Pentostatin, Cyclophosphamide, and Rituximab Followed By Campath-1H in Patients With Relapsed or Refractory B-Cell CLL



Status:Completed
Conditions:Blood Cancer, Leukemia
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - 120
Updated:3/1/2019
Start Date:December 16, 2004
End Date:May 6, 2018

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Phase II Trial of Pentostatin, Cyclophosphamide and Rituximab (PCR) Followed by Campath-1H for Previously Treated Relapsed or Refractory Patients With Chronic Lymphocytic Leukemia

RATIONALE: Drugs used in chemotherapy, such as pentostatin, cyclophosphamide, and
lenalidomide work in different ways to stop cancer cells from dividing so they stop growing
or die. Monoclonal antibodies, such as rituximab can locate cancer cells and either kill them
or deliver cancer-killing substances to them without harming normal cells. Combining
chemotherapy with monoclonal antibody therapy may kill more tumor cells.

PURPOSE: This phase II trial is studying how well pentostatin, cyclophosphamide, rituximab,
and lenalidomide work in treating patients with relapsed or refractory B-cell chronic
lymphocytic leukemia.

OBJECTIVES:

Primary

- Determine the objective response rate (complete remission, partial remission [PR], or
nodular PR) in patients with relapsed or refractory B-cell chronic lymphocytic leukemia
(CLL) treated with pentostatin, cyclophosphamide, and rituximab (PCR) followed by
lenalidomide.

- Determine the presence of minimal residual disease in patients treated with this
regimen.

Secondary

- Determine the toxicity of this regimen in these patients.

- Evaluate the toxicity of the combined therapy, PCR with lenalidomide, in patients with
previously treated B-CLL.

- Determine the overall and progression-free survival of patients treated with this
regimen.

- Evaluate the number of patients who after PCR (or during PCR for PD), only achieve a PR,
SD, or PD and who subsequently convert to a higher response category after lenalidomide.

- Correlate V_H gene mutation status and CD38 expression of the CLL B-cell clones with
clinical outcome in patients treated with this regimen.

- Correlate the differential expression of genes in the leukemic cells with clinical
outcome in patients treated with this regimen.

- Correlate surface phenotype and genetic defects of the CLL B-cell clones with clinical
outcome and gene expression patterns in patients treated with this regimen.

Exploratory

- Assess the angiogenic profile (i.e., secretion levels of pro- versus anti-angiogenic
molecules) of CLL B cell clones as well as bone marrow angiogenesis (i.e., vascular
density by immunohistochemistry) at baseline, after PCR, after lenalidomide, every six
months (serum only), and at time of response assessment (marrow).

- Determine the V_H gene mutation status and CD38 expression of the B-CLL clones at study
entry and at the end of the therapy and assess the association between the VH gene
mutation status and CD38 expression and clinical outcome.

- Determine surface phenotype (by flow cytometry) and genetic defects (by CLL FISH panel)
information on CLL-B cell clones and associate with clinical outcome.

- Monitor the T-cell status by repertoire and flow cytometry analysis to determine the
nature and extent of T-cell deficiency induced by the PCR and lenalidomide treatment and
assess any association with clinical outcome and toxicities.

OUTLINE: This is a multicenter study.

Pentostatin, cyclophosphamide, and rituximab (PCR)* therapy: Patients receive pentostatin IV
over 10-30 minutes, cyclophosphamide IV over 30-60 minutes, and rituximab** IV on day 1.
Patients also receive filgrastim (G-CSF) subcutaneously (SC) beginning on day 3 or
pegfilgrastim SC on day 1 and continuing until blood counts recover. Treatment repeats every
28 days for a total of 6 courses in the absence of unacceptable toxicity.

NOTE: *Patients demonstrating progression while receiving PCR must have completed 2 courses
of PCR prior to proceeding to lenalidomide therapy.

NOTE: **Patients receive rituximab IV on days 1, 3, and 5 for course 1 only; for courses 2-6,
patients receive rituximab on day 1 only.

Lenalidomide*** therapy: Eight weeks after completion of PCR therapy or when diagnosed with
progressive disease, patients receive lenalidomide orally (PO) on days 1-28. In the absence
of disease progression or unacceptable toxicity, treatment repeats every 28 days for patients
with partial remission (PR), stable disease, or progressive disease after PCR. Patients who
achieve complete remission proceed to clinical observation.

NOTE: ***The alemtuzumab therapy was replaced by lenalidomide therapy in May, 2011.

Patients are followed every 3 months for 2 years and then every 6 months for 3 years.

PROJECTED ACCRUAL: A total of 26-110 patients will be accrued for this study within 1.5
years.

Inclusion criteria:

- Diagnosis of B-cell chronic lymphocytic leukemia (CLL) meeting the following criteria:

- Peripheral blood absolute lymphocyte count greater than 5,000/mm^3

- Lymphocytosis must comprise small to moderate size lymphocytes with no greater
than 55% prolymphocytes, atypical lymphocytes, or lymphoblasts morphologically

- Phenotypically characterized CLL defined by the following:

- Predominant population of cells share B-cell antigens with CD5 in the
absence of other pan-T-cell markers (CD3 or CD2)

- B cell expresses either kappa or lambda light chains

- Surface immunoglobulin with low cell surface density expression

- Requires chemotherapy, as indicated by any of the following:

- Disease-related symptoms

- Weight loss of 10% or more within the past 6 months

- Extreme fatigue

- Fevers greater than 100.5°F for 2 weeks without evidence of infection

- Night sweats without evidence of infection

- Evidence of progressive marrow failure manifested by the development of or
worsening anemia (hemoglobin no greater than 10 g/dL) and/or thrombocytopenia
(platelet count no greater than 100,000/mm^3)

- Massive (i.e., greater than 6 cm below left costal margin) or progressive
splenomegaly

- Massive nodes or clusters (i.e., greater than 10 cm in longest diameter) or
progressive adenopathy

- Progressive lymphocytosis with an increase of greater than 50% over a 2-month
period OR an anticipated doubling time of less than 6 months

- Demonstrated progression after at least 1 course of either an alkylating agent-based
or purine nucleoside-based (e.g., fludarabine) regimen OR failed to achieve a
meaningful response OR relapsed after prior therapy

- Patients who have relapsed after a pentostatin-based regimen are eligible
provided the response was greater than 12 months prior to study entry

- 18 and over

- ECOG 0-2

- Bilirubin no greater than 2 mg/dL (unless secondary to tumor, hemolysis, or Gilbert
syndrome)

- Creatinine no greater than 2.0 mg/dL

- Creatinine clearance ≥ 30 mL/min

- Negative pregnancy test

- Fertile patients must use 2 methods of effective contraception (including 1 barrier
method) for at least 28 days before starting lenalidomide, while participating in the
study, and for at least 28 days after discontinuation/stopping lenalidomide

- At least 8 weeks since prior rituximab

- At least 6 weeks since prior chemotherapy

- At least 1 year since prior pentostatin, cyclophosphamide, and rituximab (PCR) therapy

- PCR therapy at least 1 year prior to study entry allowed

Exclusion criteria:

- Bone marrow dysplasia related to prior therapy

- New York Heart Association class III or IV heart failure

- Prior lenalidomide

- Other malignancy within the past 2 years except squamous cell or basal cell skin
cancer or carcinoma in situ of the cervix

- Pregnant or nursing

- Concurrent oral or IV antibiotics for active infection
We found this trial at
143
sites
800 S Washington Ave
Saginaw, Michigan 48601
(989) 907-8115
Seton Cancer Institute at Saint Mary's - Saginaw At St. Mary's of Michigan, we continue...
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675 N Saint Clair St # 21-100
Chicago, Illinois 60611
(312) 695-1156
Robert H. Lurie Comprehensive Cancer Center at Northwestern University The cancer center was first established...
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2500 Metrohealth Dr # C2100
Cleveland, Ohio 44109
(216) 778-5802
MetroHealth Cancer Care Center at MetroHealth Medical Center At the MetroHealth Cancer Care Center, we...
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100 North Academy Ave
Danville, Pennsylvania 17822
570-271-6211
Geisinger Cancer Institute at Geisinger Health Since 1915, Geisinger Medical Center has been known as...
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1719 East 19th Avenue
Denver, Colorado 80218
(303) 839-6000
Presbyterian - St. Luke's Medical Center Presbyterian/St. Luke's Medical Center and the Rocky Mountain Hospital...
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1 Hurley Plaza
Flint, Michigan 48503
(810) 262-9000
Hurley Medical Center From its founding in 1908, Hurley Medical Center has devoted itself to...
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1920 Libal Street
Green Bay, Wisconsin 54307
(920) 433-8889
St. Vincent Hospital Regional Cancer Center Our group of 19 oncologists, including the region's only...
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19229 Mack Ave
Grosse Pointe Woods, Michigan 48236
(866) 246-4673
Van Elslander Cancer Center at St. John Hospital and Medical Center We built the Van...
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500 University Drive
Hershey, Pennsylvania 17033
(717) 531-8521
Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center Penn State Milton S....
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524 South Park Street
Kalamazoo, Michigan 49007
(269) 341-7654
Bronson Methodist Hospital Our healthcare system serves patients and families throughout southwest Michigan and northern...
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200 North Park Street
Kalamazoo, Michigan 49007
(269) 382-2500
West Michigan Cancer Center In 1994, Borgess Health Alliance and Bronson Healthcare Group opened the...
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902 Savannah Road
Lewes, Delaware 19958
(302) 645-3770
Tunnell Cancer Center at Beebe Medical Center The Robert & Eolyne Tunnell Cancer Center at...
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216.844.8797
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(313) 593-8620
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2300 N. Edward Street
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217-876-8121
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11600 W 2nd Pl
Denver, Colorado 80204
(720) 321-0000
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4567 E 9th Ave
Denver, Colorado 80220
(303) 320-2121
Rose Medical Center Well known as a Denver institution and a 9th Avenue landmark for...
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2020 Central Ave
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(620) 227-2488
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East Orange, New Jersey 07018
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6401 France Ave S
Edina, Minnesota 55435
(952) 924-5000
Fairview Southdale Hospital Fairview Health Services is an award-winning nonprofit health care system based in...
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700 West Central
El Dorado, Kansas 67042
(316) 889-0099
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600 East Blvd
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(574) 294-2621
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501 E. Hampden Ave.
Englewood, Colorado 80113
303-788-5000
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820 4th Street North
Fargo, North Dakota 58122
(701) 234-6292
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302 Kensington Ave
Flint, Michigan 48503
(810) 762-8490
Genesys Hurley Cancer Institute Bringing the most advanced cancer treatment services, technologies and programs available...
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(620) 223-8589
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550 Osborne Road
Fridley, Minnesota 55432
763-236-5000
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1801 16th St
Greeley, Colorado 80631
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1740 E Broad St
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(570) 459-2901
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Hinsdale, Illinois 60521
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1095 Minnesota 15
Hutchinson, Minnesota 55350
(320) 234-5000
Hutchinson Area Health Care Hutchinson Health is a team of medical professionals and support staff...
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800 W. Laurel
Independence, Kansas 67301
620-331-4099
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205 North East Avenue
Jackson, Michigan 49201
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800 Prudential Drive
Jacksonville, Florida 32207
904.202.2000
Baptist Cancer Institute - Jacksonville For more than 20 years, health care consumers have named...
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1521 Gull Rd
Kalamazoo, Michigan 49048
269) 226-7000
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100 Provena Way
Kankakee, Illinois 60914
815.937.8780
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750 Avenue D West
Kingman, Kansas 67068
(620) 532-3147
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Kokomo, Indiana 46904
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1007 LINCOLNWAY
La Porte, Indiana 46350
219.326.1234
Center for Cancer Therapy at LaPorte Hospital and Health Services United in our mission, the...
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1215 E Michigan Ave
Lansing, Michigan 48912
(517) 364-2890
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325 Maine Street
Lawrence, Kansas 66044
(785) 505-5000
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400 Highland Ave
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315 W. 15th St.
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1800 Hollister Drive, Suite 112
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Niles, IL
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1902 S. US Hwy 59
Parsons, Kansas 67357
(620) 421-2855
Cancer Center of Kansas, PA - Parsons Dr. H.E. Hynes founded Cancer Center of Kansas,...
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Parsons, KS
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44405 Woodward Ave
Pontiac, Michigan 48341
(248) 858-3000
St. Joseph Mercy Oakland St. Joseph Mercy Oakland (SJMO) is a 443-bed comprehensive, community and...
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Pontiac, MI
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2601 Electric Ave
Port Huron, Michigan 48060
(810) 985-1500
Mercy Regional Cancer Center at Mercy Hospital The Mercy Regional Cancer Center at St. Joseph...
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Port Huron, MI
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124 Commodore, Ste. A
Pratt, Kansas 67124
(620) 672-2478
Cancer Center of Kansas, PA - Pratt Dr. H.E. Hynes founded Cancer Center of Kansas,...
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Pratt, KS
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Pueblo, CO
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Spruce St
Reading, Pennsylvania 19611
(484) 628-4357
McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center Cancer is an unknown...
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Reading, PA
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2251 North Shore Drive
Rhinelander, Wisconsin 54501
715.361.2000
Ministry Medical Group at Saint Mary's Hospital Ministry Saint Mary
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Rhinelander, WI
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Rice Lake, Wisconsin 54868
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Rice Lake, WI
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