Collecting and Storing Samples of Bone Marrow and Blood From Patients With Relapsed Acute Lymphoblastic Leukemia or Non-Hodgkin Lymphoma



Status:Active, not recruiting
Conditions:Blood Cancer, Lymphoma, Leukemia
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any - 30
Updated:7/21/2018
Start Date:September 25, 2006

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A Children's Oncology Group Protocol for Collecting and Banking Relapsed Acute Lymphoblastic Leukemia Research Specimens

This research study is collecting and storing samples of bone marrow and blood from patients
with relapsed acute lymphoblastic leukemia or relapsed non-Hodgkin lymphoma. Collecting and
storing samples of bone marrow and blood from patients with cancer to study in the laboratory
may help doctors learn more about cancer and help predict the recurrence of cancer.

OBJECTIVES:

I. Establish a mechanism to bank specimens of tumor cells and host germline DNA from patients
with acute lymphoblastic leukemia (ALL) at first and subsequent relapse.

II. Make these specimens available to qualified researchers to study the biology of ALL.

OUTLINE: This is a multicenter study.

Patients undergo collection of bone marrow and peripheral blood at diagnosis of relapse
and/or at the end of the first month of treatment.

Patients are followed periodically for up to 10 years.

Inclusion Criteria:

- Diagnosis of acute lymphoblastic leukemia (ALL) or prior history of non-Hodgkin
lymphoma

- In first or subsequent marrow relapse with ? 25% blasts in bone marrow and/or
peripheral blood

- Bone marrow and/or peripheral blood samples (? 5 mL) required at the time of diagnosis
of relapse

- No concurrent systemic antileukemic treatment administered for current relapse

- Intrathecal chemotherapy allowed

- On-therapy relapse allowed
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Akron, Ohio 44308
Principal Investigator: Steven J. Kuerbitz
Phone: 330-543-3193
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666 Elm Street
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11100 Euclid Avenue
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(216) 844-1000
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700 Childrens Drive
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1200 West Harrison Stree
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Honolulu, Hawaii 96826
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Knoxville, Tennessee 37916
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601 South Rancho Drive Suite C-26
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1 Medical Center Dr
Lebanon, New Hampshire 03756
 (603) 650-5000
Principal Investigator: Sara Chaffee
Phone: 800-639-6918
Dartmouth Hitchcock Medical Center Dartmouth-Hitchcock is a national leader in patient-centered health care and building...
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Lexington, Kentucky
Principal Investigator: Lars M. Wagner
Phone: 859-257-3379
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