Home Away From Home - Medical Outcomes



Status:Recruiting
Conditions:Blood Cancer, Blood Cancer, Infectious Disease, Hematology, Hematology
Therapuetic Areas:Hematology, Immunology / Infectious Diseases, Oncology
Healthy:No
Age Range:Any - 19
Updated:9/7/2018
Start Date:June 2015
End Date:December 2019
Contact:Richard Aplenc, MD, PhD
Email:aplenc@chop.edu

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Home or Away From Home: Comparing Clinical Outcomes Relevant to the Care of Pediatric Acute Myeloid Leukemia During Periods of Neutropenia

Treatment for pediatric acute myeloid leukemia (AML) involves intensive chemotherapy regimens
that result in periods of profound neutropenia leaving patients susceptible to severe
infectious complications. Infectious complications are the leading cause of treatment related
mortality among AML patients, but there are little clinical data to inform whether management
of neutropenia post AML chemotherapy should occur in an outpatient or inpatient setting. The
primary objective of this study is to compare the clinical effectiveness of outpatient versus
inpatient management of neutropenia in children with AML.

This is a bidirectional observational cohort study.

Participants will be patients less that 19 years of age at diagnosis receiving or having
received chemotherapy for AML from seventeen participating pediatric hospitals across the
United States. There is no study intervention; this is a medical record abstraction study
only. Investigators will abstract subjects medical record data over the study period in order
to study clinical outcomes including the occurrence of bacteremia and time to the start of
the next course in the chemotherapy regimen, in relation to neutropenia management strategy.

Inclusion Criteria:

1. Males or females of age less than 19 at diagnosis.

2. Receipt or planned receipt of AML chemotherapy between January 1, 2012 and December
31, 2019.

Exclusion Criteria:

1. Patients being treated for relapsed AML

2. Patients with Acute Promyelocytic Leukemia (APML)

3. Patients undergoing stem cell transplant (SCT)

4. Patients receiving reduced intensity frontline chemotherapy
We found this trial at
17
sites
Boston, Massachusetts 02115
Phone: 617-632-4688
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Ann Arbor, MI 48109Bus: -
Ann Arbor, Michigan 48109
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2500 N State St
Jackson, Mississippi 39216
(601) 984-1000
University of Mississippi Medical Center The University of Mississippi Medical Center, located in Jackson, is...
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South 34th Street
Philadelphia, Pennsylvania 19104
 215-590-1000
Phone: 267-426-7252
Children's Hospital of Philadelphia Since its start in 1855 as the nation's first hospital devoted...
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1600 Rockland Road
Wilmington, Delaware 19803
(302) 651-4200
Alfred I. duPont Hospital for Children Nemours began more than 70 years ago with the...
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1405 Clifton Road NE
Atlanta, Georgia 30322
404-785-6000
Children's Healthcare of Atlanta Whether treating a toddler in an emergency or supporting a teen...
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13123 E 16th Ave
Aurora, Colorado 80045
(720) 777-1234
Children's Hospital Colorado At Children's Hospital Colorado, we see more, treat more and heal more...
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1935 Medical District Dr
Dallas, Texas 75235
(214) 456-7000
Children's Medical Center of Dallas Children's Medical Center is private, not-for-profit, and is the fifth-largest...
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3901 Beaubien St
Detroit, Michigan 48201
(313) 745-5437
Children's Hospital of Michigan Since 1886, the Children's Hospital of Michigan has been dedicated to...
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6621 Fannin St
Houston, Texas 77030
(832) 824-1000
Texas Children's Hospital Texas Children's Hospital, located in Houston, Texas, is a not-for-profit organization whose...
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1 Children's Way
Little Rock, Arkansas 72202
(501) 364-1100
Arkansas Children's Hospital Arkansas Children's Hospital (ACH) is the only pediatric medical center in Arkansas...
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1514 Jefferson Hwy.
New Orleans, Louisiana 70121
504-842-3000
Ochsner Medical Center Ochsner Medical Center is located near uptown New Orleans and includes acute...
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Palo Alto, California 94304
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Salt Lake City, Utah 84143
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San Diego, California 92123
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4800 Sand Point Way NE
Seattle, Washington 98105
(206) 987-2000
Seattle Children's Hospital Seattle Children’s Hospital specializes in meeting the unique physical, emotional and developmental...
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