Bevacizumab With or Without Anti-Endoglin Monoclonal Antibody TRC105 in Treating Patients With Recurrent Glioblastoma Multiforme



Status:Completed
Conditions:Brain Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:5/25/2018
Start Date:November 2012
End Date:April 15, 2017

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Phase I/Comparative Randomized Phase II Trial of TRC105 Plus Bevacizumab Versus Bevacizumab in Bevacizumab-Naive Patients With Recurrent Glioblastoma Multiforme

This partially randomized phase I/II trial studies the side effects and the best dose of
anti-endoglin monoclonal antibody TRC105 when given together with bevacizumab and to see how
well they work in treating patients with glioblastoma multiforme that has come back.
Monoclonal antibodies, such as anti-endoglin monoclonal antibody TRC105 and bevacizumab, may
find tumor cells and help kill them. Giving anti-endoglin monoclonal antibody TRC105 together
with bevacizumab may be an effective treatment for glioblastoma multiforme.

PRIMARY OBJECTIVES:

I. To establish a maximum tolerated dose (MTD) of TRC105 (anti-endoglin monoclonal antibody
TRC105) combined with bevacizumab in this patient population. (Phase I) II. To assess the
safety and adverse events of TRC105 in combination with bevacizumab in this patient
population. (Phase II) III. To determine the efficacy of TRC105 in combination with
bevacizumab in recurrent glioblastoma as measured by progression-free survival and compare it
with the efficacy of bevacizumab alone in this patient population. (Phase II)

SECONDARY OBJECTIVES:

I. To assess the proportion of patients, who are progression free at 6 months, treated with
TRC105 in combination with bevacizumab as compared to bevacizumab alone. (Phase II) II. To
assess the overall survival of patients treated with TRC105 in combination with bevacizumab
compared to bevacizumab alone. (Phase II) III. To compare the impact of the treatment on the
patients quality of life (QOL) using the European Organization for Research and Treatment of
Cancer (EORTC) Quality of Life questionnaire (QLQ)-C15-Palliative Care (PAL) and QLQ-brain
neoplasm (BN)20 Patient Questionnaires. (Phase II) IV. To estimate patient recommendations
for study participation to others using the Was It Worth It (WIWI) Questionnaire. (Phase II)

TERTIARY OBJECTIVES:

I. To evaluate the pharmacokinetics of TRC105. (Phase I) II. To evaluate the immunogenicity
of TRC105. (Phase I) III. To determine the relationship between tumor biomarkers, circulating
biomarkers of vascular response and vascular endothelial growth factor (VEGF)/VEGF receptor
(VEGFR) single-nucleotide polymorphisms (SNPs) in predicting efficacy and/or toxicity of
treatment. (Phase II) IV. To assess the utility of magnetic resonance imaging (MRI) imaging
including apparent diffusion coefficient (ADC) as a predictor of response and survival.
(Phase II) V. To assess the utility of dynamic contrast enhanced (DCE) MRI as a predictor of
response to bevacizumab with or without TRC105. (Phase II)

OUTLINE: This is a phase I dose-escalation study of anti-endoglin monoclonal antibody TRC105,
followed by a randomized phase II study.

Phase I (closed to accrual 1/14/14): Patients receive bevacizumab intravenously (IV) over
30-90 minutes on day 1 and anti-endoglin monoclonal antibody TRC105 IV over 1-4 hours on days
8 and 11 of course 1 and days 1 and 8 of all subsequent courses. Courses repeat every 14 days
in the absence of disease progression or unacceptable toxicity.

Phase II: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive bevacizumab IV over 30-90 minutes on day 1 and anti-endoglin
monoclonal antibody TRC105 IV over 1-4 hours on days 8 and 11 of course 1 and days 1 and 8 of
all subsequent courses. Courses repeat every 14 days in the absence of disease progression or
unacceptable toxicity.

ARM II: Patients receive bevacizumab as in arm I. Courses repeat every 14 days in the absence
of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for 3 years.

Inclusion Criteria:

- Histological confirmation of grade 3 or 4 glioma, including astrocytoma,
oligodendroglioma, and mixed gliomas, as determined by pre-registration central
pathology review (Phase I)

- Histological confirmation of glioblastoma multiforme (grade 4 astrocytoma) as
determined by pre-registration central pathology review; note: gliosarcomas and other
grade 4 astrocytoma variants (e.g., giant cell) are eligible; glioblastoma (GBM) with
oligodendroglial features are NOT PERMITTED in this study if they are 1p19q
co-deleted; sites submitting GBM with oligodendroglial features will be asked to
provide results of 1p/19q co-deletion status (Phase II)

- Evidence of tumor progression by MRI or computed tomography (CT) scan following
radiation therapy or following the most recent anti-tumor therapy; note: patients who
have had surgical treatment at recurrence are eligible if they had a resection with
measurable or non-measurable residual disease on postoperative imaging or if there is
imaging evidence of disease progression as compared to the first postoperative scan

- Measurable or evaluable disease by gadolinium MRI or contrast CT scan; note: patients
who have had a gross total resection (GTR) are eligible on the basis of evaluable
disease

- Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0, 1, or 2

- Absolute neutrophil count (ANC) >= 1,500/mm^3

- Platelet count >= 100,000/mm^3

- White blood cells (WBC) >= 3,000/mL

- Hemoglobin >= 10.0 g/dL; note: this level may be reached by transfusion

- Total bilirubin =< institutional upper limit of normal (ULN)

- Serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) =< 2
x ULN

- Creatinine =< ULN

- Life expectancy >= 12 weeks

- Negative serum pregnancy test done =< 7 days prior to registration, for women of
childbearing potential only

- Urine protein creatinine (UPC) ratio < 1; note: urine protein must be screened by
urine analysis for UPC ratio; for UPC ratio >= 1.0, 24-hour urine protein must be
obtained and the level should be < 1,000 mg for registration

- Fixed or decreasing dose of corticosteroids (or no corticosteroids) >= 7 days prior to
registration

- Calculated glomerular filtration rate (GFR) must be >= 60 ml/min; GFR will be
calculated as needed per institutional guidelines

- Any number of prior chemotherapy regimens for recurrent disease (Phase I); =< 1
chemotherapy or other non-antiangiogenic regimen for recurrent disease (Phase II)

- Last dose of bevacizumab >= 2 weeks prior to registration (Phase I); note: for the
phase II study only, prior exposure to bevacizumab is not allowed

- Surgery >= 4 weeks prior to registration

- Completion of radiation therapy >= 12 weeks prior to registration and prior
chemotherapy >= 4 weeks prior to registration (>= 6 weeks from nitrosourea-containing
regimens)

- Small molecular cell cycle inhibitors >= 2 weeks from registration

- Ability to provide informed written consent

- Ability to complete questionnaire(s) by themselves or with assistance

- Willing to return to enrolling institution for follow-up

- Willing to discontinue use of medications that inhibit platelet function >= 10 days
prior to registration; aspirin at doses greater than 325 mg/day must be discontinued
>= 10 days prior to registration and avoided through the study; note: nonsteroidal
anti-inflammatory drug (NSAID) medications are recommended in place of aspirin; if
NSAIDs or aspirin are used, histamine (H)-2 blockers and proton pump inhibitor (PPI)
medications are recommended

- Willing to provide mandatory blood and tissue samples for correlative research
purposes (Phase I and II)

Exclusion Criteria:

- Any of the following:

- Pregnant women

- Nursing women

- Men or women of childbearing potential who are unwilling to employ adequate
contraception throughout the duration of the study and for at least 6 months
after treatment has ended

- Prior hypersensitivity to bevacizumab or toxicity requiring discontinuation of
bevacizumab (Phase I)

- Any prior exposure to any VEGF or VEGF inhibitor including, but not limited to,
bevacizumab, cediranib, vandetanib, sunitinib, pazopanib, aflibercept, or sorafenib
(Phase II)

- Prior hypersensitivity to Chinese hamster ovary cell products or other recombinant
human antibodies (Phase I and II)

- Prior hypersensitivity to triptan derivatives (Phase I and II)

- Other active malignancy =< 3 years prior to registration; exceptions: non-melanotic
skin cancer or carcinoma-in-situ of the cervix; note: if there is a history of prior
malignancy, they must not be receiving other specific treatment (other than hormonal
therapy) for their cancer

- Uncontrolled infection

- Immunocompromised patients or patients known to be human immunodeficiency virus (HIV)
positive and currently receiving combination antiretroviral therapy; patients known to
be HIV positive, but without clinical evidence of an immunocompromised state, are
eligible for this trial

- Co-morbid systemic illnesses or other severe concurrent disease which, in the judgment
of the investigator, would make the patient inappropriate for entry into this study or
interfere significantly with the proper assessment of safety and adverse events of the
prescribed regimens

- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, or psychiatric illness/social situations that would limit compliance with
study requirements

- History of hypertensive crisis or hypertensive encephalopathy

- Clinically significant cardiovascular disease defined as follows:

- Inadequately controlled hypertension (i.e., systolic blood pressure [SBP] > 160
mm Hg and/or diastolic blood pressure [DBP] > 90 mm Hg despite antihypertensive
therapy)

- History of cerebrovascular accident (CVA) within 6 months

- Myocardial infarction or unstable angina within 6 months

- New York Heart Association classification II, III, or IV cardiovascular disease

- Serious and inadequately controlled cardiac arrhythmia

- Significant vascular disease (i.e., aortic aneurysm, history of aortic
dissection)

- Clinically significant peripheral vascular disease

- Evidence or history of bleeding diathesis (greater than normal risk of bleeding, i.e.,
hereditary hemorrhagic telangiectasia type I or HHT-1) or coagulopathy in the absence
of therapeutic anti-coagulation or any hemorrhage/bleeding event > grade 3 within 4
weeks prior to registration; note: patients with full-dose anticoagulants are eligible
provided the patient has been on a stable dose for at least 2 weeks of low molecular
weight heparin; therapeutic Coumadin and aspirin doses > 325 mg daily are not allowed

- Receiving any other investigational agent that would be considered as a treatment for
the primary neoplasm

- Prior treatment with TRC105

- Serious or non-healing wound, active ulcer, or untreated bone fracture

- History of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess
=< 6 months prior to registration

- History of invasive procedures defined as follows:

- Major surgical procedure, open biopsy, or significant traumatic injury =< 28 days
prior to registration

- Anticipation of need for major surgical procedures during the study

- Core biopsy =< 7 days prior to registration

- History of significant vascular disease (i.e., aortic aneurysm requiring surgical
repair, or recent peripheral arterial thrombosis) within 6 months prior to
registration
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(810) 762-8490
Genesys Hurley Cancer Institute Bringing the most advanced cancer treatment services, technologies and programs available...
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Flint, MI
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Fort Dodge, IA
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Fort Scott, Kansas 66701
(620) 223-8589
Cancer Center of Kansas - Fort Scott Dr. H.E. Hynes founded Cancer Center of Kansas,...
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Fort Scott, KS
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One Medical Center Drive
Franklin, Ohio 45005
(513) 424-2111
Atrium Medical Center - Middletown Regional Hospital Atrium Medical Center (Atrium) is built on the...
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Franklin, OH
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