PROSPECT: Chemotherapy Alone or Chemotherapy Plus Radiation Therapy in Treating Patients With Locally Advanced Rectal Cancer Undergoing Surgery



Status:Active, not recruiting
Conditions:Colorectal Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:3/7/2019
Start Date:January 2012

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A Phase II/III Trial of Neoadjuvant FOLFOX With Selective Use of Combined Modality Chemoradiation Versus Preoperative Combined Modality Chemoradiation for Locally Advanced Rectal Cancer Patients Undergoing Low Anterior Resection With Total Mesorectal Excision (PROSPECT)

The standard treatment for locally advanced rectal cancer involves chemotherapy and
radiation, known as 5FUCMT, (the chemotherapy drugs 5-fluorouracil/capecitabine and radiation
therapy) prior to surgery. Although radiation therapy to the pelvis has been a standard and
important part of treatment for rectal cancer and has been shown to decrease the risk of the
cancer coming back in the same area in the pelvis, some patients experience undesirable side
effects from the radiation and there have been important advances in chemotherapy, surgery,
and radiation which may be of benefit. The purpose of this study is to compare the effects,
both good and bad, of the standard treatment of chemotherapy and radiation to chemotherapy
using a combination regimen known as FOLFOX, (the drugs 5-fluorouracil (5-FU), oxaliplatin
and leucovorin) and selective use of the standard treatment, depending on response to the
FOLFOX. The drugs in the FOLFOX regimen are all FDA (Food and Drug Administration) approved
and have been used routinely to treat patients with advanced colorectal cancer.

OUTLINE: This is a multicenter, phase II/III study. Patients are stratified according to ECOG
performance status (0 or 1 vs 2) and randomized to 1 of 2 treatment regimens. Patients will
receive full supportive care while on this study.

OBJECTIVES:

Primary

1. Phase II component: To assure that neoadjuvant FOLFOX followed by selective use of
5FUCMT group (Group 1) maintains the current high rate of pelvic R0 resection and is
consistent with non-inferiority for time to local recurrence (TLR).

2. Phase III component: To compare neoadjuvant FOLFOX followed by selective use of 5FUCMT
(Group 1) to standard 5FUCMT (Group 2) with respect to the co-primary endpoints of the
Time to Local Recurrence (TLR) and Disease-Free Survival (DFS).

Secondary

1. To determine if the neoadjuvant FOLFOX followed by selective use of 5FUCMT (Group 1) is
non-inferior to the standard group 5FUCMT (Group 2) with respect to the proportion of
patients who achieve a pathologic complete response (pCR) at the time of surgical
resection.

2. To determine if the neoadjuvant FOLFOX followed by selective use of 5FUCMT (Group 1) is
non-inferior to the standard 5FUCMT (Group 2) with respect to overall survival.

3. To evaluate and compare the adverse event profile and surgery complications between two
groups.

4. To estimate the proportion of patients in the selective group (Group 1) who receive: 1)
pre-operative 5FUCMT; 2) post-operative 5FUCMT; 3) either pre- or post-operative 5FUCMT.

Event monitoring of patients will continue up to 8 years post randomization.

Registration Inclusion Criteria:

1. Age ≥ 18 years at diagnosis

2. Diagnosis of rectal adenocarcinoma

3. Radiologically measurable or clinically evaluable disease as defined in the protocol

4. ECOG Performance Status (PS): 0, 1 or 2

5. For this patient, the standard treatment recommendation in the absence of a clinical
trial would be combined modality neoadjuvant chemoradiation followed by curative
intent surgical resection

6. Candidate for sphincter-sparing surgical resection prior to neoadjuvant therapy
according to the primary surgeon

7. Primary surgeon is credentialed or is willing to be credentialed in Total Mesorectal
Excision (TME), which entails submission of photos of a single TME specimen either
before enrolling the first patient or by using the surgeon's 1st accrued case.

8. Clinical Stage: T2N1, T3N0, T3N1.

- N2 disease is to be estimated as four or more lymph nodes that are ≥ 10 mm.

- Clinical staging should be estimated based on the combination of the following
assessments: physical exam by the primary surgeon, CT or PET/CT scan of the
chest/abdomen/pelvis and either a pelvic MRI or an ultrasound (ERUS). If a pelvic
MRI is peformed, it is acceptable to perform CT of the chest/abdomen, ommitting
CT imaging of the pelvis.

9. The following laboratory values obtained ≤ 28 days prior to registration:

- Absolute neutrophil count (ANC) ≥ 1500/mm^3

- Platelet count ≥ 100,000/mm^3

- Hemoglobin > 8.0 g/dL

- Total bilirubin ≤ 1.5 x upper limit of normal (ULN)

- SGOT (AST) ≤ 3 x ULN

- SGPT (ALT) ≤ 3 x ULN

- Creatinine ≤1.5 x ULN

10. Negative pregnancy test done ≤ 7 days prior to registration, for women of childbearing
potential only

11. Patient of child-bearing potential is willing to employ adequate contraception

12. Provide informed written consent

13. Willing to return to enrolling medical site for all study assessments

Registration Exclusion Criteria:

1. Clinical T4 tumors

2. Primary surgeon indicates need for abdominoperineal (APR) at baseline

3. Evidence that the tumor is adherent to or invading the mesorectal fascia on imaging
studies such that the surgeon would not be able to perform an R0 resection (one with
negative margins)

4. Tumor is causing symptomatic bowel obstruction (patients who have had a temporary
diverting ostomy are eligible).

5. Chemotherapy within 5 years prior to registration. Hormonal therapy is allowable if
the disease free interval is ≥ 5 years.

6. Any prior pelvic radiation

7. Other invasive malignancy ≤ 5 years prior to registration. Exceptions are colonic
polyps, non-melanoma skin cancer, ductal carcinoma in situ, bladder carcinoma in situ,
or carcinoma-in-situ of the cervix.

8. Any of the following because this study involves an agent that has known genotoxic,
mutagenic and teratogenic effects.

- Pregnant women

- Nursing women

- Men or women of childbearing potential who are unwilling to employ adequate
contraception

9. Co-morbid illnesses or other concurrent disease which, in the judgment of the
clinician obtaining informed consent, would make the patient inappropriate for entry
into this study or interfere significantly with the proper assessment of safety and
toxicity of the prescribed regimens.
We found this trial at
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550 Osborne Rd NE
Fridley, Minnesota 55432
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1201 Camino de Salud Northeast
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75 Francis street
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330 Brookline Ave
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666 Elm Street
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1 South Prospect Street
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1300 Jefferson Park Avenue
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5301 McAuley Drive
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Beavercreek, OH
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Bel Air, Maryland 21014
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Bel Air, MD
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2500 Bellevue Medical Center Drive
Bellevue, Nebraska 68123
Principal Investigator: Jean L. Grem
Phone: 402-559-6941
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Bellevue, NE
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Bellevue, Washington 98004
Principal Investigator: John A. Keech
Phone: 425-688-5407
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Bellevue, WA
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mi
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Bellevue, WA
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Bellflower, California 90706
Principal Investigator: Jonathan A. Polikoff
Phone: 626-564-3455
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mi
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Bellflower, CA
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Bellingham, Washington 98225
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mi
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Bellingham, WA
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800 Farson Street
Belpre, Ohio 45714
(740) 401-0417
Principal Investigator: Timothy D. Moore
Phone: 800-523-3977
Strecker Cancer Center-Belpre The Memorial Health System's Strecker Cancer Center, Belpre combines the clinical expertise...
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mi
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Belpre, OH
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Bemidji, Minnesota 56601
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mi
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Bemidji, MN
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Bend, Oregon 97701
Principal Investigator: Alison K. Conlin
Phone: 541-706-2909
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mi
from
Bend, OR
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