Lung-MAP: Biomarker-Targeted Second-Line Therapy in Treating Patients With Recurrent Stage IV Squamous Cell Lung Cancer



Status:Recruiting
Conditions:Lung Cancer, Lung Cancer, Cancer, Cancer, Cancer, Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:9/2/2018
Start Date:June 16, 2014
End Date:April 1, 2022

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A Biomarker-Driven Master Protocol for Previously Treated Squamous Cell Lung Cancer (Lung-Map)

This screening and multi-sub-study randomized phase II/III trial will establish a method for
genomic screening of similar large cancer populations followed by assigning and accruing
simultaneously to a multi-sub-study hybrid ?Master Protocol? (S1400). The type of cancer
trait (biomarker) will determine to which sub-study, within this protocol, a participant will
be assigned to compare new targeted cancer therapy, designed to block the growth and spread
of cancer, or combinations to standard of care therapy with the ultimate goal of being able
to approve new targeted therapies in this setting. In addition, the protocol includes a
?non-match? sub-study which will include all screened patients not eligible for any of the
biomarker-driven sub-studies. This sub-study will compare a non-match therapy to standard of
care also with the goal of approval.

PRIMARY OBJECTIVES:

Screening component:

I. To establish a National Clinical Trials Network (NCTN) mechanism for genomically screening
large but homogeneous cancer populations and subsequently assigning and accruing
simultaneously to a multi-sub-study ?Master Protocol.? II. To evaluate the screen success
rate defined as the percentage of screened patients that register for a therapeutic
sub-study.

Sub-study-specific Objectives:

Design #1: Phase II/III Design:

III. To evaluate if there is sufficient evidence to continue to the Phase III component of
the sub-study by comparing investigator-assessed progression-free survival (IA-PFS) between
investigational therapy versus standard therapy (SoC) in patients with advanced stage
refractory squamous cell carcinoma (SCCA) of the lung. (Phase II) IV. To determine if there
is both a statistically and clinically-meaningful difference in IA-PFS among advanced stage
refractory SCCA of the lung randomized to receive investigational therapy versus SoC. (Phase
III) V. To compare overall survival (OS) in patients with advanced stage refractory SCCA of
the lung randomized to investigational therapy versus SoC. (Phase III)

Design #2: Phase II followed by Phase III (Sequential Phase II to Phase III):

VI. To evaluate the objective response rate (confirmed and unconfirmed, complete and
partial). (Phase II) VII. To determine if there is both a statistically and
clinically-meaningful difference in IA-PFS among advanced stage refractory SCCA of the lung
randomized to receive investigational therapy versus SoC. (Phase III) VIII. To compare
overall survival (OS) in patients with advanced stage refractory SCCA of the lung randomized
to investigational therapy versus SoC. (Phase III)

SECONDARY OBJECTIVES:

Sub-study-specific Objectives:

Design #1: Phase II/III Design:

I. To compare response rates (confirmed and unconfirmed, complete and partial responses)
among patients randomized to receive investigational therapy versus SoC. (Phase II) II. To
evaluate the frequency and severity of toxicities associated with investigational therapy
versus SoC. (Phase II) III. To evaluate the duration of response (DoR) among patients who
achieve a complete response (CR) or a partial response (PR) by Response Evaluation Criteria
in Solid Tumors (RECIST) (1.1). (Phase II) III. To compare the response rates (confirmed and
unconfirmed, complete and partial) among patients randomized to receive investigational
therapy versus SoC. (Phase III) IV. To evaluate the frequency and severity of toxicities
associated with investigational therapy versus SoC. (Phase III)

Design #2: Phase II followed by Phase III (Sequential Phase II to Phase III):

V. To evaluate PFS and OS with investigational therapy. (Phase II) VI. To evaluate the DoR
among patients who achieve a CR or PR (confirmed and unconfirmed) by RECIST 1.1. (Phase II)
VII. To evaluate the frequency and severity of toxicities associated with investigational
therapy. (Phase II) VIII. To compare the response rates (confirmed and unconfirmed, complete
and partial) among patients randomized to receive investigational therapy versus SoC. (Phase
III) IX. To evaluate the frequency and severity of toxicities associated with investigational
therapy versus SoC. (Phase III)

TERTIARY OBJECTIVES:

I. To evaluate the treatment arm randomization acceptance rate (TARAR) within each treatment
arm of each sub-study defined as the percentage of patients randomized to a treatment arm
that receive any protocol treatment. (Design #1: Phase II/III Design) II. To identify
additional predictive tumor/blood biomarkers that may modify response or define resistance to
the targeted therapy (TT)/targeted therapy combination (TTC) beyond the chosen biomarker for
biomarker-driven sub-studies.

III. To evaluate potentially predictive biomarkers for non-match therapy (NMT) in the
non-match studies.

IV. To identify potential resistance biomarkers at disease progression. V. To establish a
tissue/ blood repository from patients with refractory SCCA of the lung.

OUTLINE: Patients are assigned to a biomarker-driven targeted therapy phase II study. If the
objectives response rate observed is judged sufficient, patients proceed to a randomized
phase III trial and are randomized to biomarker-driven targeted therapy or standard of care.

S1400A: (CLOSED TO ACCRUAL 12/18/2015) Patients with tumors that do not match one of the
currently active drug-biomarker combinations or did not meet the eligibility requirements for
that bio-marker driven sub-study are assigned to Arm I. Upon evidence of progression
following discontinuation of 12 months of treatment, patients may restart treatment for up to
12 months with the same treatment guidelines followed during the initial 12-month treatment
period (Arm III).

ARM I: (CLOSED TO ACCRUAL 12/18/2015) Patients receive anti-B7H1 monoclonal antibody MEDI4736
intravenously (IV) over 60 minutes on day 1. Treatment repeats every 14 days for 12 months in
the absence of disease progression or unacceptable toxicity.

ARM II (CLOSED TO ACCRUAL 4/2015): Patients receive docetaxel IV on day 1. Courses repeat
every 21 days in the absence of disease progression or unacceptable toxicity. (closed to
accrual with Revision #2 4/22/15)

ARM III: For patients assigned to Arm 1, MEDI4736: Upon evidence of progression following
discontinuation of 12 months of treatment, patients may restart treatment with Arm 3,
MEDI4736 for up to 12 months with the same treatment guidelines followed during the initial
12-month treatment period. Patients will only be able to restart treatment once; thus a
maximum of two 12-month periods will be allowed. Patients receive anti-B7H1 monoclonal
antibody MEDI4736 intravenously (IV) over 60 minutes on day 1. Treatment repeats every 14
days for 12 months in the absence of disease progression or unacceptable toxicity.

S1400B (CLOSED TO ACCRUAL 12/12/2016): Patients with tumors positive for phosphoinositide
3-kinase (PI3KCA) are assigned to Arm I. Patients currently on Arm 2, docetaxel will be given
the option to re-register to Arm 3, GCD-0032 after disease progression on current treatment
(Arm III).

ARM I: Patients receive taselisib orally (PO) daily on days 1-21. Courses repeat every 21
days in the absence of disease progression or unacceptable toxicity.

ARM II (CLOSED TO ACCRUAL 12/18/2015): Patients receive docetaxel IV on day 1. Courses repeat
every 21 days in the absence of disease progression or unacceptable toxicity. (closed to
accrual with Revision #3 12/18/2015)

ARM III: Re-Registration Treatment with GDC-0032 (Taselisib) Upon progression patients in Arm
2 may be eligible for Re-Registration to receive GDC-0032. Patients receive taselisib orally
(PO) daily on days 1-21. Courses repeat every 21 days in the absence of disease progression
or unacceptable toxicity.

S1400C (CLOSED TO ACCRUAL 09/01/2016): Patients with tumors positive for cyclin dependent
kinase 4 (CDK4), cyclin D1 (CCND1), cyclin D2 (CCND2), and cyclin D3 (CCND3) are assigned to
Arm I. Patients currently on Arm 2, docetaxel will be given the option to re-register to Arm
3, palbociclib, after disease progression on current treatment (Arm III).

ARM I: Patients receive palbociclib PO on days 1-21. Courses repeat every 28 days in the
absence of disease progression or unacceptable toxicity.

ARM II (CLOSED TO ACCRUAL 12/18/2015): Patients receive docetaxel IV on day 1. Courses repeat
every 21 days in the absence of disease progression or unacceptable toxicity. (closed to
accrual with Revision #3 12/18/2015)

ARM III: Re-Registration Treatment with Palbociclib. Upon progression patients in Arm 2 may
be eligible for Re-Registration to receive palbociclib. Patients receive palbociclib PO on
days 1-21. Courses repeat every 28 days in the absence of disease progression or unacceptable
toxicity.

S1400D (CLOSED TO ACCRUAL 10/31/2016): Patients with tumors positive for fibroblast growth
factor receptor (FGFR) 1, FGFR2, and FGFR3 are assigned to Arm I. Patients currently on Arm
2, docetaxel will be given the option to re-register to Arm 3, AZD4547, after disease
progression on current treatment (Arm III).

ARM I: Patients receive FGFR inhibitor AZD4547 PO BID on days 1-21. Courses repeat every 21
days in the absence of disease progression or unacceptable toxicity.

ARM II (CLOSED TO ACCRUAL 12/18/2015): Patients receive docetaxel IV on day 1. Courses repeat
every 21 days in the absence of disease progression or unacceptable toxicity. (closed to
accrual with Revision #3 12/18/2015)

ARM III: Re-Registration Treatment with AZD4547. Upon progression patients in Arm 2 may be
eligible for Re-Registration to receive AZD4547. Patients receive FGFR inhibitor AZD4547 PO
BID on days 1-21. Courses repeat every 21 days in the absence of disease progression or
unacceptable toxicity.

S1400E (CLOSED TO ACCRUAL 11/25/2014): Patients with tumors positive for met proto-oncogene
(MET) are randomized to 1 of 2 treatment arms. (permanently closed to accrual on 11/25/14)

ARM I: Patients receive rilotumumab IV on day 1 and erlotinib hydrochloride PO daily on days
1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable
toxicity.

ARM II: Patients receive erlotinib hydrochloride PO daily on days 1-21. Courses repeat every
21 days in the absence of disease progression or unacceptable toxicity.

S1400F: Patients with disease progression during or after prior anti-PD-1 or anti-PD-L1
antibody monotherapy as their most recent line of treatment receive durvalumab (IV over 60
minutes) and tremelimumab (IV over 60 minutes) on day 1 for courses 1-4 and durvalumab IV
alone on day 1 of course 5 and subsequent courses until disease progression or unacceptable
toxicity. Courses repeat every 28 days.

S1400G: Patients with tumors positive for homologous recombination repair deficiency receive
talazoparib PO daily on days 1-21. Courses repeat every 21 days in the absence of disease
progression or unacceptable toxicity.

S1400I: Patients with tumors that do not match one of the currently active drug-biomarker
combinations or did not meet the eligibility requirements for that bio-marker driven
sub-study are randomized to 1 of 2 treatment arms.

ARM I: Patients receive nivolumab IV over 30 minutes on day 1 and ipilimumab IV over 60
minutes on day 1 of every third course. Courses repeat every 14 days in the absence of
disease progression or unacceptable toxicity.

ARM II: Patients receive nivolumab IV over 30 minutes on day 1. Courses repeat every 14 days
in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, all patients are followed up periodically for up to 3
years from date of screening registration.

Inclusion Criteria:

- SCREENING/PRE-SCREENING REGISTRATION:

- Patients must have pathologically proven squamous cell carcinoma (SCCA) cancer of the
lung confirmed by tumor biopsy and/or fine-needle aspiration; disease must be stage IV
SCCA, or recurrent; the primary diagnosis of SCCA should be established using the
current World Health Organization (WHO)/International Association for the Study of
Lung Cancer (IASLC)-classification of Thoracic Malignancies; the diagnosis is based on
hematoxylin and eosin (H&E) stained slides with or without specific defined
immunohistochemistry (IHC) characteristic (p40/p63 positive, transcription termination
factor [TTF1] negative) if required for diagnosis; mixed histologies are not allowed

- Patients must either be eligible to be screened at progression on prior treatment or
to be pre-screened prior to progression on current treatment; patients will either
consent to the screening consent or the pre-screening consent, not both; these
criteria are:

- Screening at progression on prior treatment: to be eligible for screening at
progression, patients must have received at least one line of systemic therapy
for any stage of disease (stages I-IV) and must have progressed during or
following their most recent line of therapy; for patients whose prior systemic
therapy was for stage I-III disease only (i.e. patient has not received any
treatment for stage IV or recurrent disease), the prior systemic therapy must
have been a platinum-based chemotherapy regimen and disease progression on the
platinum-based chemotherapy must have occurred within one year from the last date
that patient received that therapy; for patients whose prior therapy was for
stage IV or recurrent disease, the patient must have received at least one line
of a platinum-based chemotherapy regimen or checkpoint inhibitor therapy (e.g.
nivolumab or pembrolizumab)

- Pre-screening prior to progression on current treatment: to be eligible for
pre-screening, current treatment must be for stage IV or recurrent disease and
patient must have received at least one dose of the current regimen; patients
must have previously received or currently be receiving a platinum-based
chemotherapy regimen or checkpoint inhibitor therapy (e.g. nivolumab or
pembrolizumab); patients on first-line platinum-based treatment are eligible upon
receiving cycle 1, day 1 infusion; Note: patients will not receive their
sub-study assignment until they progress and the S1400 Notice of Progression is
submitted

- Patients must have adequate tumor tissue available, defined as >= 20% tumor cells and
>= 0.2 mm^3 tumor volume

- The local interpreting pathologist must review the specimen

- The pathologist must sign the S1400 Local Pathology Review Form confirming tissue
adequacy prior to screening/pre-screening registration

- Patients must agree to have this tissue submitted to Foundation Medicine for
common broad platform Clinical Laboratory Improvement Act (CLIA) biomarker
profiling; if archival tumor material is exhausted, then a new fresh tumor biopsy
that is formalin-fixed and paraffin-embedded (FFPE) must be obtained; a tumor
block or FFPE slides 4-5 microns thick must be submitted; bone biopsies are not
allowed; if FFPE slides are to be submitted, at least 12 unstained slides plus an
H&E stained slide, or 13 unstained slides must be submitted; however it is
strongly recommended that 20 FFPE slides be submitted; Note: previous
next-generation deoxyribonucleic acid (DNA) sequencing (NGS) will be repeated if
done outside this study for sub-study assignment; patients must agree to have any
tissue that remains after NGS testing retained for the use of the translational
medicine (TM) studies (if such TM studies are defined) within any sub-study the
patient is enrolled in

- Patients must not have a known epidermal growth factor receptor (EGFR) mutation or
anaplastic lymphoma kinase (ALK) fusion; EGFR/ALK testing is not required prior to
registration and is included in the Foundation Medicine Incorporated (FMI) testing for
screening/prescreening

- Patients must have Zubrod performance status 0-1 documented within 28 days prior to
screening/pre-screening registration

- Patients must also be offered participation in banking for future use of specimens

- Patients must be willing to provide prior smoking history as required on the S1400
Onstudy Form

- As a part of the Oncology Patient Enrollment Network (OPEN) registration process the
treating institution's identity is provided in order to ensure that the current
(within 365 days) date of institutional review board approval for this study has been
entered in the system

- Patients must be informed of the investigational nature of this study and must sign
and give written informed consent in accordance with institutional and federal
guidelines

- SUB-STUDY REGISTRATION:

- Patients whose biomarker profiling results indicate the presence of an EGFR mutation
or echinoderm microtubule-associated protein-like 4 (EML4)/ALK fusion are not eligible

- Patients must have progressed (in the opinion of the treating investigator) following
the most recent line of therapy

- Patients must not have received any prior systemic therapy (systemic chemotherapy,
immunotherapy or investigational drug) within 21 days prior to sub-study registration;
patients must have recovered (=< grade 1) from any side effects of prior therapy;
patients must not have received any radiation therapy within 14 days prior to
sub-study registration

- Patients must have measurable disease documented by computed tomography (CT) or
magnetic resonance imaging (MRI); the CT from a combined positron emission tomography
(PET)/CT may be used to document only non-measurable disease unless it is of
diagnostic quality; measurable disease must be assessed within 28 days prior to
sub-study registration; pleural effusions, ascites and laboratory parameters are not
acceptable as the only evidence of disease; non-measurable disease must be assessed
within 42 days prior to sub-study registration; all disease must be assessed and
documented on the Baseline Tumor Assessment Form; patients whose only measurable
disease is within a previous radiation therapy port must demonstrate clearly
progressive disease (in the opinion of the treating investigator) prior to
registration

- Patients must have a CT or MRI scan of the brain to evaluate for central nervous
system (CNS) disease within 42 days prior to sub-study registration; patient must not
have leptomeningeal disease, spinal cord compression or brain metastases unless: (1)
metastases have been locally treated and have remained clinically controlled and
asymptomatic for at least 14 days following treatment and prior to registration, AND
(2) patient has no residual neurological dysfunction and has been off corticosteroids
for at least 24 hours prior to sub-study registration

- Patient must have fully recovered from the effects of prior surgery at least 14 days
prior to sub-study registration

- Patients must not be planning to receive any concurrent chemotherapy, immunotherapy,
biologic or hormonal therapy for cancer treatment; concurrent use of hormones for
non-cancer-related conditions (e.g., insulin for diabetes and hormone replacement
therapy) is acceptable

- Absolute neutrophil count (ANC) >= 1,500/mcl obtained within 28 days prior to
sub-study registration

- Platelet count >= 100,000 mcl obtained within 28 days prior to sub-study registration

- Hemoglobin >= 9 g/dL obtained within 28 days prior to sub-study registration

- Serum bilirubin =< institutional upper limit of normal (IULN) within 28 days prior to
sub-study registration; for patients with liver metastases, bilirubin must be =< 5 x
IULN

- Either alanine aminotransferase (ALT) or aspartate aminotransferase (AST) =< 2 x IULN
within 28 days prior to sub-study registration (if both ALT and AST are done, both
must be =< 2 IULN); for patients with liver metastases, either ALT or AST must be =< 5
x IULN (if both ALT and AST are done, both must be =< 5 x IULN)

- Serum creatinine =< the IULN OR measured or calculated creatinine clearance >= 50
mL/min using the following Cockcroft-Gault Formula within 28 days prior to sub-study
registration

- Patients must have Zubrod performance status 0-1 documented within 28 days prior to
sub-study registration

- Patients must not have any grade III/IV cardiac disease as defined by the New York
Heart Association Criteria (i.e., patients with cardiac disease resulting in marked
limitation of physical activity or resulting in inability to carry on any physical
activity without discomfort), unstable angina pectoris, and myocardial infarction
within 6 months, or serious uncontrolled cardiac arrhythmia

- Patients must not have documented evidence of acute hepatitis or have an active or
uncontrolled infection

- Patients with a known history of human immunodeficiency virus (HIV) seropositivity:

- Must have undetectable viral load using standard HIV assays in clinical practice

- Must have cluster of differentiation (CD)4 count >= 400/mcL

- Must not require prophylaxis for any opportunistic infections (i.e., fungal,
Mycobacterium avium complex [mAC], or pneumocystis jiroveci pneumonia [PCP]
prophylaxis)

- Must not be newly diagnosed within 12 months prior to sub-study registration

- Prestudy history and physical exam must be obtained within 28 days prior to sub-study
registration

- No other prior malignancy is allowed except for the following: adequately treated
basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated
stage I or II cancer from which the patient is currently in complete remission, or any
other cancer from which the patient has been disease free for five years

- Patients must not be pregnant or nursing; women/men of reproductive potential must
have agreed to use an effective contraceptive method; a woman is considered to be of
"reproductive potential" if she has had menses at any time in the preceding 12
consecutive months; in addition to routine contraceptive methods, "effective
contraception" also includes heterosexual celibacy and surgery intended to prevent
pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy,
bilateral oophorectomy or bilateral tubal ligation; however, if at any point a
previously celibate patient chooses to become heterosexually active during the time
period for use of contraceptive measures outlined in the protocol, he/she is
responsible for beginning contraceptive measures

- As part of the OPEN registration process the treating institution?s identity is
provided in order to ensure that the current (within 365 days) date of institutional
review board approval for this study has been entered into the system

- Patients with impaired decision-making capacity are eligible as long as their
neurological or psychological condition does not preclude their safe participation in
the study (e.g., tracking pill consumption and reporting adverse events to the
investigator)

- Patients must be informed of the investigational nature of this study and must sign
and give written informed consent in accordance with institutional and federal
guidelines.
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Principal Investigator: Jeffrey L. Berenberg
Phone: 808-678-9000
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Aberdeen, South Dakota 57401
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Adrian, Michigan 49221
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Albany, Georgia 31701
Principal Investigator: Sharad A. Ghamande
Phone: 229-312-0405
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Albany, New York 12208
Principal Investigator: Makenzi C. Evangelist
Phone: 518-489-3612
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Albuquerque, New Mexico 87102
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Albuquerque, New Mexico 87109
Principal Investigator: Ian Rabinowitz
Phone: 505-272-0530
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Albuquerque, New Mexico 87102
Principal Investigator: Ian Rabinowitz
Phone: 505-272-0530
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Allentown, Pennsylvania 18103
Principal Investigator: Philip J. Stella
Phone: 734-712-3671
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Amarillo, Texas 79106
Principal Investigator: Anita Ravipati
Phone: 806-212-1985
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170 North 1100 East
American Fork, Utah 84003
Principal Investigator: Derrick S. Haslem
Phone: 435-688-4901
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Ames, Iowa 50010
Principal Investigator: Joseph J. Merchant
Phone: 515-239-2621
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Ames, Iowa 50010
Principal Investigator: Joseph J. Merchant
Phone: 515-239-2621
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Anaconda, Montana 59711
Principal Investigator: Benjamin T. Marchello
Phone: 406-969-6060
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Anaheim, California 92806
Principal Investigator: Han A. Koh
Phone: 800-398-3996
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Anchorage, Alaska 99508
Principal Investigator: Gary E. Goodman
Phone: 206-215-3962
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Anchorage, Alaska 99508
Principal Investigator: Gary E. Goodman
Phone: 907-212-6871
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Anchorage, Alaska 99508
Principal Investigator: Gary E. Goodman
Phone: 907-212-6871
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Anchorage, Alaska 99508
Principal Investigator: Gary E. Goodman
Phone: 907-212-6871
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Anchorage, Alaska 98508
Principal Investigator: Gary E. Goodman
Phone: 907-212-6871
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Anchorage, Alaska 99508
Principal Investigator: Gary E. Goodman
Phone: 907-212-6871
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Anchorage, Alaska 99508
Principal Investigator: Gary E. Goodman
Phone: 907-212-6871
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2000 E Greenville St
Anderson, South Carolina 29621
(864) 512-4640
Principal Investigator: John E. Doster
Phone: 864-512-4665
AnMedical Health Cancer Center Cancer is the general term for a group of more than...
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5301 McAuley Drive
Ann Arbor, Michigan 48197
734-712-3456
Principal Investigator: Philip J. Stella
Phone: 734-712-3671
Saint Joseph Mercy Hospital St. Joseph Mercy Ann Arbor Hospital is a 537-bed teaching hospital...
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1500 East Medical Center Drive
Ann Arbor, Michigan 48109
800-865-1125
Principal Investigator: Gregory P. Kalemkerian
University of Michigan Comprehensive Cancer Center The U-M Comprehensive Cancer Center's mission is the conquest...
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Antigo, Wisconsin 54409
Principal Investigator: Harish G. Ahuja
Phone: 715-623-9869
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Antioch, California 94531
Principal Investigator: Jennifer M. Suga
Phone: 877-642-4691
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921 North Oak Park Boulevard
Arroyo Grande, California 93420
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364 White Oak St
Asheboro, North Carolina 27203
(336) 625-5151
Principal Investigator: Vinay K. Gudena
Phone: 336-832-0836
Randolph Hospital Since 1932, Randolph Hospital has been fortunate to employ dedicated and loyal personnel...
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Asheville, North Carolina 28801
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Asheville, North Carolina 28801
Principal Investigator: Christopher H. Chay
Phone: 828-213-4150
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Ashland, Kentucky 41101
Principal Investigator: David K. Goebel
Phone: 888-823-5923
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550 Peachtree St NE
Atlanta, Georgia 30308
(404) 686-4411
Principal Investigator: Taofeek K. Owonikoko
Phone: 888-946-7447
Emory University Hospital Midtown Emory University Hospital Midtown is a 511-bed community-based, acute care teaching...
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1968 Peachtree Rd NW
Atlanta, Georgia 30309
(404) 605-5000
Piedmont Hospital For more than a century, Piedmont Healthcare has been a recognized leader in...
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1000 Johnson Ferry Rd NE
Atlanta, Georgia 30342
(404) 851-8000
Principal Investigator: Sreekanth C. Reddy
Phone: 404-303-3355
Northside Hospital Northside Hospital-Atlanta (in Sandy Springs) opened in 1970. The original facility had 250...
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Atlanta, Georgia 30322
Principal Investigator: Taofeek K. Owonikoko
Phone: 404-778-1868
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Atlanta, Georgia 30342
Principal Investigator: Taofeek K. Owonikoko
Phone: 888-823-5923
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Auburn, California 95602
Principal Investigator: Ari D. Baron
Phone: 415-209-2686
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Auburn, Washington 98001
Principal Investigator: John A. Keech
Phone: 253-887-9333
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Augusta, Georgia 30912
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12605 East 16th Avenue
Aurora, Colorado 80045
720-848-0000
Principal Investigator: Jose M. Pacheco
Phone: 720-848-0650
University of Colorado Hospital, Site Top medical professionals, superior medicine and progressive change make University...
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2000 Ogden Ave
Aurora, Illinois 60504
(630) 978-6200
Rush - Copley Medical Center Rush-Copley is proud to be the leading provider of health...
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1500 Red River Street
Austin, Texas 78701
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Aventura, Florida 33180
Principal Investigator: Michael A. Schwartz
Phone: 888-823-5923
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Baldwin Park, California 91706
Principal Investigator: Han A. Koh
Phone: 800-398-3996
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Baltimore, Maryland 21229
Principal Investigator: Carole B. Miller
Phone: 410-951-4046
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22 South Greene Street
Baltimore, Maryland 21201
410-328-7904
Principal Investigator: Katherine A. Scilla
Phone: 800-888-8823
University of Maryland Greenebaum Cancer Center The University of Maryland Marlene and Stewart Greenebaum Cancer...
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2401 W Belvedere Ave
Baltimore, Maryland 21215
(410) 601-9000
Principal Investigator: Roberto F. Martinez
Phone: 410-601-6120
Sinai Hospital of Baltimore Sinai Hospital of Baltimore provides a broad array of high-quality, cost-effective...
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401 North Broadway
Baltimore, Maryland 21287
410-955-5000
Principal Investigator: Julie R. Brahmer
Phone: 410-955-8804
Johns Hopkins University-Sidney Kimmel Cancer Center The name Johns Hopkins has become synonymous with excellence...
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Baltimore, Maryland 21218
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6701 N Charles St
Baltimore, Maryland 21204
(443) 849-2000
Principal Investigator: Mei Tang
Phone: 443-849-3706
Greater Baltimore Medical Center The 255-bed medical center (acute and sub-acute care) is located on...
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Baltimore, Maryland 21244
Principal Investigator: Leon C. Hwang
Phone: 301-816-7218
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489 State St
Bangor, Maine 04401
(207) 973-7000
Principal Investigator: Thomas H. Openshaw
Phone: 207-973-4274
Eastern Maine Medical Center Located in Bangor, Eastern Maine Medical Center (EMMC) serves communities throughout...
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4305 New Shepherdsville Road
Bardstown, Kentucky 40004
Principal Investigator: Mehmet S. Copur
Phone: 308-398-6518
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Bartlett, Tennessee 38133
Principal Investigator: Raymond U. Osarogiagbon
Phone: 901-448-3303
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Baton Rouge, Louisiana 70805
Principal Investigator: David S. Hanson
Phone: 225-215-1353
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Baton Rouge, Louisiana 70806
Principal Investigator: Hana F. Safah
Phone: 504-988-2368
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Baton Rouge, Louisiana 70809
Principal Investigator: David S. Hanson
Phone: 225-215-1353
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Baton Rouge, Louisiana 70809
Principal Investigator: David S. Hanson
Phone: 225-215-1353
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Baton Rouge, Louisiana 70809
Principal Investigator: Marc R. Matrana
Phone: 225-761-5346
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4950 Essen Lane
Baton Rouge, Louisiana 70809
Principal Investigator: David S. Hanson
Phone: 225-215-1353
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Baton Rouge, Louisiana 70816
Principal Investigator: Marc R. Matrana
Phone: 225-761-5346
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265 Fremont St
Battle Creek, Michigan 49017
(269) 245-8166
Principal Investigator: Kathleen J. Yost
Phone: 616-391-1230
Bronson Battle Creek As a proud member of the Battle Creek community, we believe everyone...
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Beachwood, Ohio 44122
Principal Investigator: Joel N. Saltzman
Phone: 800-641-2422
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3535 Pentagon Boulevard
Beavercreek, Ohio 45431
Principal Investigator: Howard M. Gross
Phone: 937-775-1350
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118 Northport Avenue
Belfast, Maine 04915
Principal Investigator: Peter Rubin
Phone: 207-338-2500
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Bellevue, Washington 98004
Principal Investigator: John A. Keech
Phone: 425-688-5407
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