Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia



Status:Recruiting
Conditions:Other Indications, Blood Cancer
Therapuetic Areas:Oncology, Other
Healthy:No
Age Range:2 - 21
Updated:2/17/2019
Start Date:July 28, 2017
End Date:June 30, 2028

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International Phase 3 Trial in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph+ALL) Testing Imatinib in Combination With Two Different Cytotoxic Chemotherapy Backbones

This randomized phase III trial studies how well imatinib mesylate and combination
chemotherapy work in treating patients with newly diagnosed Philadelphia chromosome positive
acute lymphoblastic leukemia. Imatinib mesylate may stop the growth of cancer cells by
blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, work in
different ways to stop the growth of cancer cells, either by killing the cells, by stopping
them from dividing, or by stopping them from spreading. Giving imatinib mesylate and
combination chemotherapy may work better in treating patients with Philadelphia chromosome
positive acute lymphoblastic leukemia.

PRIMARY OBJECTIVES:

I. To compare disease-free survival (DFS) of standard risk pediatric Philadelphia chromosome
(Ph)+ acute lymphoblastic leukemia (ALL) treated with continuous imatinib mesylate (imatinib)
combined with either a high-risk Children's Oncology Group (COG) ALL chemotherapy backbone or
the more intensive European (Es)PhALL chemotherapy backbone.

SECONDARY OBJECTIVES:

I. To determine the feasibility of administration of imatinib after allogeneic hematopoietic
stem cell transplantation (HSCT) in high risk Ph+ ALL patients.

II. To determine event-free survival (EFS) of high risk pediatric Ph+ ALL patients treated
with EsPhALL chemotherapy, HSCT in first complete remission and post-HSCT imatinib.

III. To compare rates of grade 3 or higher infections in standard risk (SR) Ph+ ALL patients
between the two randomized arms.

IV. To evaluate event free survival (EFS) and overall survival (OS) of all enrolled
participants.

V. To evaluate OS in SR patients. VI. To evaluate OS in high risk (HR) patients.

TERTIARY OBJECTIVES:

I. To describe the toxicities associated with post-HSCT administration of imatinib.

II. To evaluate the long-term toxicities in SR patients treated with chemotherapy plus
imatinib (no transplant), overall and between both randomized arms.

III. To determine prognostic significance of minimal residual disease (MRD) in Ph+ ALL at
various time points during therapy.

IV. To evaluate MRD in HR patients just prior to HSCT and then at regular intervals post-HSCT
and explore the association of these measurements with long-term outcome.

V. To evaluate concordance of MRD assessments made by IGH-T cell receptor (TCR) polymerase
chain reaction (PCR) assay and next generation sequencing (NGS) assays.

VI. To determine prognostic significance of IKZF1 gene aberrations and deletions.

VII. To determine frequency and prognostic significance of p190 and p210 BCR-ABL1 fusion
variants in pediatric Ph+ ALL.

VIII. To measure adherence to oral chemotherapeutic agents (imatinib, 6-mercaptopurine, and
methotrexate) during the maintenance phase in SR Ph+ ALL patients.

IX. To identify factors associated with poor adherence. X. To determine association between
relapse risk and adherence to each oral chemotherapeutic agent (separately and combined).

XI. To measure adherence to imatinib after allogeneic HSCT in HR Ph+ ALL patients and
identify factors associated with poor adherence.

OUTLINE:

INDUCTION IA PART 1: Patients receive induction IA according to standard of care on days
1-14.

INDUCTION IA PART 2: Patients receive imatinib mesylate orally (PO) once daily (QD) or twice
daily (BID) on days 15-33, prednisolone PO twice daily (BID) or methylprednisolone
intravenously (IV) on days 15-28, vincristine sulfate IV over 1 minute on days 15 and 22,
daunorubicin hydrochloride IV over 1-15 minutes on days 15 and 22, and methotrexate
intrathecally (IT) on day 29.

INDUCTION IB: Patients receive imatinib mesylate PO QD or BID on days 1-35, cyclophosphamide
IV over 30-60 minutes on days 1 and 28, mercaptopurine PO on days 1-28, cytarabine IV or
subcutaneously (SC) on days 1-4, 8-11, 15-18, and 22-25, and methotrexate IT on days 8 and
22.

POST-INDUCTION THERAPY: Patients with standard risk are randomized to 1 of 2 arms. Patients
with high risk are assigned to Arm C.

ARM A:

CONSOLIDATION BLOCK 1: Patients receive imatinib mesylate PO QD or BID on days 1-21,
methotrexate IT, cytarabine IT, and therapeutic hydrocortisone IT on day 1, high dose
methotrexate IV over 24 hours on day 1, vincristine sulfate IV over 1 minute on days 1 and 6,
dexamethasone PO BID or IV on days 1-5, cyclophosphamide IV over 30-60 minutes on days 2-4,
leucovorin calcium PO or IV on days 3 and 4, high dose cytarabine IV over 3 hours and
pegaspargase IV over 1-2 hours on day 5, and filgrastim SC on days 7-11 in the absence of
disease progression or unexpected toxicity.

CONSOLIDATION BLOCK 2: Patients receive imatinib mesylate PO QD or BID on days 1-21,
methotrexate IT, cytarabine IT, and therapeutic hydrocortisone IT on day 1, high dose
methotrexate IV over 24 hours on day 1, dexamethasone PO BID or IV on days 1-5, vincristine
sulfate IV over 1 minute on days 1 and 6, ifosfamide IV over 1 hour on days 2-4, leucovorin
calcium PO or IV on days 3 and 4, dexrazoxane hydrochloride IV over 5-15 minutes and
daunorubicin hydrochloride IV over 1-15 minutes on day 5, pegaspargase IV over 1-2 hours on
day 6, and filgrastim SC on days 7-11 in the absence of disease progression or unexpected
toxicity.

CONSOLIDATION BLOCK 3: Patients receive imatinib mesylate PO QD or BID on days 1-21, high
dose cytarabine IV over 3 hours on days 1-2, dexamethasone PO BID or IV on days 1-5,
etoposide IV over 1-2 hours on days 3-5, methotrexate IT, cytarabine IT, and therapeutic
hydrocortisone IT on day 5, pegaspargase IV over 1-2 hours on day 6, and filgrastim SC on
days 7-11 in the absence of disease progression or unexpected toxicity.

DELAYED INTENSIFICATION 1 PART 1: Patients receive imatinib mesylate PO QD or BID on days
1-35, methotrexate IT on day 1, dexamethasone PO BID or IV on days 1-7 and 15-21, vincristine
sulfate IV over 1 minute, dexrazoxane hydrochloride IV over 5-15 minutes, and doxorubicin IV
over 1-15 minutes on days 8, 15, 22, and 29, and pegaspargase IV over 1-2 hours on day 8 in
the absence of disease progression or unexpected toxicity.

DELAYED INTENSIFICATION 1 PART 2: Patients receive imatinib mesylate PO QD on days 36-63,
cyclophosphamide IV over 30-60 minutes on day 36, thioguanine PO on days 36-49, cytarabine IV
over 1-30 minutes or SC on days 36-39 and 43-46, and methotrexate IT on days 36 and 43 in the
absence of disease progression or unexpected toxicity.

INTERIM MAINTENANCE: Patients receive imatinib mesylate PO QD or BID on days 1-28,
methotrexate PO on days 1, 8, 15, and 22, and mercaptopurine PO on days 1-28 in the absence
of disease progression or unexpected toxicity.

DELAYED INTENSIFICATION 2 PART 1: Patients receive imatinib mesylate PO QD or BID on days
1-35, methotrexate IT on day 1, dexamethasone PO BID or IV on days 1-7 and 15-21, vincristine
sulfate IV over 1 minute, dexrazoxane hydrochloride IV over 5-15 minutes, and doxorubicin IV
over 1-15 minutes on days 8, 15, 22, and 29, and pegaspargase IV over 1-2 hours on day 8 in
the absence of disease progression or unexpected toxicity.

DELAYED INTENSIFICATION 2 PART 2: Patients receive imatinib mesylate PO QD on days 36-49,
cyclophosphamide IV over 30-60 minutes on day 36, thioguanine PO on days 36-49, cytarabine IV
over 1-30 minutes or SC on days 36-39 and 43-46, and methotrexate IT on days 36 and 43 in the
absence of disease progression or unexpected toxicity.

MAINTENANCE: Patients receive imatinib mesylate PO QD or BID on days 1-84, methotrexate PO
once weekly (QW) and IT on days 1 and 43 of courses 1, 2, and 3, and mercaptopurine PO on
days 1-84. Courses with imatinib mesylate and mercaptopurine repeat every 84 days for up to
104 weeks from the start of Induction IA in the absence of disease progression or unexpected
toxicity.

ARM B:

INTERIM MAINTENANCE: Patients receive imatinib mesylate PO QD or BID on days 1-63,
vincristine sulfate IV over 1 minute and high dose methotrexate IV over 24 hours on days 1,
15, 29, and 43, leucovorin calcium PO or IV on days 3-4, 17-18, 31-32, and 45-46,
mercaptopurine PO on days 1-56, and methotrexate IT on days 1 and 29 in the absence of
disease progression or unexpected toxicity.

DELAYED INTENSIFICATION PART 1: Patients receive imatinib mesylate PO QD or BID on days 1-28,
methotrexate IT on day 1, dexamethasone PO BID or IV on days 1-7 and 15-21, vincristine
sulfate IV over 1 minute, dexrazoxane hydrochloride IV over 5-15 minutes, and doxorubicin IV
over 1-15 minutes on days 1, 8, and 15, and pegaspargase IV over 1-2 hours on day 4 in the
absence of disease progression or unexpected toxicity.

DELAYED INTENSIFICATION PART 2: Patients receive imatinib mesylate PO QD on days 29-56,
cyclophosphamide IV over 30-60 minutes on day 29, thioguanine PO on days 29-42, cytarabine IV
over 1-30 minutes or SC on days 29-32 and 36-39, methotrexate IT on days 29 and 36,
vincristine sulfate IV over 1 minute on days 43 and 50, and pegaspargase IV over 1-2 hours on
day 43 in the absence of disease progression or unexpected toxicity.

INTERIM MAINTENANCE WITH CAPIZZI METHOTREXATE: Patients receive imatinib mesylate PO QD or
BID on days 1-56, vincristine sulfate IV over 1 minute and methotrexate IV over 2-15 minutes
on days 1, 11, 21, 31, and 41, methotrexate IT on days 1 and 31, and pegaspargase IV over 1-2
hours on days 2 and 22 in the absence of disease progression or unexpected toxicity.

MAINTENANCE: Patients receive imatinib mesylate PO QD or BID on days 1-84, vincristine
sulfate IV over 1 minute on days 1, 29, and 57, prednisolone PO BID (or methylprednisolone IV
for course 1 and 2) on days 1-5, 29-33, and 57-61, mercaptopurine PO on days 1-84,
methotrexate PO QW, and methotrexate IT on day 1 (and day 29 for course 1 and 2). Courses
repeat every 84 days for up to 104 weeks from the start of Induction IA in the absence of
disease progression or unexpected toxicity.

ARM C:

CONSOLIDATION BLOCK 1: Patients receive imatinib mesylate, methotrexate, cytarabine,
therapeutic hydrocortisone, high dose methotrexate, vincristine sulfate, dexamethasone,
leucovorin calcium, high dose cytarabine, and pegaspargase as in Arm A Consolidation Block 1,
and filgrastim SC on day 7 in the absence of disease progression or unexpected toxicity.

CONSOLIDATION BLOCK 2: Patients receive imatinib mesylate, methotrexate, cytarabine,
therapeutic hydrocortisone, high dose methotrexate, dexamethasone, vincristine sulfate,
ifosfamide, leucovorin calcium, dexrazoxane hydrochloride, daunorubicin hydrochloride,
pegaspargase, and filgrastim as Arm A Consolidation Block 2 in the absence of disease
progression or unexpected toxicity.

CONSOLIDATION BLOCK 3: Patients receive imatinib mesylate, dexamethasone, etoposide,
methotrexate, cytarabine, therapeutic hydrocortisone, pegaspargase, and filgrastim as in Arm
A Consolidation Block 3, and high dose cytarabine IV over 3 hours on days 1-2 in the absence
of disease progression or unexpected toxicity.

HSCT: Patients undergo HSCT on day 0. Patients who do not proceed to HSCT receive Delayed
Intensification 1, Interim Maintenance, Delayed Intensification 2, and Maintenance as in Arm
A.

POST-HSCT: Patients receive imatinib mesylate PO QD or BID starting on days 56-365 in the in
the absence of disease progression or unexpected toxicity.

After completion of study treatment, patients are followed up every year for 3 years.

Inclusion Criteria:

- For patients enrolled on AALL08B1 or APEC14B1 (if open for ALL patients) prior to
enrollment on AALL1631, the required diagnostic bone marrow sample has been fulfilled

- For patients who have not previously enrolled on AALL08B1 or APEC14B1 (if open
for ALL patients) prior to enrollment on AALL1631, a baseline diagnostic sample
must be available to develop an MRD probe

- In addition, laboratory reports detailing evidence of BCR-ABL1 fusion must be
submitted for rapid central review within 72 hours of study enrollment

- Newly diagnosed de novo ALL (B-ALL or T-ALL) with definitive evidence of BCR-ABL1
fusion by karyotype, fluorescence in situ hybridization (FISH) and/or reverse
transcriptase (RT)-PCR

- Patient must have previously started induction therapy, which includes vincristine, a
corticosteroid, pegaspargase, with or without anthracycline, and/or other standard
cytotoxic chemotherapy

- Patient has not received more than 14 days of multiagent induction therapy beginning
with the first dose of vinCRIStine

- Patient may have started imatinib prior to study entry but has not received more than
14 days of imatinib

- Patients must have a performance status corresponding to Eastern Cooperative Oncology
Group (ECOG) scores of 0, 1, or 2

- Direct bilirubin =< 2.0 mg/dL

- Shortening fraction of >= 27% by echocardiogram

- Ejection fraction of >= 50% by radionuclide angiogram or echocardiogram

- Corrected QT interval, QTc < 480 msec

- Note: Repeat echocardiogram is not required if echocardiogram was obtained within
21 days of study enrollment

- Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70
mL/min/1.73 m^2

- Serum creatinine within normal limits based on age/gender, as follows:

- 1 to < 2 years: maximum serum creatinine 0.6 mg/dL (both male and female)

- 2 to < 6 years: maximum serum creatinine 0.8 mg/dL (both male and female)

- 6 to < 10 years: maximum serum creatinine 1 mg/dL (both male and female)

- 10 to < 13 years: maximum serum creatinine 1.2 mg/dL (both male and female)

- 13 to < 16 years: maximum serum creatinine 1.5 mg/dL (male), 1.4 mg/dL (female)

- >= 16 years: maximum serum creatinine 1.7 mg/dL (male), 1.4 mg/dL (female)

Exclusion Criteria:

- Known history of chronic myelogenous leukemia (CML)

- ALL developing after a previous cancer treated with cytotoxic chemotherapy

- Active, uncontrolled infection, or active systemic illness that requires ongoing
vasopressor support or mechanical ventilation

- Down syndrome

- Pregnancy and breast feeding

- Female patients who are pregnant; a pregnancy test is required for female
patients of childbearing potential

- Lactating females who plan to breastfeed their infants

- Sexually active patients of reproductive potential who have not agreed to use an
effective contraceptive method for the duration of their study participation

- Patients with congenital long QT syndrome, history of ventricular arrhythmias or heart
block

- Prior treatment with dasatinib, or any BCR-ABL1 inhibitor other than imatinib

- All patients and/or their parents or legal guardians must sign a written informed
consent

- All institutional, Food and Drug Administration (FDA), and National Cancer Institute
(NCI) requirements for human studies must be met
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Denver, Colorado 80218
Principal Investigator: Jennifer J. Clark
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Denver, CO
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9333 Imperial Highway
Downey, California 90242
Principal Investigator: Robert M. Cooper
Phone: 626-564-3455
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Downey, CA
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El Paso, Texas 79905
Principal Investigator: Lisa L. Hartman
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El Paso, TX
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Fort Myers, Florida 33908
Principal Investigator: Emad K. Salman
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Fort Myers, FL
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801 7th Avenue
Fort Worth, Texas 76104
(682) 885-4000
Principal Investigator: Kenneth M. Heym
Cook Children's Medical Center Cook Children's Health Care System is a not-for-profit, nationally recognized pediatric...
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Fort Worth, TX
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1600 Southwest Archer Road
Gainesville, Florida 32610
Principal Investigator: William B. Slayton
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Gainesville, FL
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835 S Van Buren St
Green Bay, Wisconsin 54301
Principal Investigator: Catherine A. Long
Phone: 920-433-8889
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Green Bay, WI
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1001 E 5th St
Greenville, North Carolina 27858
(252) 328-6131
Principal Investigator: Andrea R. Whitfield
Phone: 252-744-2391
East Carolina University Whether it's meeting the demand for more teachers and healthcare professionals or...
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Greenville, NC
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900 West Faris Rd.
Greenville, South Carolina 29605
(864)455-8898
Principal Investigator: Nichole L. Bryant
BI-LO Charities Children's Cancer Center The BI-LO Charities Children
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Greenville, SC
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30 Prospect Ave
Hackensack, New Jersey 07601
(201) 996-2000
Principal Investigator: Burton E. Appel
Phone: 201-996-2879
Hackensack University Medical Center Hackensack University Medical Center, part of the Hackensack University Health Network,...
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Hackensack, NJ
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Hershey, Pennsylvania 17033
Principal Investigator: Lisa M. McGregor
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Hershey, PA
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Hollywood, Florida 33021
Principal Investigator: Iftikhar Hanif
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Hollywood, FL
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1319 Punahou St
Honolulu, Hawaii 96826
(808) 983-6000
Principal Investigator: Wade T. Kyono
Phone: 808-983-6090
Kapiolani Medical Center for Women and Children Hawai‘i Pacific Health is an integrated health care...
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Honolulu, HI
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Houston, Texas 77030
Principal Investigator: Rachel E. Rau
Phone: 713-798-1354
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Houston, TX
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Houston, Texas 77030
Principal Investigator: Najat C. Daw
Phone: 877-312-3961
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Houston, TX
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705 Riley Hospital Dr
Indianapolis, Indiana 46202
(317) 944-5000
Principal Investigator: Kamnesh R. Pradhan
Phone: 800-248-1199
Riley Hospital for Children Riley Hospital for Children at IU Health is a place of...
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Indianapolis, IN
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Indianapolis, Indiana 46260
Principal Investigator: Bassem I. Razzouk
Phone: 317-338-2194
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Indianapolis, IN
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Iowa City, Iowa 52242
Principal Investigator: Mariko Sato
Phone: 800-237-1225
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Iowa City, IA
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Jacksonville, Florida 32207
Principal Investigator: Emi H. Caywood
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Jacksonville, FL
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2018 W Clinch Ave
Knoxville, Tennessee 37916
(865) 541-8000
Principal Investigator: Ray C. Pais
Phone: 865-541-8266
East Tennessee Children's Hospital East Tennessee Children's Hospital is a not-for-profit, private, independent pediatric medical...
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Las Vegas, Nevada 89109
Principal Investigator: Alan K. Ikeda
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Las Vegas, NV
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Las Vegas, Nevada 89109
Principal Investigator: Alan K. Ikeda
Phone: 702-384-0013
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Las Vegas, Nevada 89144
Principal Investigator: Alan K. Ikeda
Phone: 702-384-0013
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1 Medical Center Dr
Lebanon, New Hampshire 03756
 (603) 650-5000
Principal Investigator: Sara Chaffee
Phone: 800-639-6918
Dartmouth Hitchcock Medical Center Dartmouth-Hitchcock is a national leader in patient-centered health care and building...
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Lebanon, NH
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Lexington, Kentucky
Principal Investigator: Vlad C. Radulescu
Phone: 859-257-3379
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Lexington, KY
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1 Children's Way
Little Rock, Arkansas 72202
(501) 364-1100
Principal Investigator: David L. Becton
Arkansas Children's Hospital Arkansas Children's Hospital (ACH) is the only pediatric medical center in Arkansas...
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Little Rock, AR
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11234 Anderson St
Loma Linda, California 92354
(909) 558-4000
Principal Investigator: Albert Kheradpour
Phone: 909-558-3375
Loma Linda University Medical Center An outgrowth of the original Sanitarium on the hill in...
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Loma Linda, CA
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Louisville, Kentucky 40202
Principal Investigator: Ashok B. Raj
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Louisville, KY
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600 Highland Ave
Madison, Wisconsin 53792
(608) 263-6400
Principal Investigator: Kenneth B. De Santes
Phone: 800-622-8922
University of Wisconsin Hospital and Clinics UW Health strives to meet the health needs of...
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Madison, WI
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Marshfield, Wisconsin 54449
Principal Investigator: Michael J. McManus
Phone: 800-782-8581
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Miami, Florida 33136
Principal Investigator: Julio C. Barredo
Phone: 305-243-2647
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Miami, FL
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9000 W Wisconsin Ave #270
Milwaukee, Wisconsin 53226
(414) 266-2000
Principal Investigator: Michael J. Burke
Phone: 414-955-4727
Children's Hospital of Wisconsin Nothing matters more than our children. At Children's Hospital of Wisconsin,...
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2525 Chicago Ave
Minneapolis, Minnesota 55404
(612) 813-6000
Principal Investigator: Michael K. Richards
Children's Hospitals and Clinics of Minnesota - Minneapolis Children's Hospitals and Clinics of Minnesota is...
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Minneapolis, Minnesota 55455
Principal Investigator: Peter M. Gordon
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Morgantown, West Virginia 26505
Principal Investigator: Stephan R. Paul
Phone: 304-293-7374
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Morristown, New Jersey 07962
Principal Investigator: Steven L. Halpern
Phone: 973-971-5900
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Nashville, Tennessee 37203
Principal Investigator: Haydar A. Frangoul
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New Orleans, Louisiana 70121
Principal Investigator: Craig Lotterman
Phone: 504-703-8712
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Oak Lawn, Illinois 60453
Principal Investigator: Rebecca E. McFall
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Oakland, California 94611
Principal Investigator: Steven K. Bergstrom
Phone: 877-642-4691
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940 NE 13th St
Oklahoma City, Oklahoma 73190
(405) 271-6458
Principal Investigator: Rene Y. McNall-Knapp
Phone: 405-271-8777
University of Oklahoma Health Sciences Center The OU Health Sciences Center is composed of seven...
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8200 Dodge St
Omaha, Nebraska 68114
(402) 955-5400
Principal Investigator: Minnie Abromowitch
Children's Hospital and Medical Center of Omaha Children's Hospital & Medical Center has a rich...
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Emile St
Omaha, Nebraska 68198
(402) 559-4000
Principal Investigator: Minnie Abromowitch
Phone: 402-559-6941
Univ of Nebraska Med Ctr A vital enterprise in the nation’s heartland, the University of...
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Orlando, Florida 32803
Principal Investigator: Fouad M. Hajjar
Phone: 407-303-2090
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Orlando, FL
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Orlando, Florida 32806
Principal Investigator: Vincent F. Giusti
Phone: 321-843-2584
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13535 Nemours Parkway
Orlando, Florida 32827
(407) 567-4000
Principal Investigator: Emi H. Caywood
Nemours Children's Hospital Nemours Children's Hospital in Orlando brings pediatric specialty care never before offered...
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725 Welch Rd
Palo Alto, California 94304
(650) 497-8000
Principal Investigator: Sheri L. Spunt
Lucile Packard Children's Hospital Stanford University Stanford Children's Health is the only network in the...
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Park Ridge, Illinois 60068
Principal Investigator: Caroline Y. Hu
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Perth, Western Australia
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Perth,
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Philadelphia, Pennsylvania 19104
Principal Investigator: Lewis B. Silverman
Phone: 877-442-3324
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Philadelphia, PA
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3601 A St
Philadelphia, Pennsylvania 19134
(215) 427-5000
Principal Investigator: Gregory E. Halligan
Saint Christopher's Hospital for Children St. Christopher's Hospital for Children offers a wide range of...
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1919 E Thomas Rd
Phoenix, Arizona 85006
(602) 933-1000
Principal Investigator: Jessica Boklan
Phone: 602-546-0920
Phoenix Children's Hospital Phoenix Children's Hospital has provided hope, healing, and the best healthcare for...
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Royal Oak, Michigan 48073
Principal Investigator: Laura K. Gowans
Phone: 248-551-0360
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Royal Oak, MI
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