Childhood Cancer Survivor Study



Status:Recruiting
Conditions:Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any
Updated:10/26/2018
Start Date:January 5, 1995
End Date:November 2021
Contact:Gregory T. Armstrong, MD, MSCE
Email:referralinfo@stjude.org
Phone:1-866-278-5833

Use our guide to learn which trials are right for you!

The Childhood Cancer Survivor Study (CCSS) will investigate the long-term effects of cancer
and its associated therapies. A retrospective cohort study will be conducted through a
multi-institutional collaboration, which will involve the identification and active follow-up
of a cohort of approximately 50,000 survivors of cancer, diagnosed before 21 years of age,
between 1970 and 1999 and 10,000 sibling controls. This project will study children and young
adults exposed to specific therapeutic modalities, including radiation, chemotherapy, and/or
surgery, who are at increased risk of late-occurring adverse health outcomes. A group of
sibling controls will be identified and data collected for comparison purposes.

The study will focus on the following objectives:

- Characterize survivors' health with respect to disease- and treatment-related factors.

- Investigate the consequences of various intensities of exposure to chemotherapy and/or
radiation on health outcomes (e.g., cardiovascular, reproductive, second cancers, etc…).

- Compare the mortality experience of survivors with the general population.

- Characterize the health-related behaviors, patterns of medical care, and medical
follow-up needs of survivors.

- Describe patterns of familial aggregation of cancer, including known (and variations of)
cancer family syndromes.

- Collect and store biologic samples (saliva, blood, second tumor tissue) to correlate
with health outcomes and use for future research.

Inclusion Criteria:

Initial Cohort:

- Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor,
Wilms tumor, neuroblastoma, or soft tissue sarcoma before age 21 years between January
1, 1970 and December 31, 1986 at one of participating centers.

Expanded cohort:

- Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor,
kidney tumor, neuroblastoma, or rhabdomyosarcoma before age 21 years between January
1, 1987 and December 31, 1999 at one of participating centers.

- English- or Spanish-speaking and living in the U.S. or Canada at the time of
diagnosis.

Exclusion Criteria:

- Diagnosis of non-malignant tumors (i.e., Langerhans cell histiocytosis, meningioma,
craniopharyngioma, etc.) treated with radiation and/or chemotherapy.

- Non-English speaking or residence outside the US or Canada.

Sibling Controls:

- For comparison purposes, a group of sibling controls will be identified to represent a
stratified random sample based on the distribution of survivors with regard to cancer
diagnosis, age, sex, race, and geographic location.
We found this trial at
31
sites
Ann Arbor, Michigan 48109
Principal Investigator: Raymond Hutchinson, MD
Phone: 734-764-7126
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666 Elm Street
Buffalo, New York 14263
(716) 845-2300
Principal Investigator: Denise Rokitka, MD
Phone: 716-845-2333
Roswell Park Cancer Institute Welcome to Roswell Park Cancer Institute (RPCI), America's first cancer center...
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Buffalo, NY
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5801 South Ellis Avenue
Chicago, Illinois 60637
 773.702.1234
Principal Investigator: Tara Henderson, MD, MPH
Phone: 773-702-2501
University of Chicago One of the world's premier academic and research institutions, the University of...
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Chicago, IL
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700 Childrens Drive
Columbus, Ohio 43205
(616) 722-2000
Principal Investigator: Randy Olshefki
Phone: 614-722-3553
Nationwide Children's Hospital At Nationwide Children’s, we are creating the future of pediatric health care....
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Columbus, OH
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4650 Sunset Blvd
Los Angeles, California 90027
 (323) 660-2450
Principal Investigator: David Freyer, DO
Phone: 323-361-8953
Childrens Hospital Los Angeles Children's Hospital Los Angeles is a 501(c)(3) nonprofit hospital for pediatric...
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Los Angeles, California 90095
310-825-4321
Principal Investigator: Jacqueline Casillas, MD
Phone: 310-794-2474
University of California at Los Angeles The University of California, Los Angeles (UCLA) is an...
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262 Danny Thomas Pl
Memphis, Tennessee 38105
(901) 495-3300
Principal Investigator: Gregory T. Armstrong, MD, MSCE
Phone: 866-278-5833
St. Jude Children's Research Hospital St. Jude is unlike any other pediatric treatment and research...
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Memphis, TN
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Minneapolis, Minnesota 55455
(612) 625-5000
Principal Investigator: Karim Sadak, MD,MPH,MSE
Phone: 612-626-2778
Univ of Minnesota With a flagship campus in the heart of the Twin Cities, and...
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1201 W La Veta Ave
Orange, California 92868
(714) 997-3000
Principal Investigator: Leonard Sender, MD
Phone: 714-509-8636
Children's Hospital of Orange County For more than 45 years, CHOC Children’s has been steadfastly...
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South 34th Street
Philadelphia, Pennsylvania 19104
 215-590-1000
Principal Investigator: Jill Ginsberg, MD
Phone: 215-590-7399
Children's Hospital of Philadelphia Since its start in 1855 as the nation's first hospital devoted...
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291 Campus Dr
Stanford, California 94305
(650) 725-3900
Principal Investigator: Sheri Spunt, MD
Phone: 650-723-5535
Stanford University School of Medicine Vast in both its physical scale and its impact on...
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Atlanta, Georgia 30322
Principal Investigator: Lillian Meacham, MD
Phone: 404-727-0480
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13123 E 16th Ave
Aurora, Colorado 80045
(720) 777-1234
Principal Investigator: Robert Greffe, MD
Phone: 720-777-6787
Children's Hospital Colorado At Children's Hospital Colorado, we see more, treat more and heal more...
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Birmingham, Alabama 35294
Principal Investigator: Kimberly Whelan, MD
Phone: 202-939-9285
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Birmingham, AL
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450 Brookline Ave
Boston, Massachusetts 2215
617-632-3000
Principal Investigator: Lisa Diller, MD
Phone: 617-632-5642
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
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Boston, MA
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Chicago, Illinois 60611
Principal Investigator: Jennifer Reichek, MD, MSW
Phone: 312-227-4777
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Chicago, IL
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1801 Inwood Rd
Dallas, Texas 75390
(214) 645-3300
Principal Investigator: Daniel Bowers, MD
Phone: 214-648-3150
University of Texas Southwestern Medical Center UT Southwestern is an academic medical center, world-renowned for...
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1500 East Duarte Road
Duarte, California 91010
626-256-HOPE (4673)
Principal Investigator: Saro Armenian, DO
Phone: 626-471-7205
City of Hope National Medical Center City of Hope is dedicated to making a difference...
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801 7th Avenue
Fort Worth, Texas 76104
(682) 885-4000
Principal Investigator: Donald Beam, MD
Phone: 682-885-4007
Cook Children's Medical Center Cook Children's Health Care System is a not-for-profit, nationally recognized pediatric...
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Fort Worth, TX
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Houston, Texas 77030
Principal Investigator: Louise Strong, MD
Phone: 713-792-2589
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Houston, TX
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6621 Fannin St
Houston, Texas 77030
(832) 824-1000
Principal Investigator: ZoAnn E. Dreyer, MD
Phone: 832-822-4209
Texas Children's Hospital Texas Children's Hospital, located in Houston, Texas, is a not-for-profit organization whose...
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Indianapolis, Indiana 46202
Principal Investigator: Terry Vik, MD
Phone: 317-944-8784
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Indianapolis, IN
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Minneapolis, Minnesota 55404
Principal Investigator: Katharine R. Lange, MD
Phone: 612-813-6560
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1275 York Ave
New York, New York 10021
(212) 639-2000
Principal Investigator: Danielle Friedman, MD
Phone: 212-639-8138
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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3414 Fifth Avenue
Pittsburgh, Pennsylvania 15213
Principal Investigator: Jean Tersak, MD
Phone: 412-692-5963
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Rochester, Minnesota 55905
Principal Investigator: Vilmarie Rodriguez, MD
Phone: 507-284-2695
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1 Childrens Place
Saint Louis, Missouri 63110
Principal Investigator: Mark Hayashi, PhD
Phone: 314-454-4118
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Saint Louis, MO
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San Francisco, California 94143
Principal Investigator: Robert Goldsby, MD
Phone: 415-476-3831
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4800 Sand Point Way NE
Seattle, Washington 98105
(206) 987-2000
Principal Investigator: Scott Baker, MD
Phone: 206-884-1018
Seattle Children's Hospital Seattle Children’s Hospital specializes in meeting the unique physical, emotional and developmental...
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555 University Avenue
Toronto, Ontario M5G 1X8
Principal Investigator: Paul Nathan, MD
Phone: 416-813-8795
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Toronto,
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111 Michigan Ave NW
Washington, District of Columbia
(202) 476-5000
Principal Investigator: Jennifer Dean, MD
Phone: 703-531-3627
Childrens National Medical Center As the nation’s children’s hospital, the mission of Children’s National Medical...
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