Everolimus in Treating Patients With Pleural Malignant Mesothelioma That Cannot Be Removed By Surgery



Status:Archived
Conditions:Lung Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:December 2008

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Phase II Trial of mTOR Inhibitor, Everolimus (RAD001), in Malignant Pleural Mesothelioma (MPM)


RATIONALE: Everolimus may stop the growth of tumor cells by blocking some of the enzymes
needed for cell growth.

PURPOSE: This phase II trial is studying how well everolimus works in treating patients with
pleural malignant mesothelioma that cannot be removed by surgery.


OBJECTIVES:

Primary

- To determine the 4-month progression-free survival in patients with unresectable
malignant pleural mesothelioma treated with everolimus.

Secondary

- To determine the response rate (confirmed and unconfirmed, complete and partial
responses) and disease control rate (response or stable disease) in patients with
measurable disease by RECIST and modified RECIST criteria.

- To determine overall survival of these patients.

- To evaluate the frequency and severity of toxicities associated with this treatment
regimen.

OUTLINE: This is a multicenter study.

Patients receive oral everolimus once daily on days 1-28. Courses repeat every 28 days in
the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed for 3 years.


We found this trial at
126
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90 Poly Drive, Suite 2
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1201 Camino de Salud Northeast
Albuquerque, New Mexico 87131
(505) 272-4946
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2720 Clare Avenue
Bremerton, Washington 98310
360-479-6154
Olympic Hematology and Oncology We provide outpatient cancer services in a refined environment designed specifically...
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200 Hawthorne Lane
Charlotte, North Carolina 28233
704-384-4000
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1 Hurley Plaza
Flint, Michigan 48503
(810) 262-9000
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Gainesville, Florida 30501
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2700 Wayne Memorial Drive
Goldsboro, North Carolina 27534
(919) 736-1110
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1415 E. Kincaid
Mount Vernon, Washington 98273
360-424-4111
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19500 10th Ave NE # 100
Poulsbo, Washington 98370
(360) 598-7500
Harrison Poulsbo Hematology and Onocology Harrison Poulsbo's new Hematology & Oncology center provides outpatient cancer...
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2279 45th Street
Sacramento, California 95817
(916) 734-5800
University of California Davis Cancer Center At UC Davis Comprehensive Cancer Center, specialized teams of...
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1100 Fairview Avenue North
Seattle, Washington 98109
(206) 667-5000
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1959 NE Pacific St
Seattle, Washington 98195
(206) 598-4100
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201 16th Avenue East
Seattle, Washington 98112
(206) 326-3000
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601 South Sherman Street
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(509) 228-1000
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Wenatchee, Washington 98801
509) 663-8711
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Ann Arbor, Michigan 48706
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Ann Arbor, Michigan 48106
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5301 East Huron River Drive
Ann Arbor, Michigan 48106
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1500 East Medical Center Drive
Ann Arbor, Michigan 48109
800-865-1125
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205 Palmer Ave.
Bellefontaine, Ohio 43311
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1101 N 27th St # 201
Billings, Montana 59101
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931 Highland Blvd
Bozeman, Montana 59715
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Chanute, Kansas 66720
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272 Hospital Rd
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9280 SE Sunnybrook Blvd #100
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142 S Main St
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Dayton, Ohio 45415
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3123 Research Boulevard Suite 150
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800 W. Laurel
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7360 W. Deschutes
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750 Avenue D West
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720 Medical Center Drive
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Pueblo, Colorado 81004
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Richmond, Indiana 47374
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Saginaw, Michigan 48601
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