Combination Chemotherapy Plus Bevacizumab With or Without Oxaliplatin in Treating Older Patients With Metastatic Colorectal Cancer



Status:Recruiting
Conditions:Colorectal Cancer, Cancer, Cognitive Studies, Neurology
Therapuetic Areas:Neurology, Oncology, Psychiatry / Psychology
Healthy:No
Age Range:Any
Updated:11/18/2012
Start Date:January 2011

Use our guide to learn which trials are right for you!

Randomized Phase III Trial of mFOLFOX7 or XELOX Plus Bevacizumab Versus 5-Fluorouracil/Leucovorin or Capecitabine Plus Bevacizumab as First-line Treatment in Elderly Patients With Metastatic Colorectal Cancer


RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor
cells, either by killing the cells or by stopping them from dividing. Giving more than one
drug (combination chemotherapy) may kill more tumor cells. Monoclonal antibodies, such as
bevacizumab, can block cancer growth in different ways. Some block the ability of cancer
cells to grow and spread. Others find cancer cells and help kill them or carry
cancer-killing substances to them. Bevacizumab may also stop the growth of cancer by
blocking blood flow to the tumor. It is not yet known whether combination chemotherapy plus
bevacizumab is more effective with or without oxaliplatin in treating colorectal cancer.

PURPOSE: This randomized phase III clinical trial is studying how well combination
chemotherapy plus bevacizumab with or without oxaliplatin works in treating older patients
with metastatic colorectal cancer.


OBJECTIVES:

Primary

- To compare the progression-free survival (PFS) of elderly patients with metastatic
colorectal carcinoma who are randomized to receive fluoropyrimidine-based therapy plus
bevacizumab, with or without oxaliplatin.

Secondary

- In a prospectively planned pooled analysis with a similar trial to be conducted by the
Japanese Clinical Oncology Group (JCOG), evaluate and compare the overall survival (OS)
of elderly patients with metastatic colorectal carcinoma who are randomized to receive
fluoropyrimidine-based therapy plus bevacizumab, with or without oxaliplatin.

- To assess and compare response rates and adverse events of elderly patients with
metastatic colorectal carcinoma randomized to receive fluoropyrimidine-based therapy
plus bevacizumab, with or without oxaliplatin.

Tertiary (correlative)

- To evaluate the quality of life (QoL) in elderly patients with metastatic colorectal
carcinoma randomized to receive fluoropyrimidine-based therapy plus bevacizumab, with
or without oxaliplatin.

- To determine whether a geriatric/frailty assessment predicts overall ≥ grade 3 toxicity
to chemotherapy and is associated with PFS, OS, overall QoL, hospitalization, dose
modification (delay or reduction), or discontinuation of chemotherapy due to toxicity,
morbidity, or mortality in elderly patients with metastatic colorectal cancer
randomized to receive fluoropyrimidine-based therapy plus bevacizumab, with or without
oxaliplatin.

- Determine whether a geriatric/frailty assessment tool can identify a subgroup of
elderly patients who benefit from oxaliplatin-based chemotherapy as first-line
treatment of metastatic colorectal carcinoma.

- To analyze relevant pharmacogenetic markers in tissue and blood that may predict
toxicity and/or tumor response in elderly patients with metastatic colorectal carcinoma
randomized to receive fluoropyrimidine-based therapy plus bevacizumab, with or without
oxaliplatin.

- To evaluate the association of tissue-based biomarkers (e.g., KRAS and BRAF status) and
outcome in elderly patients with metastatic colorectal carcinoma randomized to receive
fluoropyrimidine-based therapy plus bevacizumab, with or without oxaliplatin.

- To analyze pharmacokinetics and circulating biomarkers prior to and during therapy and
to assess these alterations with outcome in elderly patients with metastatic colorectal
carcinoma randomized to receive fluoropyrimidine-based therapy plus bevacizumab, with
or without oxaliplatin.

OUTLINE: This is a multicenter study. Patients are stratified according to age (≥ 85 years
vs 80-84 years vs 75-79 years vs 70-74 years), ECOG performance status (0-1 vs 2), and
number of metastatic sites (1 vs > 1). Patients are randomized to 1 of 2 treatment arms.

- Arm A: Patients are assigned to 1 of 2 treatment groups based on physician decision for
fluoropyrimidine.

- Arm A1: Patients receive fluorouracil IV over 46-48 hours, leucovorin calcium IV
over 2 hours, and bevacizumab IV over 10-90 minutes on day 1. Courses repeat every
14 days in the absence of disease progression or unacceptable toxicity.

- Arm A2: Patients receive capecitabine orally (PO) twice daily on days 1-14 and
bevacizumab IV over 30-90 minutes on day 1. Courses repeat every 21 days in the
absence of disease progression or unacceptable toxicity.

- Arm B: Patients are assigned to 1 of 2 treatment groups based on physician decision for
fluoropyrimidine.

- Arm B1: Patients receive mFOLFOX7 comprising oxaliplatin IV over 2 hours,
leucovorin calcium IV over 2 hours, and fluorouracil IV over 46-48 hours on day 1.
Patients also receive bevacizumab IV over 10-90 minutes on day 1. Courses repeat
every 14 days in the absence of disease progression or unacceptable toxicity.

- Arm B2: Patients receive XELOX comprising oxaliplatin IV over 2 hours on day 1 and
capecitabine PO twice daily on days 1-14. Patients also receive bevacizumab IV
over 30-90 minutes on day 1. Courses repeat every 21 days in the absence of
disease progression or unacceptable toxicity.

Patients may undergo blood and tissue sample collection at baseline and additional blood
sample collection during and after study for correlative biomarker, pharmacogenetic, and
pharmacological research studies.

Patients undergo neurotoxicity, quality of life, and geriatric/frailty assessments at
baseline and periodically during and after study treatment.

After completion of study treatment, patients are followed up periodically for 5 years.

DISEASE CHARACTERISTICS:

- Patients must have metastatic colorectal cancer that has been histologically or
cytologically confirmed

- Histologic confirmation can be obtained from the primary tumor with appropriate
imaging studies confirming metastatic spread

- No known central nervous system or brain metastasis that are either symptomatic or
untreated

- If a patient has a resection of the metastasis and is no longer symptomatic, the
patient is eligible for the study

- Patients with neurological symptoms must undergo a CT scan/MRI of the brain to
exclude brain metastasis

PATIENT CHARACTERISTICS:

- Eastern Cooperative Oncology Group Performance Status (ECOG PS) 0, 1, or 2

- Life expectancy ≥ 3 months

- Absolute neutrophil count (ANC) ≥ 1,500/mm^3

- Peripheral platelet count (PLT) ≥ 100,000/mm^3

- Hemoglobin (HgB) > 9.0 g/dL

- Total bilirubin ≤ 1.5 x upper limit of normal (ULN)

- Aspartate transaminase (AST) ≤ 2.5 x ULN (≤ 5 x ULN for patients with liver
involvement)

- Alkaline phosphatase ≤ 3 x ULN (≤ 5 x ULN for patients with liver involvement)

- Creatinine ≤ 1.5 x ULN

- No calculated creatinine clearance < 60 mL/minute

- NOTE: If calculated creatinine clearance does not meet eligibility requirement,
a 24-hour urine can be collected for a creatinine clearance, and the patient can
be enrolled if measured creatinine clearance ≥ 60 mL/minute.

- INR < 1.5 x ULN unless patients are receiving anti-coagulation therapy

- Patients receiving prophylactic anti-coagulation therapy with an agent such as
warfarin or heparin are allowed to participate if INR ≤ 3.0

- UPC ratio < 1 or urine dipstick < 2+

- NOTE: Urine protein must be screened by urine analysis for urine protein
creatinine (UPC) ratio or by dipstick. For UPC ratio ≥ 1.0 or urine dipstick ≥
2+, 24-hour urine protein must be obtained and the level should be < 1,000 mg.

- No men of childbearing potential who are unwilling to employ adequate contraception
during and for 6 months after the last dose of bevacizumab

- Ability to complete questionnaire(s) by themselves or with assistance

- Willing to provide mandatory blood samples for correlative research purposes

- No co-morbid systemic illnesses or other severe concurrent disease that, in the
judgment of the investigator, would make the patient inappropriate for entry into
this study or interfere significantly with the proper assessment of the safety and
adverse events of the prescribed regimens

- No immunocompromised patients (other than that related to the use of corticosteroids)
including patients known to be HIV positive with CD4 < 100 cells/uL

- No uncontrolled intercurrent illness including, but not limited to:

- Ongoing or active infection

- Symptomatic congestive heart failure

- Unstable angina pectoris

- Cardiac arrhythmia

- Psychiatric illness/social situations that would limit compliance with study
requirements

- No other active malignancy ≤ 3 years prior to randomization EXCEPT for nonmelanotic
skin cancer or carcinoma-in-situ of the cervix

- No New York Heart Association (NYHA) classification III or IV congestive heart
failure

- No inadequately controlled hypertension (systolic blood pressure of > 150 mm Hg or
diastolic blood pressure > 100 mm Hg on anti-hypertensive medications)

- No significant traumatic injury ≤ 28 days prior to randomization

- No active or recent hemoptysis (≥ ½ teaspoon of bright red blood per episode) ≤ 30
days prior to randomization

- No history of abdominal fistula, gastrointestinal perforation, or intra-abdominal
abscess ≤ 6 months prior to randomization

- No serious non-healing wound, active ulcer, or untreated bone fracture

- NOTE: Patients with fractures secondary to metastatic disease are eligible after
appropriate radiotherapy.

- No history of hypertensive crisis or hypertensive encephalopathy

- No patient that has experienced any arterial thromboembolic events including, but not
limited to:

- Myocardial infarction

- Stroke

- Transient ischemic attack (TIA)

- Cerebrovascular accident

- Unstable angina ≤ 6 months prior to randomization

- Congestive heart failure requiring use of ongoing maintenance therapy for
life-threatening ventricular arrhythmias

- No significant vascular disease (e.g., aortic aneurysm, aortic dissection) or recent
peripheral arterial thrombosis ≤ 6 months prior to randomization

- No evidence or history of bleeding diathesis (greater than normal risk of bleeding),
coagulopathy (in the absence of therapeutic anticoagulation), or hemorrhage/bleeding
event > grade 3 ≤ 4 weeks prior to randomization

- No known hypersensitivity to any of the components of 5-fluorouracil/leucovorin,
capecitabine, oxaliplatin, or bevacizumab

- No clinically significant peripheral neuropathy at the time of randomization (defined
in the NCI Common Terminology Criteria for Adverse Events [CTCAE] v4.0 as ≥ grade 2
neurosensory or neuromotor toxicity)

PRIOR CONCURRENT THERAPY:

- No prior chemotherapy, radiation therapy, immunotherapy, or biological therapy for
recurrent or metastatic colorectal cancer

- NOTE: Prior chemotherapy or radiotherapy is permitted if they had been
administered as adjuvant or neoadjuvant therapy and a complete surgical
resection of the original colorectal cancer had been achieved.

- No progressive disease ≤ 12 months of completing oxaliplatin-containing adjuvant
therapy

- No prior radiation to > 30% of the bone marrow at any time

- No major surgical procedures or open biopsy ≤ 28 days prior to randomization or
anticipation of need for elective or planned major surgical procedure during the
course of the study

- No core biopsy or other minor surgical procedures ≤ 7 days prior to randomization

- NOTE: Placement of a vascular access device is allowed.

- If there is a history of prior malignancy, patients must not be receiving other
specific treatment (other than hormonal therapy) for this prior cancer

- Not receiving any other investigational agent which would be considered as a
treatment for the primary neoplasm

- Patients receiving full-dose anticoagulants are eligible provided the patient has
been on a stable dose, for at least 2 weeks, of low molecular weight heparin or
warfarin and has an INR range 2-3

- No aspirin doses > 325 mg daily
We found this trial at
381
sites
405 W Grand Ave
Dayton, Ohio 45405
(937) 723-3200
Grandview Hospital You'll feel like part of our family when you visit Grandview Medical Center...
?
mi
from
Dayton, OH
Click here to add this to my saved trials
361 Old Belgrade Road
Augusta, Maine 04330
(207) 621-6100
Harold Alfond Center for Cancer Care MaineGeneral's Harold Alfond Center for Cancer Care (HACCC) is...
?
mi
from
Augusta, ME
Click here to add this to my saved trials
2401 West Belvedere Avenue
Baltimore, Maryland 21215
(410) 601-4688
Alvin and Lois Lapidus Cancer Institute at Sinai Hospital The Alvin & Lois Lapidus Cancer...
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
417 State St #30
Bangor, Maine 04401
(207) 973-7478
CancerCare of Maine at Eastern Maine Medical Center Our compassionate, experienced physicians specialize in the...
?
mi
from
Bangor, ME
Click here to add this to my saved trials
185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
?
mi
from
Boston, MA
Click here to add this to my saved trials
450 Brookline Ave
Boston, Massachusetts 2215
(617) 632-3000
Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute Founded in 1997, Dana-Farber/Harvard Cancer Center (DF/HCC) was...
?
mi
from
Boston, MA
Click here to add this to my saved trials
2600 6th Street Southwest
Canton, Ohio 44710
330-452-9911
Aultman Cancer Center at Aultman Hospital Serving Stark and surrounding counties since 1892, Aultman Hospital...
?
mi
from
Canton, OH
Click here to add this to my saved trials
5841 S Maryland Ave # Mc1140
Chicago, Illinois 60637
1-773-702-6180
University of Chicago Cancer Research Center The University of Chicago Comprehensive Cancer Center (UCCCC) is...
?
mi
from
Chicago, IL
Click here to add this to my saved trials
2500 Metrohealth Dr # C2100
Cleveland, Ohio 44109
(216) 778-5802
MetroHealth Cancer Care Center at MetroHealth Medical Center At the MetroHealth Cancer Care Center, we...
?
mi
from
Cleveland, OH
Click here to add this to my saved trials
3535 Olentangy River Road
Columbus, Ohio 43214
(614) 566-5000
Riverside Methodist Hospital Cancer Care Serving central Ohio since 1892, Riverside Methodist is consistently ranked...
?
mi
from
Columbus, OH
Click here to add this to my saved trials
100 North Academy Ave
Danville, Pennsylvania 17822
570-271-6211
Geisinger Cancer Institute at Geisinger Health Since 1915, Geisinger Medical Center has been known as...
?
mi
from
Danville, PA
Click here to add this to my saved trials
1719 East 19th Avenue
Denver, Colorado 80218
(303) 839-6000
Presbyterian - St. Luke's Medical Center Presbyterian/St. Luke's Medical Center and the Rocky Mountain Hospital...
?
mi
from
Denver, CO
Click here to add this to my saved trials
1 Hurley Plaza
Flint, Michigan 48503
(810) 262-9000
Hurley Medical Center From its founding in 1908, Hurley Medical Center has devoted itself to...
?
mi
from
Flint, MI
Click here to add this to my saved trials
2700 Wayne Memorial Drive
Goldsboro, North Carolina 27534
(919) 736-1110
Wayne Memorial Hospital, Incorporated Wayne Memorial Hospital, an affiliate of Wayne Health Corporation, is home...
?
mi
from
Goldsboro, NC
Click here to add this to my saved trials
1920 Libal Street
Green Bay, Wisconsin 54307
(920) 433-8889
St. Vincent Hospital Regional Cancer Center Our group of 19 oncologists, including the region's only...
?
mi
from
Green Bay, WI
Click here to add this to my saved trials
900 West Faris Road
Greenville, South Carolina 29605
(864) 679-3900
Cancer Centers of the Carolinas - Faris Road Cancer Centers of the Carolinas is now...
?
mi
from
Greenville, SC
Click here to add this to my saved trials
3 Butternut Drive, Suite B
Greenville, South Carolina 29605
(864) 241-7272
Cancer Centers of the Carolinas - Grove Commons Cancer Centers of the Carolinas is now...
?
mi
from
Greenville, SC
Click here to add this to my saved trials
33 Villa Road, Suite 400
Greenville, South Carolina 29615
(864) 404-2045
CCOP - Greenville Cancer care in the last decade has made many advances. Most of...
?
mi
from
Greenville, SC
Click here to add this to my saved trials
701 Grove Rd # 1
Greenville, South Carolina 29605
(864) 455-7000
Greenville Hospital Cancer Center Greenville Health System (GHS) is a public not-for-profit academic healthcare delivery...
?
mi
from
Greenville, SC
Click here to add this to my saved trials
340 Medical Pkwy
Greer, South Carolina 29650
(864) 334-4900
Cancer Centers of the Carolinas - Greer Medical Oncology Cancer Centers of the Carolinas is...
?
mi
from
Greer, SC
Click here to add this to my saved trials
19229 Mack Ave
Grosse Pointe Woods, Michigan 48236
(866) 246-4673
Van Elslander Cancer Center at St. John Hospital and Medical Center We built the Van...
?
mi
from
Grosse Pointe Woods, MI
Click here to add this to my saved trials
4500 San Pablo Rd S
Jacksonville, Florida 32224
(904) 953-2000
Mayo Clinic - Jacksonville Thousands of people come to Mayo Clinic in Jacksonville, Fla., annually...
?
mi
from
Jacksonville, FL
Click here to add this to my saved trials
524 South Park Street
Kalamazoo, Michigan 49007
(269) 341-7654
Bronson Methodist Hospital Our healthcare system serves patients and families throughout southwest Michigan and northern...
?
mi
from
Kalamazoo, MI
Click here to add this to my saved trials
200 North Park Street
Kalamazoo, Michigan 49007
(269) 382-2500
West Michigan Cancer Center In 1994, Borgess Health Alliance and Bronson Healthcare Group opened the...
?
mi
from
Kalamazoo, MI
Click here to add this to my saved trials
3535 Southern Boulevard
Kettering, Ohio 45429
(937) 298-4331
Charles F. Kettering Memorial Hospital Our flagship hospital, Kettering Medical Center, stands proudly in Kettering,...
?
mi
from
Kettering, OH
Click here to add this to my saved trials
701 Doctors Dr
Kinston, North Carolina 28504
(252) 559-2200
Kinston Medical Specialists offers comprehensive medical services for all ages. Whether it’s a case of...
?
mi
from
Kinston, NC
Click here to add this to my saved trials
1900 South Avenue
La Crosse, Wisconsin 54601
(608) 782-7300
Gundersen Lutheran Center for Cancer and Blood Gundersen Health System is where caring meets excellence...
?
mi
from
La Crosse, WI
Click here to add this to my saved trials
902 Savannah Road
Lewes, Delaware 19958
(302) 645-3770
Tunnell Cancer Center at Beebe Medical Center The Robert & Eolyne Tunnell Cancer Center at...
?
mi
from
Lewes, DE
Click here to add this to my saved trials
800 NE 10th Street
Oklahoma City, Oklahoma 73104
(855) 750-2273
Oklahoma University Cancer Institute The Peggy and Charles Stephenson Cancer Center is located on the...
?
mi
from
Oklahoma City, OK
Click here to add this to my saved trials
1400 South Orange Avenue
Orlando, Florida 32806
(407) 648-3800
M.D. Anderson Cancer Center at Orlando For more than twenty years, our cancer center has...
?
mi
from
Orlando, FL
Click here to add this to my saved trials
660 S Euclid Ave #8100
Saint Louis, Missouri 63110
(314) 362-5196
Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis The Alvin J. Siteman Cancer Center...
?
mi
from
Saint Louis, MO
Click here to add this to my saved trials
4502 Medical Drive
San Antonio, Texas 78284
(210) 567-7000
University of Texas Health Science Center at San Antonio The University of Texas Health Science...
?
mi
from
San Antonio, TX
Click here to add this to my saved trials
Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center The Curtis and...
?
mi
from
Savannah, GA
Click here to add this to my saved trials
131 Lila Doyle Drive
Seneca, South Carolina 29672
(864) 888-3717
Cancer Centers of the Carolinas - Seneca Cancer Centers of the Carolinas is now Cancer...
?
mi
from
Seneca, SC
Click here to add this to my saved trials
3900 W Avera Drive
Sioux Falls, South Dakota 57108
(605) 322-4700
Avera Cancer Institute Avera, the health ministry of the Benedictine and Presentation Sisters, is a...
?
mi
from
Sioux Falls, SD
Click here to add this to my saved trials
120 Dillon Dr
Spartanburg, South Carolina 29307
(864) 699-5700
Cancer Centers of the Carolinas - Spartanburg Cancer Centers of the Carolinas is now Cancer...
?
mi
from
Spartanburg, SC
Click here to add this to my saved trials
?
mi
from
Stuart, FL
Click here to add this to my saved trials
750 E Adams St
Syracuse, New York 13210
(315) 464-5540
SUNY Upstate Medical University Hospital SUNY Upstate Medical University in Syracuse, NY, is the only...
?
mi
from
Syracuse, NY
Click here to add this to my saved trials
42 E Laurel Rd # 2545
Voorhees, New Jersey 08043
(800) 826-6737
Cancer Institute of New Jersey at Cooper - Voorhees Cooper University Health Care, the clinical...
?
mi
from
Voorhees, NJ
Click here to add this to my saved trials
825 N Emporia Ave
Wichita, Kansas 67214
(316) 261-3200
Via Christi Cancer Center at Via Christi Regional Medical Center Via Christi Health's rich history...
?
mi
from
Wichita, KS
Click here to add this to my saved trials
Aberdeen, South Dakota 57401
?
mi
from
Aberdeen, SD
Click here to add this to my saved trials
777 Kimole Ln
Adrian, Michigan 49221
517-265-0900
Hickman Cancer Center at Bixby Medical Center At ProMedica Bixby Hospital, we
?
mi
from
Adrian, MI
Click here to add this to my saved trials
161 North Forge Street
Akron, Ohio 44304
(330) 375-7280
Summa Center for Cancer Care at Akron City Hospital Summa Health System is a leader...
?
mi
from
Akron, OH
Click here to add this to my saved trials
1 Akron General Ave
Akron, Ohio 44307
(330) 344-6000
McDowell Cancer Center at Akron General Medical Center Learning that you or someone you love...
?
mi
from
Akron, OH
Click here to add this to my saved trials
1415 Tulane Ave., HC-62
Alexandria, Louisiana 70112
504-988-6121
Tulane Cancer Center Office of Clinical Research As an academic cancer center, Tulane offers our...
?
mi
from
Alexandria, LA
Click here to add this to my saved trials
Alexandria, Louisiana 71301
?
mi
from
Alexandria, LA
Click here to add this to my saved trials
Ames, Iowa 50010
McFarland Clinic, PC It has been over 65 years since the founders of McFarland Clinic...
?
mi
from
Ames, IA
Click here to add this to my saved trials
5301 East Huron River Drive
Ann Arbor, Michigan 48106
1.877.590.5995
CCOP - Michigan Cancer Research Consortium The Community Clinical Oncology Program (CCOP) is a comprehensive...
?
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
5301 McAuley Drive
Ann Arbor, Michigan 48197
734-712-4673
Saint Joseph Mercy Cancer Center Saint Joseph Mercy Health System is one of Michigan's most...
?
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
Atlanta, Georgia 30342
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
5665 Peachtree Dunwoody Rd NE
Atlanta, Georgia 30342
(678) 843-7001
Saint Joseph's Hospital of Atlanta Founded by the Sisters of Mercy in 1880, Saint Joseph
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
Atlanta, Georgia 30342
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
1968 Peachtree Rd NW
Atlanta, Georgia 30309
(404) 605-5000
Piedmont Hospital For more than a century, Piedmont Healthcare has been a recognized leader in...
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
Attleboro, Massachusetts 02703
?
mi
from
Attleboro, MA
Click here to add this to my saved trials
700 Potomac St
Aurora, Colorado 80012
(303) 363-7200
Aurora Presbyterian Hospital At The Medical Center of Aurora and Centennial Medical Plaza, we treat...
?
mi
from
Aurora, CO
Click here to add this to my saved trials
Austell, Georgia 30106
?
mi
from
Austell, GA
Click here to add this to my saved trials
900 Caton Ave.
Baltimore, Maryland 21229
410-368-6000
St. Agnes Hospital Cancer Center Saint Agnes Hospital is leading Maryland in the battle against...
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
155 5th St NE
Barberton, Ohio 44203
(330) 615-3000
Summa Barberton Hospital Summa Barberton Hospital is a full member of Summa Health System and...
?
mi
from
Barberton, OH
Click here to add this to my saved trials
Baton Rouge, Louisiana 70809
?
mi
from
Baton Rouge, LA
Click here to add this to my saved trials
8111 South Emerson Avenue
Beech Grove, Indiana 46237
(317) 528-5000
St. Francis Hospital and Health Centers - Beech Grove Campus A trusted leader in providing...
?
mi
from
Beech Grove, IN
Click here to add this to my saved trials
?
mi
from
Bettendorf, IA
Click here to add this to my saved trials
720 E Rosser Ave
Bismarck, North Dakota 58501
(701) 323-6741
Medcenter One Hospital Cancer Care Center Sanford Health is an integrated health system headquartered in...
?
mi
from
Bismarck, ND
Click here to add this to my saved trials
900 E Broadway Ave
Bismarck, North Dakota 58501
(701) 530-5550
Mid Dakota Clinic, PC We're your family clinic, with the doctors you know and trust...
?
mi
from
Bismarck, ND
Click here to add this to my saved trials
900 East Broadway
Bismarck, North Dakota 58501
701.530.7000
St. Alexius Medical Center Cancer Center Throughout the healing continuum we are dedicated to our...
?
mi
from
Bismarck, ND
Click here to add this to my saved trials
2200 E Washington St,
Bloomington, Illinois 61701
(309) 662-3311
St. Joseph Medical Center Located in Bloomington, Illinois, OSF St. Joseph Medical Center is a...
?
mi
from
Bloomington, IL
Click here to add this to my saved trials
1505 Eastland Drive
Bloomington, Illinois 61701
309-662-2102
Illinois CancerCare-Bloomington Illinois CancerCare, P.C. is a comprehensive practice treating patients withcancer andblood diseases. Our...
?
mi
from
Bloomington, IL
Click here to add this to my saved trials
1055 N Curtis Rd
Boise, Idaho 83706
(208) 367-2121
Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center Saint Alphonsus Health System...
?
mi
from
Boise, ID
Click here to add this to my saved trials
44 Binney St
Boston, Massachusetts 02115
(617) 632-6364
Dana-Farber/Brigham and Women's Cancer Center Boston's Brigham and Women's Hospital (BWH) is an international leader...
?
mi
from
Boston, MA
Click here to add this to my saved trials
1100 Balsam Ave
Boulder, Colorado 80304
(303) 440-2273
Boulder Community Hospital Founded in 1922 as a community-owned and operated not-for-profit hospital, Boulder Community...
?
mi
from
Boulder, CO
Click here to add this to my saved trials
960 W. Wooster
Bowling Green, Ohio 43402
419-352-9498
Wood County Oncology Center The Cancer Care Center at Wood County Hospital opened March 2014,...
?
mi
from
Bowling Green, OH
Click here to add this to my saved trials
Brainerd, Minnesota 56401
?
mi
from
Brainerd, MN
Click here to add this to my saved trials
130 S Bryn Mawr Ave
Bryn Mawr, Pennsylvania 19010
(484) 337-3000
Bryn Mawr Hospital Bryn Mawr Hospital, a nationally recognized community teaching hospital, is conveniently located...
?
mi
from
Bryn Mawr, PA
Click here to add this to my saved trials
?
mi
from
Burbank, CA
Click here to add this to my saved trials
201 E Nicollet Blvd
Burnsville, Minnesota 55337
(952) 892-2000
Fairview Ridges Hospital Fairview Ridges Hospital is a 150-bed, Level III Trauma Care facility, offering...
?
mi
from
Burnsville, MN
Click here to add this to my saved trials
210 W Walnut St
Canton, Illinois 61520
(309) 647-5240
Graham Hospital At Graham Hospital, we have a proud and rich history of serving the...
?
mi
from
Canton, IL
Click here to add this to my saved trials
210 W Walnut St
Canton, Illinois 61520
309-647-5240
Illinois CancerCare - Canton Illinois CancerCare is one of the largest private oncology and hematology...
?
mi
from
Canton, IL
Click here to add this to my saved trials
211 Saint Francis Drive
Cape Girardeau, Missouri 63703
573-331-3000
Saint Francis Medical Center Saint Francis Medical Center is a 282-bed facility serving more than...
?
mi
from
Cape Girardeau, MO
Click here to add this to my saved trials
789 Mt Auburn Rd
Cape Girardeau, Missouri 63703
(573) 519-4725
Southeast Cancer Center SoutheastHEALTH is a far-reaching network of providers and facilities including Southeast Hospital...
?
mi
from
Cape Girardeau, MO
Click here to add this to my saved trials
160 S Adams St
Carthage, Illinois 62321
(217) 357-6877
Illinois CancerCare - Carthage Illinois CancerCare, P.C. is a comprehensive practice treating patients withcancer andblood...
?
mi
from
Carthage, IL
Click here to add this to my saved trials
1454 North County Road 2050
Carthage, Illinois 62321
(217) 357-8500
Memorial Hospital Memorial Hospital is a vital force in establishing and maintaining the well-being of...
?
mi
from
Carthage, IL
Click here to add this to my saved trials
701 10th St SE
Cedar Rapids, Iowa 52403
(319) 365-4673
Mercy Regional Cancer Center at Mercy Medical Center Hall-Perrine Cancer Center is a part of...
?
mi
from
Cedar Rapids, IA
Click here to add this to my saved trials
525 10th St SE
Cedar Rapids, Iowa 52403
(319) 363-8303
Cedar Rapids Oncology Associates Oncology Associates at Mercy Medical Center in Cedar Rapids (also known...
?
mi
from
Cedar Rapids, IA
Click here to add this to my saved trials
505 S Plummer Ave
Chanute, Kansas 66720
(620) 431-7580
Cancer Center of Kansas, PA - Chanute Dr. H.E. Hynes founded Cancer Center of Kansas,...
?
mi
from
Chanute, KS
Click here to add this to my saved trials
Charleston, South Carolina 29401
?
mi
from
Charleston, SC
Click here to add this to my saved trials
1801 West Taylor, Suite 1E
Chicago, Illinois 60612
312.355.1625
University of Illinois Cancer Center The University of Illinois Cancer Center is dedicated to reducing...
?
mi
from
Chicago, IL
Click here to add this to my saved trials
?
mi
from
Chicago, IL
Click here to add this to my saved trials
?
mi
from
Chicago, IL
Click here to add this to my saved trials
Chicago, Illinois 60640
?
mi
from
Chicago, IL
Click here to add this to my saved trials
272 Hospital Rd
Chillicothe, Ohio 45601
740-779-7500
Adena Regional Medical Center Since 1895, Adena Health System has remained focused on its commitment...
?
mi
from
Chillicothe, OH
Click here to add this to my saved trials
12961 27th Ave
Chippewa Falls, Wisconsin 54729
715-738-3700
Marshfield Clinic - Chippewa Center The 15,000 square foot Lake Hallie Center provides urgent care...
?
mi
from
Chippewa Falls, WI
Click here to add this to my saved trials
12495 University Ave
Clive, Iowa 50325
(515) 358-9700
Mercy Cancer Center - West Lakes When it comes to cancer care, there
?
mi
from
Clive, IA
Click here to add this to my saved trials
2222 N. Nevada Avenue
Colorado Springs, Colorado 80907
(719) 776-5000
Penrose Cancer Center at Penrose Hospital Through a full range of clinical trials, genetic counseling,...
?
mi
from
Colorado Springs, CO
Click here to add this to my saved trials
1831 Fifth Avenue
Columbus, Georgia 31904
(706) 320-8700
John B. Amos Cancer Center The John B. Amos Cancer Center located in Columbus, Georgia,...
?
mi
from
Columbus, GA
Click here to add this to my saved trials
111 S Grant Avenue
Columbus, Ohio 43215
(614) 566-4321
?
mi
from
Columbus, OH
Click here to add this to my saved trials
Columbus, Ohio 43219
?
mi
from
Columbus, OH
Click here to add this to my saved trials
5100 W Broad St
Columbus, Ohio 43228
(614) 544-1000
Doctors Hospital Nationally recognized for care quality and patient safety and satisfaction, Doctors Hospital is...
?
mi
from
Columbus, OH
Click here to add this to my saved trials
1335 Dublin Road, Suite 124A
Columbus, Ohio 43215
(614) 488-2118
CCOP - Columbus As one of the original 20 CCOPs, the Columbus Community Clinical Oncology...
?
mi
from
Columbus, OH
Click here to add this to my saved trials
793 West State Street
Columbus, Ohio 43222
614-234-5000
Mount Carmel Health - West Hospital Located near downtown Columbus, Mount Carmel West is the...
?
mi
from
Columbus, OH
Click here to add this to my saved trials
300 W 10th Ave
Columbus, Ohio 43210
(800) 293-5066
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center...
?
mi
from
Columbus, OH
Click here to add this to my saved trials
11850 Blackfoot St. NW Suite 130
Coon Rapids, Minnesota 55433
763-236-0808
Mercy and Unity Cancer Center at Mercy Hospital The Virginia Piper Cancer Institute - Mercy...
?
mi
from
Coon Rapids, MN
Click here to add this to my saved trials
1 Wyoming St
Dayton, Ohio 45409
(937) 208-2300
?
mi
from
Dayton, OH
Click here to add this to my saved trials