Pazopanib Hydrochloride in Treating Patients With Metastatic Kidney Cancer Who Have No Evidence of Disease After Surgery



Status:Active, not recruiting
Conditions:Cancer, Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:2/17/2019
Start Date:August 8, 2012

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Randomized, Double-Blind Phase III Study of Pazopanib vs. Placebo in Patients With Metastatic Renal Cell Carcinoma Who Have No Evidence of Disease Following Metastatectomy

This randomized phase III trial studies how well pazopanib hydrochloride works compared to
placebo in treating patients with kidney cancer that has spread to other parts of the body
and have no evidence of disease after surgery. Pazopanib hydrochloride may stop the growth of
tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow
to the tumor.

PRIMARY OBJECTIVES:

I. To evaluate disease-free survival with pazopanib (pazopanib hydrochloride) as compared to
placebo, defined as the time from randomization to the development of recurrent disease,
second primary cancer (other than localized breast, localized prostate, or non-melanoma skin
cancer) or death from any cause for patients with metastatic renal cell carcinoma (RCC) with
no evidence of disease following metastasectomy.

SECONDARY OBJECTIVES:

I. To describe the overall survival of patients with advanced RCC randomly assigned to
receive placebo or pazopanib for one year following metastasectomy to no evidence of disease
(NED).

II. To describe treatment and (at recurrence) disease-related adverse events in the two
treatment arms.

III. To analyze quality-adjusted time without symptoms of disease or treatment (Q-TWiST) for
subjects in the two treatment arms.

IV. To characterize changes in patient-reported fatigue and (at recurrence) kidney
cancer-related symptoms during and following treatment with pazopanib compared to placebo.

V. To explore the association between plasma trough levels of pazopanib and disease-free and
overall survival.

VI. To prospectively bank preserved tissue from primary tumors and associated metastatic
sites in patients with RCC.

OUTLINE: Patients are randomized to 1of 2 treatment arms.

ARM I: Patients receive pazopanib hydrochloride orally (PO) once daily (QD) on days 1-28.
Treatment repeats every 28 days for up to 13 courses in the absence of disease progression or
unacceptable toxicity.

ARM II: Patients receive placebo PO QD on days 1-28. Treatment repeats every 28 days for up
to 13 courses in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for the first
two years, every 6 months for the next 3 years, and then annually up to 10 years.

Inclusion Criteria:

- Patient must have pathologically confirmed renal cell carcinoma with a clear cell
component; pure papillary and chromophobe histologies are excluded; there must be
pathologic confirmation of metastatic disease in the resected metastasectomy specimen

- Patient must have undergone nephrectomy or partial nephrectomy to remove primary renal
cell carcinoma (at any time in the past)

- Patient must have undergone surgical resection to remove one or more sites of
metastatic disease, with successful removal of all known sites 2-12 weeks prior to
randomization; any number of prior metastasectomies may have been performed in the
past, so long as the most recent procedure was within the 12 weeks of registration;
the most recent procedure may be nephrectomy for a renal primary tumor

- Patients with synchronous disease at initial diagnosis must have metastatic (M1)
disease (American Joint Committee on Cancer [AJCC] 7th edition T1-4N0-1M1)

- Positive surgical margins are permitted if the surgeon confirms complete resection of
gross metastatic disease, and post-operative scans are negative

- Patients presenting with metachronous disease may have distant metastases, regional
lymph node or renal bed recurrence; recurrences at a partial nephrectomy resection
site are not eligible if it is the only site of disease

- Patients presenting with tumors within the kidneys (multiple synchronous or
single/multiple metachronous) are not eligible if there are no extrarenal sites of
disease (i.e. potential multifocal primary disease)

- Patient must have no evidence of disease on post-operative imaging:

- A computed tomography (CT) of the chest must be obtained within 4 weeks prior to
randomization with or without contrast

- A CT of the abdomen/pelvis must be obtained within 4 weeks prior to randomization
with intravenous (IV) contrast (oral contrast may be added at the radiologist's
discretion); an magnetic resonance imaging (MRI) of the abdomen/pelvis with
gadolinium may be substituted for the CT if the CT with IV contrast is
contra-indicated

- An MRI of the brain with and without gadolinium must be done within 8 weeks prior
to randomization; a CT of the brain with and without IV contrast is permitted if
MRI is contra-indicated (i.e., pacemaker)

- Patient must not have received any prior or concurrent systemic therapy for RCC;
adjuvant placebo administration is permitted

- Patient must have no active peptic ulcer disease

- Patient must have no active inflammatory bowel disease

- Patient must have no New York Heart Association (NYHA) class II or greater congestive
heart failure

- Patient must have no prior history or current clinically apparent central nervous
system metastases

- Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0
or 1 at the time of randomization

- Absolute granulocyte count > 1,500/mcL

- Platelets > 100,000/mcL

- Total bilirubin < 1.5 x institutional upper limit of normal (ULN)

- Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase
[SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT])
< 2.5 x upper limit of normal (ULN)

- Calculated creatinine clearance (CrCl) > 30 mL/min

- Subjects must have a urine protein/creatinine (UPC) ratio < 1; if UPC >= 1, then a
24-hour urine total protein must be obtained; subjects must have a 24-hour urine
protein value < 1 g to be eligible; use of urine dipstick for renal function
assessment is not acceptable

- Women must not be pregnant or breast-feeding

- All females of childbearing potential must have a blood test or urine study
within 2 weeks prior to randomization to rule out pregnancy; a female of
childbearing potential is any woman, regardless of sexual orientation or whether
they have undergone tubal ligation, who meets the following criteria: 1) has not
undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally
postmenopausal for at least 24 consecutive months (i.e., has had menses at any
time in the preceding 24 consecutive months)

- Women of childbearing potential and sexually active males must be strongly advised to
use an accepted and effective method of contraception or to abstain from sexual
intercourse for the duration of their participation in the study; should a woman
become pregnant while participating in this study, she should inform her treating
physician immediately; if a man impregnates a woman while participating in this study,
he should inform his treating physician immediately

- Patient must be able to swallow pills and have no significant impairment in
gastrointestinal absorption including history of gastric bypass surgery

- Patient must have no history of allergic reactions attributed to compounds of similar
chemical or biologic composition to pazopanib

- Patient must have no uncontrolled intercurrent illness including, but not limited to,
ongoing or active infection, symptomatic congestive heart failure, unstable angina
pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would
limit compliance with study requirements

- Patient must have a corrected QT (QTc) interval on electrocardiogram (ECG) =< 0.48
seconds by Bazett's calculation (=< Common Terminology Criteria for Adverse Events
[CTCAE] version [v.]4 grade 2) prior to randomization

- Patient must have a systolic blood pressure =< 140 mmHg and diastolic blood pressure
must be =< 90 mmHg, measured within 4 weeks prior to randomization; initiation or
adjustment of anti-hypertensives prior to starting study treatment is allowed

- Patient must not have serious or non-healing wound, ulcer, or bone fracture at the
time of randomization

- Patient must have no history of abdominal fistula, gastrointestinal perforation, or
intra-abdominal abscess within 4 weeks prior to randomization

- Patient must have no history of cerebrovascular accident (CVA) within 6 months of
randomization

- Patient must have no history of myocardial infarction, hospital admission for unstable
angina, cardiac angioplasty or stenting within 6 months of randomization

- Patient must have no history of venous thrombosis within 12 weeks of randomization

- Patient cannot be taking strong cytochrome P450, family 3, subfamily A, polypeptide 4
(CYP3A4) inhibitors such as:

- Antibiotics: clarithromycin, telithromycin, troleandomycin

- Human immunodeficiency virus (HIV) antiviral protease inhibitors: ritonavir,
indinavir, saquinavir, nelfinavir, amprenavir, lopinavir

- Antifungals: itraconazole, ketoconazole, voriconazole, fluconazole

- Antidepressants: nefazodone

- Patient must not have history of hemoptysis in excess of 2.5 mL (1/2 teaspoon) within
8 weeks prior to randomization

- Patient must not be taking drugs known to prolong the QTc interval; such drugs should
be discontinued at least 5 half-lives prior to randomization

- Patients must not have any history of other cancer within 3 years from time of
randomization with the exception of basal cell skin cancer, squamous cell skin cancer,
in situ cervical cancer, ductal or lobular carcinoma in situ of the breast, or
resected non-invasive (Ta) urothelial carcinoma
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Chattanooga, Tennessee 37403
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Chattanooga, TN
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Chattanooga, Tennessee 37404
Principal Investigator: Mehmet S. Copur
Phone: 800-998-2119
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775 South Main Street
Chelsea, Michigan 48118
Principal Investigator: Philip J. Stella
Phone: 734-712-4673
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Chelsea, MI
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14650 East Old US Highway 12
Chelsea, Michigan 48118
Principal Investigator: Philip J. Stella
Phone: 734-712-4673
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Chelsea, MI
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232 S Woods Mill Rd
Chesterfield, Missouri 63017
(314) 205-6491
Saint Luke's Hospital St. Luke's Hospital, located in Chesterfield, Missouri, is a regional healthcare provider...
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Chesterfield, MO
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676 N St Clair St #2140
Chicago, Illinois 60611
(312) 664-5400
Hematology and Oncology Associates Northwestern Medical Faculty Foundation (the Foundation) is a premier, multi-specialty physician...
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Chicago, IL
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Chicago, Illinois 60631
Principal Investigator: Lisa L. Baddi
Phone: 773-792-5116
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Chicago, IL
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303 East Superior Street
Chicago, Illinois 60611
Principal Investigator: Benedito A. Carneiro
Phone: 312-695-1301
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Chicago, IL
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272 Hospital Rd
Chillicothe, Ohio 45601
740-779-7500
Principal Investigator: Timothy D. Moore
Phone: 614-488-2745
Adena Regional Medical Center Since 1895, Adena Health System has remained focused on its commitment...
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Chillicothe, OH
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12961 27th Ave
Chippewa Falls, Wisconsin 54729
715-738-3700
Principal Investigator: Seth O. Fagbemi
Phone: 715-389-4457
Marshfield Clinic - Chippewa Center The 15,000 square foot Lake Hallie Center provides urgent care...
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Chippewa Falls, WI
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Cincinnati, Ohio 45242
Principal Investigator: Mehmet S. Copur
Phone: 800-998-2119
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Cincinnati, OH
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