Chemotherapy With or Without Bevacizumab in Treating Women With Stage I, Stage II, or Stage IIIA Breast Cancer That Can Be Removed By Surgery



Status:Active, not recruiting
Conditions:Breast Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - 120
Updated:4/21/2016
Start Date:November 2006
End Date:March 2016

Use our guide to learn which trials are right for you!

A Randomized Phase III Trial of Neoadjuvant Therapy in Patients With Palpable and Operable Breast Cancer Evaluating the Effect on Pathologic Complete Response (pCR) of Adding Capecitabine or Gemcitabine to Docetaxel When Administered Before AC With or Without Bevacizumab and Correlative Science Studies Attempting to Identify Predictors of High Likelihood for pCR With Each of the Regimens

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor
cells, either by killing the cells or by stopping them from dividing. Giving more than one
drug (combination chemotherapy) may kill more tumor cells. Monoclonal antibodies, such as
bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells
to grow and spread. Others find tumor cells and help kill them or carry tumor-killing
substances to them. Bevacizumab may also stop the growth of breast cancer by blocking blood
flow to the tumor. Giving chemotherapy and bevacizumab before surgery may make the tumor
smaller and reduce the amount of normal tissue that needs to be removed. Giving bevacizumab
after surgery may kill any tumor cells that remain after surgery. It is not yet known which
chemotherapy regimen is more effective with or without bevacizumab in treating breast
cancer.

PURPOSE: This randomized phase III trial is studying six different chemotherapy regimens to
compare how well they work with or without bevacizumab in treating women with stage I, stage
II, or stage IIIA breast cancer that can be removed by surgery.

OBJECTIVES:

Primary

- Compare the efficacy of docetaxel followed by doxorubicin hydrocloride and
cyclophosphamide (AC) vs docetaxel and capecitabine followed by AC vs docetaxel and
gemcitabine hydrochloride followed by AC, with or without bevacizumab, in terms of an
increase in the rate of pathologic complete response (pCR) in the breast, in women with
palpable or operable breast cancer.

Secondary

- Compare docetaxel/capecitabine with AC vs docetaxel/gemcitabine hydrochloride with AC
vs docetaxel with AC, with or without bevacizumab, in terms of the rate of pCR in the
breast and all post-therapy lymph nodes evaluated histologically (pCR breast and
nodes).

- Determine whether the addition of bevacizumab to the docetaxel/anthracycline-based
regimens (docetaxel with AC, docetaxel and capecitabine with AC, and docetaxel and
gemcitabine hydrochloride with AC) will increase the rate of pCR of the breast and
nodes compared to the same docetaxel/anthracycline-based regimens without bevacizumab
in these patients.

- Determine whether the addition of capecitabine or gemcitabine hydrochloride to
docetaxel, with or without bevacizumab, will increase the rate of clinical overall
response (cOR) compared to docetaxel alone with or without bevacizumab in these
patients.

- Determine whether the addition of bevacizumab to the docetaxel/anthracycline-based
regimens will increase the rate of cOR compared to the same
docetaxel/anthracycline-based regimens without bevacizumab in these patients.

- Determine whether the addition of capecitabine or gemcitabine hydrochloride to
docetaxel, with or without bevacizumab, will increase the rate of clinical complete
response (cCR) compared to docetaxel alone with or without bevacizumab in these
patients.

- Determine whether the addition of bevacizumab to the docetaxel/anthracycline-based
regimens (docetaxel with AC, docetaxel/capecitabine with AC, and docetaxel/gemcitabine
hydrochloride with AC) will increase the rate of cCR compared to the same
docetaxel/anthracycline-based regimens without bevacizumab in these patients.

- Identify gene expression profiles that can predict pCR in patients treated with the
different sequential docetaxel/anthracycline-based regimens with or without
bevacizumab.

- Identify gene expression profiles that can predict cOR in patients treated with
docetaxel alone, docetaxel/capecitabine, or docetaxel/gemcitabine hydrochloride with or
without bevacizumab.

- Determine the accuracy of an in vitro chemoresponse assay (ChemoFx®) as a predictor of
pCR in patients treated with the different sequential docetaxel/anthracycline-based
regimens without bevacizumab.

- Determine the accuracy of ChemoFx® as a predictor of cOR in patients treated with
docetaxel alone, docetaxel/capecitabine, or docetaxel/gemcitabine hydrochloride without
bevacizumab in these patients.

- Determine the impact of preoperative bevacizumab and sequential chemotherapy regimens
and postoperative bevacizumab therapy on cardiac function in these patients.

- Determine the impact of bevacizumab on surgical complications in these patients.

- Determine the toxicity of the preoperative regimens and the toxicity of postoperative
bevacizumab in these patients.

- Compare the docetaxel/anthracycline-based regimens with vs without bevacizumab, in
terms of an increase in disease-free survival, of these patients.

OUTLINE: This is a randomized, multicenter study. Patients are stratified according to tumor
size (2-4 cm vs > 4 cm), nodal status (negative vs positive), hormone receptor status
(estrogen receptor [ER]-positive and/or progesterone-receptor [PgR]-positive vs ER- and
PgR-negative), and age (< 50 years vs ≥ 50 years). Patients are randomized to 1 of 6
treatment arms.

Core needle biopsies are performed at baseline. Tumor tissue samples are also collected
during definitive surgery. Samples are examined for gene expression and polymorphism by
reverse transcriptase-polymerase chain reaction analysis and chemoresponse assay (ChemoFx®).

After completion of study therapy, patients are followed periodically for 10 years.

PROJECTED ACCRUAL: A total of 1,200 patients will be accrued for this study.

Inclusion Criteria:

- The patient must have consented to participate and must have signed and dated an
appropriate Institutional Review Board (IRB)-approved consent form that conforms to
federal and institutional guidelines for the study treatment and submission of
pre-entry core biopsy material for correlative studies.

- Patients must be female.

- Patients must be 18 years of age or older.

- Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of
0 or 1.

- The diagnosis of invasive adenocarcinoma of the breast must have been made by core
needle biopsy.

- The primary breast tumor must be palpable and measure greater than or equal to 2.0 cm
on physical exam.

- All patients must have their left ventricular ejection fraction (LVEF) assessed by
multigated acquisition (MUGA) scan or echocardiogram within 3 months prior to study
entry. The LVEF must be greater than or equal to the lower limit of normal (LLN) for
the cardiac imaging facility performing the study. Note: If the cardiac imaging
facility cannot provide a LLN, use 50% as the LLN value.

- Note: Since the pre-entry LVEF serves as the baseline for comparing subsequent LVEF
assessments to determine if bevacizumab therapy can be continued, it is critical that
this baseline study be an accurate assessment of the patient's LVEF. If the baseline
LVEF is greater than 75%, the investigator should have the study reviewed for
accuracy prior to study entry. Following study entry, the LVEF determination may be
reviewed up until the time of the post-chemotherapy (preoperative) evaluation. Please
note that if a more accurate value is obtained from the review of the baseline MUGA
or echocardiogram, the correct value must be submitted to the NSABP before the
post-chemotherapy (preoperative) MUGA or echocardiogram is performed or it cannot be
used for managing postoperative bevacizumab.

- All patients must have an EKG within 3 months prior to study entry.

- At the time of randomization:

- Absolute neutrophil count (ANC) must be greater than or equal to 1200/mm3.

- Platelet count must be greater than or equal to 100,000/mm3.

- Hemoglobin must be greater than or equal to 10 g/dL.

- There must be evidence of adequate hepatic function by these criteria:

- Total bilirubin must be less than or equal to the ULN for the lab unless the
patient has a grade 1 bilirubin elevation (greater than ULN to 1.5 x ULN)
resulting from Gilbert's disease or similar syndrome due to slow conjugation of
bilirubin; and

- Alkaline phosphatase must be less than or equal 2.5 x ULN for the lab; and

- Aspartate Aminotransferase (AST) must be less than or equal to 1.5 x ULN for the
lab.

- Alkaline phosphatase and AST may not both be greater than the ULN. For example,
if the alkaline phosphatase is greater than the ULN but less than or equal 2.5 x
ULN, then the AST must be less than or equal the ULN. If the AST is greater than
the ULN but less than or equal 1.5 x ULN, then the alkaline phosphatase must be
less than or equal ULN.

- Patients with either skeletal pain or alkaline phosphatase that is greater than ULN
but less than or equal 2.5 x ULN are eligible for inclusion in the study if bone
scans do not demonstrate metastatic disease. Suspicious findings on bone scan must be
confirmed as benign by x-ray, MRI, or biopsy.

- Patients with AST or alkaline phosphatase greater than ULN are eligible for inclusion
in the study if liver imaging does not demonstrate metastatic disease and adequate
bone marrow and liver function results as described above are met.

- The following criteria for evidence of adequate renal function must be met:

- Serum creatinine less than or equal ULN for the lab.

- Calculated creatinine clearance must be greater than 50 mL/min.

- Urine protein/urine creatinine (UPC) ratio must be less than 1.0.

- Patient must be able to swallow oral medications.

Exclusion criteria:

- Tumor determined to be strongly human epidermal growth factor receptor 2
(HER2)-positive by immunohistochemistry (3+) or by fluorescent in situ hybridization
(positive for gene amplification).

- Excisional or incisional biopsy for this primary breast tumor.

- Surgical axillary staging procedure prior to study entry. Exceptions: 1) Fine Needle
Aspiration (FNA) or core biopsy of an axillary node is permitted for any patient, and
2) although not recommended, a pre-neoadjuvant therapy sentinel lymph node biopsy for
patients with clinically negative axillary nodes is permitted.

- Tumors clinically staged as T4.

- Ipsilateral cN2b or cN3 disease. (Patients with cN1 or cN2a disease are eligible.)

- Definitive clinical or radiologic evidence of metastatic disease.

- Synchronous bilateral breast cancer (invasive or DCIS).

- Treatment including radiation therapy, chemotherapy, biotherapy, and/or hormonal
therapy for the currently diagnosed breast cancer prior to study entry.

- Any sex hormonal therapy, e.g., birth control pills, ovarian hormonal replacement
therapy, etc. (These patients are eligible if this therapy is discontinued prior to
randomization.)

- Therapy with any hormonal agent such as raloxifene, tamoxifen, or other selective
estrogen receptor modulator (SERM), either for osteoporosis or breast cancer
prevention. (Patients are eligible only if these medications are discontinued prior
to randomization.)

- Prior history of breast cancer, including DCIS. (Patients with a history of lobular
carcinoma in situ [LCIS] are eligible.)

- Prior therapy with anthracyclines, taxanes, capecitabine, 5-FU, gemcitabine, or
bevacizumab for any malignancy.

- Other malignancies unless the patient is considered to be disease-free for 5 or more
years prior to randomization and is deemed by her physician to be at low risk for
recurrence. Patients with the following cancers are eligible if diagnosed and treated
within the past 5 years: carcinoma in situ of the cervix, carcinoma in situ of the
colon, melanoma in situ, and basal cell and squamous cell carcinoma of the skin.

- Cardiac disease that would preclude the use of anthracyclines. This includes:

- angina pectoris that requires the use of anti-anginal medication;

- history of documented congestive heart failure;

- serious cardiac arrhythmia requiring medication;

- severe conduction abnormality;

- valvular disease with documented cardiac function compromise; and

- uncontrolled hypertension defined as BP greater than 150/90 on antihypertensive
therapy. (Patients with hypertension that is well controlled on medication are
eligible.)

- History of myocardial infarction documented by elevated cardiac enzymes or persistent
regional wall abnormalities on assessment of LV function.

- History of transient ischemic attack (TIA) or cerebrovascular accident (CVA).

- History of other arterial thrombotic event within 12 months before study entry.

- Symptomatic peripheral vascular disease.

- Any significant non-traumatic bleeding within 6 months before study entry.

- Serious or non-healing wound, skin ulcers, or incompletely healed bone fracture.

- Gastroduodenal ulcer(s) determined by endoscopy to be active.

- Invasive procedures defined as follows:

- Major surgical procedure, open biopsy, or significant traumatic injury within 28
days prior to planned start of study therapy. (Note: Placement of a vascular
access device is not considered a major surgical procedure.)

- Anticipation of need for major surgical procedures (other than the required
breast surgery) during the course of the study.

- Known bleeding diathesis or coagulopathy. (Patients on warfarin with an in-range
international normalized ration [INR] [usually between 2 and 3] are eligible.)

- Sensory/motor neuropathy greater than or equal grade 2, as defined by the NCI's
Common Terminology Criteria for Adverse Events Version 3.0 (CTCAE v3.0).

- Other non-malignant systemic disease (cardiovascular, renal, hepatic, etc.) that
would preclude treatment with any of the treatment regimens or would prevent required
follow-up.

- Conditions that would prohibit administration of corticosteroids.

- History of severe hypersensitivity reaction to drugs formulated with polysorbate 80.

- Administration of any investigational agents within 30 days before study entry.

- Pregnancy or lactation at the time of proposed randomization.
We found this trial at
433
sites
4300 Alton Road
Miami Beach, Florida 33140
(305) 674-2625
CCOP - Mount Sinai Medical Center The Mount Sinai Community Clinical Oncology Program (MSCCOP) is...
?
mi
from
Miami Beach, FL
Click here to add this to my saved trials
1200 S Cedar Crest Blvd
Allentown, Pennsylvania 18103
(610) 402-8000
Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest Lehigh Valley Hospital provides a...
?
mi
from
Allentown, PA
Click here to add this to my saved trials
2600 6th Street Southwest
Canton, Ohio 44710
330-452-9911
Aultman Cancer Center at Aultman Hospital Serving Stark and surrounding counties since 1892, Aultman Hospital...
?
mi
from
Canton, OH
Click here to add this to my saved trials
86 Jonathan Lucas Street
Charleston, South Carolina 29425
(843) 792-0700
Hollings Cancer Center at Medical University of South Carolina Located at the Medical University of...
?
mi
from
Charleston, SC
Click here to add this to my saved trials
1025 Morehead Medical Dr # 600
Charlotte, North Carolina 28204
(704) 355-2884
Blumenthal Cancer Center at Carolinas Medical Center As our patients wage their personal wars against...
?
mi
from
Charlotte, NC
Click here to add this to my saved trials
200 Hawthorne Lane
Charlotte, North Carolina 28233
704-384-4000
Presbyterian Cancer Center at Presbyterian Hospital At Novant Health Presbyterian Medical Center, we are welcoming...
?
mi
from
Charlotte, NC
Click here to add this to my saved trials
115 Business loop 70 w
Columbia, Missouri 65203
(573) 882-2100
Ellis Fischel Cancer Center at University of Missouri - Columbia At Ellis Fischel Cancer Center,...
?
mi
from
Columbia, MO
Click here to add this to my saved trials
100 North Academy Ave
Danville, Pennsylvania 17822
570-271-6211
Geisinger Cancer Institute at Geisinger Health Since 1915, Geisinger Medical Center has been known as...
?
mi
from
Danville, PA
Click here to add this to my saved trials
1719 East 19th Avenue
Denver, Colorado 80218
(303) 839-6000
Presbyterian - St. Luke's Medical Center Presbyterian/St. Luke's Medical Center and the Rocky Mountain Hospital...
?
mi
from
Denver, CO
Click here to add this to my saved trials
1 Hurley Plaza
Flint, Michigan 48503
(810) 262-9000
Hurley Medical Center From its founding in 1908, Hurley Medical Center has devoted itself to...
?
mi
from
Flint, MI
Click here to add this to my saved trials
1600 South Andrews Avenue
Fort Lauderdale, Florida 33316
?
mi
from
Fort Lauderdale, FL
Click here to add this to my saved trials
4725 North Federal Highway
Fort Lauderdale, Florida 33308
(954) 492-5764
Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital Holy Cross Hospital's Michael...
?
mi
from
Fort Lauderdale, FL
Click here to add this to my saved trials
11143 Parkview Plaza Dr # 100
Fort Wayne, Indiana 46845
(260) 484-8830
Fort Wayne Medical Oncology and Hematology Fort Wayne Medical Oncology and Hematology provides state-of-the-art cancer...
?
mi
from
Fort Wayne, IN
Click here to add this to my saved trials
33 Villa Road, Suite 400
Greenville, South Carolina 29615
(864) 404-2045
CCOP - Greenville Cancer care in the last decade has made many advances. Most of...
?
mi
from
Greenville, SC
Click here to add this to my saved trials
19229 Mack Ave
Grosse Pointe Woods, Michigan 48236
(866) 246-4673
Van Elslander Cancer Center at St. John Hospital and Medical Center We built the Van...
?
mi
from
Grosse Pointe Woods, MI
Click here to add this to my saved trials
85 Retreat Ave # 2
Hartford, Connecticut 06102
?
mi
from
Hartford, CT
Click here to add this to my saved trials
701 Ilalo Street Suite 600
Honolulu, Hawaii 96813
808-586-3010
Cancer Research Center of Hawaii The University of Hawaii Cancer Center is the only National...
?
mi
from
Honolulu, HI
Click here to add this to my saved trials
2001 86th Street West
Indianapolis, Indiana 46260
(317) 338-2345
St. Vincent Indianapolis Hospital At St.Vincent Indianapolis, everything we do begins with a focus on...
?
mi
from
Indianapolis, IN
Click here to add this to my saved trials
200 Hawkins Drive
Iowa City, Iowa 52242
800-237-1225
Holden Comprehensive Cancer Center at University of Iowa Holden Comprehensive Cancer Center is dedicated to...
?
mi
from
Iowa City, IA
Click here to add this to my saved trials
1240 S Old Dixie Hwy
Jupiter, Florida 33458
(561) 263-4400
Ella Milbank Foshay Cancer Center at Jupiter Medical Center The Foshay Cancer Center is one...
?
mi
from
Jupiter, FL
Click here to add this to my saved trials
200 North Park Street
Kalamazoo, Michigan 49007
(269) 382-2500
West Michigan Cancer Center In 1994, Borgess Health Alliance and Bronson Healthcare Group opened the...
?
mi
from
Kalamazoo, MI
Click here to add this to my saved trials
524 South Park Street
Kalamazoo, Michigan 49007
(269) 341-7654
Bronson Methodist Hospital Our healthcare system serves patients and families throughout southwest Michigan and northern...
?
mi
from
Kalamazoo, MI
Click here to add this to my saved trials
1900 South Avenue
La Crosse, Wisconsin 54601
(608) 782-7300
Gundersen Lutheran Center for Cancer and Blood Gundersen Health System is where caring meets excellence...
?
mi
from
La Crosse, WI
Click here to add this to my saved trials
902 Savannah Road
Lewes, Delaware 19958
(302) 645-3770
Tunnell Cancer Center at Beebe Medical Center The Robert & Eolyne Tunnell Cancer Center at...
?
mi
from
Lewes, DE
Click here to add this to my saved trials
800 Rose St
Lexington, Kentucky 40536
(859) 257-4488
Lucille P. Markey Cancer Center at University of Kentucky The Markey Cancer Center was founded...
?
mi
from
Lexington, KY
Click here to add this to my saved trials
11234 Anderson Street
Loma Linda, California 92354
(909) 558-4126
Loma Linda University Cancer Institute at Loma Linda University Medical Center Loma Linda University Cancer...
?
mi
from
Loma Linda, CA
Click here to add this to my saved trials
?
mi
from
Louisville, KY
Click here to add this to my saved trials
2501 N Orange Ave # 235
Orlando, Florida 32804
(407) 303-1700
Florida Hospital Cancer Institute at Florida Hospital Orlando FHCI is the largest cancer center in...
?
mi
from
Orlando, FL
Click here to add this to my saved trials
1400 South Orange Avenue
Orlando, Florida 32806
(407) 648-3800
M.D. Anderson Cancer Center at Orlando For more than twenty years, our cancer center has...
?
mi
from
Orlando, FL
Click here to add this to my saved trials
4800 Friendship Avenue
Pittsburgh, Pennsylvania 15224
?
mi
from
Pittsburgh, PA
Click here to add this to my saved trials
401 College Street
Richmond, Virginia 23298
(804) 828-0450
Virginia Commonwealth University Massey Cancer Center Founded in 1974, VCU Massey Cancer Center is a...
?
mi
from
Richmond, VA
Click here to add this to my saved trials
4502 Medical Drive
San Antonio, Texas 78284
(210) 567-7000
University of Texas Health Science Center at San Antonio The University of Texas Health Science...
?
mi
from
San Antonio, TX
Click here to add this to my saved trials
Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center The Curtis and...
?
mi
from
Savannah, GA
Click here to add this to my saved trials
1717 S J St
Tacoma, Washington 98405
(253) 426-4101
Franciscan Cancer Center at St. Joseph Medical Center St. Joseph Medical Center is a 361-bed...
?
mi
from
Tacoma, WA
Click here to add this to my saved trials
42 E Laurel Rd # 2545
Voorhees, New Jersey 08043
(800) 826-6737
Cancer Institute of New Jersey at Cooper - Voorhees Cooper University Health Care, the clinical...
?
mi
from
Voorhees, NJ
Click here to add this to my saved trials
825 N Emporia Ave
Wichita, Kansas 67214
(316) 261-3200
Via Christi Cancer Center at Via Christi Regional Medical Center Via Christi Health's rich history...
?
mi
from
Wichita, KS
Click here to add this to my saved trials
1 Medical Center Blvd
Winston-Salem, North Carolina 27103
(336) 716-2011
Wake Forest University Comprehensive Cancer Center Our newly expanded Comprehensive Cancer Center is the region’s...
?
mi
from
Winston-Salem, NC
Click here to add this to my saved trials
777 Kimole Ln
Adrian, Michigan 49221
517-265-0900
Hickman Cancer Center at Bixby Medical Center At ProMedica Bixby Hospital, we
?
mi
from
Adrian, MI
Click here to add this to my saved trials
98-1079 Moanalua Rd
Aiea, Hawaii 96701
(808) 486-6000
Kapiolani Medical Center at Pali Momi Pali Momi Medical Center is a nonprofit hospital located...
?
mi
from
Aiea, HI
Click here to add this to my saved trials
1 Akron General Ave
Akron, Ohio 44307
(330) 344-6000
McDowell Cancer Center at Akron General Medical Center Learning that you or someone you love...
?
mi
from
Akron, OH
Click here to add this to my saved trials
161 North Forge Street
Akron, Ohio 44304
(330) 375-7280
Summa Center for Cancer Care at Akron City Hospital Summa Health System is a leader...
?
mi
from
Akron, OH
Click here to add this to my saved trials
?
mi
from
Albany, GA
Click here to add this to my saved trials
?
mi
from
Alton, IL
Click here to add this to my saved trials
American Fork, Utah 84003
?
mi
from
American Fork, UT
Click here to add this to my saved trials
Ames, Iowa 50010
McFarland Clinic, PC It has been over 65 years since the founders of McFarland Clinic...
?
mi
from
Ames, IA
Click here to add this to my saved trials
Anderson, South Carolina 29621
?
mi
from
Anderson, SC
Click here to add this to my saved trials
5301 McAuley Drive
Ann Arbor, Michigan 48197
734-712-4673
Saint Joseph Mercy Cancer Center Saint Joseph Mercy Health System is one of Michigan's most...
?
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
5301 East Huron River Drive
Ann Arbor, Michigan 48106
1.877.590.5995
CCOP - Michigan Cancer Research Consortium The Community Clinical Oncology Program (CCOP) is a comprehensive...
?
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
364 White Oak St
Asheboro, North Carolina 27203
(336) 625-5151
Randolph Hospital Since 1932, Randolph Hospital has been fortunate to employ dedicated and loyal personnel...
?
mi
from
Asheboro, NC
Click here to add this to my saved trials
Asheville, North Carolina 28816
?
mi
from
Asheville, NC
Click here to add this to my saved trials
?
mi
from
Ashland, KY
Click here to add this to my saved trials
Auburn, Washington 98002
?
mi
from
Auburn, WA
Click here to add this to my saved trials
700 Potomac St
Aurora, Colorado 80012
(303) 363-7200
Aurora Presbyterian Hospital At The Medical Center of Aurora and Centennial Medical Plaza, we treat...
?
mi
from
Aurora, CO
Click here to add this to my saved trials
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
6701 North Charles Street
Baltimore, Maryland 21204
443-849-3051
Greater Baltimore Medical Center Cancer Center The Sandra & Malcolm Berman Cancer Institute's comprehensive, multidisciplinary...
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
900 Caton Ave.
Baltimore, Maryland 21229
410-368-6000
St. Agnes Hospital Cancer Center Saint Agnes Hospital is leading Maryland in the battle against...
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
Barberton, Ohio 44203
?
mi
from
Barberton, OH
Click here to add this to my saved trials
Baton Rouge, Louisiana 70809
?
mi
from
Baton Rouge, LA
Click here to add this to my saved trials
4950 Essen Ln
Baton Rouge, Louisiana 70809
(225) 767-0847
Mary Bird Perkins Cancer Center - Baton Rouge Mary Bird Perkins Cancer Center (MBPCC) and...
?
mi
from
Baton Rouge, LA
Click here to add this to my saved trials
8111 South Emerson Avenue
Beech Grove, Indiana 46237
(317) 528-5000
St. Francis Hospital and Health Centers - Beech Grove Campus A trusted leader in providing...
?
mi
from
Beech Grove, IN
Click here to add this to my saved trials
130 Fisher Road
Berlin, Vermont 05602
(802) 225-5400
Mountainview Medical Our medical oncologists, hematologist, and oncology advanced practice nurse, along with other dedicated...
?
mi
from
Berlin, VT
Click here to add this to my saved trials
Bethlehem, Pennsylvania 18015
?
mi
from
Bethlehem, PA
Click here to add this to my saved trials
Billings, Montana 59101
?
mi
from
Billings, MT
Click here to add this to my saved trials
?
mi
from
Billings, MT
Click here to add this to my saved trials
Billings, Montana 59107
?
mi
from
Billings, MT
Click here to add this to my saved trials
2900 12th Ave N Ste 160W
Billings, Montana 59101
(406) 238-6290
Hematology-Oncology Centers of the Northern Rockies - Billings The physicians and staff of Hematology-Oncology Centers...
?
mi
from
Billings, MT
Click here to add this to my saved trials
1101 N 27th St # 201
Billings, Montana 59101
(406) 237-3585
St. Vincent Healthcare Cancer Care Services The Sisters of Charity of Leavenworth, Kansas, founded St....
?
mi
from
Billings, MT
Click here to add this to my saved trials
1505 Eastland Drive
Bloomington, Illinois 61701
309-662-2102
Illinois CancerCare-Bloomington Illinois CancerCare, P.C. is a comprehensive practice treating patients withcancer andblood diseases. Our...
?
mi
from
Bloomington, IL
Click here to add this to my saved trials
2200 E Washington St,
Bloomington, Illinois 61701
(309) 662-3311
St. Joseph Medical Center Located in Bloomington, Illinois, OSF St. Joseph Medical Center is a...
?
mi
from
Bloomington, IL
Click here to add this to my saved trials
1100 Balsam Ave
Boulder, Colorado 80304
(303) 440-2273
Boulder Community Hospital Founded in 1922 as a community-owned and operated not-for-profit hospital, Boulder Community...
?
mi
from
Boulder, CO
Click here to add this to my saved trials
960 W. Wooster
Bowling Green, Ohio 43402
419-352-9498
Wood County Oncology Center The Cancer Care Center at Wood County Hospital opened March 2014,...
?
mi
from
Bowling Green, OH
Click here to add this to my saved trials
931 Highland Blvd
Bozeman, Montana 59715
(406) 585-5070
Bozeman Deaconess Cancer Center Bozeman Deaconess Cancer Center provides the latest cancer technologies and treatment...
?
mi
from
Bozeman, MT
Click here to add this to my saved trials
?
mi
from
Bronx, NY
Click here to add this to my saved trials
130 S Bryn Mawr Ave
Bryn Mawr, Pennsylvania 19010
(484) 337-3000
Bryn Mawr Hospital Bryn Mawr Hospital, a nationally recognized community teaching hospital, is conveniently located...
?
mi
from
Bryn Mawr, PA
Click here to add this to my saved trials
?
mi
from
Burlington, NC
Click here to add this to my saved trials
?
mi
from
Burlington, VT
Click here to add this to my saved trials
201 E Nicollet Blvd
Burnsville, Minnesota 55337
(952) 892-2000
Fairview Ridges Hospital Fairview Ridges Hospital is a 150-bed, Level III Trauma Care facility, offering...
?
mi
from
Burnsville, MN
Click here to add this to my saved trials
400 S Clark St
Butte, Montana 59701
(406) 723-2616
St. James Healthcare Cancer Care The St. James Cancer Center is an integrated cancer treatment...
?
mi
from
Butte, MT
Click here to add this to my saved trials
210 W Walnut St
Canton, Illinois 61520
(309) 647-5240
Graham Hospital At Graham Hospital, we have a proud and rich history of serving the...
?
mi
from
Canton, IL
Click here to add this to my saved trials
210 W Walnut St
Canton, Illinois 61520
309-647-5240
Illinois CancerCare - Canton Illinois CancerCare is one of the largest private oncology and hematology...
?
mi
from
Canton, IL
Click here to add this to my saved trials
211 Saint Francis Drive
Cape Girardeau, Missouri 63703
573-331-3000
Saint Francis Medical Center Saint Francis Medical Center is a 282-bed facility serving more than...
?
mi
from
Cape Girardeau, MO
Click here to add this to my saved trials
160 S Adams St
Carthage, Illinois 62321
(217) 357-6877
Illinois CancerCare - Carthage Illinois CancerCare, P.C. is a comprehensive practice treating patients withcancer andblood...
?
mi
from
Carthage, IL
Click here to add this to my saved trials
1454 North County Road 2050
Carthage, Illinois 62321
(217) 357-8500
Memorial Hospital Memorial Hospital is a vital force in establishing and maintaining the well-being of...
?
mi
from
Carthage, IL
Click here to add this to my saved trials
20126 Stanton Ave
Castro Valley, California 94546
(510) 581-0556
East Bay Radiation Oncology Center East Bay Radiation Oncology Center offers superior medical and technical...
?
mi
from
Castro Valley, CA
Click here to add this to my saved trials
Castro Valley, California 94546
?
mi
from
Castro Valley, CA
Click here to add this to my saved trials
20055 Lake Chabot Rd #130
Castro Valley, California 94546
(510) 888-0657
Valley Medical Oncology Consultants - Castro Valley Valley Medical Oncology Consultants (VMOC) has been helping...
?
mi
from
Castro Valley, CA
Click here to add this to my saved trials
1303 North Main Street
Cedar City, Utah 84721
(435) 868-5680
Sandra L. Maxwell Cancer Center The Huntsman-Intermountain Cancer Center at Valley View Medical Center in...
?
mi
from
Cedar City, UT
Click here to add this to my saved trials
914 S Scheuber Rd
Centralia, Washington 98531
(360) 736-2803
Providence Centralia Hospital We are a 127-bed, not for profit hospital providing emergency, diagnostic, cancer,...
?
mi
from
Centralia, WA
Click here to add this to my saved trials
505 S Plummer Ave
Chanute, Kansas 66720
(620) 431-7580
Cancer Center of Kansas, PA - Chanute Dr. H.E. Hynes founded Cancer Center of Kansas,...
?
mi
from
Chanute, KS
Click here to add this to my saved trials
Charleston, South Carolina 29401
?
mi
from
Charleston, SC
Click here to add this to my saved trials
3110 MacCorkle Ave. S.E.
Charleston, West Virginia 25304
304-347-1206
West Virginia University Health Sciences Center - Charleston The West Virginia University Robert C. Byrd...
?
mi
from
Charleston, WV
Click here to add this to my saved trials
Chicago, Illinois 60608
?
mi
from
Chicago, IL
Click here to add this to my saved trials
1969 W Ogden Ave
Chicago, Illinois 60612
(312) 864-6000
John H. Stroger, Jr. Hospital of Cook County The Level 1 Trauma Center is one...
?
mi
from
Chicago, IL
Click here to add this to my saved trials
1653 W. Congress Parkway
Chicago, Illinois 60612
(312) 942-5000
Rush University Medical Center Rush University Medical Center encompasses a 664-bed hospital serving adults and...
?
mi
from
Chicago, IL
Click here to add this to my saved trials
12961 27th Ave
Chippewa Falls, Wisconsin 54729
715-738-3700
Marshfield Clinic - Chippewa Center The 15,000 square foot Lake Hallie Center provides urgent care...
?
mi
from
Chippewa Falls, WI
Click here to add this to my saved trials
11100 Euclid Avenue
Cleveland, Ohio 44106
216.844.8797
Case Comprehensive Cancer Center The Case Comprehensive Cancer Center (Case CCC) based at Case Western...
?
mi
from
Cleveland, OH
Click here to add this to my saved trials
?
mi
from
Clyde, OH
Click here to add this to my saved trials
Coeur d'Alene, Idaho 83814
?
mi
from
Coeur d'Alene, ID
Click here to add this to my saved trials
Colorado Springs, Colorado 80909
?
mi
from
Colorado Springs, CO
Click here to add this to my saved trials
2222 N. Nevada Avenue
Colorado Springs, Colorado 80907
(719) 776-5000
Penrose Cancer Center at Penrose Hospital Through a full range of clinical trials, genetic counseling,...
?
mi
from
Colorado Springs, CO
Click here to add this to my saved trials