Sunitinib Malate or Sorafenib Tosylate in Treating Patients With Kidney Cancer That Was Removed By Surgery



Status:Completed
Conditions:Colorectal Cancer, Cancer, Cancer, Cancer, Cancer, Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:3/28/2019
Start Date:April 2006
End Date:August 2015

Use our guide to learn which trials are right for you!

ASSURE: Adjuvant Sorafenib or Sunitinib for Unfavorable Renal Carcinoma

This randomized phase III trial studies sunitinib malate and sorafenib tosylate to see how
well they work compared to placebo in treating patients with kidney cancer that has been
removed by surgery. Sunitinib malate and sorafenib tosylate may stop the growth of tumor
cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to
the tumor. Giving sunitinib malate or sorafenib tosylate after surgery may kill any tumor
cells that remain after surgery. It is not yet known whether sunitinib malate or sorafenib
tosylate is more effective than placebo in treating kidney cancer.

PRIMARY OBJECTIVES:

I. To demonstrate an improvement in disease-free survival in locally advanced renal cell
carcinoma patients randomly assigned to adjuvant sunitinib (sunitinib malate) (Arm A) or
sorafenib (sorafenib tosylate) (Arm B) versus placebo (Arm C) after radical or partial
nephrectomy.

SECONDARY OBJECTIVES:

I. To compare overall survival of patients randomized to each of the two regimens with
placebo.

II. To further define the toxicity of prolonged administration of sunitinib or sorafenib in
this patient population.

III. To evaluate cardiac function in each arm

OTHER PRE-SPECIFIED OBJECTIVES:

I. To prospectively collect tumor and biological specimens to assess their characteristics
and associations: novel approaches to assess angiogenesis markers in tissue, blood and urine
as predictors of disease-free survival and of therapeutic benefit.

II. To prospectively collect tumor and biological specimens to assess their characteristics
and associations: the frequency of oncogene and tumor suppressor gene mutations as predictors
of disease-free survival and therapeutic benefit.

III. To prospectively collect tumor and biological specimens to assess their characteristics
and associations: tumor and genetic polymorphisms as predictors of disease-free survival and
therapeutic benefit.

IV. To prospectively collect tumor and biological specimens to assess their characteristics
and associations: deoxyribonucleic acid (DNA) methylation profiles as predictors of outcome
and of therapeutic benefit.

V. To prospectively collect tumor and biological specimens to assess their characteristics
and associations: The relationship of polymorphisms in drug metabolizing enzymes with steady
state concentrations of sorafenib and sunitinib in selected patients.

VI. To study the effect of vascular endothelial growth factor (VEGF) targeted therapy on
circulating endothelial cells and circulating endothelial progenitors.

VII. To prospectively assess patient-reported fatigue in order to compare the magnitude and
trajectory of fatigue among renal cell carcinoma (RCC) patients randomized to adjuvant
sunitinib (Arm A) or sorafenib (Arm B) to placebo (Arm C). (Quality of life objectives) VIII.
To evaluate the Patient Reported Outcomes Measurement Information System (PROMIS)
Fatigue-Short Form (SF)1, a newly developed state-of-the-science PROMIS measure for fatigue
and to calibrate the PROMIS Fatigue-SF1 with the established, validated Functional Assessment
of Chronic Illness Therapy (FACIT) -Fatigue scale. (Quality of life objectives)

OUTLINE: Patients are randomized to 1 of 3 treatment arms.

ARM A: Beginning 4-12 weeks following radical or partial nephrectomy, patients receive
sunitinib malate orally (PO) once daily (QD) for 4 weeks and placebo sorafenib tosylate PO QD
or twice daily (BID) for 6 weeks.

ARM B: Beginning 4-12 weeks following radical or partial nephrectomy, patients receive
sorafenib tosylate PO QD or BID for 6 weeks and placebo sunitinib malate PO QD for 4 weeks
followed.

ARM C: Beginning 4-12 weeks following radical or partial nephrectomy, patients receive
placebo sorafenib tosylate as in Arm A and placebo sunitinib malate as in Arm B.

In all arms, treatment repeats every 6 weeks for 9 courses in the absence of disease
progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for 2 years,
every 6 months for 3 years, and then every 12 months for 5 years.

Pre-Registration Inclusion Criteria:

- Pre-surgical criteria:

- Patients must have primary-intact renal cell carcinoma, eligible for nephrectomy
with curative intent

- Tumors >= 4 cm AND/OR macroscopic fully resectable nodes AND/OR surgically
resectable renal vein thrombus AND/OR surgically resectable inferior vena caval
thrombus by radiologic criteria to be clinically >= pT1bNany (resectable) M0
disease

- Multifocal ipsilateral renal cell carcinoma is allowed provided fully resectable
and does not exceed inclusion criteria

- Patients must have corrected QT (QTc) interval < 500 msec on baseline
electrocardiogram (EKG)

- Women of child-bearing potential and men must agree to use an accepted and effective
method of contraception prior to study entry and for the duration of study
participation; should a woman become pregnant while participating in this study, she
should inform her treating physician immediately; if a man impregnates a woman while
participating in this study, he should inform his treating physician immediately as
well

- The date of randomization must be less than 12 weeks after the date of surgery;
patients must have recovered from any surgical related complications

Inclusion Criteria at Randomization:

- Within 4 weeks prior to randomization, patients must meet preoperative eligibility
requirements

- Patients must complete surgery less than 12 weeks prior to randomization

- Patients must have histologically or cytologically confirmed renal cell carcinoma.
Using 2002 (American Joint Committee on Cancer [AJCC] 6th edition) TNM Staging,
patients must be one of the following:

- pT1b G3-4 N0 (or pNX where clinically N0) M0

- pT2 G (any) N0 (or pNX where clinically N0) M0

- pT3 G (any) N0 (or pNX where clinically N0) M0

- pT4 G (any) N0 (or pNX where clinically N0) M0 or

- T (any) G (any) N+ (fully resected) M0

- Patients with microvascular invasion of the renal vein of any grade or stage
(as long as M0) are also eligible

- Patients must have undergone a full surgical resection (radical nephrectomy
or partial nephrectomy) by either open or laparoscopic technique; clinical
evidence of lymph node positivity requires removal of all clinically
positive nodes; surgeons should designate extent of node dissection; all
surgical specimens must have negative margins; patients with positive renal
vein margins are eligible unless there is invasion of the renal vein wall at
the margin (provided no other margins are positive)

- Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of
0-1

- Patients must have an absolute baseline left ventricular ejection fraction (LVEF) of
>= 50% by multigated acquisition (MUGA) scan within 4 weeks prior to randomization

- Patients must have paraffin-embedded tumor specimen available for central core review
of tumor histology and other correlative studies; tumor samples will be shipped as
specified

- Patients must have no evidence of residual or metastatic renal cell cancer as
documented on computed tomography (CT) scans of the chest, abdomen, and pelvis, all
with oral and intravenous (IV) contrast (magnetic resonance imaging [MRI] scans of the
abdomen and pelvis with gadolinium and a non-contrast CT of the chest may be
substituted if patient is not able to have CT scans with intravenous contrast);
patients unable to tolerate either gadolinium or IV contrast should not participate in
this study (limitations to a patient's renal function should be taken into
consideration when screening for this study)

- Scans must be obtained within 4 weeks of randomization; changes on these scans
that are felt to be post surgical must be documented

- Patients without reported lymph nodes in the resected surgical specimen and a
reported pathologic stage (post-nephrectomy) of pNX MUST undergo a post-operative
contrast-enhanced CT scan (or MRI with gadolinium) within 4 weeks of
randomization to document that there is no evidence of residual disease

- Absolute granulocyte count (AGC) >= 1,500/mm^3

- Platelet count >= 100,000/mm^3

- Serum creatinine =< 2.0 x upper limit of normal (ULN) or calculated creatinine
clearance (CrCl) >= 30 mL/min (neither drug is cleared by the kidney)

- Total bilirubin =< 1.5 x upper limit of normal (ULN)

- Serum glutamic oxaloacetic transaminase (SGOT) and serum glutamate pyruvate
transaminase (SGPT) =< 2.5 x ULN

- Patients must be able to swallow pills

Exclusion Criteria:

- History of distant metastases

- Prior anti-cancer therapy for renal cell carcinoma in either the adjuvant or
neoadjuvant setting; this includes metastatectomy for renal cell carcinoma, or
radiation therapy to the renal bed

- Other current malignancies, other than basal cell skin cancer, squamous cell skin
cancer, in situ cervical cancer, ductal or lobular carcinoma in situ of the breast;
patients with other malignancies are eligible if they have been continuously
disease-free for >= 5 years prior to the time of registration

- Serious intercurrent illness including, but not limited to, the following: clinically
significant cardiovascular disease (e.g. uncontrolled hypertension, myocardial
infarction, unstable angina); New York Heart Association grade II or greater
congestive heart failure; serious cardiac arrhythmia requiring medication; grade II or
greater peripheral vascular disease; or psychiatric illness/social situations that
would limit compliance with study requirements

- Any of the following within the 6 months prior to study drug administration:
myocardial infarction, severe/unstable angina, coronary/peripheral artery bypass
graft, symptomatic congestive heart failure, cerebrovascular accident or transient
ischemic attack, or pulmonary embolism

- Ongoing ventricular cardiac dysrhythmias of National Cancer Institute Common
Terminology Criteria for Adverse Events (NCI CTCAE) version 4.0 grade >= 2; history of
serious ventricular arrhythmia (ventricular tachycardia [VT] or ventricular
fibrillation [VF] >= 3 beats in a row); ongoing atrial fibrillation

- Hypertension that cannot be controlled by medications (>= diastolic blood pressure 100
mm Hg despite optimal medical therapy)

- Pre-existing thyroid abnormality with thyroid stimulating hormone that cannot be
maintained in the normal range with medication

- Pregnant or breastfeeding; all females of childbearing potential must have a blood
test or urine study within 2 weeks prior to pre-registration to rule out pregnancy; if
pre-registration occurs prior to surgery, the blood or urine study must be repeated
within 2 weeks prior to randomization to rule out pregnancy; (note: should a woman
become pregnant while participating in this study, she should inform her treating
physician immediately)

- Patients with known human immunodeficiency virus (HIV)

- Collecting duct carcinomas or medullary carcinomas

- Patients taking cytochrome P450 enzyme-inducing antiepileptic drugs (phenytoin,
carbamazepine or phenobarbital), St John's Wort, ketoconazole, dexamethasone, the
dysrhythmic drugs (terfenadine, quinidine, procainamide, sotalol, probucol, bepridil,
indapamide or flecainide), haloperidol, risperidone, rifampin, grapefruit, or
grapefruit juice within two weeks of randomization and during the course of therapy;
(medications are not prohibited unless listed above); topical and inhaled steroids are
permitted

- Receiving any other investigational anti-cancer agents during the period on study

- Serious intercurrent illness, including ongoing or active infection requiring parental
antibiotics
We found this trial at
900
sites
701 Grove Rd
Greenville, South Carolina 29605
(864) 455-7000
Greenville Memorial Hospital Greenville Memorial Medical Campus is a regional referral center for the diagnosis...
?
mi
from
Greenville, SC
Click here to add this to my saved trials
1201 Camino de Salud Northeast
Albuquerque, New Mexico 87131
(505) 272-4946
University of New Mexico Cancer Center It’s been 40 years since the New Mexico State...
?
mi
from
Albuquerque, NM
Click here to add this to my saved trials
361 Old Belgrade Road
Augusta, Maine 04330
(207) 621-6100
Harold Alfond Center for Cancer Care MaineGeneral's Harold Alfond Center for Cancer Care (HACCC) is...
?
mi
from
Augusta, ME
Click here to add this to my saved trials
8600 Old Georgetown Road
Bethesda, Maryland 20814
301-896-3100
Suburban Hospital Suburban Hospital is a community-based, not-for-profit hospital serving Montgomery County and the surrounding...
?
mi
from
Bethesda, MD
Click here to add this to my saved trials
330 Brookline Ave
Boston, Massachusetts 02215
617-667-7000
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
?
mi
from
Boston, MA
Click here to add this to my saved trials
666 Elm Street
Buffalo, New York 14263
(716) 845-2300
Roswell Park Cancer Institute Welcome to Roswell Park Cancer Institute (RPCI), America's first cancer center...
?
mi
from
Buffalo, NY
Click here to add this to my saved trials
1 South Prospect Street
Burlington, Vermont 05401
802-656-8990
?
mi
from
Burlington, VT
Click here to add this to my saved trials
1300 Jefferson Park Avenue
Charlottesville, Virginia 22908
434-243-6784
University of Virginia Cancer Center We are fortunate in having state of the art clinical...
?
mi
from
Charlottesville, VA
Click here to add this to my saved trials
1500 E Duarte Rd
Duarte, California 91010
(626) 256-4673
City of Hope Comprehensive Cancer Center City of Hope is a leading research and treatment...
?
mi
from
Duarte, CA
Click here to add this to my saved trials
1 Hurley Plaza
Flint, Michigan 48503
(810) 262-9000
Hurley Medical Center From its founding in 1908, Hurley Medical Center has devoted itself to...
?
mi
from
Flint, MI
Click here to add this to my saved trials
4725 North Federal Highway
Fort Lauderdale, Florida 33308
(954) 771-8000
Holy Cross Hospital While spirituality plays an essential role in the way that we minister...
?
mi
from
Fort Lauderdale, FL
Click here to add this to my saved trials
3551 Roger Brooke Dr
Fort Sam Houston, Texas 78234
(210) 916-4141
Brooke Army Medical Center Brooke Army Medical Center (BAMC) is the Flagship of Army Medicine!...
?
mi
from
Fort Sam Houston, TX
Click here to add this to my saved trials
1147 NW 64th Ter
Gainesville, Florida 32605
?
mi
from
Gainesville, FL
Click here to add this to my saved trials
Gainesville, Florida 32610
(352) 392-3261
University of Florida The University of Florida (UF) is a major, public, comprehensive, land-grant, research...
?
mi
from
Gainesville, FL
Click here to add this to my saved trials
340 Medical Pkwy
Greer, South Carolina 29650
(864) 334-4900
Cancer Centers of the Carolinas - Greer Medical Oncology Cancer Centers of the Carolinas is...
?
mi
from
Greer, SC
Click here to add this to my saved trials
2500 N State St
Jackson, Mississippi 39216
(601) 984-1000
University of Mississippi Medical Center The University of Mississippi Medical Center, located in Jackson, is...
?
mi
from
Jackson, MS
Click here to add this to my saved trials
Jupiter, Florida 33458
?
mi
from
Jupiter, FL
Click here to add this to my saved trials
524 South Park Street
Kalamazoo, Michigan 49007
(269) 341-7654
Bronson Methodist Hospital Our healthcare system serves patients and families throughout southwest Michigan and northern...
?
mi
from
Kalamazoo, MI
Click here to add this to my saved trials
200 North Park Street
Kalamazoo, Michigan 49007
(269) 382-2500
West Michigan Cancer Center In 1994, Borgess Health Alliance and Bronson Healthcare Group opened the...
?
mi
from
Kalamazoo, MI
Click here to add this to my saved trials
701 Doctors Dr
Kinston, North Carolina 28504
(252) 559-2200
Kinston Medical Specialists offers comprehensive medical services for all ages. Whether it’s a case of...
?
mi
from
Kinston, NC
Click here to add this to my saved trials
3525
Lakeland, Florida 33805
?
mi
from
Lakeland, FL
Click here to add this to my saved trials
1800 West Charleston Boulevard
Las Vegas, Nevada 89102
(702) 383-2000
University Medical Center of Southern Nevada University Medical Center is dedicated to providing the highest...
?
mi
from
Las Vegas, NV
Click here to add this to my saved trials
9832 US Highway 441 # 101
Leesburg, Florida 34788
?
mi
from
Leesburg, FL
Click here to add this to my saved trials
529 West Markham Street
Little Rock, Arkansas 72205
(501) 686-7000
University of Arkansas for Medical Sciences The University of Arkansas for Medical Sciences (UAMS) in...
?
mi
from
Little Rock, AR
Click here to add this to my saved trials
777 Hemlock Street
Macon, Georgia 31201
(478) 633-1000
Medical Center of Central Georgia Navicent Health is a designated Level I Trauma Center and...
?
mi
from
Macon, GA
Click here to add this to my saved trials
300 Community Drive
Manhasset, New York 11030
(516) 562-0100
North Shore University Hospital North Shore-LIJ Health System includes 16 award-winning hospitals and nearly 400...
?
mi
from
Manhasset, NY
Click here to add this to my saved trials
305 1st Avenue # Dazian 7
New York, New York 10003
(212) 420-2806
Beth Israel Med Ctr The physicians and staff of Mount Sinai Beth Israel's Heart Institute...
?
mi
from
New York, NY
Click here to add this to my saved trials
4805 Northeast Glisan Street
Portland, Oregon 97213
(503) 215-1111
Providence Portland Medical Center We strive to give those we serve exceptional, compassionate health care...
?
mi
from
Portland, OR
Click here to add this to my saved trials
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
?
mi
from
Portland, OR
Click here to add this to my saved trials
593 Eddy Street
Providence, Rhode Island 02903
401-444-4000
Rhode Island Hospital Founded in 1863, Rhode Island Hospital in Providence, RI, is a private,...
?
mi
from
Providence, RI
Click here to add this to my saved trials
401 College Street
Richmond, Virginia 23298
(804) 828-0450
Virginia Commonwealth University Massey Cancer Center Founded in 1974, VCU Massey Cancer Center is a...
?
mi
from
Richmond, VA
Click here to add this to my saved trials
60 Crittenden Blvd # 70
Rochester, New York 14642
(585) 275-2121
University of Rochester The University of Rochester is one of the country's top-tier research universities....
?
mi
from
Rochester, NY
Click here to add this to my saved trials
4502 Medical Drive
San Antonio, Texas 78284
(210) 567-7000
University of Texas Health Science Center at San Antonio The University of Texas Health Science...
?
mi
from
San Antonio, TX
Click here to add this to my saved trials
?
mi
from
Sarasota, FL
Click here to add this to my saved trials
3900 W Avera Drive
Sioux Falls, South Dakota 57108
(605) 322-4700
Avera Cancer Institute Avera, the health ministry of the Benedictine and Presentation Sisters, is a...
?
mi
from
Sioux Falls, SD
Click here to add this to my saved trials
601 South Sherman Street
Spokane, Washington 99202
(509) 228-1000
Cancer Care Northwest - Spokane South Cancer Care Northwest is the Inland Northwest’s premier cancer...
?
mi
from
Spokane, WA
Click here to add this to my saved trials
808 North 39th Avenue
Yakima, Washington 98902
?
mi
from
Yakima, WA
Click here to add this to my saved trials
98-1079 Moanalua Road
'Aiea, Hawaii 96701
?
mi
from
'Aiea, HI
Click here to add this to my saved trials
Aberdeen, South Dakota 57401
?
mi
from
Aberdeen, SD
Click here to add this to my saved trials
1200 Old York Road
Abington, Pennsylvania 19001
(215) 481–2000
Abington Memorial Hospital Abington Memorial Hospital (AMH) is a 665-bed, regional referral center and teaching...
?
mi
from
Abington, PA
Click here to add this to my saved trials
Adrian, Michigan 49221
?
mi
from
Adrian, MI
Click here to add this to my saved trials
818 Riverside Ave.
Adrian, Michigan 49221
(517) 265-0900
Bixby Medical Center ProMedica's Mission is to improve your health and well-being. Which is why,...
?
mi
from
Adrian, MI
Click here to add this to my saved trials
?
mi
from
Akron, OH
Click here to add this to my saved trials
1 Akron General Ave
Akron, Ohio 44307
(330) 344-6000
Akron General Medical Center It
?
mi
from
Akron, OH
Click here to add this to my saved trials
Albany, Georgia 31701
?
mi
from
Albany, GA
Click here to add this to my saved trials
?
mi
from
Albany, NY
Click here to add this to my saved trials
?
mi
from
Albany, NY
Click here to add this to my saved trials
Albuquerque, New Mexico 87106
?
mi
from
Albuquerque, NM
Click here to add this to my saved trials
Albuquerque, New Mexico 87110
?
mi
from
Albuquerque, NM
Click here to add this to my saved trials
Alexandria, Minnesota 56308
?
mi
from
Alexandria, MN
Click here to add this to my saved trials
Alexandria, Minnesota 56308
?
mi
from
Alexandria, MN
Click here to add this to my saved trials
Allentown, Pennsylvania 18103
?
mi
from
Allentown, PA
Click here to add this to my saved trials
Alton, Illinois 62002
?
mi
from
Alton, IL
Click here to add this to my saved trials
?
mi
from
Amarillo, TX
Click here to add this to my saved trials
American Fork, Utah 84003
?
mi
from
American Fork, UT
Click here to add this to my saved trials
1111 Duff Ave
Ames, Iowa 50010
(866) 972-5477
McFarland Clinic PC-William R Bliss Cancer Center The William R. Bliss Cancer Center at Mary...
?
mi
from
Ames, IA
Click here to add this to my saved trials
?
mi
from
Amsterdam, NY
Click here to add this to my saved trials
Anchorage, Alaska 99508
?
mi
from
Anchorage, AK
Click here to add this to my saved trials
Anderson, South Carolina 29621
?
mi
from
Anderson, SC
Click here to add this to my saved trials
5301 McAuley Drive
Ann Arbor, Michigan 48197
734-712-3456
Saint Joseph Mercy Hospital St. Joseph Mercy Ann Arbor Hospital is a 537-bed teaching hospital...
?
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
1500 East Medical Center Drive
Ann Arbor, Michigan 48109
800-865-1125
University of Michigan Comprehensive Cancer Center The U-M Comprehensive Cancer Center's mission is the conquest...
?
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
Ann Arbor, Michigan 48106
?
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
Annapolis, Maryland 21401
?
mi
from
Annapolis, MD
Click here to add this to my saved trials
?
mi
from
Anthony, KS
Click here to add this to my saved trials
Antigo, Wisconsin 54409
?
mi
from
Antigo, WI
Click here to add this to my saved trials
?
mi
from
Appleton, WI
Click here to add this to my saved trials
Asheville, North Carolina 28801
?
mi
from
Asheville, NC
Click here to add this to my saved trials
?
mi
from
Athens, GA
Click here to add this to my saved trials
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
Atlanta, Georgia 30342
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
5665 Peachtree Dunwoody Rd NE
Atlanta, Georgia 30342
(678) 843-7001
Saint Joseph's Hospital of Atlanta Founded by the Sisters of Mercy in 1880, Saint Joseph
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
1968 Peachtree Rd NW
Atlanta, Georgia 30309
(404) 605-5000
Piedmont Hospital For more than a century, Piedmont Healthcare has been a recognized leader in...
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
1000 Johnson Ferry Rd NE
Atlanta, Georgia 30342
(404) 851-8000
Northside Hospital Northside Hospital-Atlanta (in Sandy Springs) opened in 1970. The original facility had 250...
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
Auburn, Washington 98001
?
mi
from
Auburn, WA
Click here to add this to my saved trials
Augusta, Georgia 30912
?
mi
from
Augusta, GA
Click here to add this to my saved trials
1501 S Potomac St
Aurora, Colorado 80012
(303) 695-2600
Medical Center of Aurora At The Medical Center of Aurora and Centennial Medical Plaza patients...
?
mi
from
Aurora, CO
Click here to add this to my saved trials
Austell, Georgia 30106
?
mi
from
Austell, GA
Click here to add this to my saved trials
Austin, Texas 78705
?
mi
from
Austin, TX
Click here to add this to my saved trials
?
mi
from
Austin, TX
Click here to add this to my saved trials
?
mi
from
Austin, TX
Click here to add this to my saved trials
Austin, Texas 78759
?
mi
from
Austin, TX
Click here to add this to my saved trials
Austin, Texas 78759
?
mi
from
Austin, TX
Click here to add this to my saved trials
Baltimore, Maryland 21229
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
22 South Greene Street
Baltimore, Maryland 21201
410-328-7904
University of Maryland Greenebaum Cancer Center The University of Maryland Marlene and Stewart Greenebaum Cancer...
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
6701 N Charles St
Baltimore, Maryland 21204
(443) 849-2000
Greater Baltimore Medical Center The 255-bed medical center (acute and sub-acute care) is located on...
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
401 North Broadway
Baltimore, Maryland 21287
410-955-5000
Johns Hopkins University-Sidney Kimmel Cancer Center The name Johns Hopkins has become synonymous with excellence...
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
489 State St
Bangor, Maine 04401
(207) 973-7000
Eastern Maine Medical Center Located in Bangor, Eastern Maine Medical Center (EMMC) serves communities throughout...
?
mi
from
Bangor, ME
Click here to add this to my saved trials
Baton Rouge, Louisiana 70806
?
mi
from
Baton Rouge, LA
Click here to add this to my saved trials
Baton Rouge, Louisiana 70809
?
mi
from
Baton Rouge, LA
Click here to add this to my saved trials
Baton Rouge, Louisiana 70809
?
mi
from
Baton Rouge, LA
Click here to add this to my saved trials
265 Fremont St
Battle Creek, Michigan 49017
(269) 245-8166
Bronson Battle Creek As a proud member of the Battle Creek community, we believe everyone...
?
mi
from
Battle Creek, MI
Click here to add this to my saved trials
?
mi
from
Beachwood, OH
Click here to add this to my saved trials
Beech Grove, Indiana 46107
?
mi
from
Beech Grove, IN
Click here to add this to my saved trials
205 Palmer Ave.
Bellefontaine, Ohio 43311
937.592.4015
Mary Rutan Hospital The hospital was endowed by the sale of a farm in Ridgeway...
?
mi
from
Bellefontaine, OH
Click here to add this to my saved trials
Bellingham, Washington 98225
?
mi
from
Bellingham, WA
Click here to add this to my saved trials
1300 Anne Street NW
Bemidji, Minnesota 56601
(218) 751-5430
Sanford Clinic North-Bemidgi Sanford Health is a voluntary, not-for-profit health care organization. Through its entities,...
?
mi
from
Bemidji, MN
Click here to add this to my saved trials
Bend, Oregon 97701
?
mi
from
Bend, OR
Click here to add this to my saved trials
?
mi
from
Bend, OR
Click here to add this to my saved trials
Bennington, Vermont 05201
?
mi
from
Bennington, VT
Click here to add this to my saved trials
?
mi
from
Berkeley, CA
Click here to add this to my saved trials