Assessing Ear Damage in Young Cancer Patients Treated With Cisplatin



Status:Completed
Conditions:Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:1 - 18
Updated:4/21/2016
Start Date:May 2007

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A Group-Wide, Prospective Study of Ototoxicity Assessment in Children Receiving Cisplatin Chemotherapy

RATIONALE: New ways to find out about hearing loss after treatment with chemotherapy may
improve the ability to plan cancer treatment and may help patients live more comfortably.

PURPOSE: This clinical trial is assessing ear damage in young cancer patients treated with
cisplatin.

OBJECTIVES:

- Determine the optimal criteria for determination of ototoxicity in younger cancer
patients treated with cisplatin.

- Determine the feasibility of including ultrahigh frequency and evoked otoacoustic
emission testing as adjunctive measures of ototoxicity.

- Determine the feasibility and necessity of central review of audiometry data.

OUTLINE: This is a multicenter, prospective, cohort study.

Patients undergo hearing tests (conventional, otoscopy, ultrahigh frequency, and otoacoustic
emission testing) before the first course of planned cisplatin, before each subsequent
course of cisplatin, and 4 weeks after the last dose of cisplatin.

Patients who are scheduled to receive hematopoietic progenitor stem cell transplantation
undergo hearing tests before the transplantation and 4 weeks after transplantation.

PROJECTED ACCRUAL: A total of 282 patients will be accrued for this study.

DISEASE CHARACTERISTICS:

- Planning to undergo treatment with any cisplatin-containing therapeutic regimen for
cancer

- Treatment does not need to be on a COG therapeutic study

- Planning to enroll on clinical trial ACCL0431

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

- No prior cisplatin
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