Stanford RAD-AT Study (Research on Anxiety and Depression - Anhedonia Treatment)

Conditions:Anxiety, Depression, Depression, Major Depression Disorder (MDD), Psychiatric, Psychiatric
Therapuetic Areas:Psychiatry / Psychology, Pulmonary / Respiratory Diseases
Age Range:18 - 65
Start Date:August 2013
End Date:June 2019
Contact:Bailey Holt-Gosselin, B.S.
Phone:650) 497-2615

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Neural Dimensions of Threat Reactivity and Regulation for Understanding Anxiety

This research study is aimed at understanding behaviors and brain circuits that relate to
anxiety and depression. Our goal is to learn which circuits of the brain are involved in
anxiety and how these circuits might affect daily functioning.

This study has recently added an additional treatment component: participants undergo a 12
week course of either Pramipexole medication or rTMS therapy (explained below). The ultimate
goal of the study is to offer participants experiencing anxiety and depression a treatment
that is alternative to ones that have failed them in the past, and to apply the knowledge we
gain from investigating the brain circuits involved in anxiety and depression to help
personalize treatments.

We invite anyone who has recently experienced any symptoms of anxiety and/or depression to
participate (no diagnosis is required to participate).

If you are eligible and choose to participate, we'll ask you to come in for 2 separate
testing visits and 8 weeks of treatment in between.

In both the pre-treatment and post-treatment testing visit, you would complete game-like
tasks on the computer, undergo a non-invasive MRI brain scan, and answer some questions about
your emotional health. The entire visit takes place during 1-2 days at Stanford and lasts
about 4-5 hours. We'll also ask you to complete a follow-up 12 weeks later, from home, during
which we'll again ask you some questions on your emotional health.

The 8-week treatment phase will consist of your choice of either TMS (transcranial magnetic
stimulation) or Pramipexole (a medication for depression). You will meet with study
coordinators and MDs each week (Pramipexole) or each day (TMS) to receive treatment. You will
also be asked to complete weekly online surveys to monitor your mood during the 2-month
course of treatment.

To inquire more about participation, you can either sign up online or contact us.

Sign up online: Contact us:
Call or text (650) 600-1609 or email

Inclusion Criteria:

- Recent experiences of anxiety and/or depression

- Ages 18-65

Exclusion Criteria:

- Specific psychiatric medications (case-by-case basis)

- A diagnosis of Bipolar 1 Disorder, Schizophrenia, or Obsessive Compulsive Disorder

- Any of the following medical conditions: Parkinson's disease; liver or kidney disease;
history of epilepsy or seizures; history of cardiovascular disorders (specifically
orthostatic hypotension)
We found this trial at
5150 El Camino Real
Los Altos, California 94022
Los Altos, CA
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Palo Alto, California 94304
Palo Alto, CA
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Stanford, California 94304
Principal Investigator: Leanne M Williams, PhD
Stanford, CA
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