Brentuximab Vedotin and Combination Chemotherapy in Treating Children and Young Adults With Stage IIB or Stage IIIB-IVB Hodgkin Lymphoma



Status:Recruiting
Conditions:Lymphoma, Lymphoma
Therapuetic Areas:Oncology
Healthy:No
Age Range:2 - 22
Updated:3/31/2019
Start Date:March 16, 2015

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A Randomized Phase 3 Study of Brentuximab Vedotin (SGN-35) for Newly Diagnosed High-Risk Classical Hodgkin Lymphoma (cHL) in Children and Young Adults

This randomized phase III trial studies brentuximab vedotin and combination chemotherapy to
see how well they work compared to combination chemotherapy alone in treating children and
young adults with stage IIB or stage IIIB-IVB Hodgkin lymphoma. Combinations of biological
substances in brentuximab vedotin may be able to carry cancer-killing substances directly to
Hodgkin lymphoma cells. Drugs used in chemotherapy, such as doxorubicin hydrochloride,
bleomycin sulfate, vincristine sulfate, etoposide, prednisone, and cyclophosphamide, work in
different ways to stop the growth of cancer cells, either by killing the cells, by stopping
them from dividing, or by stopping them from spreading. It is not yet known if combination
chemotherapy is more effective with or without brentuximab vedotin in treating Hodgkin
lymphoma.

PRIMARY OBJECTIVES:

I. To assess the event free survival (EFS) of a novel regimen incorporating brentuximab
vedotin (Bv; Adcetris) in the chemotherapy backbone of doxorubicin (Adriamycin) (doxorubicin
hydrochloride), vincristine (vincristine sulfate), etoposide, prednisone and cyclophosphamide
(Bv-AVEPC) in newly diagnosed high-risk classical Hodgkin lymphoma (cHL) compared to those
treated with Adriamycin, bleomycin sulfate, vincristine sulfate, etoposide, prednisone, and
cyclophosphamide (ABVE-PC).

SECONDARY OBJECTIVES:

I. To determine whether children/young adults with high-risk cHL treated with Bv-AVEPC have a
higher rate of early response (determined by fludeoxyglucose F 18 [FDG]-positron emission
tomography [PET]) and a reduction in protocol directed radiation therapy (RT) compared to
those treated with ABVE-PC.

II. To compare the rate of neuropathy (>= grade 3) among patients treated on the Bv-AVEPC
(experimental arm) to patients treated on the ABVE-PC (standard arm).

TERTIARY OBJECTIVES:

I. To validate and compare the Childhood Hodgkin International Prognostic Score (CHIPS) to
conventional Ann Arbor stage (stages II B with bulk, III B, IV A or B) in predicting outcome
in high-risk childhood cHL.

II. To determine the incidence of preferentially expressed antigen in melanoma (PRAME) and
testis-specific antigens in Epstein-Barr virus (EBV)- cHL tumors and the incidence of EBV
antigens (Epstein-Barr nuclear antigen 1 [EBNA1], Epstein-Barr virus latent membrane protein
1 [LMP1], large multifunctional peptidase 2 [LMP2]) in EBV+ cHL tumors, with the goal of
developing strategies to integrate cellular therapy into treatment for newly diagnosed
high-risk cHL. (Biology) III. To incorporate qualitative visual FDG-PET into
response-directed treatment algorithms and explore quantitative FDG-PET and computed
tomography (CT) definitions of tumor burden and response for incorporation into next
generation pediatric cHL risk-stratification schemes, exploring the extension of these
algorithms to young adults. (Imaging) IV. To evaluate the reduction in normal tissue
irradiation associated with the current treatment approach compared to the volume of historic
involved field radiation therapy (IFRT) fields. (Radiation Therapy) V. To evaluate EFS and
patterns of relapse following protocol-specified RT utilization and treatment volumes.
(Radiation Therapy) VI. To characterize the extent of chemotherapy induced peripheral
neuropathy (CIPN), as reported by patients and parent proxies, through serial administration
of the Functional Assessment of Cancer Therapy-Gynecologic Oncology Group-Neurotoxicity
(FACT-GOG-NTX). (Patient Reported Outcomes [PRO] of Peripheral Neuropathy and Health-Related
Quality of Life) VII. To describe the Health-Related Quality of Life (HRQL) consequences of
peripheral neuropathy over time by correlating total neuropathy scale scores with the
individual items with the Child Health Ratings Inventories (CHRIs)-Global scale (e.g.,
physical health, pain, emotional functioning). (PRO of Peripheral Neuropathy and
Health-Related Quality of Life) VIII. To perform a cross validation of the FACT-GOG-NTX with
the Total Neuropathy Score-Pediatric Vincristine (TNS-PV) to determine the performance of
both measures with the use of brentuximab vedotin in a limited institutional approach in
children and adolescents with cHL. (PRO of Peripheral Neuropathy and Health-Related Quality
of Life) IX. To assess the resource use and cost implications of Bv in combination with
chemotherapy and radiotherapy (RT) for newly diagnosed high-risk cHL in children and young
adults. (Economic) X. To estimate the risk of relapse among rapidly responding lesions (RRL)
subjects that have at least one lesion that is Deauville 3 at PET 2. (Follow-up of Deauville
score 3 lesions on FDG-PET imaging [confirmed by central imaging review]) XI. To characterize
the pharmacokinetics of brentuximab vedotin in children < 13 years of age.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I (ABVE-PC): Patients receive doxorubicin hydrochloride intravenously (IV) over 1-15
minutes on days 1-2, bleomycin sulfate IV over 10 minutes or subcutaneously (SC) on days 1
and 8, vincristine sulfate IV over 1 minute on days 1 and 8, etoposide IV over 60-120 minutes
on days 1-3, prednisone orally (PO) twice daily (BID) on days 1-7, and cyclophosphamide IV
over 30-60 minutes on days 1 and 2.

ARM II (Bv-AVEPC): Patients receive brentuximab vedotin IV over 30 minutes on day 1. Patients
also receive doxorubicin hydrochloride, etoposide, prednisone, and cyclophosphamide as in Arm
I and vincristine sulfate IV over 1 minute on day 8.

In both arms, treatment repeats every 21 days for 5 courses in the absence of disease
progression or unacceptable toxicity.

After completion of study treatment, patients are followed up at 3, 6, 9, 12, 18, 24, 30, 36,
and 48 months.

Inclusion Criteria:

- Patients with newly diagnosed, pathologically confirmed cHL meeting one of the
following Ann Arbor stages are eligible:

- Stage IIB with bulk

- Stage IIIB

- Stage IVA

- Stage IVB

- If study eligibility by staging is uncertain, consultation with Imaging and
Radiation Oncology Core (IROC) Rhode Island (RI) may be obtained prior to
study enrollment

- Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70
mL/min/1.73 m^2 or a serum creatinine based on age/gender as follows:

- 2 to < 6 years: male 0.8 mg/dL, female 0.8 mg/dL

- 6 to < 10 years: male 1 mg/dL, female 1 mg/dL

- 10 to < 13 years: male 1.2 mg/dL, female 1.2 mg/dL

- 13 to < 16 years: male 1.5 mg/dL, female 1.4 mg/dL

- >= 16 years: male 1.7 mg/dL, female 1.4 mg/dL

- Total bilirubin =< 1.5 x upper limit of normal (ULN) for age

- Serum glutamic oxaloacetic transaminase (SGOT) (aspartate transaminase [AST]) or serum
glutamate pyruvate transaminase (SGPT) (alanine transaminase [ALT]) < 2.5 x upper
limit of normal (ULN) for age

- Shortening fraction of >= 27% by echocardiogram, or ejection fraction of >= 50% by
radionuclide angiogram

- Forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) > 60% by
pulmonary function test (PFT), unless due to large mediastinal mass from Hodgkin
lymphoma (HL)

- For children who are unable to cooperate for PFTs, the criteria are: no evidence of
dyspnea at rest, no exercise intolerance, and a pulse oximetry reading of > 92% on
room air

- All patients and/or their parents or legal guardians must sign a written informed
consent

- All institutional, Food and Drug Administration (FDA), and National Cancer Institute
(NCI) requirements for human studies must be met

Exclusion Criteria:

- Patients with nodular lymphocyte-predominant HL

- Patients with an immunodeficiency that existed prior to diagnosis, such as primary
immunodeficiency syndromes, organ transplant recipients and children on current
systemic immunosuppressive agents are not eligible

- Patients who are pregnant; (a negative pregnancy test is required for female patients
of childbearing potential)

- Lactating females who plan to breastfeed

- Sexually active patients of reproductive potential who have not agreed to use an
effective contraceptive method for the duration of their study participation and for
30 days after the last dose of chemotherapy

- Patients known to be positive for human immunodeficiency virus (HIV) are not eligible

- Patients who have received any previous chemotherapy or radiation therapy are not
eligible

- Patients who received systemic corticosteroids within 28 days of enrollment on this
protocol, except as specified, are not eligible
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Cleveland, Ohio 44106
(216) 444-2200
Principal Investigator: Rabi Hanna
Phone: 866-223-8100
Cleveland Clinic Foundation The Cleveland Clinic (formally known as The Cleveland Clinic Foundation) is a...
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Cleveland, OH
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Columbia, Missouri 65201
Principal Investigator: Barbara A. Gruner
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Columbia, MO
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5 Richland Medical Park Dr
Columbia, South Carolina 29203
(803) 434-7000
Principal Investigator: Stuart L. Cramer
Phone: 803-434-3680
Palmetto Health Richland Palmetto Health Richland, originally founded in 1892 as Columbia Hospital, has a...
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Dallas, Texas 75390
Principal Investigator: Martha M. Pacheco
Phone: 214-648-7097
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Dallas, TX
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100 North Academy Avenue
Danville, Pennsylvania 17822
570-271-6211
Principal Investigator: Jagadeesh Ramdas
Phone: 570-271-5251
Geisinger Medical Center Since 1915, Geisinger Medical Center has been known as the region’s resource...
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Danville, PA
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Dayton, Ohio 45404
Principal Investigator: Ayman A. El-Sheikh
Phone: 800-228-4055
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Dayton, OH
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Denver, Colorado 80218
Principal Investigator: Jennifer J. Clark
Phone: 866-775-6246
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Denver, CO
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4160 John R St #2122
Detroit, Michigan 48201
(313) 833-1785
Principal Investigator: Sureyya Savasan
Phone: 313-576-9790
Wayne State University/Karmanos Cancer Institute Karmanos is based in southeast Michigan, in midtown Detroit, and...
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Detroit, Michigan 48236
Principal Investigator: Adonis N. Lorenzana
Phone: 734-712-3671
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Detroit, MI
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9333 Imperial Highway
Downey, California 90242
Principal Investigator: Robert M. Cooper
Phone: 510-891-3400
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Downey, CA
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2301 Erwin Rd
Durham, North Carolina 27710
919-684-8111
Principal Investigator: Susan G. Kreissman
Phone: 888-275-3853
Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
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Durham, NC
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East Lansing, Michigan 48824
Principal Investigator: Renuka Gera
Phone: 517-975-9547
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East Lansing, MI
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El Paso, Texas 79905
Principal Investigator: Lisa L. Hartman
Phone: 915-298-5444
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801 Broadway North
Fargo, North Dakota 58122
Principal Investigator: Samuel O. Anim
Phone: 701-323-5760
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Fargo, ND
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1600 S Andrews Ave
Fort Lauderdale, Florida 33316
(954) 355-4400
Principal Investigator: Hector M. Rodriguez-Cortes
Phone: 954-355-5346
Broward Health Medical Center Broward Health, providing service for more than 75 years, is a...
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Fort Myers, Florida 33908
Principal Investigator: Emad K. Salman
Phone: 877-680-0008
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Fort Myers, FL
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801 7th Avenue
Fort Worth, Texas 76104
(682) 885-4000
Principal Investigator: Kenneth M. Heym
Phone: 682-885-2103
Cook Children's Medical Center Cook Children's Health Care System is a not-for-profit, nationally recognized pediatric...
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Fort Worth, TX
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1600 Southwest Archer Road
Gainesville, Florida 32610
Principal Investigator: William B. Slayton
Phone: 352-273-8010
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Gainesville, FL
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835 S Van Buren St
Green Bay, Wisconsin 54301
Principal Investigator: Catherine A. Long
Phone: 920-433-8889
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Green Bay, WI
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1001 E 5th St
Greenville, North Carolina 27858
(252) 328-6131
Principal Investigator: Andrea R. Whitfield
Phone: 252-744-1015
East Carolina University Whether it's meeting the demand for more teachers and healthcare professionals or...
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900 West Faris Rd.
Greenville, South Carolina 29605
(864)455-8898
Principal Investigator: Nichole L. Bryant
Phone: 864-241-6251
BI-LO Charities Children's Cancer Center The BI-LO Charities Children
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30 Prospect Ave
Hackensack, New Jersey 07601
(201) 996-2000
Principal Investigator: Burton E. Appel
Phone: 201-996-2879
Hackensack University Medical Center Hackensack University Medical Center, part of the Hackensack University Health Network,...
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Hershey, Pennsylvania 17033
Principal Investigator: Lisa M. McGregor
Phone: 717-531-6012
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Hershey, PA
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Hollywood, Florida 33021
Principal Investigator: Iftikhar Hanif
Phone: 954-265-2234
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1319 Punahou St
Honolulu, Hawaii 96826
(808) 983-6000
Principal Investigator: Wade T. Kyono
Phone: 808-983-6090
Kapiolani Medical Center for Women and Children Hawai‘i Pacific Health is an integrated health care...
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Houston, Texas 77030
Principal Investigator: Cesar A. Nunez
Phone: 877-312-3961
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Houston, TX
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Houston, Texas 77030
Principal Investigator: Rayne H. Rouce
Phone: 713-798-1354
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705 Riley Hospital Dr
Indianapolis, Indiana 46202
(317) 944-5000
Principal Investigator: Kamnesh R. Pradhan
Phone: 800-248-1199
Riley Hospital for Children Riley Hospital for Children at IU Health is a place of...
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Indianapolis, IN
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Indianapolis, Indiana 46260
Principal Investigator: Bassem I. Razzouk
Phone: 317-338-2194
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Iowa City, Iowa 52242
Principal Investigator: Mariko Sato
Phone: 800-237-1225
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Jacksonville, Florida 32207
Principal Investigator: Ramamoorthy Nagasubramanian
Phone: 407-650-7150
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Kansas City, Missouri 64108
Principal Investigator: Keith J. August
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2018 W Clinch Ave
Knoxville, Tennessee 37916
(865) 541-8000
Principal Investigator: Ray C. Pais
Phone: 865-541-8266
East Tennessee Children's Hospital East Tennessee Children's Hospital is a not-for-profit, private, independent pediatric medical...
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