A Prospective Observational Study of TPIAT



Status:Recruiting
Conditions:Gastrointestinal, Gastrointestinal, Diabetes
Therapuetic Areas:Endocrinology, Gastroenterology
Healthy:No
Age Range:Any
Updated:9/13/2018
Start Date:January 1, 2017
End Date:April 1, 2021
Contact:Melena Bellin, MD
Email:bell0130@umn.edu
Phone:612-625-4686

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Advancing Treatment for Pancreatitis: A Prospective Observational Study of TPIAT (POST)

Multi-center, prospective, observational cohort study of patients undergoing total
pancreatectomy with islet autotransplantation (TPIAT)

Patients who are undergoing TPIAT at one of the participating center are invited to
participate in this observational study, with 450 participants anticipated. The aims of the
study are:

Aim 1: To determine (1a) whether patient and disease characteristics are associated with
favorable pain and health-related quality-of-life outcomes (HRQOL) after TPIAT; (1b) the
optimal timing of the TPIAT intervention to resolve pain and improve HRQOL; and (1c) in a
subset of patients, the impact of central sensitization on pain resolution.

Aim 2: To determine (2a) whether patient and disease characteristics are associated with
favorable glycemic outcomes from the IAT procedure; and (2b) the optimal timing of TPIAT to
obtain post-surgical insulin independence.

Aim 3: To determine the cost-effectiveness of TPIAT.

Inclusion Criteria:

1. Any patient with chronic or recurrent acute pancreatitis undergoing total or completion
pancreatectomy with islet autotransplantation at a participating center.

Exclusion Criteria:

1. Partial pancreatectomy

2. TPIAT performed for a diagnosis other than chronic or recurrent acute pancreatitis
(for example benign or malignant pancreatic tumor)
We found this trial at
11
sites
500 S Preston St
Louisville, Kentucky
(502) 852-5555
Phone: 502-852-7507
University of Louisville The University of Louisville is a state supported research university located in...
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3333 Burnet Avenue # Mlc3008
Cincinnati, Ohio 45229
 1-513-636-4200 
Phone: 513-803-1971
Cincinnati Children's Hospital Medical Center Patients and families from across the region and around the...
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Cincinnati, OH
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3500 Gaston Avenue
Dallas, Texas 75246
1.800.422.9567
Phone: 214-818-7876
Baylor University Medical Center Baylor University Medical Center in Dallas, TX is ranked nationally in...
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Dallas, TX
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Minneapolis, Minnesota 55455
(612) 625-5000
Phone: 612-626-5905
Univ of Minnesota With a flagship campus in the heart of the Twin Cities, and...
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Minneapolis, MN
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1800 Orleans St.
Baltimore, Maryland 21287
410-955-5000
Phone: 443-761-9157
Johns Hopkins Hospital Patients are the focus of everything we do at The Johns Hopkins...
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Baltimore, MD
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171 Ashley Avenue
Charleston, South Carolina 29425
843-792-1414
Phone: 843-792-7558
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
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Charleston, SC
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5841 S Maryland Ave
Chicago, Illinois 60637
(773) 702-1000
Phone: 773-702-2504
University of Chicago Medical Center The University of Chicago Medicine has been at the forefront...
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Chicago, IL
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410 W 10th Ave
Columbus, Ohio 43210
(614) 293-8652
Phone: 614-688-9575
The Ohio State University, Wexner Medical Center Located in Columbus, The Ohio State University Wexner...
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Columbus, OH
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1 Medical Center Dr
Lebanon, New Hampshire 03756
 (603) 650-5000
Phone: 603-653-9033
Dartmouth Hitchcock Medical Center Dartmouth-Hitchcock is a national leader in patient-centered health care and building...
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Lebanon, NH
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Pittsburgh, PA
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San Francisco, California 94143
Phone: 415-476-2574
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San Francisco, CA
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