Whole-Brain Radiation Therapy or Stereotactic Radiosurgery With or Without Lapatinib Ditosylate in Treating Patients With Brain Metastasis From HER2-Positive Breast Cancer



Status:Recruiting
Conditions:Breast Cancer, Cancer, Cancer, Cancer, Cancer, Brain Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:4/6/2019
Start Date:July 26, 2012

Use our guide to learn which trials are right for you!

Phase II Randomized Study of Whole Brain Radiotherapy/Stereotactic Radiosurgery in Combination With Concurrent Lapatinib in Patients With Brain Metastasis From HER2-Positive Breast Cancer: A Collaborative Study of NRG Oncology and KROG

This randomized phase II trial studies how well whole-brain radiation therapy or stereotactic
radiosurgery with or without lapatinib ditosylate works in treating patients with breast
cancer that has too many of a protein called human epidermal growth factor receptor 2 (HER2)
on its cells and has spread to the brain. Radiation therapy uses high energy x rays to kill
tumor cells and shrink tumors. Stereotactic radiosurgery is a specialized radiation therapy
that delivers a single, high dose of radiation directly to the tumor and may kill more tumor
cells and cause less damage to normal tissue. Lapatinib ditosylate may stop the growth of
tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known
whether whole-brain radiation therapy or stereotactic radiosurgery together with lapatinib
ditosylate is an effective treatment for brain metastasis from breast cancer.

PRIMARY OBJECTIVES:

I. To determine if there is a signal for an increase in complete response (CR) rate in the
measurable brain metastases at 12 weeks post radiation therapy (RT) (whole brain or
stereotactic radiosurgery [SRS]) as determined by magnetic-resonance imaging (MRI) scan of
the brain, with the addition of lapatinib (lapatinib ditosylate) to whole-brain radiation
therapy (WBRT)/SRS compared to WBRT/SRS alone.

SECONDARY OBJECTIVES:

I. To evaluate CR rate of the measurable brain metastases at 4 weeks post RT (WBRT/SRS) as
determined by MRI scan of the brain, with the addition of lapatinib to WBRT/SRS compared to
WBRT/SRS alone.

II. To evaluate objective response rate of measurable brain metastases at 4 and 12 weeks post
RT (WBRT/SRS) as determined by MRI scan of the brain, with the addition of lapatinib to
WBRT/SRS compared to WBRT/SRS alone.

III. To evaluate targeted lesion-specific objective response rate (CR + partial response
[PR]) at 4 and 12 weeks post WBRT/SRS.

IV. To evaluate central nervous system (CNS) progressive disease outside the targeted
measurable disease with addition of lapatinib to WBRT/SRS compared to WBRT/SRS alone.

V. To evaluate targeted lesion-specific progression at 4 and 12 weeks post WBRT/SRS.

VI. To evaluate treatment related adverse events when adding lapatinib to WBRT/SRS compared
to WBRT/SRS alone.

VII. To evaluate overall CNS complete response: disappearance of all CNS target lesions
sustained for at least 4 weeks; with no new lesions, no use of corticosteroids, and patient
is stable or improved clinically, when adding lapatinib to WBRT/SRS compared to WBRT/SRS
alone.

VIII. To evaluate overall CNS progressive disease (within or outside targeted measurable
disease) with addition of lapatinib to WBRT/SRS compared to WBRT/SRS alone.

IX. To evaluate overall survival when adding lapatinib to WBRT/SRS compared to WBRT/SRS
alone.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM A: Patients undergo WBRT 5 days a week for 3 weeks for a total of 15 treatments or SRS
for 1 treatment.

ARM B: Patients undergo WBRT or SRS as in Arm A. Patients also receive lapatinib ditosylate
orally (PO) once daily (QD) for 6 weeks.

After completion of study treatment, patients are followed up at 4 and 12 weeks and then
every 12 weeks thereafter.

Inclusion Criteria:

- Pathologically (histologically or cytologically) proven diagnosis of invasive breast
cancer

- HER2-overexpressing breast cancer (3+ staining by immunohistochemistry or HER2 gene
amplification by fluorescent in situ hybridization [FISH] or silver in situ
hybridization [SISH] >= 2.0)

- At least 1 measurable unirradiated parenchymal brain metastasis within 21 days prior
to study entry; patients who are to undergo SRS must have no more than 10 brain
metastases; there is no limit on number of brain metastases for WBRT; the minimum size
as measured on T1-weighted gadolinium-enhanced MRI must be as follows according to the
number of brain metastases:

- For a single solitary lesion the size must be >= 10 mm

- For 2 or more lesions, the size of at least 2 of the lesions must be >= 5 mm

- Patients may also have the following provided the size requirements above are
met:

- Progressive parenchymal brain metastasis following stereotactic radiosurgery
for 1-3 brain metastases, with at least 1 new measurable brain lesion

- Progressive parenchymal brain metastasis following surgical resection of 1-3
brain metastases, with at least 1 measurable brain lesion

- History/physical examination within 21 days prior to study entry

- Karnofsky performance status >= 60 within 21 days prior to study entry

- Able to swallow and retain oral medication (note: for patients unable to swallow
tablets, an oral suspension preparation is acceptable)

- Absolute neutrophil count (ANC) >= 1,200 cells/mm^3, within 21 days prior to study
entry

- Platelets >= 70,000 cells/mm^3, within 21 days prior to study entry

- Hemoglobin >= 8.0 g/dL (note: the use of transfusion or other intervention to achieve
hemoglobin [Hgb] >= 8.0 g/dL is acceptable), within 21 days prior to study entry

- Creatinine < 1.5 times institutional upper limit of normal, within 21 days prior to
study entry

- Bilirubin < 1.5 times institutional upper limit of normal, within 21 days prior to
study entry

- Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3.0 times
institutional upper limit of normal with or without liver metastasis, within 21 days
prior to study entry

- Patient must provide study specific informed consent prior to study entry

- Women of childbearing potential must have a negative serum pregnancy test within 21
days prior to study entry

- Sexually active women of childbearing potential and sexually active men must practice
adequate contraception during therapy and for 12 months after protocol treatment
completion

- Prior lapatinib is allowed as long as the last dose received was > 21 days prior to
study entry and provided the patient has not received it at any time after the
diagnosis of brain metastasis

Exclusion Criteria:

- Prior WBRT

- Prior radiation therapy (RT) (any site) with concurrent lapatinib defined as 1 or more
days on which the patient received both radiation therapy and lapatinib on the same
day

- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, or psychiatric illness/social situations that would limit compliance with
study requirements

- Prior invasive malignancy (except non-melanomatous skin cancer, curatively resected
thyroid papillary carcinoma, and invasive and non-invasive cancers related to the
breast cancer) unless disease free for a minimum of 3 years

- Leptomeningeal disease

- Prior radiotherapy to the region of the study cancer that would result in overlap of
radiation therapy fields except patients who have progressed following stereotactic
radiosurgery for 1-3 brain metastases, with at least one new lesion

- Severe, active co-morbidity, defined as follows:

- Unstable angina and/or congestive heart failure requiring hospitalization within
the last 6 months

- Transmural myocardial infarction within the last 6 months

- Acute bacterial or fungal infection requiring intravenous antibiotics at the time
of study entry

- Chronic obstructive pulmonary disease exacerbation or other respiratory illness
requiring hospitalization or precluding study therapy at the time of study entry

- Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects;
hepatic or biliary disease that is acute or currently active or that requires
antiviral therapy (with the exception of patients with Gilbert's syndrome,
asymptomatic gallstones, liver metastases, or stable chronic liver disease per
investigator assessment)

- History of left ventricular ejection fraction (LVEF) below institutional normal
unless repeated and within institutional normal range within 90 days of study
entry

- Grade 2 or greater rash of any cause at time of study entry

- Grade 2 or greater diarrhea of any cause at time of study entry
We found this trial at
290
sites
100 Michigan St NE
Grand Rapids, Michigan 49503
(616) 391-1774
Principal Investigator: Kathleen J. Yost
Phone: 616-391-1230
Spectrum Health at Butterworth Campus Butterworth Hospital is one of four facilities that make up...
?
mi
from
Grand Rapids, MI
Click here to add this to my saved trials
1201 Camino de Salud Northeast
Albuquerque, New Mexico 87131
(505) 272-4946
Principal Investigator: Benny J. Liem
Phone: 505-925-0366
University of New Mexico Cancer Center It’s been 40 years since the New Mexico State...
?
mi
from
Albuquerque, NM
Click here to add this to my saved trials
2545 Schoenersville Rd
Bethlehem, Pennsylvania 18017
(484) 884-2200
Principal Investigator: Samir Narayan
Phone: 734-712-3671
Lehigh Valley Hospital - Muhlenberg At Lehigh Valley Health Network, we continually go the extra...
?
mi
from
Bethlehem, PA
Click here to add this to my saved trials
666 Elm Street
Buffalo, New York 14263
(716) 845-2300
Principal Investigator: Dheerendra Prasad
Phone: 877-275-7724
Roswell Park Cancer Institute Welcome to Roswell Park Cancer Institute (RPCI), America's first cancer center...
?
mi
from
Buffalo, NY
Click here to add this to my saved trials
1 South Prospect Street
Burlington, Vermont 05401
802-656-8990
Principal Investigator: Deborah Z. Rubin
Phone: 802-656-4101
?
mi
from
Burlington, VT
Click here to add this to my saved trials
1 Hurley Plaza
Flint, Michigan 48503
(810) 262-9000
Principal Investigator: Samir Narayan
Phone: 734-712-3671
Hurley Medical Center From its founding in 1908, Hurley Medical Center has devoted itself to...
?
mi
from
Flint, MI
Click here to add this to my saved trials
2500 N State St
Jackson, Mississippi 39216
(601) 984-1000
Principal Investigator: Srinivasan Vijayakumar
Phone: 601-815-6700
University of Mississippi Medical Center The University of Mississippi Medical Center, located in Jackson, is...
?
mi
from
Jackson, MS
Click here to add this to my saved trials
524 South Park Street
Kalamazoo, Michigan 49007
(269) 341-7654
Principal Investigator: Gilbert D. Padula
Phone: 616-685-5225
Bronson Methodist Hospital Our healthcare system serves patients and families throughout southwest Michigan and northern...
?
mi
from
Kalamazoo, MI
Click here to add this to my saved trials
200 North Park Street
Kalamazoo, Michigan 49007
(269) 382-2500
Principal Investigator: Kathleen J. Yost
Phone: 616-391-1230
West Michigan Cancer Center In 1994, Borgess Health Alliance and Bronson Healthcare Group opened the...
?
mi
from
Kalamazoo, MI
Click here to add this to my saved trials
401 College Street
Richmond, Virginia 23298
(804) 828-0450
Principal Investigator: Timothy J. Harris
Virginia Commonwealth University Massey Cancer Center Founded in 1974, VCU Massey Cancer Center is a...
?
mi
from
Richmond, VA
Click here to add this to my saved trials
60 Crittenden Blvd # 70
Rochester, New York 14642
(585) 275-2121
Principal Investigator: Yuhchyau Chen
Phone: 585-275-5830
University of Rochester The University of Rochester is one of the country's top-tier research universities....
?
mi
from
Rochester, NY
Click here to add this to my saved trials
4502 Medical Drive
San Antonio, Texas 78284
(210) 567-7000
University of Texas Health Science Center at San Antonio The University of Texas Health Science...
?
mi
from
San Antonio, TX
Click here to add this to my saved trials
1200 Old York Road
Abington, Pennsylvania 19001
(215) 481–2000
Principal Investigator: Wayne H. Pinover
Phone: 215-481-2402
Abington Memorial Hospital Abington Memorial Hospital (AMH) is a 665-bed, regional referral center and teaching...
?
mi
from
Abington, PA
Click here to add this to my saved trials
Adrian, Michigan 49221
?
mi
from
Adrian, MI
Click here to add this to my saved trials
818 Riverside Ave.
Adrian, Michigan 49221
(517) 265-0900
Bixby Medical Center ProMedica's Mission is to improve your health and well-being. Which is why,...
?
mi
from
Adrian, MI
Click here to add this to my saved trials
?
mi
from
Akron, OH
Click here to add this to my saved trials
1 Akron General Avenue
Akron, Ohio 44307
?
mi
from
Akron, OH
Click here to add this to my saved trials
Allentown, Pennsylvania 18103
Principal Investigator: Samir Narayan
Phone: 734-712-3671
?
mi
from
Allentown, PA
Click here to add this to my saved trials
Alliance, Ohio 44601
?
mi
from
Alliance, OH
Click here to add this to my saved trials
2000 E Greenville St
Anderson, South Carolina 29621
(864) 512-4640
AnMedical Health Cancer Center Cancer is the general term for a group of more than...
?
mi
from
Anderson, SC
Click here to add this to my saved trials
5301 McAuley Drive
Ann Arbor, Michigan 48197
734-712-3456
Principal Investigator: Samir Narayan
Phone: 734-712-3671
Saint Joseph Mercy Hospital St. Joseph Mercy Ann Arbor Hospital is a 537-bed teaching hospital...
?
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
1500 East Medical Center Drive
Ann Arbor, Michigan 48109
800-865-1125
Principal Investigator: James A. Hayman
University of Michigan Comprehensive Cancer Center The U-M Comprehensive Cancer Center's mission is the conquest...
?
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
1968 Peachtree Rd NW
Atlanta, Georgia 30309
(404) 605-5000
Principal Investigator: Adam W. Nowlan
Phone: 404-425-7943
Piedmont Hospital For more than a century, Piedmont Healthcare has been a recognized leader in...
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
1000 Johnson Ferry Rd NE
Atlanta, Georgia 30342
(404) 851-8000
Principal Investigator: Nancy H. Wiggers
Phone: 404-303-3355
Northside Hospital Northside Hospital-Atlanta (in Sandy Springs) opened in 1970. The original facility had 250...
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
Auburn, California 95602
Principal Investigator: Christopher U. Jones
Phone: 415-209-2686
?
mi
from
Auburn, CA
Click here to add this to my saved trials
Auburn, California 95603
Principal Investigator: Christopher U. Jones
Phone: 415-209-2686
?
mi
from
Auburn, CA
Click here to add this to my saved trials
2000 Ogden Ave
Aurora, Illinois 60504
(630) 978-6200
Principal Investigator: Kalika P. Sarma
Phone: 630-978-6212
Rush - Copley Medical Center Rush-Copley is proud to be the leading provider of health...
?
mi
from
Aurora, IL
Click here to add this to my saved trials
6701 N Charles St
Baltimore, Maryland 21204
(443) 849-2000
Principal Investigator: Geoffrey A. Neuner
Phone: 443-849-3706
Greater Baltimore Medical Center The 255-bed medical center (acute and sub-acute care) is located on...
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
155 5th St NE
Barberton, Ohio 44203
(330) 615-3000
Summa Barberton Hospital Summa Barberton Hospital is a full member of Summa Health System and...
?
mi
from
Barberton, OH
Click here to add this to my saved trials
265 Fremont St
Battle Creek, Michigan 49017
(269) 245-8166
Principal Investigator: Kathleen J. Yost
Phone: 616-391-1230
Bronson Battle Creek As a proud member of the Battle Creek community, we believe everyone...
?
mi
from
Battle Creek, MI
Click here to add this to my saved trials
Beachwood, Ohio 44122
Principal Investigator: Samuel T. Chao
Phone: 866-223-8100
?
mi
from
Beachwood, OH
Click here to add this to my saved trials
Beachwood, Ohio 44122
Principal Investigator: Mitchell Machtay
Phone: 800-641-2422
?
mi
from
Beachwood, OH
Click here to add this to my saved trials
?
mi
from
Berkeley, CA
Click here to add this to my saved trials
?
mi
from
Berlin, VT
Click here to add this to my saved trials
Big Rapids, Michigan 49307
?
mi
from
Big Rapids, MI
Click here to add this to my saved trials
Birmingham, Alabama 35233
Principal Investigator: Jennifer F. De Los Santos
Phone: 800-828-8816
?
mi
from
Birmingham, AL
Click here to add this to my saved trials
Birmingham, Alabama 35243
Principal Investigator: Jennifer F. De Los Santos
Phone: 800-828-8816
?
mi
from
Birmingham, AL
Click here to add this to my saved trials
Boise, Idaho 83706
Principal Investigator: Samir Narayan
Phone: 734-712-3671
?
mi
from
Boise, ID
Click here to add this to my saved trials
Bolivar, Missouri 65613
Principal Investigator: Rakesh Gaur
Phone: 800-328-6010
?
mi
from
Bolivar, MO
Click here to add this to my saved trials
Boston, Massachusetts 02118
Principal Investigator: Minh T. Truong
Phone: 617-638-8265
?
mi
from
Boston, MA
Click here to add this to my saved trials
960 W Wooster St
Bowling Green, Ohio 43402
419-353-5419
Toledo Clinic Cancer Centers-Bowling Green Our doctors evaluate and make recommendations regarding cancer treatment for...
?
mi
from
Bowling Green, OH
Click here to add this to my saved trials
?
mi
from
Bronx, NY
Click here to add this to my saved trials
263 7th Avenue
Brooklyn, New York 11215
Principal Investigator: Hani L. Ashamalla
Phone: 718-780-3677
?
mi
from
Brooklyn, NY
Click here to add this to my saved trials
Brownstown, Michigan 48183
Principal Investigator: Eleanor M. Walker
Phone: 313-916-3721
?
mi
from
Brownstown, MI
Click here to add this to my saved trials
1501 Trousdale Drive
Burlingame, California 94010
?
mi
from
Burlingame, CA
Click here to add this to my saved trials
Burlington, Vermont 05405
Principal Investigator: Deborah Z. Rubin
Phone: 802-656-4101
?
mi
from
Burlington, VT
Click here to add this to my saved trials
201 E Nicollet Blvd
Burnsville, Minnesota 55337
(952) 892-2000
Principal Investigator: Paul W. Sperduto
Phone: 952-993-1517
Fairview Ridges Hospital Fairview Ridges Hospital is a 150-bed, Level III Trauma Care facility, offering...
?
mi
from
Burnsville, MN
Click here to add this to my saved trials
3123 Medical Dr
Caldwell, Idaho 83605
Principal Investigator: Samir Narayan
Phone: 734-712-3671
?
mi
from
Caldwell, ID
Click here to add this to my saved trials
Cameron Park, California 95682
Principal Investigator: Christopher U. Jones
Phone: 415-209-2686
?
mi
from
Cameron Park, CA
Click here to add this to my saved trials
Canton, Ohio 44708
Principal Investigator: Edward J. Walsh
Phone: 888-293-4673
?
mi
from
Canton, OH
Click here to add this to my saved trials
211 Saint Francis Drive
Cape Girardeau, Missouri 63703
573-331-3000
Saint Francis Medical Center Saint Francis Medical Center is a 282-bed facility serving more than...
?
mi
from
Cape Girardeau, MO
Click here to add this to my saved trials
Carmichael, California 95608
?
mi
from
Carmichael, CA
Click here to add this to my saved trials
Cedar Rapids, Iowa 52402
Principal Investigator: Nagendra (Bobby) S. Koneru
Phone: 412-339-5294
?
mi
from
Cedar Rapids, IA
Click here to add this to my saved trials
Centerville, Ohio 45459
Principal Investigator: Howard M. Gross
Phone: 937-775-1350
?
mi
from
Centerville, OH
Click here to add this to my saved trials
Centerville, Ohio 45459
Principal Investigator: Howard M. Gross
Phone: 937-775-1350
?
mi
from
Centerville, OH
Click here to add this to my saved trials
Chapel Hill, North Carolina 27599
Principal Investigator: Colette Shen
Phone: 877-668-0683
?
mi
from
Chapel Hill, NC
Click here to add this to my saved trials
Chardon, Ohio 44024
Principal Investigator: Mitchell Machtay
Phone: 800-641-2422
?
mi
from
Chardon, OH
Click here to add this to my saved trials
171 Ashley Avenue
Charleston, South Carolina 29425
843-792-1414
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
?
mi
from
Charleston, SC
Click here to add this to my saved trials
1969 W Ogden Ave
Chicago, Illinois 60612
(312) 864-6000
Principal Investigator: Thomas E. Lad
Phone: 312-864-6000
John H. Stroger, Jr. Hospital of Cook County The Level 1 Trauma Center is one...
?
mi
from
Chicago, IL
Click here to add this to my saved trials
Chicago, Illinois 60657
Principal Investigator: Nicholas S. Galanopoulos
Phone: 773-665-3109
?
mi
from
Chicago, IL
Click here to add this to my saved trials
Cincinnati, Ohio 45236
Principal Investigator: Howard M. Gross
Phone: 937-775-1350
?
mi
from
Cincinnati, OH
Click here to add this to my saved trials
10900 Euclid Ave
Cleveland, Ohio 44106
216-368-2000
Principal Investigator: Mitchell Machtay
Phone: 800-641-2422
Case Western Reserve Univ Continually ranked among America's best colleges, Case Western Reserve University has...
?
mi
from
Cleveland, OH
Click here to add this to my saved trials
18101 Lorain Avenue
Cleveland, Ohio 44111
216.476.7000
Principal Investigator: Samuel T. Chao
Phone: 866-223-8100
Cleveland Clinic Cancer Center at Fairview Hospital Fairview Hospital is a 488-bed hospital located at...
?
mi
from
Cleveland, OH
Click here to add this to my saved trials
2049 E 100th St
Cleveland, Ohio 44106
(216) 444-2200
Principal Investigator: Samuel T. Chao
Phone: 866-223-8100
Cleveland Clinic Foundation The Cleveland Clinic (formally known as The Cleveland Clinic Foundation) is a...
?
mi
from
Cleveland, OH
Click here to add this to my saved trials
Clinton Township, Michigan 48038
?
mi
from
Clinton Township, MI
Click here to add this to my saved trials
Columbus, Ohio 43210
Principal Investigator: Joshua D. Palmer
Phone: 800-293-5066
?
mi
from
Columbus, OH
Click here to add this to my saved trials
4050 Coon Rapids Blvd NW
Coon Rapids, Minnesota 55433
(763) 236-6000
Principal Investigator: Paul W. Sperduto
Phone: 952-993-1517
Mercy Hospital Mercy Hospital, located in Coon Rapids, Minnesota, is a 271-bed non-profit hospital that...
?
mi
from
Coon Rapids, MN
Click here to add this to my saved trials
10 Barnes West Drive
Creve Coeur, Missouri 63141
?
mi
from
Creve Coeur, MO
Click here to add this to my saved trials
Cumming, Georgia 30041
Principal Investigator: Nancy H. Wiggers
Phone: 404-303-3355
?
mi
from
Cumming, GA
Click here to add this to my saved trials
Danville, Illinois 61832
Principal Investigator: Kalika P. Sarma
Phone: 412-339-5294
?
mi
from
Danville, IL
Click here to add this to my saved trials
Davis, California 95616
Principal Investigator: Christopher U. Jones
Phone: 415-209-2686
?
mi
from
Davis, CA
Click here to add this to my saved trials
1 Wyoming St,
Dayton, Ohio 45409
(937) 208-8000
Principal Investigator: Howard M. Gross
Phone: 937-775-1350
Miami Valley Hospital Miami Valley Hospital (MVH) is passionate about providing the most recent medical...
?
mi
from
Dayton, OH
Click here to add this to my saved trials
2222 Philadelphia Dr
Dayton, Ohio 45406
(937) 734-2612
Principal Investigator: Howard M. Gross
Phone: 937-775-1350
Good Samaritan Hospital - Dayton Good Samaritan Hospital (GSH) is passionate about providing the most...
?
mi
from
Dayton, OH
Click here to add this to my saved trials
Dayton, Ohio 45415
?
mi
from
Dayton, OH
Click here to add this to my saved trials
?
mi
from
Dayton, OH
Click here to add this to my saved trials
Dearborn, Michigan 48124
?
mi
from
Dearborn, MI
Click here to add this to my saved trials
Deerfield Beach, Florida 33442
Principal Investigator: Cristiane Takita
Phone: 305-243-2647
?
mi
from
Deerfield Beach, FL
Click here to add this to my saved trials
2799 W Grand Blvd
Detroit, Michigan 48202
(313) 916-2600
Principal Investigator: Eleanor M. Walker
Phone: 313-916-3721
Henry Ford Hospital Founded in 1915 by auto pioneer Henry Ford and now one of...
?
mi
from
Detroit, MI
Click here to add this to my saved trials
Detroit, Michigan 48236
Principal Investigator: Samir Narayan
Phone: 734-712-3671
?
mi
from
Detroit, MI
Click here to add this to my saved trials
Dublin, California 94568
Principal Investigator: James H. Feusner
Phone: 925-875-1677
?
mi
from
Dublin, CA
Click here to add this to my saved trials
East Stroudsburg, Pennsylvania 18301
Principal Investigator: Samir Narayan
Phone: 570-422-1700
?
mi
from
East Stroudsburg, PA
Click here to add this to my saved trials
?
mi
from
East Syracuse, NY
Click here to add this to my saved trials
6401 France Ave S
Edina, Minnesota 55435
(952) 924-5000
Principal Investigator: Paul W. Sperduto
Phone: 952-993-1517
Fairview Southdale Hospital Fairview Health Services is an award-winning nonprofit health care system based in...
?
mi
from
Edina, MN
Click here to add this to my saved trials
Effingham, Illinois 62401
Principal Investigator: Kalika P. Sarma
Phone: 217-383-3233
?
mi
from
Effingham, IL
Click here to add this to my saved trials
303 S Nappanee St
Elkhart, Indiana 46514
(574) 296-3200
Elkhart Clinic, LLC Informed participation in the management of your health care maximizes your Elkhart...
?
mi
from
Elkhart, IN
Click here to add this to my saved trials
500 Arcade Blvd, Ste 240
Elkhart, Indiana 46514
574-389-0414
Michiana Hematology-Oncology The Advanced Center for Cancer Care in Plymouth is part of the Cancer...
?
mi
from
Elkhart, IN
Click here to add this to my saved trials
600 East Blvd
Elkhart, Indiana 46515
(574) 294-2621
Elkhart General Hospital For over 100 years, the highly skilled professionals of Elkhart General Hospital...
?
mi
from
Elkhart, IN
Click here to add this to my saved trials
Elyria, Ohio 44035
Principal Investigator: Mitchell Machtay
Phone: 800-641-2422
?
mi
from
Elyria, OH
Click here to add this to my saved trials
Emeryville, California 94608
Principal Investigator: James H. Feusner
Phone: 510-835-9900
?
mi
from
Emeryville, CA
Click here to add this to my saved trials
Emeryville, California 94608
Principal Investigator: James H. Feusner
Phone: 510-629-6682
?
mi
from
Emeryville, CA
Click here to add this to my saved trials
3401 Ludington St
Escanaba, Michigan 49829
(800) 432-6049
Principal Investigator: Eva N. Christensen
Phone: 920-433-8889
Green Bay Oncology - Escanaba We are one of a select few physician groups in...
?
mi
from
Escanaba, MI
Click here to add this to my saved trials
1255 Hwy 54 W,
Fayetteville, Georgia 30214
(770) 719-7000
Piedmont Fayette Hospital Piedmont Fayette Hospital, a 172-bed community hospital, is among the most highly-ranked...
?
mi
from
Fayetteville, GA
Click here to add this to my saved trials
Findlay, Ohio 45840
Principal Investigator: Howard M. Gross
Phone: 937-775-1350
?
mi
from
Findlay, OH
Click here to add this to my saved trials
Findlay, Ohio 45840
Principal Investigator: Howard M. Gross
Phone: 937-775-1350
?
mi
from
Findlay, OH
Click here to add this to my saved trials
1900 S Main St
Findlay, Ohio 45840
(419) 423-4500
Principal Investigator: Howard M. Gross
Phone: 937-775-1350
Blanchard Valley Hospital For more than 100 years, Blanchard Valley Hospital has made quality care...
?
mi
from
Findlay, OH
Click here to add this to my saved trials
302 Kensington Ave
Flint, Michigan 48503
(810) 762-8490
Principal Investigator: Samir Narayan
Phone: 734-712-3671
Genesys Hurley Cancer Institute Bringing the most advanced cancer treatment services, technologies and programs available...
?
mi
from
Flint, MI
Click here to add this to my saved trials
Fort Wayne, Indiana 46804
Principal Investigator: Brian K. Chang
Phone: 260-373-8888
?
mi
from
Fort Wayne, IN
Click here to add this to my saved trials
2200 Randallia Drive
Fort Wayne, Indiana 46805
Principal Investigator: Brian K. Chang
Phone: 260-373-8888
?
mi
from
Fort Wayne, IN
Click here to add this to my saved trials
Fort Wayne, Indiana 46845
?
mi
from
Fort Wayne, IN
Click here to add this to my saved trials
Franklin, Ohio 45005
Principal Investigator: Howard M. Gross
Phone: 937-775-1350
?
mi
from
Franklin, OH
Click here to add this to my saved trials
One Medical Center Drive
Franklin, Ohio 45005
(513) 424-2111
Principal Investigator: Howard M. Gross
Phone: 937-775-1350
Atrium Medical Center - Middletown Regional Hospital Atrium Medical Center (Atrium) is built on the...
?
mi
from
Franklin, OH
Click here to add this to my saved trials