Cisplatin, Carboplatin and Etoposide or Temozolomide and Capecitabine in Treating Patients With Neuroendocrine Carcinoma of the Gastrointestinal Tract or Pancreas That Is Metastatic or Cannot Be Removed by Surgery



Status:Recruiting
Healthy:No
Age Range:18 - Any
Updated:1/3/2019
Start Date:November 6, 2015
End Date:January 1, 2029

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Randomized Phase II Study of Cisplatin and Etoposide Versus Temozolomide and Capecitabine in Patients With Advanced G3 Non-small Cell Gastroenteropancreatic Neuroendocrine Carcinomas

This randomized phase II trial studies how well temozolomide and capecitabine work compared
to standard treatment with cisplatin or carboplatin and etoposide in treating patients with
neuroendocrine carcinoma of the gastrointestinal tract or pancreas that has spread to other
parts of the body (metastatic) or cannot be removed by surgery. Drugs used in chemotherapy,
such as temozolomide, capecitabine, cisplatin, carboplatin and etoposide, work in different
ways to stop the growth of tumor cells, either by killing the cells, by stopping them from
dividing, or by stopping them from spreading. Certain types of neuroendocrine carcinomas may
respond better to treatments other than the current standard treatment of cisplatin and
etoposide. It is not yet known whether temozolomide and capecitabine may work better than
cisplatin or carboplatin and etoposide in treating patients with this type of neuroendocrine
carcinoma, called non-small cell neuroendocrine carcinoma.

PRIMARY OBJECTIVES:

I. To assess the progression free survival (PFS) of platinum (cisplatin or carboplatin) and
etoposide versus the PFS of temozolomide and capecitabine in patients with advanced G3
non-small cell gastroenteropancreatic neuroendocrine carcinomas.

SECONDARY OBJECTIVES:

I. To assess the response rate (RR) of platinum (cisplatin or carboplatin) and etoposide
versus the RR of temozolomide and capecitabine in patients with advanced G3 non-small cell
gastroenteropancreatic neuroendocrine carcinomas.

II. To assess the overall survival (OS) of platinum (cisplatin or carboplatin) and etoposide
versus the OS of temozolomide and capecitabine in patients with advanced G3 non-small cell
gastroenteropancreatic neuroendocrine carcinomas.

III. To evaluate the toxicities associated with the combination of temozolomide and
capecitabine and the combination of platinum (cisplatin or carboplatin) and etoposide,
respectively, in patients with advanced G3 non-small cell gastroenteropancreatic
neuroendocrine carcinomas.

TERTIARY OBJECTIVES:

I. To assess the impact of each treatment regimen on PFS, RR and OS based on marker of
proliferation Ki-67 index in patients with advanced G3 non-small cell gastroenteropancreatic
neuroendocrine carcinomas. (Laboratory) II. To assess the prognostic significance of well
differentiated versus poorly differentiated non-small cell gastroenteropancreatic
neuroendocrine tumors in relationship to survival and response to treatment. (Laboratory)
III. To assess the agreement in Ki-67 status between that reported by institutional
pathologist and that reported by central pathology review. (Laboratory)

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM A: Patients receive capecitabine orally (PO) twice daily (BID) on days 1-14 and
temozolomide PO once daily (QD) on days 10-14. Courses repeat every 28 days in the absence of
disease progression or unacceptable toxicity.

ARM B: Patients receive cisplatin intravenously (IV) on days 1-3 or carboplatin IV on day 1.
Patients also receive etoposide IV on days 1-3. Courses repeat every 21 days in the absence
of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for 2 years and
then every 6 months for 3 years.

Inclusion Criteria:

- Patients must have a locally advanced and unresectable or metastatic
gastroenteropancreatic neuroendocrine carcinoma that is either known or suspected to
be of gastrointestinal (GI) origin; primary tumors arising from the lung, gynecologic
organs or prostate are not permitted

- Patients must have pathologically/histologically confirmed tumor of non-small cell
histology

- Patients must have a Ki-67 proliferative index of 20-100% OR at least 10 mitotic
figures per 10 high powered fields

- Patients must have measurable disease by Response Evaluation Criteria in Solid Tumors
(RECIST) 1.1 criteria; baseline measurements and evaluations of all sites of disease
must be obtained within 4 weeks prior to randomization and must be acquired by
multiphasic computed tomography (CT) or contrast magnetic resonance imaging (MRI)

- NOTE: positron emission tomography (PET)-CT scans are allowed provided the CT
portion of the exam is equivalent to a diagnostic CT scan and includes both oral
and IV contrast

- Patients may not have had any prior systemic treatment for this malignancy (for
example chemotherapy or somatostatin analogues); prior palliative radiation is
permitted but radiated lesions may not be used for measurement

- Patients may not have received any of the protocol agents within 5 years prior to
randomization

- Any prior surgeries must have been completed at least 4 weeks prior to randomization

- Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of
0-2

- Patients may not be receiving any other investigational agents while on study
treatment

- Patients may not be receiving Coumadin while on treatment; other anticoagulants are
allowed

- Leukocytes >= 3,000/mm^3

- Absolute neutrophil count >= 1,500/mm^3

- Hemoglobin >= 9 g/dL

- Platelets >= 100,000/mm^3

- Total bilirubin =< institutional upper limit of normal (ULN) or =< 1.5 X institutional
ULN (if the patient has liver metastases)

- Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase
[SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT])
=< 2.5 X institutional ULN or (=< 5 X institutional ULN if the patient has liver
metastases)

- Serum creatinine =< 1.5 X institutional ULN and creatinine clearance >= 60 ml/min

- NOTE: creatinine clearance must be calculated using the Cockcroft-Gault equation

- Patients must have a life expectancy of >= 12 weeks as determined clinically by the
treating physician

- Patients with brain metastases (either remote or current) or presence of carcinomatous
meningitis are not eligible

- Patients with known dihydropyrimidine dehydrogenase (DPD) deficiency will be excluded

- Patients must NOT have active or uncontrolled infection, symptomatic heart failure,
unstable angina pectoris, cardiac arrhythmia or a serious psychiatric illness/social
situation that would limit compliance with study requirements

- Patients with impaired decision making capacity may participate in the study if a
legal authorized representative is available to consent

- Patients must NOT have a history of allergic reactions attributed to compounds of
similar chemical or biochemical composition to cisplatin, carboplatin, etoposide,
temozolomide or capecitabine

- Patients must NOT have absorption issues that would limit the ability to absorb study
agents

- Patients with a history of the following within =< 12 months of study entry are not
eligible:

- Arterial thromboembolic events

- Unstable angina

- Myocardial Infarction

- Patients with symptomatic peripheral vascular disease are not eligible

- Patients must NOT have previous or concurrent malignancy; exceptions are made for
patients who meet any of the following conditions:

- Non-melanoma skin cancer, in situ cervical cancer, superficial bladder cancer, or
breast cancer in situ OR

- Prior malignancy completely excised or removed and patient has been continuously
disease free for > 5 years OR

- Prior malignancy cured by non-surgical modalities and patient has been
continuously disease free for > 5 years

- Women must not be pregnant or breast-feeding

- All females of childbearing potential must have a blood test or urine study
within 2 weeks prior to randomization to rule out pregnancy

- A female of childbearing potential is any woman, regardless of sexual orientation
or whether they have undergone tubal ligation, who meets the following criteria:
1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been
naturally postmenopausal for at least 24 consecutive months (i.e., has had menses
at any time in the preceding 24 consecutive months)

- Women of childbearing potential and sexually active males must be strongly advised to
use an accepted and effective method of contraception or to abstain from sexual
intercourse for the duration of their participation in the study

- Patients must be able to swallow pills

- Patients must be able to tolerate CT or magnetic resonance (MR) imaging including
contrast agents as required for the treatment and the protocol

- Patients who are known to have human immunodeficiency virus (HIV) or are on
combination antiretroviral therapy are ineligible
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Cody, WY
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Cody, Wyoming 82414
Principal Investigator: Benjamin T. Marchello
Phone: 406-969-6060
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Cody, WY
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Coeur d'Alene, Idaho 83814
Principal Investigator: Benjamin T. Marchello
Phone: 406-969-6060
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Coeur d'Alene, ID
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6001 E Woodmen Rd
Colorado Springs, Colorado 80923
(719) 776-5000
Principal Investigator: Mehmet S. Copur
Phone: 501-622-2100
Penrose-Saint Francis Healthcare Founded by the Sisters of St. Francis and the Sisters of Charity,...
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Colorado Springs, CO
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Colorado Springs, Colorado 80907
Principal Investigator: Mehmet S. Copur
Phone: 501-622-2100
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Colorado Springs, CO
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Columbus, Ohio 43210
Principal Investigator: Manisha H. Shah
Phone: 800-293-5066
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Columbus, OH
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Columbus, Ohio 43213
Principal Investigator: Timothy D. Moore
Phone: 614-488-2745
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Columbus, OH
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Columbus, Ohio 43222
Principal Investigator: Timothy D. Moore
Phone: 614-488-2745
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Columbus, OH
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5100 W Broad St
Columbus, Ohio 43228
(614) 544-1000
Principal Investigator: Timothy D. Moore
Phone: 614-488-2745
Doctors Hospital Nationally recognized for care quality and patient safety and satisfaction, Doctors Hospital is...
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Columbus, OH
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810 Jasonway Avenue
Columbus, Ohio 43214
614/442-3130
Principal Investigator: Timothy D. Moore
Phone: 614-488-2745
Columbus Oncology and Hematology Associates Inc Columbus Oncology and Hematology Associates is a group of...
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Columbus, OH
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3535 Olentangy River Rd
Columbus, Ohio 43214
(614) 566-5000
Principal Investigator: Timothy D. Moore
Phone: 614-488-2745
Riverside Methodist Hospital Serving central Ohio since 1892, Riverside Methodist Hospital is consistently ranked one...
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Columbus, OH
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111 S Grant Ave
Columbus, Ohio 43215
(614) 566-9000
Principal Investigator: Timothy D. Moore
Phone: 614-488-2745
Grant Medical Center Founded in 1900 in Columbus' downtown, Grant has grown into one of...
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mi
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Columbus, OH
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3100 Plaza Properties Blvd
Columbus, Ohio 43219
(614) 383-6000
Principal Investigator: Timothy D. Moore
Phone: 614-488-2745
The Mark H. Zangmeister Center At The Zangmeister Center, we appreciate that our patients have...
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Columbus, OH
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4050 Coon Rapids Blvd NW
Coon Rapids, Minnesota 55433
(763) 236-6000
Principal Investigator: David M. King
Phone: 952-993-1517
Mercy Hospital Mercy Hospital, located in Coon Rapids, Minnesota, is a 271-bed non-profit hospital that...
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Coon Rapids, MN
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Corbin, Kentucky 40701
Principal Investigator: Mehmet S. Copur
Phone: 501-622-2100
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Corbin, KY
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Council Bluffs, Iowa 51503
Principal Investigator: Mehmet S. Copur
Phone: 501-622-2100
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Council Bluffs, IA
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