Study of Bone Marrow and Blood Samples From Patients With Leukemia or Other Hematopoietic Cancers



Status:Archived
Conditions:Blood Cancer, Hematology, Leukemia
Therapuetic Areas:Hematology, Oncology
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:July 1991

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Cytogenetic Studies in Leukemia Patients


RATIONALE: Studying samples of bone marrow and blood from patients with cancer in the
laboratory may help doctors learn more about changes that occur in DNA and identify
biomarkers related to cancer. It may also help doctors predict how patients will respond to
treatment.

PURPOSE: This research study is looking at bone marrow and blood samples from patients with
leukemia or other hematopoietic cancers.


OBJECTIVES:

- Determine the frequency and prognostic significance of cytogenetic abnormalities in
bone marrow or peripheral blood cells in patients with leukemia prior to treatment and
at various times during treatment undergoing treatment on a companion clinical trial.

- Correlate the presence of cytogenetic features with clinical, pathophysiological,
cellular, and molecular characteristics in these patients.

- Determine the frequency of trisomy 12 in patients with chronic lymphocytic leukemia
(CLL) by fluorescence in situ hybridization (FISH) and conventional cytogenetics.

- Determine the feasibility of FISH as a clinical diagnostic technique in patients with
CLL.

- Correlate clinical-pathological prognostic data with the presence of trisomy 12 as
detected by FISH and cytogenetics in patients with CLL.

- Develop a cooperative group mechanism to study chromosome abnormalities by FISH in
patients with leukemia.

- Provide quality control for all Southwest Oncology Group cytogenetic data.

OUTLINE: Bone marrow and/or peripheral blood samples from patients on specific treatment
protocols for leukemia are analyzed for cytogenetic abnormalities. Samples from patients
with chronic lymphocytic leukemia (CLL) are analyzed for trisomy 12 by fluorescence in situ
hybridization and conventional cytogenetics.

PROJECTED ACCRUAL: Approximately 2,500 patients (1,200 with first-line acute myeloid
leukemia [AML], 500 with first-line acute lymphoblastic leukemia [ALL], 200 with relapsed
AML, 125 with chronic phase chronic myelogenous leukemia [CML], 100 with accelerated phase
or blastic phase CML, 250 with hairy cell leukemia, and 125 with relapsed ALL or CLL) will
be accrued for this study within 5 years.


We found this trial at
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1201 Camino de Salud Northeast
Albuquerque, New Mexico 87131
(505) 272-4946
University of New Mexico Cancer Center It’s been 40 years since the New Mexico State...
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100 E. Idaho St.
Boise City, Idaho 83712
208-381-2711
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2720 Clare Avenue
Bremerton, Washington 98310
360-479-6154
Olympic Hematology and Oncology We provide outpatient cancer services in a refined environment designed specifically...
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200 Hawthorne Lane
Charlotte, North Carolina 28233
704-384-4000
Presbyterian Cancer Center at Presbyterian Hospital At Novant Health Presbyterian Medical Center, we are welcoming...
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5801 South Ellis Avenue
Chicago, Illinois 60637
 773.702.1234
University of Chicago One of the world's premier academic and research institutions, the University of...
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1 Hurley Plaza
Flint, Michigan 48503
(810) 262-9000
Hurley Medical Center From its founding in 1908, Hurley Medical Center has devoted itself to...
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9040 Fitzsimmons
Fort Lewis-DuPont, Washington 98431
253-968-2505
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2700 Wayne Memorial Drive
Goldsboro, North Carolina 27534
(919) 736-1110
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200 North Park Street
Kalamazoo, Michigan 49007
(269) 382-2500
West Michigan Cancer Center In 1994, Borgess Health Alliance and Bronson Healthcare Group opened the...
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524 South Park Street
Kalamazoo, Michigan 49007
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Bronson Methodist Hospital Our healthcare system serves patients and families throughout southwest Michigan and northern...
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701 Doctors Dr
Kinston, North Carolina 28504
(252) 559-2200
Kinston Medical Specialists offers comprehensive medical services for all ages. Whether it’s a case of...
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1800 West Charleston Boulevard
Las Vegas, Nevada 89102
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800 Rose St
Lexington, Kentucky 40536
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1415 E. Kincaid
Mount Vernon, Washington 98273
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3181 SW Sam Jackson Park Rd
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19500 10th Ave NE # 100
Poulsbo, Washington 98370
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San Antonio, Texas 78284
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1100 Fairview Avenue North
Seattle, Washington 98109
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201 16th Avenue East
Seattle, Washington 98112
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820 North Chelan Avenue
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1 Akron General Ave
Akron, Ohio 44307
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1415 Tulane Ave., HC-62
Alexandria, Louisiana 70112
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5301 East Huron River Drive
Ann Arbor, Michigan 48106
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Ann Arbor, Michigan 48109
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1000 Johnson Ferry Rd NE
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2000 Ogden Avenue
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Bellefontaine, Ohio 43311
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1351 Kimberly Rd
Bettendorf, Iowa 52722
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211 Saint Francis Drive
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Chanute, Kansas 66720
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171 Ashley Avenue
Charleston, South Carolina 29425
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272 Hospital Rd
Chillicothe, Ohio 45601
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12961 27th Ave
Chippewa Falls, Wisconsin 54729
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9280 SE Sunnybrook Blvd #100
Clackamas, Oregon 97015
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Dearborn, Michigan 48124
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1221 Pleasant St Suite 100
Des Moines, Iowa 50309
(515) 282-2921
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1221 Pleasant St Suite 100
Des Moines, Iowa 50309
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Des Moines, Iowa 50309
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411 Laurel St New Visions
Des Moines, Iowa 50314
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411 Laurel Street
Des Moines, Iowa 50314
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4201 St Antoine St
Detroit, Michigan 48201
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2799 W Grand Blvd
Detroit, Michigan 48202
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