Sorafenib Tosylate in Treating Younger Patients With Relapsed or Refractory Rhabdomyosarcoma, Wilms Tumor, Liver Cancer, or Thyroid Cancer



Status:Completed
Conditions:Liver Cancer, Cancer, Cancer, Cancer, Cancer, Endocrine
Therapuetic Areas:Endocrinology, Oncology
Healthy:No
Age Range:2 - 30
Updated:6/27/2018
Start Date:January 2012
End Date:June 2014

Use our guide to learn which trials are right for you!

A Phase II Study of the Raf Kinase and Receptor Tyrosine Kinase Inhibitor Sorafenib in Children and Young Adults With Relapsed/Refractory Rhabdomyosarcoma, Wilms Tumor, Hepatocellular Carcinoma, and Papillary Thyroid Carcinoma

This phase II trial studies how well sorafenib tosylate works in treating younger patients
with relapsed or refractory rhabdomyosarcoma, Wilms tumor, liver cancer, or thyroid cancer.
Sorafenib tosylate may stop the growth of cancer cells by blocking some of the enzymes needed
for cell growth.

PRIMARY OBJECTIVES:

I. To determine the objective response rate to sorafenib tosylate (sorafenib) in children
with relapsed or refractory rhabdomyosarcoma, Wilms tumor, hepatocellular carcinoma (HCC), or
papillary thyroid carcinoma (PTC).

SECONDARY OBJECTIVES:

I. To further define and describe the toxicities of sorafenib administered on an oral,
twice-daily continuous schedule.

II. To further characterize the pharmacokinetics of sorafenib in children with refractory
cancer.

III. To estimate the progression-free survival on sorafenib for rhabdomyosarcoma, Wilms
tumor, and hepatocellular carcinoma and compare to a group of patients enrolled on selected
closed Phase II studies of Children Oncology Group (COG).

IV. To assess the biologic activity of sorafenib on vascular endothelial growth factor (VEGF)
and soluble vascular endothelial growth factor receptor-2 (VEGFR-2) in peripheral blood
samples. (Exploratory) V. To evaluate the presence of BRAF mutations and RET/PTC
rearrangements in patients with PTC. (Exploratory)

OUTLINE: This is a multicenter study. Patients are stratified according to diagnosis
(rhabdomyosarcoma vs Wilms tumor vs hepatocellular carcinoma vs papillary thyroid carcinoma).

Patients receive sorafenib tosylate orally (PO) twice daily (BID) on days 1-28. Treatment
repeats every 28 days for up to 24 courses in the absence of disease progression or
unacceptable toxicity.

Patients undergo blood sample collection at baseline and periodically during study for
pharmacokinetic studies, and VEGF and VEGFR-2 analysis by ELISA. Previously collected
formalin-fixed paraffin-embedded tissue samples, from patients with papillary thyroid
carcinoma, are also analyzed for BRAF mutation and RET/PTC rearrangements by PCR.

After completion of study treatment, patients are followed up for up to 5 years.

Inclusion Criteria:

- Patients must have had histologic verification of one of the malignancies listed below
at original diagnosis or at relapse:

- Rhabdomyosarcoma (RMS)

- Wilms tumor

- Hepatocellular carcinoma (HCC)

- Papillary thyroid carcinoma (PTC)

- Patients must have relapsed or refractory disease (RMS, Wilms tumor, HCC, PTC)

- Patients must have radiographically measurable disease; measurable disease is
defined as the presence of at least one lesion on magnetic resonance imaging
(MRI) or computed tomography (CT) scan that can be accurately measured with the
longest diameter a minimum of 10 mm in at least one dimension (CT scan slice
thickness no greater than 5 mm)

- The following do not qualify as measurable disease:

- Malignant fluid collections (e.g., ascites, pleural effusions)

- Bone marrow infiltration

- Lesions only detected by nuclear medicine studies (e.g., bone, gallium,
or positron emission tomography [PET] scans)

- Elevated tumor markers in plasma or cerebrospinal fluid(CSF)

- Previously radiated lesions that have not demonstrated clear
progression post radiation

- Leptomeningeal lesions that do not meet the requirements noted above

- Patients with HCC must be relapsed or refractory to conventional chemotherapy

- Patients with PTC must be refractory to radioactive iodine (RAI)

- Patient's current disease state must be one for which there is no known curative
therapy or therapy proven to prolong survival with an acceptable quality of life

- Patients with known metastasis to the brain will be excluded from trial participation
unless treated surgically or with radiotherapy and stable with no recurrent lesions
for at least 3 months

- Rhabdomyosarcoma and Wilms strata: patients must be ≥ 24 months and ≤ 30 years of age
at study enrollment

- Hepatocellular carcinoma (HCC): patients must be ≥ 24 months and < 18 years of age at
study enrollment

- Papillary thyroid carcinoma (PTC): patients must be ≥ 24 months and ≤ 21 years of age
at study enrollment

- Patients must have a Lansky or Karnofsky performance status score of ≥ 50%,
corresponding to ECOG categories 0, 1, or 2

- Use Karnofsky for patients > 16 years of age and Lansky for patients ≤ 16 years
of age

- Patients who are unable to walk because of paralysis, but who are up in a
wheelchair, will be considered ambulatory for the purpose of assessing the
performance score

- Peripheral absolute neutrophil count (ANC) ≥ 1,000/μL

- Platelet count ≥ 75,000/μL (transfusion independent, defined as not receiving platelet
transfusions within a 7-day period prior to enrollment)

- Hemoglobin 8.0 g/dL (may receive red blood cell[RBC] transfusions)

- Creatinine clearance or radioisotope glomerular filtration rate(GFR) 70 mL/min OR a
serum creatinine based on age/gender as follows:

- 0.8 mg/dL (2 to < 6 years of age)

- 1.0 mg/dL (6 to < 10 years of age)

- 1.2 mg/dL (10 to < 13 years of age)

- 1.5 mg/dL (male) or 1.4 mg/dL (female) (13 to < 16 years of age)

- 1.7 mg/dL (male) or 1.4 mg/dL (female) (≥ 16 years of age)

- Total bilirubin ≤ 1.5 times upper limit of normal (ULN) for age

- SGPT (ALT) ≤ 135 U/L (for the purpose of this study, the ULN for SGPT is 45 U/L)

- PT, PTT, and INR < 1.5 times ULN

- Normal serum lipase and amylase (per institutional normal values)

- No evidence of dyspnea at rest, no exercise intolerance, and a pulse oximetry > 94% if
there is clinical indication for determination

- A blood pressure (BP) ≤ the 95^th percentile for age, height, and gender; and not
receiving medication for treatment of hypertension

- Patients who are pregnant or breast-feeding are not eligible

- Negative pregnancy tests must be obtained in girls who are post-menarchal

- Males or females of reproductive potential may not participate unless they have agreed
to use an effective contraceptive method beginning at the signing of the informed
consent until at least 30 days after the last dose of the study drug

- Patients with clinical symptoms of hepatic encephalopathy or ascites are not eligible

- Patients who have an uncontrolled infection are not eligible

- Patients with evidence of bleeding diathesis are not eligible

- Patients with known Gilbert syndrome are not eligible

- Patients who, in the opinion of the investigator, may not be able to comply with the
safety-monitoring requirements of the study are not eligible

- No concurrent chemotherapy, radiation therapy, immunomodulating agents, or other
investigational agents

- Patients must have fully recovered from the acute toxic effects of all prior
chemotherapy, immunotherapy, or radiotherapy prior to entering this study

- Patients with solid tumors must not have received myelosuppressive chemotherapy within
3 weeks of enrollment onto this study (6 weeks if prior nitrosourea)

- At least 7 days must have elapsed since the completion of therapy with a growth factor
(at least 14 days must have elapsed after receiving pegfilgrastim)

- At least 7 days must have elapsed since completion of therapy with a biologic agent;

- For agents that have known adverse events occurring beyond 7 days after
administration, this period prior to enrollment must be extended beyond the time
during which adverse events are known to occur

- At least 3 half-lives must have elapsed since prior therapy that included a monoclonal
antibody

- At least 2 weeks must have elapsed since local palliative radiotherapy (XRT) (small
port); ≥ 3 months must have elapsed if prior craniospinal XRT was received, if ≥ 50%
of the pelvis was irradiated, or if TBI was received; ≥ 6 weeks must have elapsed if
other substantial bone marrow irradiation was given

- No evidence of active graft-vs-host disease and ≥ 2 months must have elapsed since
transplant (stem cell transplant or rescue without total-body irradiation)

- For patients with papillary thyroid carcinoma (PTC) only: ≥ 3 weeks from prior
radioiodine (RAI) treatment

- Patients requiring corticosteroids that have not been on a stable or decreasing dose
of corticosteroid for 7 days prior to enrollment are not eligible

- Patients who are currently receiving another investigational drug are not eligible

- Patients who are currently receiving other anti-cancer agents are not eligible

- Patients who are receiving cyclosporine, tacrolimus or other agents to prevent either
graft-versus-host disease post bone marrow transplant or organ rejection post
transplant are not eligible for this trial

- Patients who take cytochrome P450 enzyme-inducing anti-epileptic drugs (phenytoin,
carbamazepine, or phenobarbital), rifampin, grapefruit juice, or St. Johns wort will
not be eligible for the trial

- Patients who have received prior treatment with sorafenib are not eligible

- Patients must not be on therapeutic anti-coagulation;

- Prophylactic anticoagulation (i.e., low-dose warfarin) of venous or arterial
devices is allowed provided that the requirements for prothrombin time(PT),
partial thromboplastin time(PTT), and international normalized ratio(INR) are met
We found this trial at
84
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3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
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1201 Camino de Salud Northeast
Albuquerque, New Mexico 87131
(505) 272-4946
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1600 7th Avenue
Birmingham, Alabama 35233
(205) 638-9100
Children's Hospital of Alabama Children
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1720 2nd Ave S
Birmingham, Alabama 35233
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666 Elm Street
Buffalo, New York 14263
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1000 Blythe Blvd
Charlotte, North Carolina 28203
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5801 South Ellis Avenue
Chicago, Illinois 60637
 773.702.1234
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3333 Burnet Avenue # Mlc3008
Cincinnati, Ohio 45229
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11100 Euclid Avenue
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700 Childrens Drive
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3533 South Alameda Street
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7777 Forest Ln # C840
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282 Washington St
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60 Crittenden Blvd # 70
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3020 Childrens way
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1600 Rockland Road
Wilmington, Delaware 19803
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Alfred I. duPont Hospital for Children Nemours began more than 70 years ago with the...
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Knoxville, Tennessee 37916
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2450 Riverside Ave
Minneapolis, Minnesota 55454
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100 Madison Ave
Morristown, New Jersey 7960
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One Robert Wood Johnson Place
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630 W 168th St
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Orlando, Florida 32803
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327 W Calhoun Ave
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Summit, New Jersey 07902
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111 Michigan Ave NW
Washington, District of Columbia
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1 Medical Center Blvd
Winston-Salem, North Carolina 27157
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