A Study of Nivolumab Plus Brentuximab Vedotin Versus Brentuximab Vedotin Alone in Patients With Advanced Stage Classical Hodgkin Lymphoma, Who Are Relapsed/ Refractory or Who Are Not Eligible for Autologous Stem Cell Transplant,
| Status: | Recruiting |
|---|---|
| Conditions: | Lymphoma |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/5/2019 |
| Start Date: | May 16, 2017 |
| End Date: | July 27, 2023 |
| Contact: | Recruiting sites have contact information. Please contact the sites directly. If there is no contact information, |
| Email: | Clinical.Trials@bms.com |
| Phone: | please email: |
Randomized, Open-label, Phase 3 Trial of Nivolumab Plus Brentuximab Vedotin Versus Brentuximab Vedotin Alone in Participants With Relapsed Refractory or Ineligible for Autologous Stem Cell Transplant (ASCT) Advanced Stage Classical Hodgkin Lymphoma (CheckMate 812: CHECKpoint Pathway and nivoluMAb Clinical Trial Evaluation 812)
The purpose of this study is to determine whether an investigational immuno-therapy
combination, nivolumab with Brentuximab vedotin compared to Brentuximab vedotin alone is safe
and effective in the treatment of relapsed and refractory Classical Hodgkin Lymphoma. The
participants of this trial will comprise of patients who have relapsed or did not respond to
treatment and are not eligible for stem cell transplant
combination, nivolumab with Brentuximab vedotin compared to Brentuximab vedotin alone is safe
and effective in the treatment of relapsed and refractory Classical Hodgkin Lymphoma. The
participants of this trial will comprise of patients who have relapsed or did not respond to
treatment and are not eligible for stem cell transplant
For more information regarding Bristol-Myers Squibb Clinical Trial participation, please
visit www.BMSStudyConnect.com
Inclusion Criteria:
- Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0 or 1
- Participants must have a pathologic diagnosis of classical Hodgkin lymphoma (cHL) who
are relapsed or refractory with one of the following:
I. Autologous stem cell transplant (ASCT) ineligible patients
ii. Patients after failure of ASCT
- Must have at least one lesion that is > 15 mm (1.5 cm) in the longest diameter and
avid by Fluoro Deoxy Glucose (FDG) Positron Emission Tomography (PET) scan
Exclusion Criteria:
- Known central nervous system lymphoma
- Participants with nodular lymphocyte-predominant Hodgkin lymphoma (HL)
- Participants with known history of pancreatitis or progressive multifocal
leukoencephalopathy (PML)
Other protocol defined inclusion/exclusion criteria could apply
We found this trial at
52
sites
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666 Elm Street
Buffalo, New York 14263
Buffalo, New York 14263
(716) 845-2300
Phone: 716-845-4359
Roswell Park Cancer Institute Welcome to Roswell Park Cancer Institute (RPCI), America's first cancer center...
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529 West Markham Street
Little Rock, Arkansas 72205
Little Rock, Arkansas 72205
(501) 686-7000
University of Arkansas for Medical Sciences The University of Arkansas for Medical Sciences (UAMS) in...
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2220 Pierce Ave
Nashville, Tennessee 37232
Nashville, Tennessee 37232
615-936-8422
Phone: 615-936-3236
Vanderbilt-Ingram Cancer Center The Vanderbilt-Ingram Cancer Center, located in Nashville, Tenn., brings together the clinical...
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171 Ashley Avenue
Charleston, South Carolina 29425
Charleston, South Carolina 29425
843-792-1414
Phone: 843-792-8856
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
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1801 Inwood Rd
Dallas, Texas 75390
Dallas, Texas 75390
(214) 645-3300
Phone: 214-648-7030
University of Texas Southwestern Medical Center UT Southwestern is an academic medical center, world-renowned for...
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1500 East Duarte Road
Duarte, California 91010
Duarte, California 91010
626-256-HOPE (4673)
Phone: 626-218-9108
City of Hope National Medical Center City of Hope is dedicated to making a difference...
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Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
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Greenville, North Carolina 27834
Phone: 252-744-4924
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92 2nd St
Hackensack, New Jersey 07601
Hackensack, New Jersey 07601
(201) 996-5900
Phone: 551-996-5168
John Theurer Cancer Center at the Hackensack University Medical Center The mission of the John...
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1515 Holcombe Blvd
Houston, Texas 77030
Houston, Texas 77030
713-792-2121
Phone: 713-792-1871
University of Texas M.D. Anderson Cancer Center The mission of The University of Texas MD...
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3001 McClelland Blvd
Joplin, Missouri 64804
Joplin, Missouri 64804
Phone: 417-556-3074
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1430 Tulane Ave Suite SL32
New Orleans, Louisiana 70112
New Orleans, Louisiana 70112
(504) 588-5912
Tulane University Health Sciences Center One of the nation's most recognized centers for medical education,...
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Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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3451 Walnut St
Philadelphia, Pennsylvania 19104
Philadelphia, Pennsylvania 19104
1 (215) 898-5000
Phone: 215-662-2062
Univ of Pennsylvania Penn has a long and proud tradition of intellectual rigor and pursuit...
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Plainville, Connecticut 06062
Phone: 860-696-4958
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4501 X St
Sacramento, California 95817
Sacramento, California 95817
(916) 734-5800
Phone: 916-734-1455
UC Davis Comprehensive Cancer Center When faced with cancer, you want the best hope for...
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3800 Reservoir Rd NW
Washington, District of Columbia 20007
Washington, District of Columbia 20007
(202) 444-2000
Phone: 202-687-7354
Georgetown University Hospital MedStar Georgetown University Hospital is a not-for-profit, acute-care teaching and research hospital...
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1 Medical Center Blvd
Winston-Salem, North Carolina 27157
Winston-Salem, North Carolina 27157
336-716-2011
Wake Forest University Health Sciences Welcome to Wake Forest Baptist Medical Center, a fully integrated...
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