Collecting and Storing Samples of Blood and Tumor Tissue From Patients With Osteosarcoma



Status:Active, not recruiting
Conditions:Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any
Updated:8/9/2018
Start Date:February 4, 2008

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A Children?s Oncology Group Protocol for Collecting and Banking Osteosarcoma Specimens

The purpose of this study is to collect and store samples of blood and tumor tissue from
patients with osteosarcoma. Collecting and storing samples of tumor tissue and blood from
patients to test in the laboratory may help the study of cancer in the future.

OBJECTIVES:

I. To collect biological specimens from patients with osteosarcoma at Children?s Oncology
Group (COG) institutions.

II. To provide a repository for long-term storage of osteosarcoma-related biological
materials.

III. To make these specimens available to qualified researchers to understand the biology of
osteosarcoma and correlate these results with the patients' clinical data.

OUTLINE:

After the initial submission of blood samples, patients may undergo open or closed biopsy in
order to obtain fresh and frozen tissue samples as well as paraffin embedded material.
Patients who are enrolled at the time of initial diagnosis but then have a definitive surgery
or develop recurrent disease may submit additional samples (paraffin block, frozen and fresh
tumor tissue, or slides together with blood samples). Autopsy tumor samples may also be
submitted.

Inclusion Criteria:

- All osteosarcoma patients seen at COG institutions are eligible, including the
following:

- Newly diagnosed patients

- Patients with recurrent disease who were not enrolled at the time of diagnosis

- The following specimens from the initial biopsy (and/or definitive surgery if an
up-front resection is performed) are required:

- Paraffin embedded block OR 30 unstained slides

- Pretreatment blood consisting of 5 mL serum, 10 mL plasma, and 10 mL heparinized
whole blood

- Fresh and frozen tumor specimens

- Patients are not required to enter a therapeutic study to enroll on this study
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1201 Camino de Salud Northeast
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