Combination Chemotherapy Followed By Peripheral Stem Cell Transplant in Treating Young Patients With Newly Diagnosed Supratentorial Primitive Neuroectodermal Tumors or High-Risk Medulloblastoma



Status:Completed
Conditions:Brain Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any - 2
Updated:10/26/2018
Start Date:October 22, 2007
End Date:December 31, 2016

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A Phase III Randomized Trial for the Treatment of Newly Diagnosed Supratentorial PNET and High Risk Medulloblastoma in Children <36 Months Old With Intensive Induction Chemotherapy With Methotrexate Followed by Consolidation With Stem Cell Rescue Versus the Same Therapy Without Methotrexate

This randomized phase III trial is studying two different combination chemotherapy regimens
to compare how well they work when given before a peripheral stem cell transplant in treating
young patients with newly diagnosed supratentorial primitive neuroectodermal tumors or
high-risk medulloblastoma. Drugs used in chemotherapy work in different ways to stop the
growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving
more than one drug (combination chemotherapy) together with a peripheral stem cell transplant
may allow more chemotherapy to be given so that more tumor cells are killed. It is not yet
known which combination chemotherapy regimen is more effective when given before a peripheral
stem cell transplant in treating supratentorial primitive neuroectodermal tumors or
medulloblastoma.

PRIMARY OBJECTIVES:

I. Determine if treatment of pediatric patients with newly diagnosed supratentorial primitive
neuroectodermal CNS tumors or high-risk medulloblastoma with intensive induction chemotherapy
comprising vincristine, etoposide, cyclophosphamide, and cisplatin in combination with
high-dose methotrexate and leucovorin calcium followed by consolidation chemotherapy
comprising carboplatin and thiotepa and peripheral blood stem cell rescue results in a higher
complete response rate then in patients treated with the same regimen without high-dose
methotrexate and leucovorin calcium.

SECONDARY OBJECTIVES:

I. Determine whether biologic characterization of these tumors will refine therapeutic
stratification separating atypical teratoid rhabdoid tumors from primitive neuroectodermal
tumors (PNETs) and possibly identifying other markers of value for stratification within the
group of PNETs.

II. Compare event-free survival and patterns of failure in patients treated with these
regimens.

III. Compare the acute, chronic, and late effects of these regimens, particularly in terms of
tolerance to the same consolidation regimen after treatment with 2 different induction
regimens, in these patients.

IV. Compare the gastrointestinal and nutritional toxicities of these regimens in these
patients.

V. Compare the quality of life outcomes in patients treated with these regimens.

VI. Compare the neuropsychological effects of these regimens in these patients.

OUTLINE: This is a randomized, multicenter study. Patients are stratified according to
diagnosis* (M0 medulloblastoma with ≥ 1.5 cm² residual tumor vs M1 medulloblastoma [positive
lumbar CSF cytology] vs M2, M3, or M4 medulloblastoma vs supratentorial PNET [any M-stage] vs
M0 medulloblastoma < 8 months without residual disease or with < 1.5 cm² radiographic
measurable residual tumor vs anaplastic M0 medulloblastoma without residual disease or with <
1.5 cm² radiographic measurable residual vs classic M0 (nondesmoplastic) medulloblastoma with
< 1.5 cm² radiographic measurable residual tumor).

NOTE: *All diagnoses are for children < 36 months unless otherwise noted.

INDUCTION THERAPY: Patients are randomized to 1 of 2 induction treatment arms.

ARM I: Patients receive vincristine IV on days 1, 8, and 15; etoposide IV over 1 hour on days
1-3; cyclophosphamide IV over 1 hour on days 1 and 2; cisplatin IV over 6 hours on day 3; and
filgrastim (G-CSF) IV or subcutaneously (SC) beginning on day 4 and continuing until blood
counts recover. Treatment repeats every 3 weeks for 3 courses in the absence of disease
progression or unacceptable toxicity.

ARM II: Patients receive vincristine IV on days 1, 8, and 15; high-dose methotrexate IV over
4 hours on day 1; and leucovorin calcium IV or orally every 6 hours beginning on day 2 and
continuing until methotrexate levels are in a safe range. Once methotrexate levels are in a
safe range, patients then receive etoposide IV over 1 hour on approximately days 4, 5, and 6,
cyclophosphamide IV over 1 hour on approximately days 4 and 5, and cisplatin IV over 6 hours
on approximately day 6. Patients also receive G-CSF IV or SC beginning 24 hours after the
completion of chemotherapy and continuing until blood counts recover. Treatment repeats every
3 weeks for 3 courses in the absence of disease progression or unacceptable toxicity.

In both arms, patients with stable disease or partial response after induction therapy
proceed to second-look surgery followed by consolidation therapy. Patients with a complete
response after induction therapy proceed directly to consolidation therapy.

CONSOLIDATION THERAPY: Beginning no more than 6 weeks after completion of induction therapy,
patients receive consolidation therapy comprising carboplatin IV over 2 hours and thiotepa IV
over 2 hours on days 1 and 2 and G-CSF IV or SC beginning on day 54 and continuing until
blood counts recover. Patients also receive autologous peripheral blood stem cells (PBSC) IV
on day 4. Treatment repeats every 3 weeks for 3 courses in the absence of disease progression
or unacceptable toxicity.

Blood and tissue samples are collected at baseline for correlative studies, including gene
expression profiling, biological marker analysis (i.e., cMyc, ErbB2/ErbB4), comparative
genome analysis, and mutation analysis.

After completion of study therapy, patients are followed up periodically for 4 years and then
annually thereafter.

Inclusion Criteria:

- Diagnosis of 1 of the following:

- High-risk medulloblastoma defined by any of the following:

- Residual disease > 1.5 cm²

- Lumbar cerebral spinal fluid cytology positive for tumor cells by analysis
of fluid collected either before definitive surgery or ≥ 10 days after
definitive surgery unless contraindicated

- M0 disease in children < 8 months of age at diagnosis

- M2 or M3 metastatic disease by MRI

- M4 disease

- Supratentorial primitive neuroectodermal tumor (PNET)(any M-stage)

- Anaplastic medulloblastoma regardless of M-stage or residual tumor

- M0 classic, non-desmoplastic medulloblastoma (R1) with radiographically
measurable residual disease < 1.5 cm^2

- MRI evidence of spinal disease

- Tumor must be negative for INI1 gene

- Has undergone definitive surgery within the past 31 days

- No atypical teratoid rhabdoid tumors

- Biological specimens must be available for correlative laboratory studies

- Life expectancy > 8 weeks

- Creatinine clearance or radioisotope glomerular filtration rate ≥ 60 mL/min

- Bilirubin ≤ 1.5 times upper limit of normal (ULN)

- AST and ALT < 2 times ULN

- Shortening fraction ≥ 27% by echocardiogram

- Ejection fraction ≥ 47% by radionuclide angiogram

- No evidence of dyspnea at rest

- Pulse oximetry > 94% on room air

- Absolute neutrophil count > 1,000/mm³

- Platelet count > 100,000/mm³ (transfusion independent)

- Hemoglobin > 8 g/dL (RBC transfusions allowed)

- Prior corticosteroids allowed

- No prior radiation therapy or chemotherapy
We found this trial at
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85 S Prospect St
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1000 Blythe Blvd
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3333 Burnet Avenue # Mlc3008
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601 E Rollins St
Orlando, Florida 32803
(407) 303-5600
Florida Hospital Florida Hospital is one of the country
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Orlando, Florida 32806
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703 Main Street
Paterson, New Jersey 07503
973.754.2000
Saint Joseph's Regional Medical Center Rich in history, St. Joseph's Healthcare System has evolved from...
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Paterson, NJ
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3601 A St
Philadelphia, Pennsylvania 19134
(215) 427-5000
Saint Christopher's Hospital for Children St. Christopher's Hospital for Children offers a wide range of...
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Philadelphia, PA
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1919 E Thomas Rd
Phoenix, Arizona 85006
(602) 933-1000
Phoenix Children's Hospital Phoenix Children's Hospital has provided hope, healing, and the best healthcare for...
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2801 N Gantenbein Ave
Portland, Oregon 97227
(503) 276-6500
Legacy Emanuel Children's Hospital For generations our children's hospital has provided outstanding care for kids...
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Portland, OR
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2801 N Gantenbein Ave
Portland, Oregon 97227
(503) 413-2200
Legacy Emanuel Hospital and Health Center Legacy Emanuel is nationally known for expertise in critical...
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Portland, OR
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Randwick, New South Wales 2031
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