S1314, Co-expression Extrapolation (COXEN) Program to Predict Chemotherapy Response in Patients With Bladder Cancer



Status:Recruiting
Conditions:Cancer, Cancer, Bladder Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:7/18/2018
Start Date:July 2014
End Date:October 2022
Contact:Nicki Trevino
Email:ntrevino@swog.org
Phone:210-614-8808

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A Randomized Phase II Study of Co-Expression Extrapolation (COXEN) With Neoadjuvant Chemotherapy for Localized, Muscle-Invasive Bladder Cancer

The primary focus of this study is to see if looking at tumor biomarkers using a program
called coexpression extrapolation or "COXEN" may predict a patient's response to chemotherapy
before surgery.

The COXEN program will not select a patient's therapy, but the type of chemotherapy that
he/she will receive will be randomly decided. The patient's response to chemotherapy will be
used to test the usefulness of the COXEN program, which is the main goal of this trial. Other
potential tests to predict a patient's response to chemotherapy will also be evaluated. In
this study, the patient may receive the treatment in Arm 1 (gemcitabine and cisplatin) or the
treatment in Arm 2 [methotrexate, vinblastine, doxorubicin, cisplatin, and filgrastim (or
pegfilgrastim)]. There will be about 184 people taking part in this study (92 in each arm).

Inclusion Criteria:

- Histologically proven bladder cancer (pure small cell carcinoma, pure adenocarcinoma,
and pure squamous cell carcinoma histologies are excluded).

- Stage cT2-T4a N0 M0 disease.

- Documented muscle invasive disease with at least one of the following: disease
measuring at least 10 mm on cross-sectional imaging OR the presence of
tumor-associated hydronephrosis.

- Staging scans with abdominal/pelvic CT or MRI scan and CT scan or x-ray of the chest
within 56 days prior to registration. If alkaline phosphatase is above the treating
institution's upper limit of normal (ULN), presence of suspicious bone pain, or if
other clinical suspicion, a whole body bone scan is required within 56 days prior to
registration.

- Performance status = 0 or 1

- 18 years of age or older

- Must have tumor tissue from transurethral resection of the bladder tumor (TURBT)
available for submission that is sufficient for COXEN testing and must agree to
submission of 20 (10 micron) slides plus 2 (5 micron) slides from the start and end of
the 20 slides for a total of 22 unstained slides.

- Must agree to collection of tissue (if residual disease is present), urine, and whole
blood.

- Must agree to participate in the translational medicine studies outlined in the
protocol

Exclusion Criteria:

- Prior systemic cytotoxic chemotherapy or systemic anthracycline

- Peripheral neuropathy >/= Grade 2

- Class III/IV heart failure or known left ventricular ejection fraction (LVEF) < 50%

- Clinically relevant hearing impairment > Grade 2

- Renal function, calculated creatinine clearance < 60 mL/min

- Hepatic function, total bilirubin > 1.5 x institutional upper limit of normal (IULN)
(or > 2.5 x IULN with Gilbert's disease); AST & ALT > 2 X IULN

- Hematologic function, absolute neutrophil count (ANC) < 1,500/mcL, hemoglobin < 9
g/dL, and platelets < 100,000/mcL

- Hypersensitivity to cisplatin, gemcitabine, doxorubicin, vinblastine, methotrexate, or
filgrastim/pegfilgrastim

- Incidence of or uncontrolled medical illness (e.g. active cardiac symptoms, active
systemic infection, etc.)

- Pregnant or nursing females

- No other prior malignancy is allowed except for the following: adequately treated
basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated
Stage I or II cancer from which the patient is currently in complete remission, or any
other cancer from which the patient has been disease free for five years. However,
patients with localized prostate cancer who are being followed by an active
surveillance program are eligible.
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Clinton, North Carolina 28328
Principal Investigator: James N. Atkins
Phone: 919-580-0000
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Clinton, NC
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Clinton Township, Michigan 48038
Principal Investigator: Robert A. Chapman
Phone: 313-916-1784
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Clinton Township, MI
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Cody, Wyoming 82414
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Cody, WY
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