A Pilot Study of Decitabine and Vorinostat With Chemotherapy for Relapsed ALL



Status:Terminated
Conditions:Blood Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:1 - 21
Updated:4/21/2016
Start Date:December 2011

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This is a pilot study using decitabine and vorinostat before and during chemotherapy with
vincristine, dexamethasone, mitoxantrone, and peg-asparaginase in pediatric patients with
acute lymphoblastic leukemia (ALL).

Decitabine is a demethylating agent and vorinostat is a HDAC inhibitor. The use of
demethylating agents and HDAC inhibitors in combination have been previously shown to have
synergistic effects in altering neoplastic pathways of cancer cells and be well tolerated in
human clinical studies. With the ability of decitabine and vorinostat to alter the abnormal
cellular pathways of leukemic blasts and essentially turn off anti-apoptotic proteins, the
leukemia cells have become primed for cytotoxic cell kill via chemotherapeutic agents. This
study will ask the question as to whether or not the combination of decitabine and
vorinostat followed by chemotherapy is feasible and whether it can positively impact outcome
in patients with relapsed or refractory acute lymphoblastic leukemia.

Inclusion Criteria:

- Patients must be ≥1 and ≤ 21 years of age when originally diagnosed with ALL.

Diagnosis

- Patients must have a diagnosis of acute lymphoblastic leukemia (ALL) with ≥ 25%
blasts in the bone marrow (M3), with or without extramedullary disease.

- Patients may have CNS 1, 2 or 3 disease.

- Karnofsky > 50% for patients > 16 years of age and Lansky > 50% for patients ≤ 16
years of age.

- Prior Therapy

- Patients must have fully recovered from the acute toxic effects of all prior
chemotherapy, immunotherapy, or radiotherapy prior to entering this study.

- Patients must have had 2 or more prior therapeutic attempts defined as:

- Relapse after going into remission from re-induction for the first or subsequent
relapse (ie: 2nd , 3rd, 4th…relapse), OR

- Refractory disease after first or greater relapse and a re-induction attempt, OR

- Failing to go into remission from original diagnosis after 2 previous induction
attempts.

- Hematopoietic Stem Cell Transplant: Patients who have experienced their relapse after
a HSCT are eligible, provided they have no evidence of Graft-versus-Host Disease
(GVHD) and are at least 60 days post-transplant at the time of enrollment.

- Prior anthracycline exposure: Patients must have less than 400 mg/m2 lifetime
exposure of anthracycline chemotherapy. (See Appendix II for calculation worksheet)

- Hematopoietic grow factors: It must have been at least 7 days since the completion of
therapy with GCSF or other growth factors at the time of enrollment. It must have
been at least 14 days since the completion of therapy with pegfilgrastim (Neulasta®).

- Biologic (anti-neoplastic) therapy: It must be at least 7 days after last does of
biologic agent. For agents that have known adverse events occurring beyond 7 days
after administration, this period must be extended beyond the time during which
adverse events are known to occur. The duration of this interval must be discussed
with the study chair

- Monoclonal antibodies: At least 3 half-lives of the antibody must have elapsed after
the last dose of monoclonal antibody. (ie. Rituximab=66 days, Epratuzumab=69 days)

- Immunotherapy: At least 42 days after the completion of any type of immunotherapy,
e.g. tumor vaccines.

Renal and Hepatic Function

- Patient's serum creatinine must be ≤ 1.5 x institutional upper limit of normal (ULN)
according to age. If the serum creatinine is greater than 1.5 times normal, the
patient must have a calculated creatinine clearance or radioisotope GRF ≥
70mL/min/1.73m2.

- Patient's ALT and AST must be < 5 x institutional upper limit of norm ULN. The
hepatic requirements are waived for patients with known or suspected liver
involvement who would otherwise be eligible after consultation with the Study Chair
or Vice Chair.

- Patient's total bilirubin must be ≤ 1.5 x ULN. The hepatic requirements are waived
for patients with known or suspected liver involvement who would otherwise be
eligible.

Cardiac Function:

- Patient must have a shortening fraction ≥ 27% by Echo or an ejection fraction ≥ 50%
by MUGA.

Reproductive Function

- Female patients of childbearing potential must have a negative urine or serum
pregnancy test confirmed prior to enrollment.

- Female patients with infants must agree not to breastfeed their infants while on this
study.

- Male and female patients of child-bearing potential must agree to use an effective
method of contraception approved by the investigator during the study.

Exclusion Criteria:

- Patients will be excluded if they are receiving Valproic Acid (VPA) therapy.

- Patients will be excluded if they have a known allergy to any of the drugs used in
the study.

- Patients will be excluded if they have a systemic fungal, bacterial, viral or other
infection that is exhibiting ongoing signs/symptoms related to the infection without
improvement despite appropriate antibiotics or other treatment.

- Patients will be excluded if there is a plan to administer non-protocol chemotherapy,
radiation therapy, or immunotherapy during the study period.

- Patients will be excluded if they have significant concurrent disease, illness,
psychiatric disorder or social issue that would compromise patient safety or
compliance with the protocol treatment or procedures, interfere with consent, study
participation, follow up, or interpretation of study results.

- Patients will be excluded if they have had any positive fungal culture in the last 30
days prior to enrollment.
We found this trial at
26
sites
South 34th Street
Philadelphia, Pennsylvania 19104
 215-590-1000
Children's Hospital of Philadelphia Since its start in 1855 as the nation's first hospital devoted...
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Ann Arbor, MI 48109Bus: -
Ann Arbor, Michigan 48109
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3400 N Charles St
Baltimore, Maryland 21205
410-516-8000
Johns Hopkins University The Johns Hopkins University opened in 1876, with the inauguration of its...
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700 Childrens Drive
Columbus, Ohio 43205
(616) 722-2000
Nationwide Children's Hospital At Nationwide Children’s, we are creating the future of pediatric health care....
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4650 Sunset Blvd
Los Angeles, California 90027
 (323) 660-2450
Childrens Hospital Los Angeles Children's Hospital Los Angeles is a 501(c)(3) nonprofit hospital for pediatric...
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3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
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Boston, Massachusetts
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Brisbane, Queensland
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Chicago, Illinois 60611
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Dallas, Texas 75390
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Forth Worth, Texas 76104
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Kansas City, Missouri 64108
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Memphis, Tennessee 38105
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Miami, Florida 33136
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Minneapolis, Minnesota 55404
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2200 Children's Way
Nashville, Tennessee 37232
(615) 936-1000
Vanderbilt Children's Hospital Monroe Carell Jr. Children's Hospital at Vanderbilt is one of the nation's...
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New York, New York 10021
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Orange, California 92868
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San Francisco, California 94143
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4800 Sand Point Way NE
Seattle, Washington 98105
(206) 987-2000
Seattle Children's Hospital Seattle Children’s Hospital specializes in meeting the unique physical, emotional and developmental...
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111 Michigan Ave NW
Washington, District of Columbia
(202) 476-5000
Childrens National Medical Center As the nation’s children’s hospital, the mission of Children’s National Medical...
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