Dasatinib and Bevacizumab in Treating Patients With Recurrent or Progressive High-Grade Glioma or Glioblastoma Multiforme



Status:Active, not recruiting
Conditions:Brain Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:8/13/2016
Start Date:October 2009

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Phase I/Randomized Phase II Double Blind Study of Either Dasatinib or Placebo Combined With Bevacizumab in Recurrent Glioblastoma

RATIONALE: Dasatinib may stop the growth of tumor cells by blocking some of the enzymes
needed for cell growth. Monoclonal antibodies, such as bevacizumab, can block tumor growth
in different ways. Some block the ability of tumor cells to grow and spread. Others find
tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may
also block the growth of the tumor by blocking blood flow to the tumor. It is not yet known
whether bevacizumab together with dasatinib are more effective than a placebo in treating
patients with recurrent or progressive high-grade glioma or glioblastoma multiforme.

PURPOSE: This randomized phase I/II trial (Phase I completed) is studying the side effects
and best dose of dasatinib when given together with bevacizumab and to see how well it works
compared to placebo in treating patients with recurrent or progressive high-grade glioma or
glioblastoma multiforme.

OUTLINE: This is a multicenter, phase I, dose-escalation study (Phase I completed) of
dasatinib followed by a phase II randomized study. Patients are grouped according to study
(1 vs 2). Patients in the phase II portion are stratified according to age (> 70 years of
age vs ≤ 70 years of age), and ECOG performance status (0 vs 1 or 2).

Phase I: Patients receive bevacizumab IV over 30-90 minutes on day 1. Patients also receive
oral dasatinib once or twice daily on days 1-14 until the maximum-tolerated dose (MTD) is
determined. Courses repeat every 14 days in the absence of disease progression or
unacceptable toxicity. (Phase I completed) Please see the Arms section for the Phase II
treatment regimens.

OBJECTIVES:

PRIMARY OBJECTIVES:

1. Determine the maximum tolerated dose (MTD) of dasatinib in combination with bevacizumab
in high grade glioma patients. (Phase I)

2. To assess the safety and adverse events of the dasatinib in combination with
bevacizumab in this patient population. (Phase I)

3. To estimate the efficacy of the bevacizumab combination with dasatinib in recurrent
glioblastoma multiforme as measured by progression free survival at six months and
compare it with the efficacy of bevacizumab alone. (Phase II)

SECONDARY OBJECTIVES:

1. To describe the overall toxicity associated with the dasatinib/bevacizumab combination.
(Phase I)

2. To describe any preliminary evidence of antitumor activity. (Phase I)

3. To assess the time to disease progression. (Phase II)

4. To assess the safety and toxicity of the bevacizumab combination with dasatinib in this
patient population. (Phase II)

5. To estimate the efficacy of the bevacizumab combination with dasatinib in recurrent
glioblastoma multiforme as measured by overall survival time and compare it with the
efficacy of bevacizumab alone. (Phase II)

6. To assess the impact of the treatment on the patient's quality of life (QOL) using the
overall score from the FACT-Br (Phase II)

Patient Eligibility:

I. Pre-registration:

1. Central pathology review submission. This review is mandatory prior to registration to
confirm eligibility.

II. Registration Inclusion Criteria:

1. ≥18 years of age

2. Study 1: Histologic confirmation of grade 3 or 4 glioma, including astrocytoma,
oligodendroglioma, and mixed gliomas, as determined by pre-registration central
pathology review.

3. Study 2: Histological confirmation of glioblastoma multiforme (grade 4 astrocytoma)
as determined by pre-registration central pathology review. NOTE: Variant
gliosarcomas are eligible

4. Evidence of tumor progression by MRI or CT scan following RT or following the most
recent anti-tumor therapy. Patients who had surgical treatment at recurrence are
eligible if there is imaging evidence of disease progression as compared to the first
postoperative scan.

5. Bidimensionally measurable or evaluable disease by MRI or CT scan.

6. ECOG Performance Status (PS) 0, 1, or 2.

7. Patient willing to discontinue use of aspirin or medications that inhibit platelet
function ≥ 1 week prior to registration.

8. Previous RT and ≥12 weeks since the completion of RT prior to registration.

9. The following laboratory values obtained ≤ 21 days prior to registration.

- ANC ≥1500

- PLT ≥100,000

- Hgb >9.0 g/dL

- T. bili ≤1.5 x ULN

- SGOT (AST) ≤ 3 x ULN

- Creatinine ≤ ULN

10. UPC ratio <1. NOTE: Urine protein must be screened by urine analysis for Urine
Protein Creatinine (UPC) ratio. For UPC ratio ≥1.0, 24-hour urine protein must be
obtained and the level should be <1000 mg

11. Negative pregnancy test done ≤7 days prior to registration, for women of childbearing
potential only.

12. Ability to complete questionnaire(s) by themselves or with assistance.

13. Provide informed written consent

14. Willingness to return to enrolling institution for follow-up.

15. Patient willing to provide mandatory tissue samples for research purposes

16. Study 1: Any number of prior chemotherapy regimens for recurrent disease. Study 2: Up
to 2 prior chemotherapy regimens with ≤1 regimen for recurrent disease.

III. Exclusion Criteria:

1. Pregnant women, nursing women and men or women of childbearing potential who are
unwilling to employ adequate contraception during this study and for up to 6 months
after bevacizumab treatment has ended. NOTE: bevacizumab and dasatinib are
investigational agents whose genotoxic effects on the developing fetus and newborn
are unknown.

2. Prior intratumoral therapy, stereotactic radiosurgery, or interstitial brachytherapy.

EXCEPTION: Separate lesion on MRI which is not part of the previous treatment field,
or convincing evidence of recurrent disease, based on biopsy, MRI spectroscopy, or
PET scan.

3. Prior treatment with bevacizumab or VEGF-Trap (Aflibercept).

4. Inadequately controlled hypertension (systolic blood pressure of >150 mmHg or
diastolic pressure >100 mmHg on anti-hypertensive medications).

NOTE: Patients with well-controlled hypertension are eligible.

5. Co-morbid systemic illnesses or other severe concurrent disease which, in the
judgment of the investigator, would make the patient inappropriate for entry into
this study or interfere significantly with the proper assessment of safety and
toxicity of the prescribed regimens.

6. Immunocompromised patients (other than that related to the use of corticosteroids).
NOTE: Patients known to be HIV positive, but without clinical evidence of an
immunocompromised state, are eligible for this study.

7. Any condition (e.g., gastrointestinal tract disease resulting in an inability to take
oral medication or a requirement for IV alimentation, or prior surgical procedures
affecting absorption) that impairs ability to swallow pills.

8. Receiving therapeutic anticoagulation with Warfarin. NOTE: Prophylactic
anticoagulation (i.e., low dose warfarin) of venous or arterial access devices is
allowed, provided that INR <1.5. Therapeutic anti-coagulation with low molecular
weight heparin is allowed at time of registration.

9. Evidence of bleeding diathesis (greater than normal risk of bleeding) or coagulopathy
(in the absence of therapeutic anticoagulation).

10. Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, or psychiatric illness/social situations that would limit compliance with
study requirements.

11. Receiving any other investigational agent which would be considered as a treatment
for the primary neoplasm.

12. Other active malignancy ≤3 years prior to registration. EXCEPTIONS: Non-melanotic
skin cancer or carcinoma in-situ of the cervix. Note: If there is a history of prior
malignancy, they must not be receiving other specific treatment (other than hormonal
therapy) for their cancer.

13. History of myocardial infarction or unstable angina ≤6 months prior to registration.

14. New York Heart Association (NYHA) classification II, III or IV congestive heart
failure.

15. Core biopsy or other minor surgical procedures ≤7 days prior to registration. Note:
Placement of a vascular access device is allowed.

16. Major surgical procedure, open biopsy, or significant traumatic injury ≤28 days prior
to registration or anticipation of need for major surgical procedure during the
course of the study.

17. Significant vascular disease (e.g., aortic aneurysm, aortic dissection) or recent
peripheral arterial thrombosis ≤6 months prior to registration.

18. History of hypertensive crisis or hypertensive encephalopathy.

19. Known hypersensitivity to any of the components of dasatinib or bevacizumab.

20. Serious, non-healing wound, active ulcer, or untreated bone fracture

21. History of abdominal fistula, gastrointestinal perforation, or intra-abdominal
abscess ≤6 months prior to registration.

22. Active or recent history of hemoptysis (≥ ½ teaspoon of bright red blood per episode)
≤30 days prior to registration.

23. History of stroke or transient ischemic attack (TIA) ≤6 months prior to registration.

24. Any evidence of CNS hemorrhage on baseline CT or MRI

25. Any of the following Category I drugs that are generally accepted to have a risk of
causing Torsades de Pointes ≤7 days prior to registration (patients must discontinue
drug 7 days prior to starting dasatinib)

- Quinidine, procainamide, disopyramide

- Amiodarone, sotalol, ibutilide, dofetilide

- Erythromycin, clarithromycin

- Chlorpromazine, haloperidol, mesoridazine, thioridazine, pimozide

- Cisapride, bepridil, droperidol, methadone, arsenic, chloroquine, domperidone,
halofantrine, levomethadyl, pentamidine, sparfloxacin, lidoflazine

- Prochlorperazine

26. Diagnosed congenital long QT syndrome

27. Any history of clinically significant ventricular arrhythmias (such as ventricular
tachycardia, ventricular fibrillation, or Torsades de Pointes)

28. Prolonged QTc interval on pre-entry electrocardiogram (>450 msec)

29. Patients may not have any clinically significant cardiovascular disease including the
following:

- Myocardial infarction or ventricular tachyarrhythmia within 6 months.

- Prolonged QTc ≥ 480 msec (Fridericia correction)

- Ejection fraction less than institutional normal

- Major conduction abnormality (unless a cardiac pacemaker is present)

Note: Patients with any cardiopulmonary symptoms of unknown cause (e.g., shortness of
breath, chest pain, etc.) should be evaluated by a baseline echocardiogram with or
without stress test as needed in addition to electrocardiogram (ECG) to rule out QTc
prolongation. The patient may be referred to a cardiologist at the discretion of the
principal investigator. Patients with underlying cardiopulmonary dysfunction should
be excluded from the study.

30. Subjects with hypokalemia or hypomagnesemia if it cannot be corrected prior to
dasatinib administration

31. Known pleural or pericardial effusion of any grade

32. Concomitant use of H2 blockers or proton pump inhibitors that cannot be discontinued
or switched to locally acting agents (i.e. famotidine or omeprazole.)

33. Use of the following Enzyme Inducing Anti-Convulsive (EIAC) medications is prohibited
≤ 7 days prior to registration: carbamazepine (Tegretol®, Tegretol XR®, Carbatrol®),
phenytoin (Dilantin®, Phenytek®), fosphenytoin (Cerebyx®), phenobarbital,
pentobarbital and primidone (Mysoline®). Note: Many antiepileptic drugs induce
hepatic enzymes. Because dasatinib is metabolized by hepatic enzymes, patients taking
antiepileptic medications that induce hepatic enzymes (EIACs) are ineligible for this
trial. To be eligible for this trial, patients taking EIACs must be switched to
non-EIACs ≥ 7 days prior to registration. The following agents are not known to
affect dasatinib metabolism and are acceptable for use: valproic acid (Depakote®,
Depacon®), gabapentin (Neurontin®), lamotrigine (Lamictal®), topiramate (Topamax®),
tiagabine (Gabitril®), zonisamide (Zonegran®), levetiracetam (Keppra®), clonazepam
(Klonopin®) and clobazam (Frisium®).
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1653 W. Congress Parkway
Chicago, Illinois 60612
(312) 942-5000
Rush University Medical Center Rush University Medical Center encompasses a 664-bed hospital serving adults and...
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2600 Clifton Ave
Cincinnati, Ohio 45267
(513) 556-6000
University of Cincinnati The University of Cincinnati offers students a balance of educational excellence and...
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Cincinnati, Ohio 45267
513-584-7698
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12495 University Ave
Clive, Iowa 50325
(515) 358-9700
Mercy Cancer Center - West Lakes When it comes to cancer care, there
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Colombus, Georgia 31904
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Colombus, GA
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2222 N. Nevada Avenue
Colorado Springs, Colorado 80907
(719) 776-5000
Penrose Cancer Center at Penrose Hospital Through a full range of clinical trials, genetic counseling,...
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Colorado Springs, CO
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1831 Fifth Avenue
Columbus, Georgia 31904
(706) 320-8700
John B. Amos Cancer Center The John B. Amos Cancer Center located in Columbus, Georgia,...
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Concord, New Hampshire 03301
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Concord, NH
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250 Pleasant Street
Concord, New Hampshire 03301
603-224-2556
New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care Our Concord office...
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Concord, NH
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11850 Blackfoot St. NW Suite 130
Coon Rapids, Minnesota 55433
763-236-0808
Mercy and Unity Cancer Center at Mercy Hospital The Virginia Piper Cancer Institute - Mercy...
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100 North Academy Avenue
Danville, Pennsylvania 17822
570-271-6211
Geisinger Medical Center Since 1915, Geisinger Medical Center has been known as the region’s resource...
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Danville, PA
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1 Wyoming St
Dayton, Ohio 45409
(937) 208-2300
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Dayton, Ohio 45406
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Dayton, Ohio 45420
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9000 North Main Street
Dayton, Ohio 45415
(937) 734-5800
Samaritan North Cancer Care Center At Good Samaritan Hospital (GSH), our licensed, board-certified staff uses...
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405 W Grand Ave
Dayton, Ohio 45405
(937) 723-3200
Grandview Hospital You'll feel like part of our family when you visit Grandview Medical Center...
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18101 Oakwood Blvd
Dearborn, Michigan 48124
(313) 593-8620
Oakwood Cancer Center at Oakwood Hospital and Medical Center In today's health care environment, a...
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Denver, Colorado 80218
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11600 W 2nd Pl
Denver, Colorado 80204
(720) 321-0000
St. Anthony Central Hospital The St. Anthony Medical Campus in Lakewood combines our heritage of...
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2525 S Downing St
Denver, Colorado 80210
(303) 778-1955
Porter Adventist Hospital Founded in 1930, Porter Adventist Hospital has provided people throughout Denver and...
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1221 Pleasant St
Des Moines, Iowa 50309
(515) 241-4141
John Stoddard Cancer Center at Iowa Methodist Medical Center Iowa's first children's cancer center opened...
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1221 Pleasant St
Des Moines, Iowa 50309
(515) 241-4141
John Stoddard Cancer Center at Iowa Methodist Medical Center Iowa's first children's cancer center opened...
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1221 Pleasant St Suite 100
Des Moines, Iowa 50309
(515) 282-2921
Medical Oncology and Hematology Associates at John Stoddard Cancer Center Iowa's first children's cancer center...
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1221 Pleasant St Suite 100
Des Moines, Iowa 50309
(515) 282-2921
Medical Oncology and Hematology Associates at John Stoddard Cancer Center Iowa's first children's cancer center...
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Des Moines, IA
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300 East Locust St., Ste 350
Des Moines, Iowa 50309
(515) 244-7586
CCOP - Iowa Oncology Research Association The Iowa Oncology Research Association (IORA) was established by...
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411 Laurel St New Visions
Des Moines, Iowa 50314
(515) 247-3970
Medical Oncology and Hematology Associates at Mercy Cancer Center When it comes to cancer care,...
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411 Laurel Street
Des Moines, Iowa 50314
(515) 247-3121
Mercy Cancer Center at Mercy Medical Center - Des Moines When it comes to cancer...
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