to Prevent Brain Injury in Sickle Cell Disease
Status: Enrolling, Phase II
Updated: 9/5/2015
mi
from
Philadelphia, PA
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Pain, Postoperative Clinical Trial
Analgesic Efficacy of Repeated Doses of Intravenous (IV) Acetaminophen in Post-operative Pediatric Spine Fusion Patients
Status: Enrolling, Phase III
Updated: 10/13/2014
mi
from
Philadelphia, PA
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Acute Lymphoblastic Leukemia Clinical Trial
Clinical Study With Blinatumomab in Pediatric and Adolescent Patients With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia
Status: Enrolling, Phase I, II
Updated: 11/20/2013
mi
from
Philadelphia, PA
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Congenital Sucrase-isomaltase Deficiency CSID Clinical Trial
Congenital Sucrase-Isomaltase Deficiency (CSID) Genetic Prevalence Study (GPS)
Status: Enrolling
Updated: 6/10/2014
mi
from
Philadelphia, PA
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Pharmacokinetics in Obese Adolescents Clinical Trial
Single Dose Study to Determine the Safety, Tolerability, and Pharmacokinetic Properties of Lorcaserin Hydrochloride (BELVIQ) in Obese Adolescents From 12 to 17 Years of Age
Status: Enrolling, Phase I
Updated: 12/23/2013
mi
from
Philadelphia, PA
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Recurrent Osteosarcoma Clinical Trial
Eribulin Mesylate in Treating Patients With Recurrent or Refractory Osteosarcoma
Status: Enrolling, Phase II
Updated: 11/7/2014
mi
from
Philadelphia, PA
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Patent Ductus Arteriosus PDA Clinical Trial
Nit-Occlud PDA Post-Approval Study
Status: Enrolling
Updated: 7/21/2015
mi
from
Philadelphia, PA
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Bone Mineral Density Reference Data Clinical Trial
Bone Mineral Accretion in Young Children
Status: Enrolling
Updated: 9/25/2015
mi
from
Philadelphia, PA
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Neurology, Psychiatry / Psychology, Other Clinical Trial
Sedation Strategy and Cognitive Outcome After Critical Illness in Early Childhood
Status: Enrolling
Updated: 6/9/2015
mi
from
Philadelphia, PA
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Cardiology / Vascular Diseases, Neurology Clinical Trial
Prompt Diagnosis and Treatment of Subclinical Seizures After Cardiac Arrest
Status: Enrolling
Updated: 11/30/2015
mi
from
Philadelphia, PA
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Crohn Disease Clinical Trial
Crohn Disease Exclusion Diet After Single Medication De-escalation
Status: Enrolling
Updated: 10/6/2015
mi
from
Philadelphia, PA
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Langerhans Cell Histiocytosis Clinical Trial
LCH-IV, International Collaborative Treatment Protocol for Children and Adolescents With Langerhans Cell Histiocytosis
Status: Enrolling, Phase II, III
Updated: 8/4/2015
mi
from
Philadelphia, PA
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Mitochondrial Diseases Clinical Trial
Glycemic Index in Mitochondrial Disease
Status: Enrolling
Updated: 12/1/2015
mi
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Philadelphia, PA
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Clinical Trial
Web-based Intervention to Prevent Risky Driving
Status: Enrolling
Updated: 12/3/2015
mi
from
Philadelphia, PA
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Cystic Fibrosis Clinical Trial
Nasal Potential Difference (NPD) for the Diagnosis of Cystic Fibrosis
Status: Enrolling
Updated: 1/4/2016
mi
from
Philadelphia, PA
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Cardiology / Vascular Diseases, Pulmonary / Respiratory Diseases Clinical Trial
Heart And Lung Failure - Pediatric INsulin Titration Trial
Status: Enrolling, Phase III
Updated: 1/5/2016
mi
from
Philadelphia, PA
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Clinical Trial
Improving Safety and Quality of Tracheal Intubation Practice in Pediatric ICUs
Status: Enrolling
Updated: 1/8/2016
mi
from
Philadelphia, PA
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Alagille Syndrome Clinical Trial
Evaluation of LUM001 in the Reduction of Pruritus in Alagille Syndrome
Status: Enrolling, Phase II
Updated: 1/15/2016
mi
from
Philadelphia, PA
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Dietary Modification Clinical Trial
COntinuous vs BOlus Nasogastric Feeding in Mechanically Ventilated Pediatric Patients 2
Status: Enrolling
Updated: 1/20/2016
mi
from
Philadelphia, PA
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Oncology Clinical Trial
A Trial of Temsirolimus With Etoposide and Cyclophosphamide in Children With Relapsed Acute Lymphoblastic Leukemia and Non-Hodgkins Lymphoma
Status: Enrolling, Phase I
Updated: 2/2/2016
mi
from
Philadelphia, PA
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Cystic Fibrosis Clinical Trial
G551D Observational Study- Expanded to Additional Genotypes and Extended for Long Therm Follow up (GOAL-e2)
Status: Enrolling
Updated: 2/9/2016
mi
from
Philadelphia, PA
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