Cabozantinib-S-Malate in Treating Younger Patients With Recurrent, Refractory, or Newly Diagnosed Sarcomas, Wilms Tumor, or Other Rare Tumors



Status:Recruiting
Conditions:Liver Cancer, Liver Cancer, Cancer, Cancer, Cancer, Cancer, Cancer, Cancer, Brain Cancer, Brain Cancer, Endocrine
Therapuetic Areas:Endocrinology, Oncology
Healthy:No
Age Range:2 - 30
Updated:4/4/2019
Start Date:May 8, 2017
End Date:June 30, 2021

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Phase 2 Trial of XL184 (Cabozantinib) an Oral Small-Molecule Inhibitor of Multiple Kinases, in Children and Young Adults With Refractory Sarcomas, Wilms Tumor, and Other Rare Tumors

This phase II trial studies how well cabozantinib-s-malate works in treating younger patients
with sarcomas, Wilms tumor, or other rare tumors that have come back, do not respond to
therapy, or are newly diagnosed. Cabozantinib-s-malate may stop the growth of tumor cells by
blocking some of the enzymes needed for tumor growth and tumor blood vessel growth.

PRIMARY OBJECTIVES:

I. To determine the objective response rate (complete response + partial response) of
cabozantinib-s-malate (XL184) in children and young adults.

II. To estimate whether XL184 therapy either improves the disease control rate at 4 months in
patients with recurrent measurable osteosarcoma as compared to a historical Childrens
Oncology Group (COG) experience or produces an objective response rate.

SECONDARY OBJECTIVES:

I. To further define XL184 related toxicities in pediatric, adolescent and young adult
patients.

II. To further define XL184 pharmacokinetics in the pediatric and adolescent patients.

III. To estimate 1-year time to progression, progression free survival (PFS) and overall
survival for each stratum, and if feasible to compare to historical controls.

EXPLORATORY OBJECTIVES:

I. To assess the effect of XL184 on patients' immune cell subsets. II. To obtain tumor tissue
(snap frozen, formalin-fixed and paraffin-embedded [FFPE] blocks, or unstained slides) from
diagnosis, recurrence, or both, for possible future studies.

OUTLINE:

Patients receive cabozantinib-s-malate orally (PO) once daily (QD) on days 1-28. Courses
repeat every 28 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up at 30 days, every 6 months for
1 year and then annually for up to 5 years.

Inclusion Criteria:

- Upper age limit of =< 18 years of age for medullary thyroid carcinoma (MTC), renal
cell carcinoma (RCC) and hepatocellular carcinoma (HCC)

- Patients must have a body surface area >= 0.35 m^2

- Patients must have recurrent or refractory disease, or newly diagnosed disease with no
known curative therapy or therapy proven to prolong survival with an acceptable
quality of life; patients must have had histologic verification of one of the
malignancies listed below at original diagnosis or at relapse:

- Ewing sarcoma

- Rhabdomyosarcoma (RMS)

- Non-rhabdomyosarcoma soft tissue sarcomas (STS) including microphthalmia
transcription factor associated STS (alveolar soft part sarcoma [ASPS] and clear
cell sarcoma [CCS])

- Osteosarcoma

- Wilms tumor

- Rare tumors

- Medullary thyroid carcinoma (MTC)

- Renal cell carcinoma (RCC)

- Hepatocellular carcinoma (HCC)

- Hepatoblastoma

- Adrenocortical carcinoma

- Pediatric solid tumors (including central nervous system [CNS] tumors) with
known molecular alterations in the targets of XL184 (i.e., MET
amplification, overexpression, activating mutation, MET translocation, MET
exon skipping mutations, activating RET mutations, RET rearrangement,
overexpression or activation of AXL); documentation of the alteration from a
Clinical Laboratory Improvement Act (CLIA) certified laboratory will be
required

- Note: Documentation of any known tumor molecular alterations and RET
mutation status for patients with MTC (germline) must be uploaded via
the RAVE system

- Patients must have radiographically measurable disease; measurable disease is defined
as the presence of at least one lesion on magnetic resonance imaging (MRI) or computed
tomography (CT) scan that can be accurately measured with the longest diameter a
minimum of 10 mm in at least one dimension (CT scan slice thickness no greater than 5
mm)

- Note: The following do NOT qualify as measurable disease:

- Malignant fluid collections (e.g., ascites, pleural effusions)

- Bone marrow infiltration

- Lesions only detected by nuclear medicine studies (e.g., bone, gallium or
positron emission tomography [PET] scans)

- Elevated tumor markers in plasma or cerebrospinal fluid (CSF)

- Previously radiated lesions that have not demonstrated clear progression
post radiation

- Leptomeningeal lesions that do not meet the measurement parameters noted
above

- Patients must have a Lansky or Karnofsky performance status score of >= 50,
corresponding to Eastern Cooperative Oncology Group (ECOG) categories 0, 1 or 2; use
Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of age;
patients who are unable to walk because of paralysis, but who are up in a wheelchair,
will be considered ambulatory for the purpose of assessing the performance score

- Patients must have fully recovered from the acute toxic effects of all prior
chemotherapy, immunotherapy, or radiotherapy prior to entering this study

- Patients with solid tumors must not have received myelosuppressive chemotherapy within
3 weeks of enrollment onto this study (6 weeks if prior nitrosourea)

- At least 7 days must have elapsed since the completion of therapy with a growth
factor. At least 14 days must have elapsed after receiving pegfilgrastim

- Anti-cancer agents not known to be myelosuppressive (e.g. not associated with reduced
platelet or absolute neutrophil count [ANC] counts): >= 7 days after the last dose of
agent

- Antibodies: >= 21 days must have elapsed from infusion of last dose of antibody, and
toxicity related to prior antibody therapy must be recovered to grade =< 1

- >= 2 weeks must have elapsed since local palliative radiation therapy (XRT) (small
port); >= 6 weeks must have elapsed since treatment with therapeutic doses of
M-Iodobenzylguanidine (MIBG); >= 3 months must have elapsed if prior craniospinal XRT
was received, if >= 50% of the pelvis was irradiated, or if total-body irradiation
(TBI) was received; >= 6 weeks must have elapsed if other substantial bone marrow
irradiation was given

- Subjects should not have any clinically relevant ongoing complications from prior
radiation therapy (i.e., radiation esophagitis or other inflammation of the
viscera)

- No evidence of active graft versus (vs.) host disease and >= 2 months must have
elapsed since transplant

- Not previously received XL184 or another MET/HGF inhibitor (tivantinib or crizotinib);
there are no limits on number of prior therapeutic regimens; patients who have been
treated with prior VEGF pathway, or RET inhibitors (except XL184) may be eligible

- Peripheral absolute neutrophil count (ANC) >= 1000/uL for patients with solid tumors
without bone marrow involvement

- Platelet count >= 100,000/uL (transfusion independent, defined as not receiving
platelet transfusions within a 7 day period prior to enrollment) for patients with
solid tumors without bone marrow involvement

- Hemoglobin >= 8.0 g/dL (may receive red blood cell [RBC] transfusions) for patients
with solid tumors without bone marrow involvement

- Peripheral absolute neutrophil count (ANC) >= 750/uL for patients with solid tumors
and known bone marrow metastatic disease

- Platelet count >= 50,000/uL for patients with solid tumors and known bone marrow
metastatic disease

- Hemoglobin >= 8.0 g/dL for patients with solid tumors and known bone marrow metastatic
disease

- Transfusions are permitted to meet both the platelet and hemoglobin criteria; patients
must not be known to be refractory to red blood cell or platelet transfusions

- Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70
mL/min/1.73 m^2 or a serum creatinine based on age/gender as follows:

- 2 to < 6 years of age

- Male and female: 0.8 (maximum serum creatinine [mg/dL])

- 6 to < 10 years of age

- Male and female: 1 (maximum serum creatinine [mg/dL])

- 10 to < 13 years of age

- Male and female: 1.2 (maximum serum creatinine [mg/dL])

- 13 to < 16 years of age

- Male 1.5 (maximum serum creatinine [mg/dL])

- Female: 1.4 (maximum serum creatinine [mg/dL])

- >= 16 years of age

- Male: 1.7 (maximum serum creatinine [mg/dL])

- Female: 1.4 (maximum serum creatinine [mg/dL])

- Urine protein: =< 30 mg/dl in urinalysis or =< 1+ on dipstick, unless quantitative
protein is < 1000 mg in a 24 hour (h) urine sample

- Total bilirubin =< 1.5 x upper limit of normal (ULN) for age

- Serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) =< 135
U/L (3 x ULN) (for the purpose of this study, the ULN for SGPT is 45 U/L)

- Serum albumin >= 2.8 g/dL

- No history of congenital prolonged corrected QT (QTc) syndrome, New York Heart
Association (NYHA) class III or IV congestive heart failure (CHF)

- No clinically significant cardiac arrhythmias, stroke or myocardial infarction within
6 months prior to enrollment

- QTc =< 480 msec; Note: Patients with grade 1 prolonged QTc (450- 480 msec) at the time
of study enrollment should have correctable causes of prolonged QTc addressed if
possible (i.e., electrolytes, medications)

- Patients with a known seizure disorder who are receiving non-enzyme inducing
anticonvulsants and have well-controlled seizures may be enrolled

- CNS toxicity =< grade 2 with the exception of decreased tendon reflex (DTR); any grade
of DTR is eligible

- A blood pressure (BP) =< the 95th percentile for age, height, and gender for pediatric
patients < 18 years old and =< 140/90 mmHg for patients >= 18 years old; patients
should not be receiving medication for treatment of hypertension (except patients with
Wilms tumor and RCC who may be eligible if on stable doses of no more than one
anti-hypertensive medication with a baseline BP =< ULN for pediatric patients and =<
140/90 for adult patients); please note that 3 serial blood pressures should be
obtained and averaged to determine baseline BP

- International normalized ratio (INR) =< 1.5

- Serum amylase =< 1.5 ULN

- Serum lipase =< 1.5 ULN

Exclusion Criteria:

- Pregnant or breast-feeding women will not be entered on this study; pregnancy tests
must be obtained in girls who are post-menarchal; males or females of reproductive
potential may not participate unless they have agreed to use two methods of birth
control- a medically accepted barrier method of contraceptive method (e.g., male or
female condom) and a second effective method of birth control-during protocol therapy
and for at least 4 months after the last dose of XL184; abstinence is an acceptable
method of birth control

- Growth factors that support platelet or white cell number or function must not have
been administered within the 7 days prior to enrollment (14 days if pegfilgrastim)

- Patients requiring corticosteroids who have not been on a stable or decreasing dose of
corticosteroid for the 7 days prior to enrollment are not eligible; if used to modify
immune adverse events related to prior therapy, >= 14 days must have elapsed since
last dose of corticosteroid

- Previous treatment with XL184 (cabozantinib) or another MET/HGF inhibitor (tivantinib,
crizotinib)

- Patients who are currently receiving another investigational drug are not eligible

- Patients who are currently receiving other anti-cancer agents are not eligible

- Patients who are receiving cyclosporine, tacrolimus or other agents to prevent either
graft-versus-host disease post bone marrow transplant or organ rejection
post-transplant are not eligible for this trial

- Patients must not be receiving any of the following potent CYP3A4 inducers or
inhibitors: erythromycin, clarithromycin, ketoconazole, azithromycin, itraconazole,
grapefruit juice or St. John's wort

- Concomitant anticoagulation with oral anticoagulants (e.g., warfarin, direct thrombin,
and Factor Xa inhibitors) or platelet inhibitors (e.g., clopidogrel) are prohibited

- Note: Low-dose aspirin for cardioprotection (per local applicable guidelines) and
low dose, low molecular weight heparins (LMWH) are permitted; anticoagulation
with therapeutic doses of LMWH is allowed in subjects without radiographic
evidence of brain metastasis, who are on a stable dose of LMWH for at least 6
weeks before first dose of study treatment, and who have had no complications
from a thromboembolic event or the anticoagulation regimen

- Patients must not have received enzyme-inducing anticonvulsants within 14 days prior
to enrollment

- Patients who are receiving drugs that prolong QTc are not eligible

- Patients who are unable to swallow intact tablets are not eligible

- Patients who have an uncontrolled infection are not eligible

- Patients who in the opinion of the investigator may not be able to comply with the
safety monitoring requirements of the study are not eligible

- Patients with active bleeding are not eligible; specifically, no clinically
significant gastrointestinal (GI) bleeding, GI perforation, intra-abdominal abscess or
fistula for 6 months prior to enrollment, no hemoptysis or other signs of pulmonary
hemorrhage for 3 months prior to enrollment; patients with evidence of an acute
intracranial or intratumoral hemorrhage on CT or MRI are not eligible (patients with
evidence of resolving hemorrhage will be eligible); in patients with CNS tumors, an
MRI with ECHO gradient sequences would be required to exclude presence of petechial
hemorrhages

- Patients who have had or are planning to have the following invasive procedures are
not eligible:

- Major surgical procedure, laparoscopic procedure, or open biopsy within 28 days
prior to enrollment

- Central line placement or subcutaneous port placement is not considered major
surgery but must be placed at least 3 days prior to enrollment for external lines
(e.g., Hickman or Broviac catheter, peripherally inserted central catheter
[PICC]) and at least 7 days prior to enrollment for a subcutaneous port

- Core biopsy within 7 days prior to enrollment

- Fine needle aspirate within 7 days prior to enrollment

- Surgical or other wounds must be adequately healed prior to enrollment

- NOTE: For purposes of this study, bone marrow aspirate and biopsy are not
considered surgical procedures and therefore are permitted within 14 days prior
to start of protocol therapy

- Patients who have had significant traumatic injury within 28 days prior to enrollment
are not eligible

- Patients with any medical or surgical conditions that would interfere with
gastrointestinal absorption of the study drug are not eligible
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2301 Erwin Rd
Durham, North Carolina 27710
919-684-8111
Principal Investigator: Lars M. Wagner
Phone: 888-275-3853
Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
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Effingham, Illinois 62401
Principal Investigator: James R. Egner
Phone: 800-446-5532
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Effingham, IL
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El Paso, Texas 79905
Principal Investigator: Lisa L. Hartman
Phone: 915-298-5444
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El Paso, Texas 79905
Principal Investigator: Lisa L. Hartman
Phone: 888-823-5923
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Fontana, California 92335
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Fort Myers, Florida 33908
Principal Investigator: Emad K. Salman
Phone: 877-680-0008
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1600 Southwest Archer Road
Gainesville, Florida 32610
Principal Investigator: William B. Slayton
Phone: 352-273-8010
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1001 E 5th St
Greenville, North Carolina 27858
(252) 328-6131
Principal Investigator: Andrea R. Whitfield
Phone: 252-744-1015
East Carolina University Whether it's meeting the demand for more teachers and healthcare professionals or...
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Greenville, South Carolina 29607
Principal Investigator: Robert D. Siegel
Phone: 864-255-1713
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1 St. Francis Drive
Greenville, South Carolina 29601
864-255-1000
Principal Investigator: Robert D. Siegel
Phone: 864-255-1713
Saint Francis Hospital This 245-bed, all-private-room facility is located near downtown Greenville, South Carolina. Formerly...
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900 West Faris Rd.
Greenville, South Carolina 29605
(864)455-8898
Principal Investigator: Nichole L. Bryant
BI-LO Charities Children's Cancer Center The BI-LO Charities Children
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30 Prospect Ave
Hackensack, New Jersey 07601
(201) 996-2000
Principal Investigator: Katharine Offer
Phone: 201-996-2879
Hackensack University Medical Center Hackensack University Medical Center, part of the Hackensack University Health Network,...
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2460 West Horizon Ridge Parkway
Henderson, Nevada 89052
Principal Investigator: Alan K. Ikeda
Phone: 702-822-2000
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Honolulu, Hawaii 96819
Principal Investigator: Wade T. Kyono
Phone: 808-432-5195
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888 S King St
Honolulu, Hawaii 96813
(808) 522-4000
Principal Investigator: Wade T. Kyono
Phone: 808-522-4333
Straub Clinic And Hospital Founded in 1921, Straub Clinic & Hospital is a fully integrated...
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1319 Punahou St
Honolulu, Hawaii 96826
(808) 983-6000
Principal Investigator: Wade T. Kyono
Phone: 808-983-6090
Kapiolani Medical Center for Women and Children Hawai‘i Pacific Health is an integrated health care...
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Houston, Texas 77030
Principal Investigator: Jodi Muscal
Phone: 713-798-1354
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705 Riley Hospital Dr
Indianapolis, Indiana 46202
(317) 944-5000
Principal Investigator: Kamnesh R. Pradhan
Phone: 800-248-1199
Riley Hospital for Children Riley Hospital for Children at IU Health is a place of...
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Indianapolis, Indiana 46260
Principal Investigator: Bassem I. Razzouk
Phone: 317-338-2194
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Iowa City, Iowa 52242
Principal Investigator: Mariko Sato
Phone: 800-237-1225
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Jacksonville, Florida 32207
Principal Investigator: Scott M. Bradfield
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Kansas City, Missouri 64108
Principal Investigator: Kevin F. Ginn
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2018 W Clinch Ave
Knoxville, Tennessee 37916
(865) 541-8000
Principal Investigator: Ray C. Pais
Phone: 865-541-8266
East Tennessee Children's Hospital East Tennessee Children's Hospital is a not-for-profit, private, independent pediatric medical...
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La Crosse, Wisconsin
Principal Investigator: Kenneth B. De Santes
Phone: 608-775-2385
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Las Vegas, Nevada 89144
Principal Investigator: Alan K. Ikeda
Phone: 702-384-0013
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Las Vegas, Nevada 89109
Principal Investigator: Alan K. Ikeda
Phone: 702-384-0013
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1 Medical Center Dr
Lebanon, New Hampshire 03756
 (603) 650-5000
Principal Investigator: Julie Kim
Phone: 800-639-6918
Dartmouth Hitchcock Medical Center Dartmouth-Hitchcock is a national leader in patient-centered health care and building...
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Lexington, Kentucky
Principal Investigator: Vlad C. Radulescu
Phone: 859-257-3379
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1 Children's Way
Little Rock, Arkansas 72202
(501) 364-1100
Principal Investigator: David L. Becton
Phone: 501-686-8274
Arkansas Children's Hospital Arkansas Children's Hospital (ACH) is the only pediatric medical center in Arkansas...
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11234 Anderson St
Loma Linda, California 92354
(909) 558-4000
Principal Investigator: Albert Kheradpour
Phone: 909-558-3375
Loma Linda University Medical Center An outgrowth of the original Sanitarium on the hill in...
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4733 Sunset Blvd
Los Angeles, California 90027
(800) 954-8000
Principal Investigator: Robert M. Cooper
Phone: 626-564-3455
Kaiser Permanente Los Angeles Medical Center We've been there for you in the past, providing...
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Louisville, Kentucky 40202
Principal Investigator: Kerry K. McGowan
Phone: 502-562-3429
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Madera, California 93638
Principal Investigator: Vonda L. Crouse
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600 Highland Ave
Madison, Wisconsin 53792
(608) 263-6400
Principal Investigator: Kenneth B. De Santes
Phone: 800-622-8922
University of Wisconsin Hospital and Clinics UW Health strives to meet the health needs of...
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Mattoon, Illinois 61938
Principal Investigator: James R. Egner
Phone: 800-446-5532
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Miami, Florida 33155
Principal Investigator: Enrique A. Escalon
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Miami, Florida 33136
Principal Investigator: Julio C. Barredo
Phone: 305-243-2647
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9000 W Wisconsin Ave #270
Milwaukee, Wisconsin 53226
(414) 266-2000
Principal Investigator: Michael J. Burke
Phone: 414-955-4727
Children's Hospital of Wisconsin Nothing matters more than our children. At Children's Hospital of Wisconsin,...
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259 1st Street
Mineola, New York 11501
Principal Investigator: Mark E. Weinblatt
Phone: 866-946-8476
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Minneapolis, Minnesota 55455
Principal Investigator: Emily G. Greengard
Phone: 612-624-2620
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2525 Chicago Ave
Minneapolis, Minnesota 55404
(612) 813-6000
Principal Investigator: Michael K. Richards
Children's Hospitals and Clinics of Minnesota - Minneapolis Children's Hospitals and Clinics of Minnesota is...
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Morristown, New Jersey 07962
Principal Investigator: Steven L. Halpern
Phone: 973-971-5900
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Nashville, Tennessee 37203
Principal Investigator: Haydar A. Frangoul
Phone: 800-811-8480
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New Brunswick, New Jersey 08903
Principal Investigator: Jocelyn A. Lewis
Phone: 732-235-8675
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New Haven, Connecticut 6520
(203) 432-4771
Principal Investigator: Nina S. Kadan-Lottick
Phone: 203-785-5702
Yale University Yale's roots can be traced back to the 1640s, when colonial clergymen led...
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