Exemestane With or Without Entinostat in Treating Patients With Recurrent Hormone Receptor-Positive Breast Cancer That is Locally Advanced or Metastatic



Status:Active, not recruiting
Conditions:Breast Cancer, Cancer, Cancer, Cancer, Cancer, Cancer, Cancer, Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:2/17/2019
Start Date:March 29, 2014

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A Randomized Phase III Trial of Endocrine Therapy Plus Entinostat/Placebo in Patients With Hormone Receptor-Positive Advanced Breast Cancer

This randomized phase III trial studies exemestane and entinostat to see how well they work
compared to exemestane alone in treating patients with hormone receptor-positive breast
cancer that has spread to nearby tissue or lymph nodes or another place in the body. Estrogen
can cause the growth of breast cancer cells. Endocrine therapy using exemestane may fight
breast cancer by lowering the amount of estrogen the body makes. Entinostat may stop the
growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet
known whether exemestane is more effective with or without entinostat in treating breast
cancer.

PRIMARY OBJECTIVES:

I. To evaluate whether the addition of entinostat to endocrine therapy (exemestane) improves
progression-free survival (PFS) and/or overall survival (OS) in patients with hormone
receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative locally
advanced or metastatic breast cancer who have previously progressed on a non-steroidal
aromatase inhibitor (Al).

SECONDARY OBJECTIVES:

I. To evaluate the safety and tolerability of entinostat in combination with exemestane, and
to compare the safety profile to that of endocrine therapy with placebo.

II. To evaluate the objective response rate of exemestane in combination with entinostat or
placebo.

III. To evaluate whether the efficacy of exemestane with entinostat varies with changes in
acetylation status in peripheral blood mononuclear cells (PBMCs).

IV. To evaluate the time to treatment deterioration (as defined by decrease in health-related
quality of life [HRQL], progression, death) of exemestane + entinostat versus exemestane +
placebo arms.

V. To evaluate the differences in overall health-related quality of life (HRQL) between the
exemestane + entinostat versus exemestane + placebo arms.

VI. To evaluate the difference with respect to specific symptoms that are associated with
entinostat, i.e., fatigue, nausea, anorexia and diarrhea, between the exemestane + entinostat
versus exemestane + placebo arms.

VII. To measure adherence to protocol therapy. VIII. To evaluate the pharmacokinetics of
entinostat in patients with advanced breast cancer.

IX. To evaluate what, if any, patient variables alter the pharmacokinetic profile of
entinostat in patients with advanced breast cancer.

EXPLORATORY OBJECTIVES:

I. To collect archival tumor samples and germline deoxyribonucleic acid (DNA) to explore
other potential biomarkers of therapeutic efficacy.

II. To collect patient ratings of adverse events (AEs) using select patient-reported outcomes
(PRO)-Common Terminology Criteria for Adverse Events (CTCAE) items to evaluate the
psychometric properties of PRO-CTCAE items and explore the incorporation of PRO-CTCAE items
into a phase III double-blind placebo-controlled trial.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM A: Patients receive exemestane orally (PO) once daily (QD) on days 1-28 and entinostat PO
on days 1, 8, 15, and 22. Courses repeat every 28 days in the absence of disease progression
or unacceptable toxicity.

ARM B: Patients receive exemestane as in Arm A and placebo PO on days 1, 8, 15, and 22.
Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

In both arms, pre/perimenopausal female patients and all male patients also receive goserelin
acetate subcutaneously (SC) on day 1.

After completion of study treatment, patients are followed up every 3 months for 2 years,
every 6 months for 3 years, and then annually for 5 years.

Inclusion Criteria:

- Estrogen receptor (ER) and/or progesterone receptor (PR) positive histologically
confirmed adenocarcinoma of the breast with staining of >= 1% cells will be considered
positive; receptor status may be based on any time during treatment prior to study
randomization, and from any site (i.e. primary, recurrent, or metastatic)

- Patients whose tumors have HER2 immunohistochemistry (IHC) 3+, in situ hybridization
(ISH) >= 2.0, or average HER2 copy number >= 6.0 signals per cell are not eligible;
receptor status may be based on any time during treatment prior to study
randomization, and from any site (i.e. primary, recurrent, or metastatic)

- Patients must have measurable or non-measurable stage III/locally advanced or
metastatic carcinoma of the breast where local therapy with curative intent is not
possible; lesions must be evaluated =< 4 weeks prior to study randomization;
diagnostic-quality computed tomography (CT) scans with both oral and intravenous (IV)
contrast are the expected radiologic method, unless an alternative is approved

- NOTE: Where baseline imaging has already been performed =< 6 weeks prior to study
randomization, repeat imaging may not be required

- NOTE: As of October 16, 2016, accrual of new patients having non-measurable
disease has stopped; the planned accrual for this target population has been
reached

- Pre/peri- and postmenopausal women and all men are eligible for this trial;
postmenopausal is defined as:

- Age >= 55 years and one year or more of amenorrhea

- Age < 55 years and one year or more of amenorrhea, with estradiol < 20 pg/ml

- Age < 55 with prior hysterectomy but intact ovaries, with estradiol < 20 pg/ml

- Prior bilateral oophorectomy

- NOTE: Women who do not fit the criteria for being postmenopausal as above
are deemed pre-or peri-menopausal; pre/perimenopausal women and all men can
enroll provided they agree to receive concomitant luteinizing
hormone-releasing hormone (LHRH) agonist; pre/perimenopausal women must have
commenced treatment with LHRH agonist at least 4 weeks prior to
randomization; if patients have received alternative LHRH agonist prior to
study entry, they must switch to goserelin for the duration of the trial

- Sexually active males and pre/perimenopausal women must agree to use an accepted and
effective method of contraception or to abstain from sexual intercourse for the
duration of their participation in the study and for 3 months after discontinuation of
therapy

- Women must not be pregnant or breast-feeding; all females of childbearing potential
must have a blood test or urine study =< 2 weeks prior to randomization

- A female of childbearing potential is any woman, regardless of sexual orientation
or whether they have undergone tubal ligation, who meets the following criteria:
1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been
naturally postmenopausal for at least 24 consecutive months (i.e., has had menses
at any time in the preceding 24 consecutive months)

- Patients must not have known central nervous system metastasis or a history of central
nervous system (CNS) metastases; patients with leptomeningeal disease are not eligible

- Patients must be disease-free of prior invasive malignancies for > 5 years with the
exception of curatively-treated basal cell or squamous cell carcinoma of the skin or
carcinoma in situ of the cervix

- NOTE: If there is a history of prior malignancy, patients must not be receiving
other specific treatment for that cancer

- Patients must meet at least one of the following criteria:

- Disease progression any time after non-steroidal AI use in the advanced disease
setting

- Relapse while on or within =< 12 months of end of adjuvant non-steroidal AI
therapy with or without prior endocrine therapy for advanced disease

- NOTE: In either setting, treatment with any prior endocrine therapy must be
completed >= 2 weeks prior to course 1 day 1 (C1D1) of study treatment with the
exception of exemestane which is permitted in the advanced disease setting within
=< 4 weeks immediately prior to C1D1; prior adjuvant exemestane is allowed if the
disease free interval is > 12 months from the discontinuation of exemestane;
prior faslodex, everolimus, palbociclib or other cyclin-dependent kinase (CDK)
inhibitor (e.g. ribociclib, abemaciclib) use are allowed and must have been
completed >= 2 weeks prior to C1D1; failure to adhere to this washout guideline
will result in a protocol violation

- Patients may have received only one prior chemotherapy regimen for metastatic disease
provided treatment was completed >= 3 weeks prior to randomization

- Patients may be treated with bone modifying agents such as bisphosphonates or
RANK-ligand agents (e.g. denosumab) per American Society of Clinical Oncology (ASCO)
guidelines; whenever possible, patients requiring bone modifying agents should start
treatment >= 7 days prior to study therapy and should continue the same agent
throughout study unless clinically compelled to change

- Prior radiotherapy must in general have been completed >= 2 weeks prior to
randomization and patients must have recovered from the toxicity of the radiation

- NOTE: Patients may receive concurrent radiation therapy to painful sites of bony
disease or areas of impending fracture as long as sites of measurable or
non-measurable disease outside the radiation therapy port are available to follow

- Patients must NOT receive concurrent anti-cancer therapy or investigational agent
unless specified in protocol

- Patients must NOT be receiving valproic acid, an histone deacetylase (HDAC) inhibitor,
and may not have previously received any HDAC inhibitor prior to enrollment (e.g.
valproic acid, entinostat, vorinostat) unless discussed with the study chair; patients
must not have received prior HDAC therapy for the treatment of their malignancy

- Patients must have no known allergies to exemestane, entinostat, or medications that
have a benzamide structure (e.g., tiapride, remoxipride, clebropride)

- Patients must NOT suffer from medical or psychiatric conditions that would interfere
with protocol compliance, the ability to provide informed consent, or assessment of
response or anticipated toxicities; this includes uncontrolled intercurrent illness
including, but not limited to ongoing or active infection

- Patients must have recovered from all clinically relevant adverse events to grade 1 or
baseline due to previous agents administered (except alopecia)

- Patients must have adequate hematologic, liver and renal function =< 28 days prior to
randomization

- NOTE: It is preferred that laboratory values for eligibility be assessed after
the last dose of prior treatment, especially in cases where most-recent treatment
prior to study entry is chemotherapy

- Hemoglobin (HgB) >= 9.0 g/dL (=< 28 days prior to randomization)

- Platelet count >= 100,000/mcL (=< 28 days prior to randomization)

- Absolute neutrophil count >= 1,500/mcL (=< 28 days prior to randomization)

- Creatinine =< 2.0 mg/dL (=< 28 days prior to randomization)

- Total bilirubin < 1.5 x institutional upper limit of normal (=< 3 mg/dL in case of
Gilbert's syndrome) (=< 28 days prior to randomization)

- Transaminases (alanine aminotransferase [ALT], aspartate aminotransferase [AST]) =<
2.5 x institutional upper limit normal (=< 28 days prior to randomization)

- Known human immunodeficiency virus (HIV)-positive patients should have a cluster of
differentiation (CD)4 count > 250/mm^3

- Patients must have Eastern Cooperative Oncology Group (ECOG) performance status 0-1

- Patients must have a life expectancy >= 12 weeks

- Patients must be able to swallow tablets
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Brewer, Maine 04412
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1100 Balsam Ave
Boulder, Colorado 80304
(303) 440-2273
Principal Investigator: Keren Sturtz
Phone: 303-777-2663
Boulder Community Hospital Founded in 1922 as a community-owned and operated not-for-profit hospital, Boulder Community...
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Boulder, Colorado 80303
Principal Investigator: Keren Sturtz
Phone: 303-777-2663
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960 W Wooster St
Bowling Green, Ohio 43402
419-353-5419
Toledo Clinic Cancer Centers-Bowling Green Our doctors evaluate and make recommendations regarding cancer treatment for...
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Bowling Green, OH
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915 Highland Blvd
Bozeman, Montana 59715
(406) 414-5000
Principal Investigator: Benjamin T. Marchello
Phone: 406-969-6060
Bozeman Deaconess Hospital Bozeman Deaconess Hospital is a Joint Commission certified, licensed Level III trauma...
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Bozeman, MT
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Brainerd, Minnesota 56401
Principal Investigator: Bret E. Friday
Phone: 888-203-7267
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Brainerd, MN
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Branson, Missouri 65616
Principal Investigator: Jay W. Carlson
Phone: 417-269-4520
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Branson, MO
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Bremerton, Washington 98310
Principal Investigator: Mehmet S. Copur
Phone: 308-398-6518
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Bremerton, WA
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Bronx, New York 10467
Principal Investigator: Della F. Makower
Phone: 718-379-6866
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Bronx, NY
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Bronx, New York 10461
Principal Investigator: Della F. Makower
Phone: 718-379-6866
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Bronx, New York 10461
Principal Investigator: Della F. Makower
Phone: 718-379-6866
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Brooklyn, New York 11203
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Brownstown, Michigan 48183
Principal Investigator: Ding Wang
Phone: 888-823-5923
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130 S Bryn Mawr Ave
Bryn Mawr, Pennsylvania 19010
(484) 337-3000
Principal Investigator: Albert S. DeNittis
Phone: 484-476-2649
Bryn Mawr Hospital Bryn Mawr Hospital, a nationally recognized community teaching hospital, is conveniently located...
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Burien, Washington 98166
Principal Investigator: Mehmet S. Copur
Phone: 308-398-6518
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Burien, WA
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Burlington, Massachusetts 01805
Principal Investigator: Corrine L. Zarwan
Phone: 781-744-8027
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Burlington, North Carolina 27216
Principal Investigator: Vinay K. Gudena
Phone: 336-538-7725
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Burlington, Wisconsin 53105
Principal Investigator: Rubina Qamar
Phone: 414-302-2304
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400 South Clark Street
Butte, Montana 59701
406-723-2500
Principal Investigator: Keren Sturtz
Phone: 406-723-2621
Saint James Community Hospital and Cancer Treatment Center St. James Healthcare has played an important...
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210 W Walnut St
Canton, Illinois 61520
309-647-5240
Principal Investigator: Bryan A. Faller
Phone: 309-243-3605
Illinois CancerCare - Canton Illinois CancerCare is one of the largest private oncology and hematology...
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211 Saint Francis Drive
Cape Girardeau, Missouri 63703
573-331-3000
Principal Investigator: Bryan A. Faller
Phone: 573-334-2230
Saint Francis Medical Center Saint Francis Medical Center is a 282-bed facility serving more than...
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789 Mt Auburn Rd
Cape Girardeau, Missouri 63703
(573) 519-4725
Principal Investigator: Bryan A. Faller
Phone: 573-651-5550
Southeast Cancer Center SoutheastHEALTH is a far-reaching network of providers and facilities including Southeast Hospital...
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Cape May Court House, New Jersey 08210
Principal Investigator: Victor G. Vogel
Phone: 888-369-2427
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Carbondale, Illinois 62902
Principal Investigator: Bryan A. Faller
Phone: 618-457-5200
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Carmel, Indiana 46032
Principal Investigator: Kathy D. Miller
Phone: 317-278-5632
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Carmichael, California 95608
Principal Investigator: Sonia E. Reichert
Phone: 916-537-5237
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160 S Adams St
Carthage, Illinois 62321
(217) 357-6877
Principal Investigator: Bryan A. Faller
Phone: 309-243-3605
Illinois CancerCare - Carthage Illinois CancerCare, P.C. is a comprehensive practice treating patients withcancer andblood...
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