Veliparib, Radiation Therapy, and Temozolomide in Treating Participants With Newly Diagnosed Malignant Glioma Without H3 K27M or BRAFV600E Mutations



Status:Recruiting
Conditions:Brain Cancer, Brain Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:3 - 25
Updated:4/6/2019
Start Date:October 31, 2018
End Date:October 29, 2024

Use our guide to learn which trials are right for you!

A Phase 2 Study of Veliparib (ABT-888) and Local Irradiation, Followed by Maintenance Veliparib and Temozolomide, in Patients With Newly Diagnosed High-Grade Glioma (HGG) Without H3 K27M or BRAFV600E Mutations

This phase II trial studies how well veliparib, radiation therapy, and temozolomide work in
treating participants with newly diagnosed malignant glioma without H3 K27M or BRAFV600E
mutations. Veliparib may stop the growth of tumor cells by blocking some of the enzymes
needed for cell growth. Radiation therapy uses high energy x-rays to kill tumor cells and
shrink tumors. Drugs used in chemotherapy, such as temozolomide, work in different ways to
stop the growth of tumor cells, either by killing the cells, by stopping them from dividing,
or by stopping them from spreading. Giving veliparib, radiation therapy, and temozolomide may
work better in treating participants with newly diagnosed malignant glioma without H3 K27M or
BRAFV600E mutations.

PRIMARY OBJECTIVES:

I. To determine whether veliparib (ABT-888), when added to radiotherapy (RT) and
temozolomide, is efficacious for the treatment of patients with newly-diagnosed high-grade
glioma (HGG) whose tumors' molecular profile are wild-type for H3 K27M, BRAFV600E, and
IDH1/2.

II. To determine whether veliparib (ABT-888), when added to RT and temozolomide, is
efficacious for the treatment of patients with newly-diagnosed HGG whose tumors' molecular
profile are wild-type for H3 K27M and BRAFV600E and harbor an IDH1/2 mutation.

SECONDARY OBJECTIVES:

I. To explore associations of genomic, transcriptomic, and/or epigenetic alterations of the
tumors with treatment response and outcome.

II. To explore the extent to which patients with BRCA1/2 gene alterations and other
deoxyribonucleic acid (DNA) damaged genes display tumor genomic features consistent with
homologous repair deficiency (HRD), including large scale state transitions (LSTs),
mutational signature 3, and an enrichment for deletions flanked by sequences of (micro)
homology.

III. To explore the burden of high, moderate, and low penetrant germline alterations in HRD
genes (such as BRCA1, BRCA2, PALB2, Fanconi complex genes, ATM, CHEK2, RAD51B/C/D), mis-match
repair genes (such as MLH1, MSH2, MSH6, PMS2, EPCAM), and energy metabolism genes (such as
SDHA, SDHB, SDHC, SDHAF2, SDHD, IDH1, IDH2, and FH).

IV. To explore constitutional imprinting abnormalities associated with EP300 and IGF2 in
peripheral blood from patients with HGGs.

OUTLINE:

CHEMORADIOTHERAPY PHASE: Participants receive veliparib orally (PO) twice daily (BID) and
undergo 30 daily fractions of radiation therapy 5 days per week for 6-7 weeks in the absence
of disease progression or unacceptable toxicity.

MAINTENANCE CHEMOTHERAPY: Beginning 4 weeks after chemoradiotherapy phase, participants
receive veliparib PO BID and temozolomide PO once daily (QD) on days 1-5. Treatment repeats
every 28 days for up to 10 courses in the absence of disease progression or unacceptable
toxicity.

Inclusion Criteria:

- Stratum 1 (IDH wild-type): Patients must be >= 3 years of age and =< 21 years of age
at the time of enrollment

- Stratum 2 (IDH mutant): Patients must be >= 3 years of age and =< 25 years of age at
the time of enrollment

- Patients must have eligibility confirmed by rapid central pathology and central
molecular screening reviews performed on APEC14B1:

- Newly-diagnosed high-grade glioma such as anaplastic astrocytoma or glioblastoma

- Negative results for H3 K27M by immunohistochemistry (IHC)

- Negative results for BRAFV600E mutation by next-generation sequencing (NGS)

- Patients must have histological verification of diagnosis. Patients with M+ disease
(defined as evidence of neuraxis dissemination) are not eligible. Cerebrospinal fluid
(CSF) cytology is not required but may be obtained if clinically indicated prior to
study enrollment. If cytology is positive, the patient would be considered to have
metastatic disease and would, therefore, be ineligible

- Pre-operative and post-operative brain magnetic resonance imaging (MRI) with and
without contrast must be obtained. The requirement for a post-operative MRI is waived
for patients who undergo biopsy only. A spine MRI is not required, but may be obtained
if clinically indicated. If the spine MRI is positive, the patient would be considered
to have M+ disease (defined as neuraxis dissemination) and would be ineligible

- Patients must have a performance status of >= 50 by Lansky or Karnofsky, corresponding
to Eastern Cooperative Oncology Group (ECOG) scores of 0, 1, or 2. Use Karnofsky for
patients > 16 years of age and Lansky for patients =< 16 years of age. Patients who
are unable to walk because of paralysis, but are up in a wheelchair will be considered
ambulatory for the purposes of assessing the performance score

- Peripheral absolute neutrophil count (ANC) >= 1,000/uL

- Platelet count >= 100,000/uL (transfusion independent)

- Hemoglobin >= 8.0 gm/dL (can be transfused)

- Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70
mL/min/1.73 m^2 OR a serum creatinine based on age/gender as follows:

- 3 to < 6 years: 0.8 (male and female) maximum serum creatinine (mg/dL)

- 6 to < 10 years: 1 (male and female) maximum serum creatinine (mg/dL)

- 10 to < 13 years: 1.2 (male and female) maximum serum creatinine (mg/dL)

- 13 to < 16 years: 1.5 (male), 1.4 (female) maximum serum creatinine (mg/dL)

- >= 16 years: 1.7 (male), 1.4 (female) maximum serum creatinine (mg/dL)

- Total bilirubin =< 1.5 x upper limit of normal (ULN) for age

- Serum glutamic-oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) or
serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) < 2.5 x
upper limit of normal (ULN) for age

- Patients with seizure disorder may be enrolled if seizures are well-controlled (i.e.,
patients must not have required rescue medications for uncontrolled seizures within 14
days prior to enrollment)

- Patients must be enrolled and protocol therapy must be projected to begin no later
than 31 days after definitive diagnostic surgery (Day 0)

- All patients and/or their parents or legal guardians must sign a written informed
consent

- All institutional, Food and Drug Administration (FDA), and National Cancer Institute
(NCI) requirements for human studies must be met

Exclusion Criteria:

- Patients with the following histologies:

- Diffuse astrocytoma (grade 2)

- Oligodendrogliomas (any grade)

- Pleomorphic xanthoastrocytoma (PXA, any grade)

- Patients with primary tumor location of brainstem or spinal cord

- Patients with M+ disease (defined as neuraxis dissemination either by imaging or by
cytology)

- Patients must not have received any prior tumor-directed therapy including radiation
therapy, chemotherapy (tumor-directed therapy), molecularly targeted agents, or
immunotherapy for the treatment of HGG other than surgical intervention

- Lumbar CSF cytology is not required, but may be performed if clinically indicated
prior to study enrollment. If lumbar CSF cytology is positive, the patient is
considered to have M+ disease and is ineligible

- Note: False positive cytology can occur within 10 days of surgery

- Patients with gliomatosis cerebri type 1 or 2

- Patients who are not able to receive protocol specified radiation therapy

- Patients must not be currently receiving other anti-cancer agents

- Patients with known constitutional mismatch repair deficiency syndrome
(CMMR-D)/biallelic mismatch repair deficiency (bMMRD)

- Female patients who are pregnant are ineligible due to risks of fetal and teratogenic
adverse events as seen in animal/human studies

- Lactating females are not eligible unless they have agreed not to breastfeed their
infants

- Female patients of childbearing potential are not eligible unless a negative pregnancy
test result has been obtained

- Sexually active patients of reproductive potential are not eligible unless they have
agreed to use an effective contraceptive method for the duration of their study
participation and for 4 months after the last dose of veliparib
We found this trial at
90
sites
801 7th Avenue
Fort Worth, Texas 76104
(682) 885-4000
Principal Investigator: Jeffrey C. Murray
Cook Children's Medical Center Cook Children's Health Care System is a not-for-profit, nationally recognized pediatric...
?
mi
from
Fort Worth, TX
Click here to add this to my saved trials
4900 Mueller Boulevard
Austin, Texas 78723
(512) 324-0000
Principal Investigator: Amy C. Fowler
Dell Children's Medical Center of Central Texas Welcome to Dell Children
?
mi
from
Austin, TX
Click here to add this to my saved trials
1600 7th Avenue
Birmingham, Alabama 35233
(205) 638-9100
Principal Investigator: Matthew A. Kutny
Children's Hospital of Alabama Children
?
mi
from
Birmingham, AL
Click here to add this to my saved trials
666 Elm Street
Buffalo, New York 14263
(716) 845-2300
Principal Investigator: Clare J. Twist
Phone: 800-767-9355
Roswell Park Cancer Institute Welcome to Roswell Park Cancer Institute (RPCI), America's first cancer center...
?
mi
from
Buffalo, NY
Click here to add this to my saved trials
3333 Burnet Avenue # Mlc3008
Cincinnati, Ohio 45229
 1-513-636-4200 
Principal Investigator: Maryam Fouladi
Cincinnati Children's Hospital Medical Center Patients and families from across the region and around the...
?
mi
from
Cincinnati, OH
Click here to add this to my saved trials
7777 Forest Ln # C840
Dallas, Texas 75230
(972) 566-7000
Principal Investigator: Stanton C. Goldman
Phone: 972-566-5588
Medical City Dallas Hospital If you have concerns for your health, that of a family...
?
mi
from
Dallas, TX
Click here to add this to my saved trials
282 Washington St
Hartford, Connecticut 06106
(860) 545-9000
Principal Investigator: Michael S. Isakoff
Connecticut Children's Medical Center Connecticut Children’s Medical Center is a nationally recognized, 187-bed not-for-profit children’s...
?
mi
from
Hartford, CT
Click here to add this to my saved trials
2500 N State St
Jackson, Mississippi 39216
(601) 984-1000
Principal Investigator: Anderson (Andy) B. Collier
Phone: 601-815-6700
University of Mississippi Medical Center The University of Mississippi Medical Center, located in Jackson, is...
?
mi
from
Jackson, MS
Click here to add this to my saved trials
1800 West Charleston Boulevard
Las Vegas, Nevada 89102
(702) 383-2000
Principal Investigator: Alan K. Ikeda
Phone: 702-384-0013
University Medical Center of Southern Nevada University Medical Center is dedicated to providing the highest...
?
mi
from
Las Vegas, NV
Click here to add this to my saved trials
4650 Sunset Blvd
Los Angeles, California 90027
 (323) 660-2450
Principal Investigator: Girish Dhall
Childrens Hospital Los Angeles Children's Hospital Los Angeles is a 501(c)(3) nonprofit hospital for pediatric...
?
mi
from
Los Angeles, CA
Click here to add this to my saved trials
262 Danny Thomas Pl
Memphis, Tennessee 38105
(901) 495-3300
Principal Investigator: Kellie B. Haworth
St. Jude Children's Research Hospital St. Jude is unlike any other pediatric treatment and research...
?
mi
from
Memphis, TN
Click here to add this to my saved trials
601 Children's Lane
Norfolk, Virginia 23507
(757) 668-7000
Principal Investigator: Eric J. Lowe
Children's Hospital of The King's Daughters Children
?
mi
from
Norfolk, VA
Click here to add this to my saved trials
1201 W La Veta Ave
Orange, California 92868
(714) 997-3000
Principal Investigator: Elyssa M. Rubin
Children's Hospital of Orange County For more than 45 years, CHOC Children’s has been steadfastly...
?
mi
from
Orange, CA
Click here to add this to my saved trials
South 34th Street
Philadelphia, Pennsylvania 19104
 215-590-1000
Principal Investigator: Jane E. Minturn
Children's Hospital of Philadelphia Since its start in 1855 as the nation's first hospital devoted...
?
mi
from
Philadelphia, PA
Click here to add this to my saved trials
4401 Penn Avenue
Pittsburgh, Pennsylvania 15224
412-692-5325
Principal Investigator: James T. Felker
Children's Hospital of Pittsburgh of UPMC UPMC is one of the leading nonprofit health systems...
?
mi
from
Pittsburgh, PA
Click here to add this to my saved trials
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
Principal Investigator: Kellie J. Nazemi
Phone: 503-494-1080
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
?
mi
from
Portland, OR
Click here to add this to my saved trials
620 John Paul Jones Cir
Portsmouth, Virginia 23708
(757) 953-5008
Principal Investigator: Bethany M. Mikles
Phone: 757-953-5939
Naval Medical Center - Portsmouth Naval Medical Center Portsmouth, Virginia has proudly served the military...
?
mi
from
Portsmouth, VA
Click here to add this to my saved trials
593 Eddy Street
Providence, Rhode Island 02903
401-444-4000
Principal Investigator: Jennifer J. Greene Welch
Phone: 401-444-1488
Rhode Island Hospital Founded in 1863, Rhode Island Hospital in Providence, RI, is a private,...
?
mi
from
Providence, RI
Click here to add this to my saved trials
60 Crittenden Blvd # 70
Rochester, New York 14642
(585) 275-2121
Principal Investigator: Angela R. Girvin
Phone: 585-275-5830
University of Rochester The University of Rochester is one of the country's top-tier research universities....
?
mi
from
Rochester, NY
Click here to add this to my saved trials
4502 Medical Drive
San Antonio, Texas 78284
(210) 567-7000
Principal Investigator: Anne-Marie R. Langevin
Phone: 210-450-3800
University of Texas Health Science Center at San Antonio The University of Texas Health Science...
?
mi
from
San Antonio, TX
Click here to add this to my saved trials
Akron, Ohio 44308
Principal Investigator: Steven J. Kuerbitz
?
mi
from
Akron, OH
Click here to add this to my saved trials
Albany, New York 12208
Principal Investigator: Kenneth G. Lucas
Phone: 518-262-5513
?
mi
from
Albany, NY
Click here to add this to my saved trials
1540 East Hospital Drive
Ann Arbor, Michigan 48109
(877) 475-6688
Principal Investigator: Carl J. Koschmann
C S Mott Children's Hospital Behind the doors of C.S. Mott Children's Hospital there exist...
?
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
Atlanta, Georgia 30322
Principal Investigator: Tobey J. MacDonald
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
401 North Broadway
Baltimore, Maryland 21287
410-955-5000
Principal Investigator: Kenneth J. Cohen
Phone: 410-955-8804
Johns Hopkins University-Sidney Kimmel Cancer Center The name Johns Hopkins has become synonymous with excellence...
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
55 Fruit St
Boston, Massachusetts 02114
(617) 724-4000
Principal Investigator: Susan N. Chi
Phone: 877-726-5130
Massachusetts General Hospital Cancer Center An integral part of one of the world
?
mi
from
Boston, MA
Click here to add this to my saved trials
450 Brookline Ave
Boston, Massachusetts 2215
617-632-3000
Principal Investigator: Susan N. Chi
Phone: 877-442-3324
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
?
mi
from
Boston, MA
Click here to add this to my saved trials
Chapel Hill, North Carolina 27599
Principal Investigator: Stuart H. Gold
Phone: 877-668-0683
?
mi
from
Chapel Hill, NC
Click here to add this to my saved trials
1200 West Harrison Stree
Chicago, Illinois 60607
(312) 996-4350
Principal Investigator: Mary L. Schmidt
Phone: 312-355-3046
Univ of Illinois A major research university in the heart of one of the world's...
?
mi
from
Chicago, IL
Click here to add this to my saved trials
5841 S Maryland Ave
Chicago, Illinois 60637
1-773-702-6180
Principal Investigator: Wendy S. Darlington
Phone: 773-702-8222
University of Chicago Comprehensive Cancer Center The University of Chicago Comprehensive Cancer Center (UCCCC) is...
?
mi
from
Chicago, IL
Click here to add this to my saved trials
2049 E 100th St
Cleveland, Ohio 44106
(216) 444-2200
Principal Investigator: Rabi Hanna
Phone: 866-223-8100
Cleveland Clinic Foundation The Cleveland Clinic (formally known as The Cleveland Clinic Foundation) is a...
?
mi
from
Cleveland, OH
Click here to add this to my saved trials
Dallas, Texas 75390
Principal Investigator: Daniel C. Bowers
Phone: 214-648-7097
?
mi
from
Dallas, TX
Click here to add this to my saved trials
100 North Academy Avenue
Danville, Pennsylvania 17822
570-271-6211
Principal Investigator: Jagadeesh Ramdas
Phone: 570-271-5251
Geisinger Medical Center Since 1915, Geisinger Medical Center has been known as the region’s resource...
?
mi
from
Danville, PA
Click here to add this to my saved trials
Dayton, Ohio 45404
Principal Investigator: Ayman A. El-Sheikh
?
mi
from
Dayton, OH
Click here to add this to my saved trials
9333 Imperial Highway
Downey, California 90242
Principal Investigator: Robert M. Cooper
Phone: 510-891-3400
?
mi
from
Downey, CA
Click here to add this to my saved trials
2301 Erwin Rd
Durham, North Carolina 27710
919-684-8111
Principal Investigator: Lars M. Wagner
Phone: 888-275-3853
Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
?
mi
from
Durham, NC
Click here to add this to my saved trials
801 Broadway North
Fargo, North Dakota 58122
Principal Investigator: Samuel O. Anim
Phone: 701-323-5760
?
mi
from
Fargo, ND
Click here to add this to my saved trials
Fort Myers, Florida 33908
Principal Investigator: Emad K. Salman
?
mi
from
Fort Myers, FL
Click here to add this to my saved trials
Hollywood, Florida 33021
Principal Investigator: Iftikhar Hanif
?
mi
from
Hollywood, FL
Click here to add this to my saved trials
1319 Punahou St
Honolulu, Hawaii 96826
(808) 983-6000
Principal Investigator: Wade T. Kyono
Phone: 808-983-6090
Kapiolani Medical Center for Women and Children Hawai‘i Pacific Health is an integrated health care...
?
mi
from
Honolulu, HI
Click here to add this to my saved trials
Houston, Texas 77030
Principal Investigator: Patricia A. Baxter
Phone: 713-798-1354
?
mi
from
Houston, TX
Click here to add this to my saved trials
705 Riley Hospital Dr
Indianapolis, Indiana 46202
(317) 944-5000
Principal Investigator: Kamnesh R. Pradhan
Phone: 800-248-1199
Riley Hospital for Children Riley Hospital for Children at IU Health is a place of...
?
mi
from
Indianapolis, IN
Click here to add this to my saved trials
Indianapolis, Indiana 46260
Principal Investigator: Bassem I. Razzouk
Phone: 317-338-2194
?
mi
from
Indianapolis, IN
Click here to add this to my saved trials
Iowa City, Iowa 52242
Principal Investigator: Mariko Sato
Phone: 800-237-1225
?
mi
from
Iowa City, IA
Click here to add this to my saved trials
Kansas City, Missouri 64108
Principal Investigator: Kevin F. Ginn
?
mi
from
Kansas City, MO
Click here to add this to my saved trials
2018 W Clinch Ave
Knoxville, Tennessee 37916
(865) 541-8000
Principal Investigator: Ray C. Pais
Phone: 865-541-8266
East Tennessee Children's Hospital East Tennessee Children's Hospital is a not-for-profit, private, independent pediatric medical...
?
mi
from
Knoxville, TN
Click here to add this to my saved trials
Las Vegas, Nevada 89135
Principal Investigator: Alan K. Ikeda
Phone: 702-384-0013
?
mi
from
Las Vegas, NV
Click here to add this to my saved trials
Las Vegas, Nevada 89144
Principal Investigator: Alan K. Ikeda
Phone: 702-384-0013
?
mi
from
Las Vegas, NV
Click here to add this to my saved trials
1 Medical Center Dr
Lebanon, New Hampshire 03756
 (603) 650-5000
Principal Investigator: Julie Kim
Phone: 800-639-6918
Dartmouth Hitchcock Medical Center Dartmouth-Hitchcock is a national leader in patient-centered health care and building...
?
mi
from
Lebanon, NH
Click here to add this to my saved trials
Lexington, Kentucky
Principal Investigator: Vlad C. Radulescu
Phone: 859-257-3379
?
mi
from
Lexington, KY
Click here to add this to my saved trials
1 Children's Way
Little Rock, Arkansas 72202
(501) 364-1100
Principal Investigator: David L. Becton
Arkansas Children's Hospital Arkansas Children's Hospital (ACH) is the only pediatric medical center in Arkansas...
?
mi
from
Little Rock, AR
Click here to add this to my saved trials
11234 Anderson St
Loma Linda, California 92354
(909) 558-4000
Principal Investigator: Albert Kheradpour
Phone: 909-558-3375
Loma Linda University Medical Center An outgrowth of the original Sanitarium on the hill in...
?
mi
from
Loma Linda, CA
Click here to add this to my saved trials
Long Beach, California 90806
Principal Investigator: Pamela H. Kempert
?
mi
from
Long Beach, CA
Click here to add this to my saved trials
Los Angeles, California 90095
Principal Investigator: Tom B. Davidson
?
mi
from
Los Angeles, CA
Click here to add this to my saved trials
Madera, California 93638
Principal Investigator: Vonda L. Crouse
?
mi
from
Madera, CA
Click here to add this to my saved trials
600 Highland Ave
Madison, Wisconsin 53792
(608) 263-6400
Principal Investigator: Kenneth B. De Santes
Phone: 800-622-8922
University of Wisconsin Hospital and Clinics UW Health strives to meet the health needs of...
?
mi
from
Madison, WI
Click here to add this to my saved trials
Marshfield, Wisconsin 54449
Principal Investigator: Michelle A. Manalang
Phone: 800-782-8581
?
mi
from
Marshfield, WI
Click here to add this to my saved trials
Mesa, Arizona 85202
Principal Investigator: Hardeo K. Panchoosingh
?
mi
from
Mesa, AZ
Click here to add this to my saved trials
Miami, Florida 33155
Principal Investigator: Enrique A. Escalon
?
mi
from
Miami, FL
Click here to add this to my saved trials
9000 W Wisconsin Ave #270
Milwaukee, Wisconsin 53226
(414) 266-2000
Principal Investigator: Jeffrey A. Knipstein
Phone: 414-955-4727
Children's Hospital of Wisconsin Nothing matters more than our children. At Children's Hospital of Wisconsin,...
?
mi
from
Milwaukee, WI
Click here to add this to my saved trials
Minneapolis, Minnesota 55455
Principal Investigator: Christopher L. Moertel
?
mi
from
Minneapolis, MN
Click here to add this to my saved trials
2525 Chicago Ave
Minneapolis, Minnesota 55404
(612) 813-6000
Principal Investigator: Michael K. Richards
Children's Hospitals and Clinics of Minnesota - Minneapolis Children's Hospitals and Clinics of Minnesota is...
?
mi
from
Minneapolis, MN
Click here to add this to my saved trials
Morgantown, West Virginia 26505
Principal Investigator: Stephan R. Paul
Phone: 304-293-7374
?
mi
from
Morgantown, WV
Click here to add this to my saved trials
Morristown, New Jersey 07962
Principal Investigator: Steven L. Halpern
Phone: 973-971-5900
?
mi
from
Morristown, NJ
Click here to add this to my saved trials
Nashville, Tennessee 37203
Principal Investigator: Haydar A. Frangoul
?
mi
from
Nashville, TN
Click here to add this to my saved trials
254 Easton Ave
New Brunswick, New Jersey 08901
(732) 745-8600
Principal Investigator: Nibal A. Zaghloul
Saint Peter's University Hospital Located in New Brunswick, NJ, Saint Peter's University Hospital has been...
?
mi
from
New Brunswick, NJ
Click here to add this to my saved trials
New Haven, Connecticut 6520
(203) 432-4771
Principal Investigator: Nina S. Kadan-Lottick
Phone: 203-785-5702
Yale University Yale's roots can be traced back to the 1640s, when colonial clergymen led...
?
mi
from
New Haven, CT
Click here to add this to my saved trials
New York, New York 10016
Principal Investigator: Sharon L. Gardner
Phone: 212-263-4434
?
mi
from
New York, NY
Click here to add this to my saved trials
1275 York Ave
New York, New York 10021
(212) 639-2000
Principal Investigator: Matthias A. Karajannis
Phone: 212-639-7592
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
?
mi
from
New York, NY
Click here to add this to my saved trials
New York, New York 10032
Principal Investigator: Alice Lee
Phone: 212-305-6361
?
mi
from
New York, NY
Click here to add this to my saved trials
Oakland, California 94611
Principal Investigator: Laura A. Campbell
Phone: 877-642-4691
?
mi
from
Oakland, CA
Click here to add this to my saved trials
940 NE 13th St
Oklahoma City, Oklahoma 73190
(405) 271-6458
Principal Investigator: Rene Y. McNall-Knapp
Phone: 405-271-8777
University of Oklahoma Health Sciences Center The OU Health Sciences Center is composed of seven...
?
mi
from
Oklahoma City, OK
Click here to add this to my saved trials
8200 Dodge St
Omaha, Nebraska 68114
(402) 955-5400
Principal Investigator: Minnie Abromowitch
Children's Hospital and Medical Center of Omaha Children's Hospital & Medical Center has a rich...
?
mi
from
Omaha, NE
Click here to add this to my saved trials
Emile St
Omaha, Nebraska 68198
(402) 559-4000
Principal Investigator: Minnie Abromowitch
Phone: 402-559-6941
Univ of Nebraska Med Ctr A vital enterprise in the nation’s heartland, the University of...
?
mi
from
Omaha, NE
Click here to add this to my saved trials
Orlando, Florida 32806
Principal Investigator: Don E. Eslin
Phone: 321-843-2584
?
mi
from
Orlando, FL
Click here to add this to my saved trials
2801 N Gantenbein Ave
Portland, Oregon 97227
(503) 276-6500
Principal Investigator: Janice F. Olson
Legacy Emanuel Children's Hospital For generations our children's hospital has provided outstanding care for kids...
?
mi
from
Portland, OR
Click here to add this to my saved trials
Rochester, Minnesota 55905
Principal Investigator: Amulya A. Nageswara Rao
Phone: 855-776-0015
?
mi
from
Rochester, MN
Click here to add this to my saved trials
660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Principal Investigator: Karen M. Gauvain
Phone: 800-600-3606
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
?
mi
from
Saint Louis, MO
Click here to add this to my saved trials
Saint Petersburg, Florida 33701
Principal Investigator: Stacie L. Stapleton
?
mi
from
Saint Petersburg, FL
Click here to add this to my saved trials
Salt Lake City, Utah 84143
Principal Investigator: Phillip E. Barnette
?
mi
from
Salt Lake City, UT
Click here to add this to my saved trials
San Antonio, Texas 78207
Principal Investigator: Timothy C. Griffin
?
mi
from
San Antonio, TX
Click here to add this to my saved trials
4700 Waters Ave
Savannah, Georgia 31404
(912) 350-8000
Principal Investigator: Andrew L. Pendleton
Phone: 912-350-7887
Memorial Health University Medical Center Memorial University Medical Center (MUMC) is a nonprofit, 622-bed tertiary...
?
mi
from
Savannah, GA
Click here to add this to my saved trials
4800 Sand Point Way NE
Seattle, Washington 98105
(206) 987-2000
Principal Investigator: Douglas S. Hawkins
Seattle Children's Hospital Seattle Children’s Hospital specializes in meeting the unique physical, emotional and developmental...
?
mi
from
Seattle, WA
Click here to add this to my saved trials
1305 W 18th St
Sioux Falls, South Dakota 57117
(605) 333-1000
Principal Investigator: Kayelyn J. Wagner
Phone: 605-312-3320
Sanford USD Medical Center - Sioux Falls Sanford
?
mi
from
Sioux Falls, SD
Click here to add this to my saved trials
101 W 8th Ave
Spokane, Washington 99204
(509) 474-3131
Principal Investigator: Judy L. Felgenhauer
Providence Sacred Heart Medical Center & Children's Hospital When Mother Joseph and the Sisters of...
?
mi
from
Spokane, WA
Click here to add this to my saved trials
Syracuse, New York 13214
Principal Investigator: Philip M. Monteleone
Phone: 315-464-5476
?
mi
from
Syracuse, NY
Click here to add this to my saved trials
311 Martin Luther King Jr Way
Tacoma, Washington 98403
(253) 403-1400
Principal Investigator: Robert G. Irwin
Mary Bridge Children's Hospital and Health Center Mary Bridge Children's Hospital was established in 1955,...
?
mi
from
Tacoma, WA
Click here to add this to my saved trials
2142 N Cove Blvd
Toledo, Ohio 43606
(419) 291-5437
Principal Investigator: Jamie L. Dargart
Phone: 419-824-1842
The Toledo Hospital/Toledo Children's Hospital ProMedica's Mission is to improve your health and well-being. And...
?
mi
from
Toledo, OH
Click here to add this to my saved trials
901 45th St
West Palm Beach, Florida 33407
(561) 844-6300
Principal Investigator: Narayana Gowda
Saint Mary's Hospital Our team of dedicated physicians, nurses and staff offer a broad spectrum...
?
mi
from
West Palm Beach, FL
Click here to add this to my saved trials
55 N Lake Ave
Worcester, Massachusetts 01655
(508) 856-8989
Principal Investigator: Christopher P. Keuker
Phone: 508-856-3216
Univ of Massachusetts Med School As the commonwealth's only public medical school, we take seriously...
?
mi
from
Worcester, MA
Click here to add this to my saved trials