Children's Hospital of Philadelphia
South 34th Street
Philadelphia, Pennsylvania 19104
 215-590-1000 http://www.chop.edu/

Use our guide to learn which trials are right for you!

Since its start in 1855 as the nation's first hospital devoted exclusively to caring for children, The Children's Hospital of Philadelphia has been the birthplace for many dramatic firsts in pediatric medicine. The Hospital has fostered medical discoveries and innovations that have improved pediatric healthcare and saved countless children’s lives. Over 150 years of innovation and service to our patients, their families and our community, reflect an ongoing commitment to exceptional patient care.

We've found
402 trials
at this facility
Biliary Atresia Clinical Trial
Biliary Atresia Study in Infants and Children
Status: Enrolling, Phase
Updated: 12/31/1969
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Philadelphia, PA
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Endocrinology Clinical Trial
PKUDOS: Phenylketonuria (PKU) Demographic, Outcomes, and Safety Registry
Status: Enrolling, Phase
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Congenital Hyperinsulinism Clinical Trial
Effect of Exendin-(9-39) On Glucose Requirements To Maintain Euglycemia
Status: Enrolling, Phase I, II
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Hematology, Oncology Clinical Trial
Study of Kidney Tumors in Younger Patients
Status: Enrolling, Phase
Updated: 12/31/1969
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Philadelphia, PA
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Hematology, Oncology Clinical Trial
Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma
Status: Enrolling
Updated: 10/11/2012
mi
from
Philadelphia, PA
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Endocrinology, Hematology, Immunology / Infectious Diseases, Oncology, Pharmacology / Toxicology, Reproductive Clinical Trial
A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)
Status: Enrolling, Phase
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Hematology, Immunology / Infectious Diseases Clinical Trial
Reduced Intensity Conditioning (RIC) Regimen for Patients With Non-malignant Disorders
Status: Enrolling, Phase II
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Oncology Clinical Trial
Temozolomide, Cixutumumab, and Combination Chemotherapy in Treating Patients With Metastatic Rhabdomyosarcoma
Status: Enrolling
Updated: 7/22/2013
mi
from
Philadelphia, PA
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Immunology / Infectious Diseases, Ophthalmology, Other, Reproductive Clinical Trial
Natural History Study of SCID Disorders
Status: Enrolling, Phase
Updated: 12/31/1969
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from
Philadelphia, PA
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Charcot Marie Tooth Disease Clinical Trial
Natural History Evaluation of Charcot Marie Tooth Disease (CMT) Types CMT1B, CMT2A, CMT4A, CMT4C, and Others
Status: Enrolling, Phase
Updated: 12/31/1969
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Philadelphia, PA
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Congenital Heart Defects Clinical Trial
Congenital Heart Disease GEnetic NEtwork Study (CHD GENES)
Status: Enrolling, Phase
Updated: 12/31/1969
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Philadelphia, PA
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Nephrology / Urology Clinical Trial
Nephrotic Syndrome Study Network
Status: Enrolling, Phase
Updated: 12/31/1969
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Philadelphia, PA
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Gastroenterology Clinical Trial
Improving Medication Adherence in Pediatric Inflammatory Bowel Disease
Status: Enrolling, Phase III
Updated: 10/28/2015
mi
from
Philadelphia, PA
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Gastroenterology, Reproductive Clinical Trial
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)
Status: Enrolling
Updated: 1/30/2017
mi
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Philadelphia, PA
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Injury of Anterior Cruciate Ligament Clinical Trial
Opioid Use in Single Shot Nerve Block vs Continuous Peripheral Nerve Infusion in Anterior Cruciate Ligament (ACL) Repair
Status: Enrolling, Phase III
Updated: 7/30/2014
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Philadelphia, PA
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Oncology, Other Clinical Trial
Cabozantinib for Plexiform Neurofibromas (PN) in Subjects With NF1 in Children and Adults
Status: Enrolling, Phase II
Updated: 12/31/1969
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Philadelphia, PA
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Acute Arterial Ischemic Stroke Clinical Trial
Optical Measurement of Cerebral Hemodynamics in Children With Acute Arterial Ischemic Stroke
Status: Enrolling, Phase
Updated: 12/31/1969
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Philadelphia, PA
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Gastroenterology, Neurology, Otolaryngology, Pharmacology / Toxicology Clinical Trial
Molecular Basis of Food Allergy
Status: Enrolling, Phase
Updated: 12/31/1969
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Philadelphia, PA
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Oncology Clinical Trial
PNOC 001: Phase II Study of Everolimus for Recurrent or Progressive Low-grade Gliomas in Children
Status: Enrolling, Phase II
Updated: 12/31/1969
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Philadelphia, PA
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Brain Concussion Clinical Trial
BCAA's in Concussion
Status: Enrolling, Phase II
Updated: 12/31/1969
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Philadelphia, PA
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Cardiology / Vascular Diseases, Pulmonary / Respiratory Diseases Clinical Trial
Coagulation and Fibrinolysis in Pediatric Insulin Titration Trial (CAF-PINT)
Status: Enrolling
Updated: 12/22/2015
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Philadelphia, PA
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Cardiology / Vascular Diseases Clinical Trial
Randomized Trial of Maternal Progesterone Therapy
Status: Enrolling, Phase II
Updated: 12/31/1969
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Philadelphia, PA
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Obstructive Sleep Apnea Syndrome Clinical Trial
Steroids for Pediatric Apnea Research in Kids
Status: Enrolling, Phase III
Updated: 12/31/1969
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Philadelphia, PA
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Cystic Fibrosis Clinical Trial
Glycerol Phenylbutyrate Corrector Therapy For CF (Cystic Fibrosis)
Status: Enrolling, Phase I, II
Updated: 12/31/1969
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Philadelphia, PA
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Duchenne Muscular Dystrophy Clinical Trial
Study of SRP-4045 and SRP-4053 in DMD Patients
Status: Enrolling, Phase III
Updated: 12/31/1969
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Philadelphia, PA
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Oncology Clinical Trial
Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors
Status: Enrolling, Phase III
Updated: 12/31/1969
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Philadelphia, PA
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Gastroenterology Clinical Trial
Fetoscopic Endoluminal Tracheal Occlusion in Severe Left Congenital Diaphragmatic Hernia
Status: Enrolling
Updated: 12/31/1969
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Philadelphia, PA
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Otolaryngology, Pulmonary / Respiratory Diseases Clinical Trial
Efficacy of Antibiotics in Children With Acute Sinusitis: Which Subgroups Benefit?
Status: Enrolling, Phase III
Updated: 12/31/1969
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Philadelphia, PA
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Oncology Clinical Trial
Selinexor in Treating Younger Patients With Recurrent or Refractory Solid Tumors or High-Grade Gliomas
Status: Enrolling, Phase I
Updated: 12/31/1969
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Philadelphia, PA
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Hospitalized Neonates and Infants, Expected to Require Parenteral Nutrition for 28 Days Clinical Trial
Phase 3 Study to Compare Safety and Efficacy of Smoflipid 20% to Intralipid 20% in Hospitalized Neonates and Infants
Status: Enrolling, Phase III
Updated: 12/31/1969
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Philadelphia, PA
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Seizures Clinical Trial
Cannabidiol Oral Solution in Pediatric Subjects With Treatment- Resistant Seizure Disorders
Status: Enrolling, Phase I, II
Updated: 4/15/2016
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Philadelphia, PA
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Hodgkin Lymphoma Clinical Trial
Pilot Study of Non-Viral, RNA-Redirected Autologous T Cells in Patients With Refractory or Relapsed Hodgkin Lymphoma
Status: Enrolling, Phase
Updated: 12/31/1969
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Philadelphia, PA
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Acute Lymphoblastic Leukemia Clinical Trial
Study Evaluating KTE-C19 in Pediatric and Adolescent Subjects With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia
Status: Enrolling, Phase I, II
Updated: 12/31/1969
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Philadelphia, PA
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Adolescent Idiopathic Scoliosis Clinical Trial
Adolescent Idiopathic Scoliosis Outcomes Database Registry
Status: Enrolling, Phase
Updated: 4/10/2018
mi
from
Philadelphia, PA
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Neurology, Other Clinical Trial
Natural History of Rett Syndrome & Related Disorders
Status: Enrolling, Phase
Updated: 4/3/2018
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Philadelphia, PA
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Other Clinical Trial
A Study of INFUSE Bone Graft (BMP-2) in the Treatment of Tibial Pseudarthrosis in Neurofibromatosis Type 1 (NF1)
Status: Enrolling, Phase II
Updated: 12/31/1969
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Philadelphia, PA
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Hyperphosphatemia Clinical Trial
An Study to Investigate the Safety and Efficacy of PA21 (Velphoro®) and Calcium Acetate (Phoslyra®) in Paediatric and Adolescent Chronic Kidney Disease (CKD) Patients With Hyperphosphataemia
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Endocrinology, Neurology Clinical Trial
Intranasal Oxytocin in Hypothalamic Obesity
Status: Enrolling, Phase II
Updated: 12/31/1969
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Philadelphia, PA
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Oncology Clinical Trial
Inotuzumab Ozogamicin in Treating Younger Patients With B-Lymphoblastic Lymphoma or Relapsed or Refractory CD22 Positive B Acute Lymphoblastic Leukemia
Status: Enrolling, Phase II
Updated: 12/31/1969
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Philadelphia, PA
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Tuberous Sclerosis Complex Clinical Trial
Preventing Epilepsy Using Vigabatrin In Infants With Tuberous Sclerosis Complex
Status: Enrolling, Phase II
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Type 2 Diabetes Clinical Trial
A Study of Dulaglutide (LY2189265) in Children and Adolescents With Type 2 Diabetes
Status: Enrolling, Phase III
Updated: 12/31/1969
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from
Philadelphia, PA
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Leukemia Clinical Trial
A Phase 2 Study of Ruxolitinib With Chemotherapy in Children With Acute Lymphoblastic Leukemia
Status: Enrolling, Phase II
Updated: 12/31/1969
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Philadelphia, PA
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Oncology Clinical Trial
Next Generation Personalized Neuroblastoma Therapy
Status: Enrolling, Phase I
Updated: 12/31/1969
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Philadelphia, PA
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Hepatitis C Virus Infection Clinical Trial
Sofosbuvir/Velpatasvir in Adolescents and Children With Chronic HCV Infection
Status: Enrolling, Phase II
Updated: 12/31/1969
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from
Philadelphia, PA
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Chronic Pancreatitis Clinical Trial
Fat Malabsorption in Chronic Pancreatitis
Status: Enrolling, Phase II
Updated: 2/2/2018
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Philadelphia, PA
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Cardiology / Vascular Diseases, Pulmonary / Respiratory Diseases, Reproductive Clinical Trial
PEEP and V/Q Mismatch in Premature Infants
Status: Enrolling, Phase I, II
Updated: 5/1/2018
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Philadelphia, PA
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Gastroenterology Clinical Trial
Vedolizumab IV in Pediatric Participants With Ulcerative Colitis (UC) or Crohn's Disease (CD)
Status: Enrolling, Phase II
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Hemophilia A Clinical Trial
A Gene Transfer Study for Hemophilia A
Status: Enrolling, Phase I, II
Updated: 12/31/1969
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Philadelphia, PA
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Migraine Clinical Trial
Migraine and CVD Risk in Women
Status: Enrolling
Updated: 12/31/1969
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Philadelphia, PA
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Oncology, Other Clinical Trial
Trametinib in Treating Patients With Relapsed or Refractory Juvenile Myelomonocytic Leukemia
Status: Enrolling, Phase II
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Severe Aplastic Anemia Clinical Trial
Unrelated Donor Transplant Versus Immune Therapy in Pediatric Severe Aplastic Anemia
Status: Enrolling
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Peanut Allergy Clinical Trial
Long-term Safety Study of AR101 in Subjects Who Participated in a Prior AR101 Study (ARC008)
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Psychiatry / Psychology Clinical Trial
Addressing Traumatic Stress Symptoms in Children
Status: Enrolling
Updated: 12/31/1969
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Philadelphia, PA
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Hematology, Immunology / Infectious Diseases, Oncology Clinical Trial
Erdafitinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With FGFR Mutations (A Pediatric MATCH Treatment Trial)
Status: Enrolling, Phase II
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Hematology, Immunology / Infectious Diseases, Oncology Clinical Trial
Larotrectinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With NTRK Fusions (A Pediatric MATCH Treatment Trial)
Status: Enrolling, Phase II
Updated: 12/31/1969
mi
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Philadelphia, PA
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Pharmacology / Toxicology Clinical Trial
Ascending Dose Study of Genome Editing by the Zinc Finger Nuclease (ZFN) Therapeutic SB-913 in Subjects With MPS II
Status: Enrolling, Phase I
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Cardiology / Vascular Diseases, Pulmonary / Respiratory Diseases, Reproductive Clinical Trial
Impact of CPAP Level on V/Q Mismatch in Premature Infants
Status: Enrolling
Updated: 5/1/2018
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from
Philadelphia, PA
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Idiopathic Scoliosis Clinical Trial
Vertebral Body Tethering Outcomes for Pediatric Idiopathic Scoliosis
Status: Enrolling
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Childhood Absence Epilepsy Clinical Trial
Cannabidiol Oral Solution in Pediatric Participants With Treatment-Resistant Childhood Absence Seizures
Status: Enrolling, Phase II
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Oncology Clinical Trial
Trial of CUDC-907 in Children and Young Adults With Relapsed or Refractory Solid Tumors, CNS Tumors, or Lymphoma
Status: Enrolling, Phase I
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Spinal Muscular Atrophy Clinical Trial
Study of Intrathecal Administration of AVXS-101 for Spinal Muscular Atrophy
Status: Enrolling, Phase I
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Psychiatry / Psychology Clinical Trial
Impact of Beds for Kids Program on Child Sleep
Status: Enrolling
Updated: 12/31/1969
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Philadelphia, PA
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Single Ventricle Heart Disease Clinical Trial
Evaluation of Fontan-Associated Liver Disease
Status: Enrolling, Phase
Updated: 12/31/1969
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Philadelphia, PA
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Clinical Trial
Study to Assess Safety and Preliminary Activity of Eribulin Mesylate in Pediatric Participants With Relapsed/Refractory Rhabdomyosarcoma (RMS), Non-rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS) and Ewing Sarcoma (EWS)
Status: Enrolling, Phase II
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Endocrinology Clinical Trial
Integrating Community Health Workers Into the Care of Children With Type 1 Diabetes
Status: Enrolling
Updated: 4/19/2018
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Philadelphia, PA
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Other Clinical Trial
Effectiveness of Contrast-Enhanced Ultrasound
Status: Enrolling, Phase IV
Updated: 12/31/1969
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Philadelphia, PA
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Precursor Cell Lymphoblastic Leukemia-Lymphoma Clinical Trial
A Study to Evaluate the Efficacy and Safety of Daratumumab in Pediatric and Young Adult Participants Greater Than or Equal to (>=)1 and Less Than or Equal to (
Status: Enrolling, Phase II
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Clinical Trial
A Study of MACI in Patients Aged 10 to
Status: Enrolling, Phase III
Updated: 12/31/1969
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Philadelphia, PA
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Oncology Clinical Trial
Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Hematology, Immunology / Infectious Diseases, Oncology Clinical Trial
Expanded Access Protocol Using Alpha/Beta T and CD19+ Depleted PBSC
Status: Enrolling, Phase
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Oncology Clinical Trial
Pilot Study of Nivolumab in Pediatric Patients With Hypermutant Cancers
Status: Enrolling, Phase I, II
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Hematology Clinical Trial
Safety and Efficacy of Early Treatment With Deferiprone in Infants and Young Children
Status: Enrolling, Phase IV
Updated: 12/31/1969
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from
Philadelphia, PA
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Clinical Trial
The Opening Doors to Early Intervention Study
Status: Enrolling
Updated: 12/31/1969
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Philadelphia, PA
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Hematology Clinical Trial
Shared-Decision Making for Hydroxyurea
Status: Enrolling
Updated: 12/31/1969
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Philadelphia, PA
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Cystic Fibrosis Clinical Trial
A Study Evaluating the Long-term Safety and Efficacy of VX-445 Combination Therapy
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Gastroenterology Clinical Trial
Flourish™ Pediatric Esophageal Atresia
Status: Enrolling, Phase
Updated: 12/31/1969
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Philadelphia, PA
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Dermatology / Plastic Surgery Clinical Trial
Evaluation of the Safety and Efficacy Study of RGN-137 Topical Gel for Junctional and Dystrophic Epidermolysis Bullosa
Status: Enrolling, Phase II
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Hypoplastic Left Heart Syndrome Clinical Trial
Intramyocardial Injection of Autologous Umbilical Cord Blood Derived Mononuclear Cells During Surgical Repair of Hypoplastic Left Heart Syndrome (AutoCell-S2)
Status: Enrolling, Phase II
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Hyperinsulinism-Hyperammonemia Syndrome Clinical Trial
Vitamin E Supplementation in Hyperinsulinism/Hyperammonemia Syndrome
Status: Enrolling
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Childhood Sleep Promotion Clinical Trial
Increasing Childhood Sleep Duration in the Primary Care Setting
Status: Enrolling
Updated: 12/31/1969
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Philadelphia, PA
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Gastroenterology Clinical Trial
A Prospective Database of Infants With Cholestasis
Status: Enrolling, Phase
Updated: 12/31/1969
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Philadelphia, PA
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Gastroenterology Clinical Trial
Evaluating the Genetic Causes and Progression of Cholestatic Liver Diseases (LOGIC)
Status: Enrolling
Updated: 2/15/2018
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Philadelphia, PA
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Cystic Fibrosis Clinical Trial
Nasal Potential Difference (NPD) for the Diagnosis of Cystic Fibrosis
Status: Enrolling
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Endocrinology, Other Clinical Trial
Improving Blood Glucose Control With a Computerized Decision Support Tool: Phase 1
Status: Enrolling, Phase II
Updated: 2/24/2015
mi
from
Philadelphia, PA
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Neurology, Orthopedics / Podiatry Clinical Trial
Prospective Database Registry Study of Scoliosis in Children With Cerebral Palsy
Status: Enrolling, Phase
Updated: 4/10/2018
mi
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Philadelphia, PA
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Hematology, Immunology / Infectious Diseases, Oncology, Other Clinical Trial
Long-Term Follow-Up of Patients Who Have Participated in Children's Oncology Group Studies
Status: Enrolling, Phase
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Brain and Central Nervous System Tumors Clinical Trial
ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors
Status: Enrolling
Updated: 6/22/2011
mi
from
Philadelphia, PA
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Adenovirus Disease Clinical Trial
The Adv Halt Trial
Status: Enrolling
Updated: 11/14/2012
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from
Philadelphia, PA
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Charcot Marie Tooth Disease Clinical Trial
Development of Charcot Marie Tooth Disease (CMT) Pediatric Scale for Children With CMT
Status: Enrolling, Phase
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Hematology, Neurology Clinical Trial
Hydroxyurea to Prevent Brain Injury in Sickle Cell Disease
Status: Enrolling, Phase II
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Brain and Central Nervous System Tumors Clinical Trial
Biomarkers in Blood Samples From Young Patients With Newly Diagnosed Brain Tumors Undergoing Standard Radiation Therapy and Chemotherapy
Status: Enrolling
Updated: 1/7/2011
mi
from
Philadelphia, PA
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Duchenne Muscular Dystrophy Clinical Trial
Study of Ataluren in Previously Treated Participants With Nonsense Mutation Dystrophinopathy (nmDBMD)
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Hypoplastic Left Heart Syndrome Clinical Trial
Safety Study of Autologous Umbilical Cord Blood Cells for Treatment of Hypoplastic Left Heart Syndrome
Status: Enrolling, Phase I
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Critical Injury (Trauma) in Children Clinical Trial
GM-CSF for Immunomodulation Following Trauma (GIFT) Study
Status: Enrolling, Phase IV
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Neuroblastoma Clinical Trial
Neuroblastoma Biology Study
Status: Enrolling
Updated: 1/17/2018
mi
from
Philadelphia, PA
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Oncology Clinical Trial
A Trial of Temsirolimus With Etoposide and Cyclophosphamide in Children With Relapsed Acute Lymphoblastic Leukemia and Non-Hodgkins Lymphoma
Status: Enrolling, Phase I
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Congenital Sucrase-isomaltase Deficiency CSID Clinical Trial
Congenital Sucrase-Isomaltase Deficiency (CSID) Genetic Prevalence Study (GPS)
Status: Enrolling
Updated: 6/10/2014
mi
from
Philadelphia, PA
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Pharmacokinetics in Obese Adolescents Clinical Trial
Single Dose Study to Determine the Safety, Tolerability, and Pharmacokinetic Properties of Lorcaserin Hydrochloride (BELVIQ) in Obese Adolescents From 12 to 17 Years of Age
Status: Enrolling, Phase I
Updated: 12/23/2013
mi
from
Philadelphia, PA
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Oncology Clinical Trial
Adavosertib and Irinotecan Hydrochloride in Treating Younger Patients With Relapsed or Refractory Solid Tumors
Status: Enrolling, Phase I, II
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Bone Mineral Density Reference Data Clinical Trial
Bone Mineral Accretion in Young Children
Status: Enrolling, Phase
Updated: 12/31/1969
mi
from
Philadelphia, PA
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