Radiation Therapy With or Without Cetuximab in Treating Patients Who Have Undergone Surgery for Locally Advanced Head and Neck Cancer



Status:Active, not recruiting
Conditions:Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:4/17/2018
Start Date:November 2009
End Date:August 2026

Use our guide to learn which trials are right for you!

A Phase III Study of Postoperative Radiation Therapy (IMRT) +/- Cetuximab for Locally-Advanced Resected Head and Neck Cancer

RATIONALE: Giving radiation therapy that uses a 3-dimensional (3-D) image of the tumor to
help focus thin beams of radiation directly on the tumor, and giving radiation therapy in
higher doses over a shorter period of time, may kill more tumor cells and have fewer side
effects. Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways.
Some block the ability of tumor cells to grow and spread. Others find tumor cells and help
kill them or carry tumor-killing substances to them. It is not yet known whether radiation
therapy is more effective when given alone or together with cetuximab in treating patients
with head and neck cancer that has been removed by surgery.

PURPOSE: This randomized phase III trial is studying radiation therapy to see how well it
works compared with radiation therapy given together with cetuximab in treating patients who
have undergone surgery for locally advanced head and neck cancer.

OBJECTIVES:

Primary

- Determine whether the addition of cetuximab to postoperative intensity-modulated
radiotherapy (IMRT) will improve overall survival (OS) in patients with locally advanced
squamous cell carcinoma of the head and neck at intermediate risk following surgery.

Secondary

- Assess the impact of the addition of cetuximab to postoperative IMRT on disease-free
survival (DFS) of these patients.

- Assess the impact of the addition of cetuximab to postoperative IMRT on acute and late
dysphagia, xerostomia, skin toxicity, and other toxicities according to common Toxicity
Criteria for Adverse Effects (CTCAE), v. 4 and their relationships with patient-reported
outcomes at 3, 12, and 24 months.

- Analyze tumor for epidermal growth factor receptor (EGFR), specifically the extent of
EGFR overexpression by immuno-histochemistry (IHC) and FISH analysis, EGFRvIII
expression, as well as the association of these assay data with OS and DFS.

- Analyze tumor for human papillomavirus (HPV) infection (as defined by in situ
hybridization), specifically, within the cohort of patients with oropharynx cancer, to
perform an exploratory analysis of the impact of HPV on DFS and OS of this patient
subset.

- Analyze tumor DNA for TP53 mutations as a predictor of response to cetuximab and
prognosis.

- Analyze germline DNA of polymorphic variants in EGFR intron repeats as a predictor of
response to cetuximab.

Tertiary

- Assess the impact of the addition of cetuximab to postoperative IMRT on loco-regional
control.

- Assess the impact of the addition of cetuximab to postoperative IMRT on patient-reported
quality of life, swallowing, xerostomia, and skin toxicity based on head and neck
specific instruments, including the Performance Status Scale for Head and Neck Cancer
(PSS-HN), the Functional Assessment of Cancer Therapy-Head & Neck (FACT-H&N), the
University of Michigan Xerostomia-Related Quality of Life Scale (XeQOLS), and the
Dermatology Life Quality Index (DLQI).

- Assess the impact of the addition of cetuximab to postoperative IMRT on cost-utility
analysis using the EuroQol (EQ-5D).

- Evaluate the utility of image-guided radiotherapy (IGRT) as a means of enhancing the
efficacy (i.e., loco-regional control) of IMRT while reducing the acute and/or late
toxicity (particularly xerostomia) and improving patient-reported outcomes (particularly
XeQOLS scores).

- Retrospectively compare the loco-regional control rate in patients treated with IMRT
alone (no IGRT or cetuximab) with similar patients treated with external beam
radiotherapy alone in the postoperative clinical trial Radiation Therapy Oncology Group
(RTOG)-95 01.

OUTLINE: This is a multicenter study. Patients are stratified according to clinical stage
(T2-3 vs T4a), EGFR expression (high [≥ 80% of cells staining positive] vs low [< 80% of
cells staining positive] vs not evaluable), primary site of disease (oral cavity vs larynx vs
oropharynx p16+ vs oropharynx p16- vs oropharynx, p16 not evaluable), and use of image-guided
radiotherapy (yes vs no). Patients are randomized to 1 of 2 treatment arms.

- Arm I: Patients undergo intensity-modulated radiotherapy (IMRT) once daily 5 days a week
for 6 weeks in the absence of disease progression or unacceptable toxicity.

- Arm II: Patients undergo IMRT as in arm I. Patients also receive cetuximab IV over 1-2
hours once weekly beginning at least 5 days prior to the start of IMRT and continuing
for 4 weeks after the completion of IMRT (for a total of 11 doses) in the absence of
disease progression or unacceptable toxicity.

Quality of life is assessed at baseline and at 3, 12, and 24 months.

Tissue samples are collected periodically for further laboratory analysis.

After completion of study treatment, patients are followed up at 1 and 3 months, every 3
months for 2 years, every 6 months for 3 years, and then annually thereafter.

DISEASE CHARACTERISTICS:

- Histologically confirmed squamous cell carcinoma (including variants, such as
verrucous carcinoma, spindle cell carcinoma, or carcinoma not otherwise specified) of
the head and neck, including the following subtypes:

- Oral cavity

- Oropharynx

- Larynx

- Clinical stage T1, N1-2, M0 OR T2-4a, N0-2, M0 disease based on the following
diagnostic workup within the past 8 weeks:

- General history and physical examination by a Radiation Oncologist and/or Medical
Oncologist

- Chest x-ray or chest CT scan (with or without contrast) or chest CT/PET scan
(with or without contrast)

- Must have undergone gross total resection of the primary tumor with curative intent
within the past 7 weeks with surgical pathology demonstrating ≥ 1 of the following
criteria for "intermediate" risk of recurrence:

- Perineural invasion

- Lymphovascular invasion

- Single lymph node > 3 cm or ≥ 2 lymph nodes (all < 6 cm) (no extracapsular
extension)

- Close margin(s) of resection, defined as cancer extending to within 5 mm of a
surgical margin, and/or an initially focally positive margin that is subsequently
superseded by intraoperative negative margins (similarly, patients whose tumors
had focally positive margins in the main specimen but negative margins from
re-excised samples in the region of the positive margin are eligible)

- Pathologically confirmed T3 or T4a primary tumor

- T2 oral cavity cancer with > 5 mm depth of invasion

- No positive margin(s) (defined as tumor present at the cut or inked edge of the
tumor), nodal extracapsular extension, and/or gross residual disease after surgery

PATIENT CHARACTERISTICS:

- Zubrod performance status 0-1

- Absolute granulocyte count ≥ 1,500/mm³

- Platelet count ≥ 100,000/mm³

- Hemoglobin ≥ 8.0 g/dL (transfusion or other intervention allowed)

- Total bilirubin < 2 times upper limit of normal (ULN)

- Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) < 3 times ULN

- Serum creatinine < 2 times ULN OR creatinine clearance ≥ 50 mL/min

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception

- No other invasive malignancy within the past 3 years, except for nonmelanomatous skin
cancer or previously treated carcinoma in situ of the breast, oral cavity, or cervix

- No simultaneous primary or bilateral tumors

- No severe, active co-morbidity, including any of the following:

- Unstable angina and/or congestive heart failure requiring hospitalization within
the past 6 months

- Transmural myocardial infarction within the past 6 months

- Acute bacterial or fungal infection requiring IV antibiotics at the time of study
registration

- Chronic obstructive pulmonary disease exacerbation or other respiratory illness
requiring hospitalization or precluding study therapy

- Idiopathic pulmonary fibrosis or other severe interstitial lung disease that
requires oxygen therapy or is thought to have required oxygen therapy within the
past year

- Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects

- AIDS based on current Centers for Disease Control (CDC) definition

- Grade 3-4 electrolyte abnormalities according to CTCAE, v. 4, including any of
the following:

- Serum calcium (ionized or adjusted for albumin) < 7 mg/dL or > 12.5 mg/dL*

- Glucose < 40 mg/dL or > 250 mg/dL

- Magnesium < 0.9 mg/dL or > 3 mg/dL*

- Potassium < 3.0 mmol/L or > 6 mmol/L*

- Sodium < 130 mmol/L or > 155 mmol/L* NOTE: *Despite intervention to
normalize levels.

- No prior allergic reaction to cetuximab

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

- No prior systemic chemotherapy or anti-epidermal growth factor (EGF) therapy for this
cancer

- Prior chemotherapy or anti-EGF therapy for a different cancer allowed

- No prior radiotherapy to the region of the study cancer that would result in overlap
of radiotherapy fields

- No concurrent amifostine as a radioprotector

- No concurrent granulocyte colony-stimulating factor or erythropoietin
We found this trial at
251
sites
Chapel Hill, North Carolina 27599
(919) 962-2211
Principal Investigator: Bhishamjit S. Chera
Phone: 877-668-0683
Univ of North Carolina Carolina’s vibrant people and programs attest to the University’s long-standing place...
?
mi
from
Chapel Hill, NC
Click here to add this to my saved trials
1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
Principal Investigator: Sharon A. Spencer
Phone: 205-934-0309
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
?
mi
from
Birmingham, AL
Click here to add this to my saved trials
800 Washington St
Boston, Massachusetts 02111
(617) 636-5000
Tufts Medical Center Tufts Medical Center is an internationally-respected academic medical center – a teaching...
?
mi
from
Boston, MA
Click here to add this to my saved trials
Bremerton, Washington 98310
?
mi
from
Bremerton, WA
Click here to add this to my saved trials
2500 Campus Rd
Honolulu, Hawaii 96822
(808) 956-8111
Principal Investigator: Paul A. DeMare
Phone: 808-545-8548
Univ of Hawaii Honolulu Community College is an integral part of the University of Hawai?i,...
?
mi
from
Honolulu, HI
Click here to add this to my saved trials
2500 N State St
Jackson, Mississippi 39216
(601) 984-1000
Principal Investigator: Shankar P. Giri
Phone: 601-815-6700
University of Mississippi Medical Center The University of Mississippi Medical Center, located in Jackson, is...
?
mi
from
Jackson, MS
Click here to add this to my saved trials
200 North Park Street
Kalamazoo, Michigan 49007
(269) 382-2500
Principal Investigator: Raymond S. Lord
Phone: 269-373-7458
West Michigan Cancer Center In 1994, Borgess Health Alliance and Bronson Healthcare Group opened the...
?
mi
from
Kalamazoo, MI
Click here to add this to my saved trials
701 Doctors Dr
Kinston, North Carolina 28504
(252) 559-2200
Principal Investigator: Peter R. Watson
Phone: 252-559-2200
Kinston Medical Specialists offers comprehensive medical services for all ages. Whether it’s a case of...
?
mi
from
Kinston, NC
Click here to add this to my saved trials
2220 Pierce Ave
Nashville, Tennessee 37232
615-936-8422
Principal Investigator: Anthony J. Cmelak
Phone: 800-811-8480
Vanderbilt-Ingram Cancer Center The Vanderbilt-Ingram Cancer Center, located in Nashville, Tenn., brings together the clinical...
?
mi
from
Nashville, TN
Click here to add this to my saved trials
305 1st Avenue # Dazian 7
New York, New York 10003
(212) 420-2806
Principal Investigator: Kenneth S. Hu
Phone: 212-844-6286
Beth Israel Med Ctr The physicians and staff of Mount Sinai Beth Israel's Heart Institute...
?
mi
from
New York, NY
Click here to add this to my saved trials
185 S Orange Ave
Newark, New Jersey 07103
(973) 972-4300
UMDNJ-New Jersey Medical School NJMS is committed to educating humanistic, culturally competent physicians who will...
?
mi
from
Newark, NJ
Click here to add this to my saved trials
4805 Northeast Glisan Street
Portland, Oregon 97213
(503) 215-1111
Principal Investigator: Matthew C. Solhjem
Phone: 503-215-6412
Providence Portland Medical Center We strive to give those we serve exceptional, compassionate health care...
?
mi
from
Portland, OR
Click here to add this to my saved trials
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
?
mi
from
Portland, OR
Click here to add this to my saved trials
60 Crittenden Blvd # 70
Rochester, New York 14642
(585) 275-2121
Principal Investigator: Yuhchyau Chen
Phone: 585-275-5830
University of Rochester The University of Rochester is one of the country's top-tier research universities....
?
mi
from
Rochester, NY
Click here to add this to my saved trials
2279 45th Street
Sacramento, California 95817
(916) 734-5800
Principal Investigator: Allen M. Chen
Phone: 916-734-3089
University of California Davis Cancer Center At UC Davis Comprehensive Cancer Center, specialized teams of...
?
mi
from
Sacramento, CA
Click here to add this to my saved trials
4502 Medical Drive
San Antonio, Texas 78284
(210) 567-7000
Principal Investigator: Ying Li
Phone: 210-567-0653
University of Texas Health Science Center at San Antonio The University of Texas Health Science...
?
mi
from
San Antonio, TX
Click here to add this to my saved trials
601 South Sherman Street
Spokane, Washington 99202
(509) 228-1000
Principal Investigator: Vivek S. Kavadi
Phone: 281-277-5200
Cancer Care Northwest - Spokane South Cancer Care Northwest is the Inland Northwest’s premier cancer...
?
mi
from
Spokane, WA
Click here to add this to my saved trials
820 North Chelan Avenue
Wenatchee, Washington 98801
509) 663-8711
Principal Investigator: George E. Laramore
Phone: 206-616-8289
Wenatchee Valley Medical Center Established on July 21, 2013, Confluence Health is an affiliation between...
?
mi
from
Wenatchee, WA
Click here to add this to my saved trials
Akron, Ohio 44304
Principal Investigator: Charles A. Kunos
Phone: 330-375-6101
?
mi
from
Akron, OH
Click here to add this to my saved trials
1 Akron General Ave
Akron, Ohio 44307
(330) 344-6000
Principal Investigator: Mitchel L. Fromm
Phone: 330-344-6348
Akron General Medical Center It
?
mi
from
Akron, OH
Click here to add this to my saved trials
Albany, New York 12206
Principal Investigator: Vivek S. Kavadi
Phone: 281-277-5200
?
mi
from
Albany, NY
Click here to add this to my saved trials
Albuquerque, New Mexico 87131
(505) 277-0111
Principal Investigator: Benny J. Liem
Phone: 505-272-6972
University of New Mexico Founded in 1889 as New Mexico’s flagship institution, the University of...
?
mi
from
Albuquerque, NM
Click here to add this to my saved trials
1200 S Cedar Crest Blvd
Allentown, Pennsylvania 18103
(610) 402-8000
Principal Investigator: Eliot L. Friedman
Phone: 610-402-2273
Lehigh Valley Hospital At Lehigh Valley Health Network, we continually go the extra mile to...
?
mi
from
Allentown, PA
Click here to add this to my saved trials
1111 Duff Ave
Ames, Iowa 50010
(866) 972-5477
Principal Investigator: Joseph J. Merchant
Phone: 515-239-2621
McFarland Clinic PC-William R Bliss Cancer Center The William R. Bliss Cancer Center at Mary...
?
mi
from
Ames, IA
Click here to add this to my saved trials
2000 E Greenville St
Anderson, South Carolina 29621
(864) 512-4640
Principal Investigator: Patricia C. Griffin
Phone: 800-486-5941
AnMedical Health Cancer Center Cancer is the general term for a group of more than...
?
mi
from
Anderson, SC
Click here to add this to my saved trials
5301 McAuley Drive
Ann Arbor, Michigan 48197
734-712-3456
Principal Investigator: Samir Narayan
Saint Joseph Mercy Hospital St. Joseph Mercy Ann Arbor Hospital is a 537-bed teaching hospital...
?
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
500 S State St
Ann Arbor, Michigan 48109
(734) 764-1817
Principal Investigator: Avraham Eisbruch
Phone: 800-865-1125
University of Michigan The University of Michigan was founded in 1817 as one of the...
?
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
Antigo, Wisconsin 54409
Principal Investigator: Darryl R. Barton
Phone: 877-405-6866
?
mi
from
Antigo, WI
Click here to add this to my saved trials
Appleton, Wisconsin 54915
Principal Investigator: Robert R. Kohl
Phone: 920-433-8889
?
mi
from
Appleton, WI
Click here to add this to my saved trials
Asheville, North Carolina 28801
Principal Investigator: Christopher H. Chay
Phone: 828-213-4150
?
mi
from
Asheville, NC
Click here to add this to my saved trials
Atlanta, Georgia 30322
Principal Investigator: Jonathan J. Beitler
Phone: 404-778-1868
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
Auburn, California 95603
Principal Investigator: Christopher U. Jones
Phone: 916-454-6500
?
mi
from
Auburn, CA
Click here to add this to my saved trials
Aurora, Colorado 80012
Principal Investigator: Keren Sturtz
Phone: 888-785-6789
?
mi
from
Aurora, CO
Click here to add this to my saved trials
13001 E. 17th Pl.
Aurora, Colorado 80045
303-724-5000
Principal Investigator: David Raben
Phone: 720-848-0650
University of Colorado Cancer Center - Anschutz Cancer Pavilion The University of Colorado Denver |...
?
mi
from
Aurora, CO
Click here to add this to my saved trials
Austin, Texas 78705
Principal Investigator: Vivek S. Kavadi
Phone: 281-277-5200
?
mi
from
Austin, TX
Click here to add this to my saved trials
Austin, Texas 78731
Principal Investigator: Vivek S. Kavadi
Phone: 281-277-5200
?
mi
from
Austin, TX
Click here to add this to my saved trials
Austin, Texas 78745
Principal Investigator: Vivek S. Kavadi
Phone: 281-277-5200
?
mi
from
Austin, TX
Click here to add this to my saved trials
22 South Greene Street
Baltimore, Maryland 21201
410-328-7904
University of Maryland Greenebaum Cancer Center The University of Maryland Marlene and Stewart Greenebaum Cancer...
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
155 5th St NE
Barberton, Ohio 44203
(330) 615-3000
Principal Investigator: Charles A. Kunos
Phone: 330-375-6101
Summa Barberton Hospital Summa Barberton Hospital is a full member of Summa Health System and...
?
mi
from
Barberton, OH
Click here to add this to my saved trials
136 Mountainview Blvd
Basking Ridge, New Jersey 7920
(908) 542-3000
Principal Investigator: Nancy Y. Lee
Phone: 212-639-7202
Memorial Sloan-Kettering Cancer Center - Basking Ridge At Memorial Sloan Kettering Basking Ridge, we offer...
?
mi
from
Basking Ridge, NJ
Click here to add this to my saved trials
Baton Rouge, Louisiana 70809
Principal Investigator: Robert W. Veith
Phone: 504-568-2428
?
mi
from
Baton Rouge, LA
Click here to add this to my saved trials
Bedford, Texas 76022
?
mi
from
Bedford, TX
Click here to add this to my saved trials
1055 N Curtis Rd
Boise, Idaho 83706
(208) 367-2121
Principal Investigator: Samir Narayan
Phone: 734-712-3456
Saint Alphonsus Regional Medical Center Saint Alphonsus Health System is a four-hospital regional, faith-based Catholic...
?
mi
from
Boise, ID
Click here to add this to my saved trials
Boston, Massachusetts 02118
Principal Investigator: Minh T. Truong
Phone: 617-638-8265
?
mi
from
Boston, MA
Click here to add this to my saved trials
Bridgeport, Connecticut 06606
Principal Investigator: Christopher M. Iannuzzi
Phone: 203-576-6329
?
mi
from
Bridgeport, CT
Click here to add this to my saved trials
4802 10th Ave
Brooklyn, New York 11219
(718) 283-6000
Principal Investigator: Jay S. Cooper
Phone: 718-765-2500
Maimonides Medical Center At 103 years old, Maimonides Medical Center remains a vital and thriving...
?
mi
from
Brooklyn, NY
Click here to add this to my saved trials
Burlington, Massachusetts 01805
Principal Investigator: Francis W. Nugent
Phone: 781-744-8027
?
mi
from
Burlington, MA
Click here to add this to my saved trials
Camden, New Jersey 08103
Principal Investigator: Gregory J. Kubicek
Phone: 856-325-6757
?
mi
from
Camden, NJ
Click here to add this to my saved trials
Cameron Park, California 95682
Principal Investigator: Christopher U. Jones
Phone: 916-454-6500
?
mi
from
Cameron Park, CA
Click here to add this to my saved trials
360 Parrish Street
Canandaigua, New York 14424
Principal Investigator: Yuhchyau Chen
Phone: 585-275-5830
?
mi
from
Canandaigua, NY
Click here to add this to my saved trials
Canton, Ohio 44708
Principal Investigator: Edward J. Walsh
Phone: 888-293-4673
?
mi
from
Canton, OH
Click here to add this to my saved trials
Cape Girardeau, Missouri 63703
?
mi
from
Cape Girardeau, MO
Click here to add this to my saved trials
Carmichael, California 95608
Principal Investigator: Christopher U. Jones
Phone: 916-454-6500
?
mi
from
Carmichael, CA
Click here to add this to my saved trials
Chardon, Ohio 44024
Principal Investigator: Min Yao
Phone: 800-641-2422
?
mi
from
Chardon, OH
Click here to add this to my saved trials
171 Ashley Avenue
Charleston, South Carolina 29425
843-792-1414
Principal Investigator: Anand K. Sharma
Phone: 843-792-9321
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
?
mi
from
Charleston, SC
Click here to add this to my saved trials
Charlottesville, Virginia 22903
(434) 924-0311
Principal Investigator: Paul W. Read
Phone: 434-243-6143
University of Virginia The University of Virginia is distinctive among institutions of higher education. Founded...
?
mi
from
Charlottesville, VA
Click here to add this to my saved trials
1969 W Ogden Ave
Chicago, Illinois 60612
(312) 864-6000
Principal Investigator: Fred R. Rosen
Phone: 312-864-6000
John H. Stroger, Jr. Hospital of Cook County The Level 1 Trauma Center is one...
?
mi
from
Chicago, IL
Click here to add this to my saved trials
1200 West Harrison Stree
Chicago, Illinois 60607
(312) 996-4350
Principal Investigator: Lawrence E. Feldman
Phone: 312-355-3046
Univ of Illinois A major research university in the heart of one of the world's...
?
mi
from
Chicago, IL
Click here to add this to my saved trials
2600 Clifton Ave
Cincinnati, Ohio 45267
(513) 556-6000
Principal Investigator: Kevin P. Redmond
Phone: 513-558-4553
University of Cincinnati The University of Cincinnati offers students a balance of educational excellence and...
?
mi
from
Cincinnati, OH
Click here to add this to my saved trials
9280 SE Sunnybrook Blvd #100
Clackamas, Oregon 97015
(503) 513-3300
Principal Investigator: Matthew C. Solhjem
Phone: 503-215-6412
Clackamas Radiation Oncology Center State-of-the-art technology and compassionate care come together at Clackamas Radiation Oncology...
?
mi
from
Clackamas, OR
Click here to add this to my saved trials
10900 Euclid Ave
Cleveland, Ohio 44106
216-368-2000
Principal Investigator: Min Yao
Phone: 800-641-2422
Case Western Reserve Univ Continually ranked among America's best colleges, Case Western Reserve University has...
?
mi
from
Cleveland, OH
Click here to add this to my saved trials
18101 Lorain Avenue
Cleveland, Ohio 44111
216.476.7000
Principal Investigator: David J. Adelstein
Phone: 866-223-8100
Cleveland Clinic Cancer Center at Fairview Hospital Fairview Hospital is a 488-bed hospital located at...
?
mi
from
Cleveland, OH
Click here to add this to my saved trials
2049 E 100th St
Cleveland, Ohio 44106
(216) 444-2200
Principal Investigator: David J. Adelstein
Phone: 866-223-8100
Cleveland Clinic Foundation The Cleveland Clinic (formally known as The Cleveland Clinic Foundation) is a...
?
mi
from
Cleveland, OH
Click here to add this to my saved trials
6001 E Woodmen Rd
Colorado Springs, Colorado 80923
(719) 776-5000
Principal Investigator: Keren Sturtz
Phone: 888-785-6789
Penrose-Saint Francis Healthcare Founded by the Sisters of St. Francis and the Sisters of Charity,...
?
mi
from
Colorado Springs, CO
Click here to add this to my saved trials
1 Hospital Dr
Columbia, Missouri 65212
(573) 882-2100
Principal Investigator: Donald C. Doll
Phone: 573-882-7440
University of Missouri-Ellis Fischel Ellis Fischel Cancer Center's team of physician specialists and other trained...
?
mi
from
Columbia, MO
Click here to add this to my saved trials
Columbus, Ohio 43210
Principal Investigator: Maura L. Gillison
Phone: 866-627-7616
?
mi
from
Columbus, OH
Click here to add this to my saved trials
650 Commack Rd
Commack, New York 11725
(631) 623-4000
Principal Investigator: Nancy Y. Lee
Phone: 212-639-7202
Memorial Sloan-Kettering Cancer Center at Commack Memorial Sloan Kettering Cancer Center - the world's oldest...
?
mi
from
Commack, NY
Click here to add this to my saved trials
4050 Coon Rapids Blvd NW
Coon Rapids, Minnesota 55433
(763) 236-6000
Principal Investigator: Paul W. Sperduto
Phone: 952-993-1517
Mercy Hospital Mercy Hospital, located in Coon Rapids, Minnesota, is a 271-bed non-profit hospital that...
?
mi
from
Coon Rapids, MN
Click here to add this to my saved trials
1801 Inwood Rd
Dallas, Texas 75390
(214) 645-3300
Principal Investigator: Lucien A. Nedzi
Phone: 214-648-7097
University of Texas Southwestern Medical Center UT Southwestern is an academic medical center, world-renowned for...
?
mi
from
Dallas, TX
Click here to add this to my saved trials
100 North Academy Avenue
Danville, Pennsylvania 17822
570-271-6211
Principal Investigator: Thomas J. Gergel
Phone: 570-271-5251
Geisinger Medical Center Since 1915, Geisinger Medical Center has been known as the region’s resource...
?
mi
from
Danville, PA
Click here to add this to my saved trials
18101 Oakwood Blvd
Dearborn, Michigan 48124
313.593.7000
Principal Investigator: Samir Narayan
Phone: 734-712-3456
Oakwood Hospital For more than 60 years, Oakwood Hospital - Dearborn (OH-D) has proudly served...
?
mi
from
Dearborn, MI
Click here to add this to my saved trials
Decatur, Georgia 30033
?
mi
from
Decatur, GA
Click here to add this to my saved trials
Deerfield Beach, Florida 33442
Principal Investigator: Michael A. Samuels
Phone: 866-574-5124
?
mi
from
Deerfield Beach, FL
Click here to add this to my saved trials
Denton, Texas 76210
Principal Investigator: Vivek S. Kavadi
Phone: 281-277-5200
?
mi
from
Denton, TX
Click here to add this to my saved trials
2525 S Downing St
Denver, Colorado 80210
(303) 778-1955
Principal Investigator: Keren Sturtz
Phone: 888-785-6789
Porter Adventist Hospital Founded in 1930, Porter Adventist Hospital has provided people throughout Denver and...
?
mi
from
Denver, CO
Click here to add this to my saved trials
1111 6th Ave
Des Moines, Iowa 50314
(515) 247-3121
Principal Investigator: Robert J. Behrens
Phone: 888-244-6061
Mercy Medical Center - Des Moines Mercy Medical Center
?
mi
from
Des Moines, IA
Click here to add this to my saved trials
1200 Pleasant St
Des Moines, Iowa 50309
(515) 241-6212
Principal Investigator: Robert J. Behrens
Phone: 888-244-6061
Iowa Methodist Medical Center Iowa Methodist Medical Center was established in 1901 in a single...
?
mi
from
Des Moines, IA
Click here to add this to my saved trials
4160 John R St #2122
Detroit, Michigan 48201
(313) 833-1785
Principal Investigator: Harold E. Kim
Phone: 313-576-9363
Wayne State University/Karmanos Cancer Institute Karmanos is based in southeast Michigan, in midtown Detroit, and...
?
mi
from
Detroit, MI
Click here to add this to my saved trials
2799 W Grand Blvd
Detroit, Michigan 48202
(313) 916-2600
Principal Investigator: Eleanor M. Walker
Phone: 313-916-1784
Henry Ford Hospital Founded in 1915 by auto pioneer Henry Ford and now one of...
?
mi
from
Detroit, MI
Click here to add this to my saved trials
22101 Moross Rd
Detroit, Michigan 48236
(313) 343-4000
Principal Investigator: Samir Narayan
Phone: 734-712-3456
Saint John Hospital and Medical Center Founded in 1952, St. John Hospital and Medical Center...
?
mi
from
Detroit, MI
Click here to add this to my saved trials
Duarte, California 91010
?
mi
from
Duarte, CA
Click here to add this to my saved trials
Duluth, Minnesota 55805
Principal Investigator: Steven R. Bonin
Phone: 888-823-5923
?
mi
from
Duluth, MN
Click here to add this to my saved trials
Dunmore, Pennsylvania 18512
Principal Investigator: Rita S. Axelrod
Phone: 215-955-6084
?
mi
from
Dunmore, PA
Click here to add this to my saved trials
East Stroudsburg, Pennsylvania 18301
Principal Investigator: Rita S. Axelrod
Phone: 215-955-6084
?
mi
from
East Stroudsburg, PA
Click here to add this to my saved trials
Edmonton, Alberta
Principal Investigator: Rufus A. Scrimger
Phone: 780-432-8500
?
mi
from
Edmonton,
Click here to add this to my saved trials
Elyria, Ohio 44035
Principal Investigator: Min Yao
Phone: 800-641-2422
?
mi
from
Elyria, OH
Click here to add this to my saved trials
501 E. Hampden Ave.
Englewood, Colorado 80113
303-788-5000
Principal Investigator: Keren Sturtz
Phone: 888-785-6789
?
mi
from
Englewood, CO
Click here to add this to my saved trials
Eugene, Oregon 97401
Principal Investigator: Vivek S. Kavadi
Phone: 281-277-5200
?
mi
from
Eugene, OR
Click here to add this to my saved trials
?
mi
from
Evanston, IL
Click here to add this to my saved trials
Exeter, New Hampshire 03833
?
mi
from
Exeter, NH
Click here to add this to my saved trials
820 4th St N
Fargo, North Dakota 58102
(701) 234-6161
Principal Investigator: Preston D. Steen
Phone: 701-234-6161
Roger Maris Cancer Center Sanford Health is an integrated health system headquartered in the Dakotas...
?
mi
from
Fargo, ND
Click here to add this to my saved trials
Fort Wayne, Indiana 46804
Principal Investigator: Brian K. Chang
Phone: 260-373-8888
?
mi
from
Fort Wayne, IN
Click here to add this to my saved trials
2200 Randallia Drive
Fort Wayne, Indiana 46805
Principal Investigator: Brian K. Chang
Phone: 260-373-8888
?
mi
from
Fort Wayne, IN
Click here to add this to my saved trials
Fort Worth, Texas 76104
Principal Investigator: Vivek S. Kavadi
Phone: 281-277-5200
?
mi
from
Fort Worth, TX
Click here to add this to my saved trials
550 Osborne Rd NE
Fridley, Minnesota 55432
(763) 236-5000
Principal Investigator: Paul W. Sperduto
Phone: 952-993-1517
Unity Hospital Unity Hospital is one of the Twin Cities
?
mi
from
Fridley, MN
Click here to add this to my saved trials
743 Spring St NE
Gainesville, Georgia 30501
770-219-9000
Principal Investigator: Frank G. Lake
Phone: 770-219-8800
Northeast Georgia Medical Center Northeast Georgia Health System (NGHS) is a not-for-profit community health system...
?
mi
from
Gainesville, GA
Click here to add this to my saved trials
40 V-Twin Drive
Gettysburg, Pennsylvania 17325
(717) 339-2640
Principal Investigator: Amit B. Shah
Phone: 877-441-7957
Adams Cancer Center Every day across central Pennsylvania, the people of WellSpan Health work together...
?
mi
from
Gettysburg, PA
Click here to add this to my saved trials
Goldsboro, North Carolina 27534
?
mi
from
Goldsboro, NC
Click here to add this to my saved trials
835 S Van Buren St
Green Bay, Wisconsin 54301
(920) 433-0111
Principal Investigator: Gregory M. Cooley
Phone: 920-699-3500
?
mi
from
Green Bay, WI
Click here to add this to my saved trials
Greenville, South Carolina 29605
Principal Investigator: David L. Grisell
Phone: 864-241-6251
?
mi
from
Greenville, SC
Click here to add this to my saved trials
?
mi
from
Greenville, SC
Click here to add this to my saved trials