Collecting and Storing Biological Samples From Young Patients With Hodgkin?s Lymphoma



Status:Active, not recruiting
Conditions:Lymphoma
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any
Updated:9/13/2018
Start Date:October 23, 2006

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Hodgkin Disease (HD) Banking Study

This laboratory study is collecting and storing samples of tissue and blood from young
patients with Hodgkin's lymphoma. Collecting and storing samples of tumor tissue and blood
from patients with cancer to study in the laboratory may help the study of cancer in the
future.

OBJECTIVES:

I. Establish a biologic specimen repository (of tumor tissue, tissue arrays, lymphoblastoid
cell lines, host DNA, tumor and host RNA, serum, and plasma) and database linked to clinical
features and outcomes from well-characterized cohorts of children and young adults with
Hodgkin's lymphoma.

II. Provide specimens from diagnosis, early response evaluation, completion of chemotherapy
and radiotherapy, long-term follow up, and relapse to study prognostic factors for early
response, relapse, long-term outcomes, and identification of new biological targets for
therapy.

OUTLINE: This is a multicenter study.

Patients enrolled on Hodgkin's lymphoma (HL) therapeutic clinical trials undergo collection
of tumor tissue samples at baseline and at relapse or disease progression. Serum and
anticoagulated peripheral blood samples are collected at baseline, at week 1, on day 1 of
course 2, after completion of chemotherapy, after completion of radiotherapy, at 1 year after
diagnosis, and at relapse or disease progression.

Patients with relapsed or progressive disease who plan to enroll on HL relapse/retrieval
clinical trials undergo collection of tumor tissue, serum, and anticoagulated peripheral
blood samples at relapse or disease progression.

Patients enrolled more than 1 year after completion of treatment undergo collection of tumor
specimens, serum, and anticoagulated peripheral blood samples at time of clinical evaluation.

Inclusion Criteria:

- Histologically confirmed Hodgkin's lymphoma (HL) meeting 1 of the following criteria:

- Newly diagnosed, untreated HL (for patients under 22 years of age)

- Past or present diagnosis of HL and past or present enrollment on a Children's
Oncology Group (COG) or legacy HL clinical trial (for patients of any age)
We found this trial at
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254 Easton Ave
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4900 Mueller Boulevard
Austin, Texas 78723
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2545 Schoenersville Rd
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1600 7th Avenue
Birmingham, Alabama 35233
(205) 638-9100
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666 Elm Street
Buffalo, New York 14263
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1 South Prospect Street
Burlington, Vermont 05401
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3333 Burnet Avenue # Mlc3008
Cincinnati, Ohio 45229
 1-513-636-4200 
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60 Crittenden Blvd # 70
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40 Sunshine Cottage Road
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1600 Rockland Road
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