Paclitaxel and Carboplatin With or Without Metformin Hydrochloride in Treating Patients With Stage III, IV, or Recurrent Endometrial Cancer



Status:Active, not recruiting
Conditions:Cervical Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:3/14/2019
Start Date:March 17, 2014

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A Randomized Phase II/III Study of Paclitaxel/Carboplatin/Metformin (NSC#91485) Versus Paclitaxel/Carboplatin/Placebo as Initial Therapy for Measurable Stage III or IVA, Stage IVB, or Recurrent Endometrial Cancer

This randomized phase II/III trial studies how well paclitaxel, carboplatin, and metformin
hydrochloride works and compares it to paclitaxel, carboplatin, and placebo in treating
patients with endometrial cancer that is stage III, IV, or has come back. Drugs used in
chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop the growth
of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping
them from spreading. Metformin hydrochloride may help paclitaxel and carboplatin work better
by making cancer cells more sensitive to the drugs. It is not yet known whether paclitaxel
and carboplatin is more effective with or without metformin hydrochloride in treating
endometrial cancer.

PRIMARY OBJECTIVES:

I. To determine if the addition of metformin (metformin hydrochloride) to the standard
regimen of carboplatin and paclitaxel prolongs progression-free survival (PFS) in women with
advanced or recurrent endometrial cancer. (Phase II) II. To determine if the addition of
metformin to the standard regimen of carboplatin and paclitaxel prolongs overall survival
(OS) in the same population if a phase III study is conducted. Both clinical trials (Phase II
and III) will utilize OS as a primary endpoint if a phase III trial is opened.

SECONDARY OBJECTIVES:

I. To estimate the proportion of patients with objective response (response rate [RR]) in the
population of patients with measurable disease by treatment.

II. To estimate the duration of response in the population of patients with measurable
disease who respond by treatment.

III. To estimate overall survival (OS) and relative hazards of death for each treatment arm
if the study stops after the phase II trial is completed. If the study continues with a phase
III clinical trial, then PFS will be a secondary endpoint.

IV. To determine the nature, frequency and degree of toxicity as assessed by Common
Terminology Criteria for Adverse Events (CTCAE) for each treatment arm.

V. To estimate possible differences in RR, PFS, OS, and toxicity rates for the treatment
regimens by the patients? level of obesity.

TERTIARY OBJECTIVES:

I. To test whether PIK3CA mutations/amplifications, PTEN mutations or PIK3R1/PIK3R2 mutations
have a lower hazard of progression or death (PFS endpoint) among patients who are treated
with metformin.

II. To test whether higher expression of MATE 2 is associated with a lower hazard of
progression or death (PFS endpoint) among patients who are treated with metformin.

III. To explore the association of metabolic factors (i.e. body mass index [BMI],
hip-to-waist ratio, diabetes status, hemoglobin A1c [HgbA1C], fasting insulin and glucose
levels, homeostatic model assessment [HOMA] scores) with treatment response to
metformin/paclitaxel/carboplatin, PFS, and OS.

IV. To test whether genomic profiles (i.e. PIK3CA mutations/amplifications, PTEN mutations or
PIK3R1/PIK3R2 mutations) differ between the tumors of obese and non-obese endometrial cancer
(EC) patients.

V. To correlate expression of key targets of the insulin/IGF-1/mTOR signaling pathway
(p-IGF1R, p-S6 and p-4EBP-1) with treatment response to metformin/paclitaxel/carboplatin,
PFS, OS and obesity status.

VI. To determine if the genetic variants of the metformin transporters correspond with
treatment response to metformin/paclitaxel/carboplatin, PFS and OS.

VII. To estimate differences in physical functioning, physical activity, and fatigue between
treatment arms.

VIII. To explore the association between metabolic factors (i.e., BMI, hip-to-waist ratio,
diabetes status, HgbA1C, fasting insulin and glucose levels, HOMA scores) and physical
functioning, physical activity, and fatigue.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive paclitaxel intravenously (IV) over 3 hours on day 1, carboplatin IV
over 30 minutes on day 1, and metformin hydrochloride orally (PO) twice daily (BID)
(approximately 10-12 hours apart) on days 1-21 (once daily [QD] in course 1). Treatment
repeats every 21 days for 6 courses in the absence of disease progression or unacceptable
toxicity. Patients then receive maintenance therapy comprising metformin hydrochloride PO BID
on days 1-21. Courses repeat every 21 days in the absence of disease progression or
unacceptable toxicity.

ARM II: Patients receive paclitaxel IV and carboplatin IV as in Arm I. Patients also receive
placebo PO BID (approximately 10-12 hours apart) on days 1-21 (QD in course 1). Treatment
repeats every 21 days for 6 courses in the absence of disease progression or unacceptable
toxicity. Patients then receive maintenance therapy comprising placebo PO BID on days 1-21.
Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.

In both arms, patients who achieve stable disease (SD) or partial response (PR) and still
have measurable disease at the completion of course 6 may continue to receive paclitaxel IV
and carboplatin IV (with metformin hydrochloride or placebo) for an additional 4 courses at
the discretion of the treating investigator.

After completion of study treatment, patients are followed up every 3 months for 2 years and
then every 6 months for 3 years.

Inclusion Criteria:

- Patients must have measurable stage III, measurable stage IVA, stage IVB (with or
without measurable disease) or recurrent (with or without measurable disease)
endometrial carcinoma

- Histologic confirmation of the original primary tumor is required; patients with
the following histologic epithelial cell types are eligible:

- Endometrioid adenocarcinoma, serous adenocarcinoma, undifferentiated
carcinoma, clear cell adenocarcinoma, mixed epithelial carcinoma,
adenocarcinoma not otherwise specified (N.O.S.)

- Measurable disease is defined by Response Evaluation Criteria in Solid Tumors (RECIST)
(version 1.1); measurable disease is defined as at least one lesion that can be
accurately measured in at least one dimension (longest diameter to be recorded); each
lesion must be >= 10 mm when measured by computed tomography (CT), magnetic resonance
imaging (MRI) or caliper measurement by clinical exam; or >= 20 mm when measured by
chest x-ray; lymph nodes must be >= 15 mm in short axis when measured by CT or MRI

- Patients must have a Gynecologic Oncology Group (GOG) performance status of 0, 1, or 2

- Absolute neutrophil count (ANC) greater than or equal to 1,500/mcl

- Platelets greater than or equal to 100,000/mcl

- Creatinine less than 1.4 mg/dl

- Bilirubin less than or equal to 1.5 x institutional/laboratory upper limit of normal
(ULN)

- Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) less than or equal
to 3 x ULN

- Alkaline phosphatase less than or equal to 2.5 x ULN

- Patients must NOT have received prior chemotherapy or targeted therapy, including
chemotherapy used for radiation sensitization for treatment of endometrial carcinoma

- Patients may have received prior radiation therapy for treatment of endometrial
carcinoma; prior radiation therapy may have included pelvic radiation therapy,
extended field pelvic/para-aortic radiation therapy, and/or intravaginal
brachytherapy; all radiation therapy must be completed at least 4 weeks prior to the
first date of study therapy

- Patients may have received prior hormonal therapy for treatment of endometrial
carcinoma; all hormonal therapy must be discontinued at least one week prior to the
first date of study therapy

- Patients must be able to swallow and retain orally-administered medication

- Patients must have signed an approved informed consent and authorization permitting
release of personal health information; individuals with impaired decision-making
capacity are not eligible to participate on the study

Exclusion Criteria:

- Patients must NOT be taking metformin or have been on metformin in the past 6 months

- Patients with a history of other invasive malignancies, with the exception of
non-melanoma skin cancer are excluded if there is any evidence of other malignancy
being present within the last three years

- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, or psychiatric illness/social situations that would limit compliance with
study requirements

- Patients who are pregnant or nursing; if patients are of reproductive age and have not
undergone hysterectomy, they must use an effective contraceptive method for the
duration of this study

- Any condition associated with increased risk of metformin-associated lactic acidosis;
(e.g. congestive heart failure defined as New York Heart Association [NYHA] class III
or IV functional status, history of acidosis of any type; habitual intake of 3 or more
alcoholic beverages per day)
We found this trial at
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Marshfield Clinic - Chippewa Center The 15,000 square foot Lake Hallie Center provides urgent care...
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Chippewa Falls, WI
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Cincinnati, Ohio 45220
Principal Investigator: Mehmet S. Copur
Phone: 501-622-2100
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Cincinnati, OH
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Cincinnati, Ohio 45242
Principal Investigator: Mehmet S. Copur
Phone: 501-622-2100
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Cincinnati, OH
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Cincinnati, Ohio 45219
Principal Investigator: Eric L. Eisenhauer
Phone: 800-293-5066
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Cincinnati, OH
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10900 Euclid Ave
Cleveland, Ohio 44106
216-368-2000
Principal Investigator: Steven E. Waggoner
Phone: 800-641-2422
Case Western Reserve Univ Continually ranked among America's best colleges, Case Western Reserve University has...
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Cleveland, OH
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18101 Lorain Avenue
Cleveland, Ohio 44111
216.476.7000
Principal Investigator: Peter G. Rose
Phone: 866-223-8100
Cleveland Clinic Cancer Center at Fairview Hospital Fairview Hospital is a 488-bed hospital located at...
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Cleveland, OH
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2049 E 100th St
Cleveland, Ohio 44106
(216) 444-2200
Principal Investigator: Peter G. Rose
Phone: 866-223-8100
Cleveland Clinic Foundation The Cleveland Clinic (formally known as The Cleveland Clinic Foundation) is a...
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Cleveland, OH
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Clinton, North Carolina 28328
Principal Investigator: James N. Atkins
Phone: 252-399-7491
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Clinton, NC
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12495 University Ave
Clive, Iowa 50325
(515) 358-9700
Principal Investigator: Mehmet S. Copur
Phone: 501-622-2100
Mercy Cancer Center - West Lakes When it comes to cancer care, there
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from
Clive, IA
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Clive, Iowa 50325
Principal Investigator: Mehmet S. Copur
Phone: 501-622-2100
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Clive, IA
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6001 E Woodmen Rd
Colorado Springs, Colorado 80923
(719) 776-5000
Penrose-Saint Francis Healthcare Founded by the Sisters of St. Francis and the Sisters of Charity,...
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Colorado Springs, CO
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Columbus, Ohio 43210
Principal Investigator: David M. O'Malley
Phone: 800-293-5066
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Columbus, OH
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3535 Olentangy River Rd
Columbus, Ohio 43214
(614) 566-5000
Principal Investigator: Timothy D. Moore
Phone: 614-488-2745
Riverside Methodist Hospital Serving central Ohio since 1892, Riverside Methodist Hospital is consistently ranked one...
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Columbus, OH
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3100 Plaza Properties Blvd
Columbus, Ohio 43219
(614) 383-6000
Principal Investigator: Timothy D. Moore
Phone: 614-488-2745
The Mark H. Zangmeister Center At The Zangmeister Center, we appreciate that our patients have...
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Columbus, OH
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Columbus, OH
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Commack, New York 11725
Principal Investigator: Carol Aghajanian
Phone: 212-639-7202
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Commack, NY
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Concord, California 94520
Principal Investigator: Babak Edraki
Phone: 925-674-2580
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Concord, CA
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