Everolimus in Treating Patients With Pleural Malignant Mesothelioma That Cannot Be Removed By Surgery



Status:Archived
Conditions:Lung Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:December 2008

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Phase II Trial of mTOR Inhibitor, Everolimus (RAD001), in Malignant Pleural Mesothelioma (MPM)


RATIONALE: Everolimus may stop the growth of tumor cells by blocking some of the enzymes
needed for cell growth.

PURPOSE: This phase II trial is studying how well everolimus works in treating patients with
pleural malignant mesothelioma that cannot be removed by surgery.


OBJECTIVES:

Primary

- To determine the 4-month progression-free survival in patients with unresectable
malignant pleural mesothelioma treated with everolimus.

Secondary

- To determine the response rate (confirmed and unconfirmed, complete and partial
responses) and disease control rate (response or stable disease) in patients with
measurable disease by RECIST and modified RECIST criteria.

- To determine overall survival of these patients.

- To evaluate the frequency and severity of toxicities associated with this treatment
regimen.

OUTLINE: This is a multicenter study.

Patients receive oral everolimus once daily on days 1-28. Courses repeat every 28 days in
the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed for 3 years.


We found this trial at
126
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1201 Camino de Salud Northeast
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(505) 272-4946
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2720 Clare Avenue
Bremerton, Washington 98310
360-479-6154
Olympic Hematology and Oncology We provide outpatient cancer services in a refined environment designed specifically...
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200 Hawthorne Lane
Charlotte, North Carolina 28233
704-384-4000
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1 Hurley Plaza
Flint, Michigan 48503
(810) 262-9000
Hurley Medical Center From its founding in 1908, Hurley Medical Center has devoted itself to...
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Gainesville, Florida 30501
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2700 Wayne Memorial Drive
Goldsboro, North Carolina 27534
(919) 736-1110
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1415 E. Kincaid
Mount Vernon, Washington 98273
360-424-4111
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19500 10th Ave NE # 100
Poulsbo, Washington 98370
(360) 598-7500
Harrison Poulsbo Hematology and Onocology Harrison Poulsbo's new Hematology & Oncology center provides outpatient cancer...
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2279 45th Street
Sacramento, California 95817
(916) 734-5800
University of California Davis Cancer Center At UC Davis Comprehensive Cancer Center, specialized teams of...
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1100 Fairview Avenue North
Seattle, Washington 98109
(206) 667-5000
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1959 NE Pacific St
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(206) 598-4100
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201 16th Avenue East
Seattle, Washington 98112
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601 South Sherman Street
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(509) 228-1000
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820 North Chelan Avenue
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Ann Arbor, Michigan 48706
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Ann Arbor, Michigan 48106
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5301 East Huron River Drive
Ann Arbor, Michigan 48106
1.877.590.5995
CCOP - Michigan Cancer Research Consortium The Community Clinical Oncology Program (CCOP) is a comprehensive...
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1500 East Medical Center Drive
Ann Arbor, Michigan 48109
800-865-1125
University of Michigan Comprehensive Cancer Center The U-M Comprehensive Cancer Center's mission is the conquest...
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205 Palmer Ave.
Bellefontaine, Ohio 43311
937.592.4015
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801 N. 29th St
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1101 N 27th St # 201
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90 Poly Drive, Suite 2
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(406) 237-5460
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6501 E 2nd St
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505 S Plummer Ave
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272 Hospital Rd
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9280 SE Sunnybrook Blvd #100
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111 S Grant Avenue
Columbus, Ohio 43215
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1 Wyoming St
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2222 Philadelphia Dr
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18101 Oakwood Blvd
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561 W. Central Avenue
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(740) 615-1000
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4201 St Antoine St
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2020 Central Ave
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700 West Central
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1101 26th Street South
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114 Woodland St, Hartford
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30 13th St
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2475 Broadway St
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1515 Holcombe Blvd
Houston, Texas 77030
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800 W. Laurel
Independence, Kansas 67301
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205 Northeast Ave
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75 Claremont St Ste E
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310 Sunnyview Ln
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7360 W. Deschutes
Kennewick, Washington 99336
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750 Avenue D West
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Lancaster, Ohio 43130
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1330 Coshocton Ave
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1320 West Main Street
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1001 Providence Dr
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1902 S. US Hwy 59
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Port Huron, Michigan 48060
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124 Commodore, Ste. A
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Pueblo, Colorado 81004
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1100 Reid Pkwy
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800 S Washington Ave
Saginaw, Michigan 48601
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Salina, Kansas 67401
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