New Clinical Trials for Depression

Enroll in a Clinical Trial for DepressionDepression clinical research has lead to many advances in its treatment and management over the last several decades. However, it is not a condition that is completely understood. The treatments for depression also need more research. While many antidepressants help most patients some of them actually make the symptoms worse in a small group of patients.

It is obvious that there is still a lot to learn from further depression clinical studies. There are ongoing depression clinical trials that could benefit from your participation if you suffer from depression. If you think you may qualify please review the list of current trials. Participation is always at no cost to you.

What is Depression?

Depression is described as a state of mind focused on sadness, hopelessness, feelings of worthlessness, and a loss of pleasure or concern with every day activities. Depressed people often have trouble sleeping or they sleep too much. The symptoms of depression leave them feeling tired, drained of all energy or enthusiasm and often contemplating suicide. Depression can range from a few weeks of mild depression to a chronic lifelong series of major depressive episodes. Depression is also known as major depressive disorder (MDD), mood disorder and clinical depression. Depression is believed to be caused by changes in the neurotransmitters in the brain such as serotonin.

Depression Treatments

Treating depression is usually done with a combination of antidepressants and psychotherapy. Today’s antidepressant medications are relatively safe with few side effects. While they have been shown less effective in mild cases of depression, they are very effective in more serious cases of depression. Treating depression in severe cases where the patient may want to harm himself or herself or someone else sometimes leads to a period of hospitalization. Less frequently electroconvulsive therapy is used to treat depression. This involves shock therapy to the brain and is a controversial treatment.

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We've found
1,845 Depression
clinical trials

Major Depressive Disorder Clinical Trial
Cellular Aging and Neurobiology of Depression Study
Status: Enrolling, Phase IV
Updated: 12/31/1969
mi
from
San Francisco, CA
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Major Depressive Disorder Clinical Trial
Deep Brain Stimulation for Treatment Resistant Depression
Status: Enrolling, Phase I, II
Updated: 12/31/1969
mi
from
Atlanta, GA
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Oncology, Psychiatry / Psychology Clinical Trial
Study of Anxiety in African American Men With Prostate Cancer
Status: Enrolling
Updated: 2/18/2011
mi
from
Brooklyn, NY
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Oncology, Psychiatry / Psychology Clinical Trial
Study of Anxiety in African American Men With Prostate Cancer
Status: Enrolling
Updated: 2/18/2011
mi
from
New York, NY
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Oncology, Psychiatry / Psychology Clinical Trial
Study of Anxiety in African American Men With Prostate Cancer
Status: Enrolling
Updated: 2/18/2011
mi
from
New York, NY
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Depression Clinical Trial
Anxiety and Depression Levels in Cancer Patients After Self-Application of EFT (Emotional Freedom Techniques)
Status: Enrolling, Phase
Updated: 4/23/2018
mi
from
Santa Rosa, CA
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Oncology, Psychiatry / Psychology Clinical Trial
Multimedia Educational Program for Patients With Early-Stage Prostate Cancer or Breast Cancer
Status: Enrolling
Updated: 1/5/2011
mi
from
Seattle, WA
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Oncology, Psychiatry / Psychology Clinical Trial
The Fibrosis-Lymphedema Continuum in Head and Neck Cancer
Status: Enrolling
Updated: 3/15/2011
mi
from
Nashville, TN
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Major Depressive Disorder Clinical Trial
Efficacy Study of Lu AA21004 on Cognitive Dysfunction in Adult Patients With Major Depressive Disorder
Status: Enrolling
Updated: 3/22/2013
mi
from
Maitland, FL
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Major Depressive Disorder Clinical Trial
Efficacy Study of Lu AA21004 on Cognitive Dysfunction in Adult Patients With Major Depressive Disorder
Status: Enrolling
Updated: 3/22/2013
mi
from
Miami, FL
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Major Depressive Disorder Clinical Trial
Efficacy Study of Lu AA21004 on Cognitive Dysfunction in Adult Patients With Major Depressive Disorder
Status: Enrolling
Updated: 3/22/2013
mi
from
New York, NY
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Endocrinology, Psychiatry / Psychology Clinical Trial
Desvenlafaxine vs. Placebo Treatment of Chronic Depression
Status: Enrolling, Phase IV
Updated: 4/13/2015
mi
from
New York, NY
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Psychiatry / Psychology Clinical Trial
Evaluating a Novel Method of Generalizing Emotion Regulation
Status: Enrolling
Updated: 8/6/2015
mi
from
Durham, NC
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Treatment Resistant Depression Clinical Trial
Trial of Low Field Magnetic Stimulation Augmentation of Antidepressant Therapy in Treatment-Resistant Depression
Status: Enrolling
Updated: 7/13/2015
mi
from
Dallas, TX
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Treatment Resistant Depression Clinical Trial
Trial of Low Field Magnetic Stimulation Augmentation of Antidepressant Therapy in Treatment-Resistant Depression
Status: Enrolling
Updated: 7/13/2015
mi
from
New Haven, CT
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Major Depressive Disorder Clinical Trial
Ketamine Versus Placebo for Treatment Resistant Major Depressive Disorder
Status: Enrolling
Updated: 6/1/2015
mi
from
Boston, MA
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Psychiatry / Psychology Clinical Trial
Excessive Sweating Caused by Antidepressants: Measurement and Treatment With Glycopyrrolate (AIDES-G)
Status: Enrolling, Phase I
Updated: 2/4/2016
mi
from
Philadelphia, PA
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Psychiatry / Psychology, Pulmonary / Respiratory Diseases Clinical Trial
PET Imaging of mGLuR5 With Drug Challenge
Status: Enrolling
Updated: 10/19/2015
mi
from
New Haven, CT
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Oncology, Psychiatry / Psychology Clinical Trial
Repetitive Transcranial Magnetic Stimulation in Cancer Patients With Depression and Anxiety
Status: Enrolling
Updated: 2/2/2016
mi
from
Chicago, IL
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Major Depressive Disorder Clinical Trial
Riluzole Augmentation Pilot in Depression (RAPID) Trial
Status: Enrolling, Phase II
Updated: 4/18/2018
mi
from
Boston, MA
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Depressive Disorder, Major Clinical Trial
A Clinical Trial for the Treatment of Depression With Repetitive Transcranial Magnetic Stimulation (rTMS)
Status: Enrolling
Updated: 1/7/2014
mi
from
Salt Lake City, UT
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Depression Clinical Trial
Mobile Phone Sensing and Outreach as Adjuncts to Internet-Based Behavioral Intervention for Depression
Status: Enrolling, Phase I
Updated: 3/21/2016
mi
from
Chicago, IL
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Psychiatry / Psychology Clinical Trial
Lithium for Suicidal Behavior in Mood Disorders
Status: Enrolling, Phase II, III
Updated: 12/31/1969
mi
from
Asheville, NC
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Psychiatry / Psychology Clinical Trial
Lithium for Suicidal Behavior in Mood Disorders
Status: Enrolling, Phase II, III
Updated: 12/31/1969
mi
from
Dallas, TX
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Psychiatry / Psychology Clinical Trial
Lithium for Suicidal Behavior in Mood Disorders
Status: Enrolling, Phase II, III
Updated: 12/31/1969
mi
from
Decatur, GA
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Psychiatry / Psychology Clinical Trial
Lithium for Suicidal Behavior in Mood Disorders
Status: Enrolling, Phase II, III
Updated: 12/31/1969
mi
from
Denver, CO
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Psychiatry / Psychology Clinical Trial
Lithium for Suicidal Behavior in Mood Disorders
Status: Enrolling, Phase II, III
Updated: 12/31/1969
mi
from
Las Vegas, NV
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Psychiatry / Psychology Clinical Trial
Lithium for Suicidal Behavior in Mood Disorders
Status: Enrolling, Phase II, III
Updated: 12/31/1969
mi
from
Milwaukee, WI
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Psychiatry / Psychology Clinical Trial
Lithium for Suicidal Behavior in Mood Disorders
Status: Enrolling, Phase II, III
Updated: 12/31/1969
mi
from
Minneapolis, MN
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Psychiatry / Psychology Clinical Trial
Lithium for Suicidal Behavior in Mood Disorders
Status: Enrolling, Phase II, III
Updated: 12/31/1969
mi
from
Orlando, FL
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Psychiatry / Psychology Clinical Trial
Lithium for Suicidal Behavior in Mood Disorders
Status: Enrolling, Phase II, III
Updated: 12/31/1969
mi
from
Temple, TX
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Psychiatry / Psychology Clinical Trial
Lithium for Suicidal Behavior in Mood Disorders
Status: Enrolling, Phase II, III
Updated: 12/31/1969
mi
from
Tucson, AZ
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Major Depressive Disorder Clinical Trial
Cognitive Behavior Therapy for Depression Depression
Status: Enrolling
Updated: 12/31/1969
mi
from
New York, NY
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Psychiatry / Psychology Clinical Trial
Managing Sleep Symptoms and Modifying Mechanisms of Traumatic Stress
Status: Enrolling
Updated: 3/23/2016
mi
from
Rochester, NY
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Depression Clinical Trial
Late-life Depression and Cerebral Perfusion
Status: Enrolling
Updated: 12/13/2012
mi
from
Nashville, TN
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Psychiatry / Psychology, Pulmonary / Respiratory Diseases Clinical Trial
Does Vilazodone Help With Antidepressant-associated Sexual Dysfunction?
Status: Enrolling, Phase IV
Updated: 2/4/2016
mi
from
Philadelphia, PA
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Psychiatry / Psychology, Pulmonary / Respiratory Diseases Clinical Trial
Does Vilazodone Help With Antidepressant-associated Sexual Dysfunction?
Status: Enrolling, Phase IV
Updated: 2/4/2016
mi
from
Philadelphia, PA
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Psychiatry / Psychology, Pulmonary / Respiratory Diseases Clinical Trial
Primary Care Internet Based Depression Prevention for Adolescents (CATCH-IT) Also Known as Promoting AdolescenT Health
Status: Enrolling
Updated: 12/7/2015
mi
from
Dyer, IN
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Cardiology / Vascular Diseases, Psychiatry / Psychology Clinical Trial
A Helping Hand Among Low-Income Patients
Status: Enrolling
Updated: 6/16/2014
mi
from
Los Angeles, CA
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Psychiatry / Psychology Clinical Trial
Iwankapiya-Healing: Historical Trauma Practice and Group IPT for American Indians
Status: Enrolling
Updated: 6/12/2015
mi
from
Albuquerque, NM
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Oncology, Psychiatry / Psychology, Other Clinical Trial
Health Education Materials With or Without a Physical Activity Program for Patients Who Have Undergone Treatment for High-Risk Stage II or Stage III Colon Cancer
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Detroit, MI
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Oncology, Psychiatry / Psychology, Other Clinical Trial
Health Education Materials With or Without a Physical Activity Program for Patients Who Have Undergone Treatment for High-Risk Stage II or Stage III Colon Cancer
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Lebanon, NH
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Psychiatry / Psychology, Pulmonary / Respiratory Diseases Clinical Trial
Stanford RAD-AT Study (Research on Anxiety and Depression - Anhedonia Treatment)
Status: Enrolling, Phase
Updated: 12/31/1969
mi
from
Los Altos, CA
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Oncology, Psychiatry / Psychology Clinical Trial
Minocycline Hydrochloride in Reducing Chemotherapy Induced Depression and Anxiety in Patients With Stage I-III Breast Cancer
Status: Enrolling
Updated: 12/31/1969
mi
from
Columbus, OH
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Psychiatry / Psychology, Pulmonary / Respiratory Diseases Clinical Trial
Self Focus in Bipolar Disorder: A Functional Magnetic Resonance Imaging (fMRI) Study
Status: Enrolling
Updated: 8/28/2017
mi
from
Boston, MA
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Depression Clinical Trial
Effectiveness and Implementation of Brief Cognitive Behavioral Therapy in CBOCs
Status: Enrolling
Updated: 12/31/1969
mi
from
Houston, TX
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Depression Clinical Trial
Inflammation-related Alterations in Neurocircuitry: Reversal With Levodopa
Status: Enrolling, Phase IV
Updated: 12/31/1969
mi
from
Atlanta, GA
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Major Depressive Disorder Clinical Trial
Heart Rate Variability in Depression
Status: Enrolling
Updated: 12/31/1969
mi
from
Atlanta, GA
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Neurology, Psychiatry / Psychology Clinical Trial
Pilot Study of Asynchronous and Synchronous Telepsychiatry for Skilled Nursing Facilities
Status: Enrolling
Updated: 9/2/2015
mi
from
Woodland, CA
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Psychiatry / Psychology, Other Clinical Trial
Neurobiology of Suicide
Status: Enrolling, Phase II
Updated: 12/31/1969
mi
from
Bethesda, MD
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Endocrinology, Psychiatry / Psychology Clinical Trial
Northern Manhattan Study of Metabolism and Mind
Status: Enrolling
Updated: 9/14/2015
mi
from
New York, NY
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Psychiatry / Psychology Clinical Trial
Magnetic Resonance Spectroscopy (MRS) in Midlife Depression
Status: Enrolling, Phase
Updated: 12/31/1969
mi
from
Atlanta, GA
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Major Depressive Disorder Clinical Trial
Adjunctive Treatment of Major Depression Utilizing Auricular Acupuncture
Status: Enrolling
Updated: 10/16/2015
mi
from
Fort Myers, FL
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Psychiatry / Psychology Clinical Trial
Late-Life Stress and Inflammation
Status: Enrolling, Phase IV
Updated: 12/31/1969
mi
from
Philadelphia, PA
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Major Depressive Disorder Clinical Trial
Safety and Efficacy of Levomilnacipran ER in Adolescent Patients With Major Depressive Disorder
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Nashville, TN
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Major Depressive Disorder Clinical Trial
Safety and Efficacy of Levomilnacipran ER in Adolescent Patients With Major Depressive Disorder
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Seattle, WA
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Major Depressive Disorder Clinical Trial
Safety and Efficacy of Levomilnacipran ER in Adolescent Patients With Major Depressive Disorder
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Anaheim, CA
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Major Depressive Disorder Clinical Trial
Safety and Efficacy of Levomilnacipran ER in Adolescent Patients With Major Depressive Disorder
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Gresham, OR
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Major Depressive Disorder Clinical Trial
Safety and Efficacy of Levomilnacipran ER in Adolescent Patients With Major Depressive Disorder
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Hialeah, FL
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Major Depressive Disorder Clinical Trial
Safety and Efficacy of Levomilnacipran ER in Adolescent Patients With Major Depressive Disorder
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Norwich, CT
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Major Depressive Disorder Clinical Trial
Safety and Efficacy of Levomilnacipran ER in Adolescent Patients With Major Depressive Disorder
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Princeton, NJ
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Major Depressive Disorder Clinical Trial
Safety and Efficacy of Levomilnacipran ER in Adolescent Patients With Major Depressive Disorder
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Sanford, FL
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Major Depressive Disorder Clinical Trial
Safety and Efficacy of Levomilnacipran ER in Adolescent Patients With Major Depressive Disorder
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Springdale, AR
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Major Depressive Disorder Clinical Trial
Safety and Efficacy of Levomilnacipran ER in Adolescent Patients With Major Depressive Disorder
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
The Woodlands, TX
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Major Depressive Disorder Clinical Trial
Safety and Efficacy of Levomilnacipran ER in Adolescent Patients With Major Depressive Disorder
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Watertown, MA
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Major Depressive Disorder Clinical Trial
Multimodal MRI Characteristics of Psychotherapy Response in Late Life Depression
Status: Enrolling
Updated: 12/31/1969
mi
from
San Francisco, CA
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Musculoskeletal, Neurology, Psychiatry / Psychology, Other Clinical Trial
A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity
Status: Enrolling
Updated: 1/11/2016
mi
from
Madison, WI
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Musculoskeletal, Neurology, Psychiatry / Psychology, Other Clinical Trial
A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity
Status: Enrolling
Updated: 1/11/2016
mi
from
New Orleans, LA
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Musculoskeletal, Neurology, Psychiatry / Psychology, Other Clinical Trial
A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity
Status: Enrolling
Updated: 1/11/2016
mi
from
St. Paul, MN
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Psychiatry / Psychology, Other Clinical Trial
Promoting Widowed Elders Lifestyle After Loss
Status: Enrolling, Phase I
Updated: 12/31/1969
mi
from
Pittsburgh, PA
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Musculoskeletal, Neurology, Psychiatry / Psychology Clinical Trial
Establishing Efficacy of a Functional-Restoration Based CAM Pain Management Program in Post-9/11 Veterans
Status: Enrolling
Updated: 12/31/1969
mi
from
San Antonio, TX
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Neurology, Psychiatry / Psychology, Other Clinical Trial
Transcranial Direct Current Stimulation for the Treatment of Deficits After Traumatic Brain Injury
Status: Enrolling
Updated: 12/31/1969
mi
from
Albuquerque, NM
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Severe Postpartum Depression Clinical Trial
A Study to Evaluate SAGE-547 in Patients With Severe Postpartum Depression
Status: Enrolling, Phase II
Updated: 5/26/2016
mi
from
Chapel Hill, NC
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Severe Postpartum Depression Clinical Trial
A Study to Evaluate SAGE-547 in Patients With Severe Postpartum Depression
Status: Enrolling, Phase II
Updated: 5/26/2016
mi
from
Philadelphia, PA
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Psychiatry / Psychology, Pulmonary / Respiratory Diseases Clinical Trial
A Study of L-DOPA for Depression and Slowing in Older Adults
Status: Enrolling
Updated: 12/31/1969
mi
from
New York, NY
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Immunology / Infectious Diseases, Musculoskeletal, Psychiatry / Psychology Clinical Trial
Treating Comorbid Pain and Depression in HIV+ Individuals
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Boston, MA
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Immunology / Infectious Diseases, Musculoskeletal, Psychiatry / Psychology Clinical Trial
Treating Comorbid Pain and Depression in HIV+ Individuals
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Providence, RI
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Depressive Disorder, Treatment-Resistant Clinical Trial
A Long-term Safety Study of Intranasal Esketamine in Treatment-resistant Depression
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Charlotte, NC
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Depressive Disorder, Treatment-Resistant Clinical Trial
A Long-term Safety Study of Intranasal Esketamine in Treatment-resistant Depression
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Houston, TX
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Depressive Disorder, Treatment-Resistant Clinical Trial
A Long-term Safety Study of Intranasal Esketamine in Treatment-resistant Depression
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Arlington, TX
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Depressive Disorder, Treatment-Resistant Clinical Trial
A Long-term Safety Study of Intranasal Esketamine in Treatment-resistant Depression
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Baltimore, MD
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Depressive Disorder, Treatment-Resistant Clinical Trial
A Long-term Safety Study of Intranasal Esketamine in Treatment-resistant Depression
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Bradenton, FL
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Depressive Disorder, Treatment-Resistant Clinical Trial
A Long-term Safety Study of Intranasal Esketamine in Treatment-resistant Depression
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Charleston, SC
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Depressive Disorder, Treatment-Resistant Clinical Trial
A Long-term Safety Study of Intranasal Esketamine in Treatment-resistant Depression
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Charlottesville, VA
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Depressive Disorder, Treatment-Resistant Clinical Trial
A Long-term Safety Study of Intranasal Esketamine in Treatment-resistant Depression
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Cincinnati, OH
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Depressive Disorder, Treatment-Resistant Clinical Trial
A Long-term Safety Study of Intranasal Esketamine in Treatment-resistant Depression
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Dallas, TX
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Depressive Disorder, Treatment-Resistant Clinical Trial
A Long-term Safety Study of Intranasal Esketamine in Treatment-resistant Depression
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Oklahoma City, OK
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Depressive Disorder, Treatment-Resistant Clinical Trial
A Long-term Safety Study of Intranasal Esketamine in Treatment-resistant Depression
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Prairie Village, KS
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Depressive Disorder, Treatment-Resistant Clinical Trial
A Long-term Safety Study of Intranasal Esketamine in Treatment-resistant Depression
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Tampa, FL
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Depressive Disorder, Treatment-Resistant Clinical Trial
A Long-term Safety Study of Intranasal Esketamine in Treatment-resistant Depression
Status: Enrolling, Phase III
Updated: 12/31/1969
mi
from
Worcester, MA
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Musculoskeletal, Psychiatry / Psychology, Reproductive Clinical Trial
Labor Pain and Postpartum Behavioral Health Outcomes Study
Status: Enrolling, Phase
Updated: 12/31/1969
mi
from
Pittsburgh, PA
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Depression Clinical Trial
Computer-assisted Cognitive-Behavior Therapy for Depression in Primary Care
Status: Enrolling
Updated: 3/1/2018
mi
from
Louisville, KY
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Treatment Resistant Major Depressive Disorder Clinical Trial
Comparative Effectiveness Research Trial for Antidepressant Incomplete and Non-responders With TRD
Status: Enrolling, Phase IV
Updated: 12/31/1969
mi
from
Atlanta, GA
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Treatment Resistant Major Depressive Disorder Clinical Trial
Comparative Effectiveness Research Trial for Antidepressant Incomplete and Non-responders With TRD
Status: Enrolling, Phase IV
Updated: 12/31/1969
mi
from
Tampa, FL
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Treatment Resistant Major Depressive Disorder Clinical Trial
Comparative Effectiveness Research Trial for Antidepressant Incomplete and Non-responders With TRD
Status: Enrolling, Phase IV
Updated: 12/31/1969
mi
from
Boston, MA
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Treatment Resistant Major Depressive Disorder Clinical Trial
Comparative Effectiveness Research Trial for Antidepressant Incomplete and Non-responders With TRD
Status: Enrolling, Phase IV
Updated: 12/31/1969
mi
from
Charlottesville, VA
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Treatment Resistant Major Depressive Disorder Clinical Trial
Comparative Effectiveness Research Trial for Antidepressant Incomplete and Non-responders With TRD
Status: Enrolling, Phase IV
Updated: 12/31/1969
mi
from
New York, NY
Click here to add this to my saved trials
Treatment Resistant Major Depressive Disorder Clinical Trial
Comparative Effectiveness Research Trial for Antidepressant Incomplete and Non-responders With TRD
Status: Enrolling, Phase IV
Updated: 12/31/1969
mi
from
Stanford, CA
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Cardiology / Vascular Diseases, Gastroenterology, Musculoskeletal, Psychiatry / Psychology, Pulmonary / Respiratory Diseases, Rheumatology Clinical Trial
Integrating Behavioral Health and Primary Care for Comorbid Behavioral and Medical Problems
Status: Enrolling
Updated: 1/10/2018
mi
from
Burlington, VT
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Neurology, Psychiatry / Psychology Clinical Trial
CBT Depression Intervention for Co-Occurring Chronic Headache
Status: Enrolling
Updated: 3/27/2017
mi
from
Detroit, MI
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