A Study of Nivolumab Plus Brentuximab Vedotin Versus Brentuximab Vedotin Alone in Patients With Advanced Stage Classical Hodgkin Lymphoma, Who Are Relapsed/ Refractory or Who Are Not Eligible for Autologous Stem Cell Transplant,



Status:Recruiting
Conditions:Lymphoma
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:4/5/2019
Start Date:May 16, 2017
End Date:July 27, 2023
Contact:Recruiting sites have contact information. Please contact the sites directly. If there is no contact information,
Email:Clinical.Trials@bms.com
Phone:please email:

Use our guide to learn which trials are right for you!

Randomized, Open-label, Phase 3 Trial of Nivolumab Plus Brentuximab Vedotin Versus Brentuximab Vedotin Alone in Participants With Relapsed Refractory or Ineligible for Autologous Stem Cell Transplant (ASCT) Advanced Stage Classical Hodgkin Lymphoma (CheckMate 812: CHECKpoint Pathway and nivoluMAb Clinical Trial Evaluation 812)

The purpose of this study is to determine whether an investigational immuno-therapy
combination, nivolumab with Brentuximab vedotin compared to Brentuximab vedotin alone is safe
and effective in the treatment of relapsed and refractory Classical Hodgkin Lymphoma. The
participants of this trial will comprise of patients who have relapsed or did not respond to
treatment and are not eligible for stem cell transplant


For more information regarding Bristol-Myers Squibb Clinical Trial participation, please
visit www.BMSStudyConnect.com

Inclusion Criteria:

- Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0 or 1

- Participants must have a pathologic diagnosis of classical Hodgkin lymphoma (cHL) who
are relapsed or refractory with one of the following:

I. Autologous stem cell transplant (ASCT) ineligible patients

ii. Patients after failure of ASCT

- Must have at least one lesion that is > 15 mm (1.5 cm) in the longest diameter and
avid by Fluoro Deoxy Glucose (FDG) Positron Emission Tomography (PET) scan

Exclusion Criteria:

- Known central nervous system lymphoma

- Participants with nodular lymphocyte-predominant Hodgkin lymphoma (HL)

- Participants with known history of pancreatitis or progressive multifocal
leukoencephalopathy (PML)

Other protocol defined inclusion/exclusion criteria could apply
We found this trial at
52
sites
Long Beach, California 90813
Phone: 562-590-0345
?
mi
from
Long Beach, CA
Click here to add this to my saved trials
666 Elm Street
Buffalo, New York 14263
(716) 845-2300
Phone: 716-845-4359
Roswell Park Cancer Institute Welcome to Roswell Park Cancer Institute (RPCI), America's first cancer center...
?
mi
from
Buffalo, NY
Click here to add this to my saved trials
529 West Markham Street
Little Rock, Arkansas 72205
(501) 686-7000
University of Arkansas for Medical Sciences The University of Arkansas for Medical Sciences (UAMS) in...
?
mi
from
Little Rock, AR
Click here to add this to my saved trials
2220 Pierce Ave
Nashville, Tennessee 37232
615-936-8422
Phone: 615-936-3236
Vanderbilt-Ingram Cancer Center The Vanderbilt-Ingram Cancer Center, located in Nashville, Tenn., brings together the clinical...
?
mi
from
Nashville, TN
Click here to add this to my saved trials
24 Sturtevant St
Orlando, Florida 32806
Phone: 321-841-1907
?
mi
from
Orlando, FL
Click here to add this to my saved trials
520 Smollett Street
Albury, New South Wales 2640
?
mi
from
Albury,
Click here to add this to my saved trials
?
mi
from
Basking Ridge, NJ
Click here to add this to my saved trials
Boston, Massachusetts 02115
Phone: 617-582-7292
?
mi
from
Boston, MA
Click here to add this to my saved trials
171 Ashley Avenue
Charleston, South Carolina 29425
843-792-1414
Phone: 843-792-8856
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
?
mi
from
Charleston, SC
Click here to add this to my saved trials
Charlottesville, Virginia 22908
?
mi
from
Charlottesville, VA
Click here to add this to my saved trials
1801 Inwood Rd
Dallas, Texas 75390
(214) 645-3300
Phone: 214-648-7030
University of Texas Southwestern Medical Center UT Southwestern is an academic medical center, world-renowned for...
?
mi
from
Dallas, TX
Click here to add this to my saved trials
Detroit, Michigan 48201
Phone: 313-576-9689
?
mi
from
Detroit, MI
Click here to add this to my saved trials
1500 East Duarte Road
Duarte, California 91010
626-256-HOPE (4673)
Phone: 626-218-9108
City of Hope National Medical Center City of Hope is dedicated to making a difference...
?
mi
from
Duarte, CA
Click here to add this to my saved trials
2301 Erwin Rd
Durham, North Carolina 27710
919-684-8111
Phone: 919-681-4769
Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
?
mi
from
Durham, NC
Click here to add this to my saved trials
Fort Wayne, Indiana 46845
Phone: 574-364-2974
?
mi
from
Fort Wayne, IN
Click here to add this to my saved trials
Greenville, North Carolina 27834
Phone: 252-744-4924
?
mi
from
Greenville, NC
Click here to add this to my saved trials
Greenville, South Carolina 29607
Phone: 864-603-6222
?
mi
from
Greenville, SC
Click here to add this to my saved trials
92 2nd St
Hackensack, New Jersey 07601
(201) 996-5900
Phone: 551-996-5168
John Theurer Cancer Center at the Hackensack University Medical Center The mission of the John...
?
mi
from
Hackensack, NJ
Click here to add this to my saved trials
500 Westchester Avenue
Harrison, New York 10604
?
mi
from
Harrison, NY
Click here to add this to my saved trials
1515 Holcombe Blvd
Houston, Texas 77030
 713-792-2121
Phone: 713-792-1871
University of Texas M.D. Anderson Cancer Center The mission of The University of Texas MD...
?
mi
from
Houston, TX
Click here to add this to my saved trials
Jacksonville, Florida
Phone: 904-202-7332
?
mi
from
Jacksonville, FL
Click here to add this to my saved trials
3001 McClelland Blvd
Joplin, Missouri 64804
Phone: 417-556-3074
?
mi
from
Joplin, MO
Click here to add this to my saved trials
Knoxville, Tennessee 37920
Phone: 865-541-1812
?
mi
from
Knoxville, TN
Click here to add this to my saved trials
Knoxville, Tennessee 37909
Phone: 865-934-2670
?
mi
from
Knoxville, TN
Click here to add this to my saved trials
La Jolla, California 92093
Phone: 858-822-1921
?
mi
from
La Jolla, CA
Click here to add this to my saved trials
Los Angeles, California 90095
Phone: 949653295920829
?
mi
from
Los Angeles, CA
Click here to add this to my saved trials
Louisville, Kentucky 40202
Phone: 502-899-6147
?
mi
from
Louisville, KY
Click here to add this to my saved trials
Miami, Florida 33143
Phone: 786-527-8866
?
mi
from
Miami, FL
Click here to add this to my saved trials
480 Red Hill Road
Middletown, New Jersey 07748
?
mi
from
Middletown, NJ
Click here to add this to my saved trials
1660 Spring Hill Avenue
Mobile, Alabama 36604
?
mi
from
Mobile, AL
Click here to add this to my saved trials
New Orleans, Louisiana 70121
Phone: 504-842-8084
?
mi
from
New Orleans, LA
Click here to add this to my saved trials
1430 Tulane Ave Suite SL32
New Orleans, Louisiana 70112
(504) 588-5912
Tulane University Health Sciences Center One of the nation's most recognized centers for medical education,...
?
mi
from
New Orleans, LA
Click here to add this to my saved trials
New York, New York 10016
?
mi
from
New York, NY
Click here to add this to my saved trials
1275 York Ave
New York, New York 10021
(212) 639-2000
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
?
mi
from
New York, NY
Click here to add this to my saved trials
420 McPhee Road Southwest
Olympia, Washington 98502
?
mi
from
Olympia, WA
Click here to add this to my saved trials
Palo Alto, California 94304
?
mi
from
Palo Alto, CA
Click here to add this to my saved trials
Philadelphia, Pennsylvania 19102
?
mi
from
Philadelphia, PA
Click here to add this to my saved trials
3451 Walnut St
Philadelphia, Pennsylvania 19104
1 (215) 898-5000
Phone: 215-662-2062
Univ of Pennsylvania Penn has a long and proud tradition of intellectual rigor and pursuit...
?
mi
from
Philadelphia, PA
Click here to add this to my saved trials
Plainville, Connecticut 06062
Phone: 860-696-4958
?
mi
from
Plainville, CT
Click here to add this to my saved trials
4050 Wake Forest Road
Raleigh, North Carolina 27609
?
mi
from
Raleigh, NC
Click here to add this to my saved trials
Rochester, Minnesota 55905
?
mi
from
Rochester, MN
Click here to add this to my saved trials
Rochester, New York 14642
?
mi
from
Rochester, NY
Click here to add this to my saved trials
?
mi
from
Rockville Centre, NY
Click here to add this to my saved trials
4501 X St
Sacramento, California 95817
(916) 734-5800
Phone: 916-734-1455
UC Davis Comprehensive Cancer Center When faced with cancer, you want the best hope for...
?
mi
from
Sacramento, CA
Click here to add this to my saved trials
San Antonio, Texas 78229
?
mi
from
San Antonio, TX
Click here to add this to my saved trials
Seattle, Washington 98104
Phone: 206-215-3350
?
mi
from
Seattle, WA
Click here to add this to my saved trials
Spartanburg, South Carolina 29307
Phone: 864-987-1258
?
mi
from
Spartanburg, SC
Click here to add this to my saved trials
Springfield, Missouri 65807
Phone: 417-820-9742
?
mi
from
Springfield, MO
Click here to add this to my saved trials
Tampa, Florida
Phone: 813-745-2591
?
mi
from
Tampa, FL
Click here to add this to my saved trials
3800 Reservoir Rd NW
Washington, District of Columbia 20007
(202) 444-2000
Phone: 202-687-7354
Georgetown University Hospital MedStar Georgetown University Hospital is a not-for-profit, acute-care teaching and research hospital...
?
mi
from
Washington,
Click here to add this to my saved trials
Westwood, Kansas 66205
Phone: 913-588-8694
?
mi
from
Westwood, KS
Click here to add this to my saved trials
1 Medical Center Blvd
Winston-Salem, North Carolina 27157
336-716-2011
Wake Forest University Health Sciences Welcome to Wake Forest Baptist Medical Center, a fully integrated...
?
mi
from
Winston-Salem, NC
Click here to add this to my saved trials