Cabozantinib S-Malate, Crizotinib, Savolitinib, or Sunitinib Malate in Treating Patients With Locally Advanced or Metastatic Kidney Cancer



Status:Recruiting
Conditions:Cancer, Cancer, Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:4/4/2019
Start Date:April 5, 2016

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A Randomized, Phase II Efficacy Assessment of Multiple MET Kinase Inhibitors (Cabozantinib [NSC #761968], Crizotinib [NSC #749005], Savolitinib [NSC #785348], and Sunitinib [NSC #736511]) in Metastatic Papillary Renal Carcinoma (PAPMET)

This randomized phase II trial studies how well cabozantinib s-malate, crizotinib,
savolitinib, or sunitinib malate work in treating patients with kidney cancer that has spread
from where it started to nearby tissue or lymph nodes or to other places in the body.
Cabozantinib s-malate, crizotinib, savolitinib, and sunitinib malate may stop the growth of
tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known
whether giving cabozantinib s-malate, crizotinib, or savolitinib will work better in treating
patients with kidney cancer compared to sunitinib malate.

PRIMARY OBJECTIVES:

I. To compare progression-free survival (PFS) in patients with metastatic papillary renal
cell carcinoma (mPRCC) treated with sunitinib malate (sunitinib) to PFS in patients with
mPRCC treated with MET kinase inhibitors.

SECONDARY OBJECTIVES:

I. To compare Response Evaluation Criteria in Solid Tumors (RECIST) response rate (RR;
defined as the combined rate of confirmed and unconfirmed partial response [PR] and complete
response [CR]) in patients with mPRCC treated with sunitinib to RR in patients treated with
putative MET inhibitors.

II. To compare overall survival (OS) in patients with mPRCC treated with sunitinib to OS in
patients with mPRCC treated with putative MET inhibitors.

III. To compare the safety profile of sunitinib and putative MET inhibitors in patients with
mPRCC.

TRANSLATIONAL OBJECTIVES:

I. To evaluate the prognostic and predictive value of MET mutations, MET copy number or other
markers of MET signaling in patients with mPRCC treated with putative MET inhibitors.

OUTLINE: Patients are randomized to 1 of 4 treatment arms. As of 12/5/18, patients will only
be randomized to Arm I or Arm II.

ARM I: Patients receive sunitinib malate orally (PO) on days 1-28.

ARM II: Patients receive cabozantinib s-malate PO on days 1-42.

ARM III (CLOSED TO ACCRUAL 12/5/18): Patients receive crizotinib PO twice daily (BID) on days
1-42.

ARM IV (CLOSED TO ACCRUAL 12/5/18): Patients receive savolitinib PO on days 1-42.

In all arms, courses repeat every 42 days in the absence of disease progression or
unacceptable toxicity.

After completion of study treatment, patients are followed up for 3 years.

Inclusion Criteria:

- Patients must have histologically or cytologically confirmed papillary histology renal
cell carcinoma which is metastatic or locally advanced disease not amenable to
surgical resection; (NOTE: a designation of type I or type II should be made by the
local pathologist if possible); mixed histologies containing type I or type II will be
allowed provided that they contain >= 50% of the papillary component

- Patients must also have measurable disease, defined as at least one lesion that can be
accurately measured in at least one dimension; disease X-rays, scans or physical
examinations used for tumor measurement must have been completed within 28 days prior
to registration; if there is clinical suspicion for bone metastases at the time of
enrollment (at the discretion of the investigator), bone scan should be performed at
baseline (within 42 days prior to registration); all disease must be assessed and
documented on the Baseline Tumor Assessment form

- Patients with a history of treated brain metastases who are asymptomatic and have not
received steroid therapy in the 14 days prior to registration are eligible;
anti-seizure medications are allowed provided they are non-enzyme inducing (e.g.
topiramate, levetiracetam, gabapentin)

- Patients must not have cavitating pulmonary lesions; patients must not have tumor
invading the gastrointestinal (GI) tract or evidence of endotracheal or endobronchial
tumor within 28 days prior to registration

- Patients may have received prior surgery; at least 28 days must have elapsed since
surgery and patient must have recovered from any adverse effects of surgery

- Patients may have received up to one prior systemic therapy for advanced or metastatic
renal cell carcinoma with the exception of another VEGF inhibitor Food and Drug
Administration (FDA)-approved for advanced RCC (i.e., pazopanib, bevacizumab,
sorafenib or axitinib); if a patient develops metastatic disease within six months of
discontinuation of adjuvant therapy, this will constitute one prior systemic therapy
for advanced or metastatic renal cell carcinoma (RCC); if a patient develops
metastatic disease and more than six months has elapsed since discontinuation of
adjuvant therapy, this will not constitute prior systemic therapy for advanced or
metastatic RCC; patients may have also received prior immunotherapy; patients must not
have received a MET/hepatocyte growth factor (HGF) inhibitor or sunitinib as prior
therapy; at least 14 days must have elapsed since completion of prior systemic
therapy; patients must have recovered from all associated toxicities at the time of
registration

- Patients may have received prior radiation therapy, but must have measurable disease
outside the radiation port; at least 14 days must have elapsed since completion of
prior radiation therapy; patients must have recovered from all associated toxicities
at the time of registration

- Patients must not be taking, nor plan to take while on protocol treatment, strong
CYP3A4 inhibitors (e.g. boceprevir, cobicistat, danoprevir, elvitegravir/RIT,
fluvoxamine, indinavir, itraconazole, ketoconazole, lopinavir/RIT, nefazodone,
nelfinavir, posaconazole, ritonavir, telaprevir, telithromycin, tipravavir/RIT, or
voriconazole); strong CYP3A4 inducers (e.g. avasimibe, phenytoin, rifampin,
rifabutin); potent inhibitors of CYP1A2 (e.g. ciprofloxacin); and/or drugs known to be
CYP3A4 substrates with a narrow therapeutic range (e.g., diergotamine, ergotamine)
within 14 days prior to randomization; moderate inhibitors or inducers of isoenzyme
CYP3A4 should be avoided, but if necessary can be used with caution

- Patients must not be receiving or planning to receive any other investigational agents

- Patients must have a complete physical examination and medical history within 28 days
prior to registration

- Patients must have a Zubrod performance status of 0 - 1

- White blood cell count (WBC) >= 2,000/mcL (must be obtained within 28 days prior to
registration)

- Absolute neutrophil count (ANC) >= 1,000/mcL (must be obtained within 28 days prior to
registration)

- Platelet count >= 75,000/mcL (must be obtained within 28 days prior to registration)

- Serum bilirubin =< 1.5 x institutional upper limits of normal (ULN) (must be obtained
within 28 days prior to registration)

- Serum transaminase (serum glutamic oxaloacetic transaminase [SGOT]/aspartate
aminotransferase [AST] and serum glutamate pyruvate transaminase [SGPT]/alanine
aminotransferase [ALT]) must be =< 2.5 x the institutional ULN unless the liver is
involved with the tumor, in which case serum transaminase (SGOT/SGPT) must be =< 5 x
the institutional ULN (must be obtained within 28 days prior to registration)

- Serum creatinine must be =< 2 x the institutional ULN OR creatinine clearance (either
measured or calculated) must be > 30 mL/min (must be obtained within 28 days prior to
registration)

- Patients must not have any clinical evidence of congestive heart failure (CHF)
(specifically, New York Heart Association [NYHA] class III [moderate] or class IV
[severe]) at the time of registration; baseline echocardiogram within 28 days of
registration must demonstrate an ejection fraction (EF) >= 50%; patients must have
corrected QT (QTc) interval < 500 msec on prestudy electrocardiogram (EKG) and no
known history of congenital long QT syndrome; patients must not have experienced
unstable angina pectoris, clinically significant cardiac arrhythmias, or stroke
(transient ischemic attack [TIA] or other ischemic event) within 3 months prior to
registration and not have experienced myocardial infarction or thromboembolic event
requiring anticoagulation within 6 months of registration; prestudy EKG must be
obtained within 28 days prior to registration

- Baseline urinalysis should show urine protein < 3+ and must be obtained within 28 days
prior to registration; if urine protein is 3+ or greater, then urine protein by 24
hour collection must show less than 3 grams of protein

- Patients must not have inadequately controlled hypertension; patients must have
documented blood pressures of systolic blood pressure (SBP) < 150 and diastolic blood
pressure (DBP) < 90 within 14 days of starting randomization; blood pressure
medications (any number) are permitted

- Patients must be able to take oral medications (i.e., swallow pills whole); patients
must not have gastrointestinal tract disease resulting in an inability to take oral
medication or a requirement for intravenous (IV) alimentation, prior surgical
procedures that could in the opinion of the treating investigator affect absorption,
or active peptic ulcer disease; patients with intractable nausea or vomiting are not
eligible

- Patients must not have had any clinically-significant GI bleeding within 6 months
prior to registration and patients must not have a GI disorder which (at the
discretion of the investigator) bears a high risk of perforation or fistula; examples
of this include (but are not limited to) Crohn's disease or tumor with transmural
extension through the gastrointestinal lining

- Patients must not have had hemoptysis of >= 0.5 teaspoon (2.5 ml) of red blood within
3 months prior registration

- Patients must not demonstrate any other signs indicative of pulmonary hemorrhage
within 3 months prior to registration

- Patient's baseline imaging must not indicate the presence of tumor invading or
encasing any major blood vessels

- Patients must not have any unresolved wounds from previous surgery

- Albumin, alkaline phosphatase, bicarbonate, blood urea (BUN), chloride, glucose,
phosphorus, and total protein must be assessed within 28 days of registration

- No other prior malignancy is allowed except for the following: adequately treated
basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated
stage I or II cancer from which the patient is currently in complete remission, or any
other cancer from which the patient has been disease free for 3 years; men receiving
active surveillance for prostate cancer may also be enrolled

- Due to the unknown effects of the study drugs, patients must not be pregnant or
nursing; women/men of reproductive potential must have agreed to use an effective
contraceptive method while receiving study drug and for three months after last dose
of study drug; a woman is considered to be of "reproductive potential" if she has had
menses at any time in the preceding 12 consecutive months; in addition to routine
contraceptive methods, "effective contraception" also includes heterosexual celibacy
and surgery intended to prevent pregnancy (or with a side-effect of pregnancy
prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal
ligation; however, if at any point a previously celibate patient chooses to become
heterosexually active during the time period for use of contraceptive measures
outlined in the protocol, he/she is responsible for beginning contraceptive measures

- Human immunodeficiency virus (HIV)-positive patients on combination antiretroviral
therapy are ineligible because of the potential for pharmacokinetic interactions with
cabozantinib, crizotinib, savolitinib or sunitinib; in addition these patients are at
increased risk of lethal infections when treated with marrow suppressive therapy;
appropriate studies will be undertaken in patients receiving combination
antiretroviral therapy when indicated

- Patients must have tissue available and be willing to submit for independent
pathologic review in order to classify type I versus type II papillary disease

- Patients must be offered the opportunity to participate in specimen banking for future
translational medicine studies

- Patients must be informed of the investigational nature of this study and must sign
and give written informed consent in accordance with institutional and federal
guidelines

- As a part of the OPEN registration process the treating institution's identity is
provided in order to ensure that the current (within 365 days) date of institutional
review board approval for this study has been entered in the system.
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Branson, Missouri 65616
Principal Investigator: Jay W. Carlson
Phone: 417-269-4520
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7575 Grand River Avenue
Brighton, Michigan 48114
Principal Investigator: Tareq Al Baghdadi
Phone: 734-712-3671
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7575 Grand River Avenue
Brighton, Michigan 48114
Principal Investigator: Tareq Al Baghdadi
Phone: 734-712-3671
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Brighton, MI
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Bronx, New York 10467
Principal Investigator: Benjamin A. Gartrell
Phone: 718-379-6866
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Bronx, NY
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Bronx, New York 10461
Principal Investigator: Benjamin A. Gartrell
Phone: 718-379-6866
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Bronx, NY
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Bronx, New York 10461
Principal Investigator: Benjamin A. Gartrell
Phone: 718-379-6866
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Bronx, NY
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Burbank, California
Principal Investigator: Gary E. Goodman
Phone: 818-847-4793
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Burbank, CA
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1501 Trousdale Drive
Burlingame, California 94010
Principal Investigator: Ari D. Baron
Phone: 650-696-4487
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Burlingame, CA
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Burlington, Wisconsin 53105
Principal Investigator: Antony Ruggeri
Phone: 414-302-2304
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Burlington, WI
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201 E Nicollet Blvd
Burnsville, Minnesota 55337
(952) 892-2000
Principal Investigator: David M. King
Phone: 952-993-1517
Fairview Ridges Hospital Fairview Ridges Hospital is a 150-bed, Level III Trauma Care facility, offering...
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Burnsville, MN
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400 South Clark Street
Butte, Montana 59701
406-723-2500
Principal Investigator: Benjamin T. Marchello
Phone: 800-648-6274
Saint James Community Hospital and Cancer Treatment Center St. James Healthcare has played an important...
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Butte, MT
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3123 Medical Dr
Caldwell, Idaho 83605
Principal Investigator: Benjamin T. Marchello
Phone: 734-712-3671
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Caldwell, ID
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Calgary, Alberta
Principal Investigator: Daniel Y. Heng
Phone: 403-521-3433
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Cameron Park, California 95682
Principal Investigator: Ari D. Baron
Phone: 415-209-2686
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210 W Walnut St
Canton, Illinois 61520
309-647-5240
Principal Investigator: Bryan A. Faller
Phone: 309-243-3605
Illinois CancerCare - Canton Illinois CancerCare is one of the largest private oncology and hematology...
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1600 South Canton Center Road
Canton, Michigan 48188
Principal Investigator: Tareq Al Baghdadi
Phone: 734-712-3671
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1600 South Canton Center Road
Canton, Michigan 48188
Principal Investigator: Tareq Al Baghdadi
Phone: 734-712-3671
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211 Saint Francis Drive
Cape Girardeau, Missouri 63703
573-331-3000
Principal Investigator: Bryan A. Faller
Phone: 573-334-2230
Saint Francis Medical Center Saint Francis Medical Center is a 282-bed facility serving more than...
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789 Mt Auburn Rd
Cape Girardeau, Missouri 63703
(573) 519-4725
Principal Investigator: Bryan A. Faller
Phone: 573-651-5550
Southeast Cancer Center SoutheastHEALTH is a far-reaching network of providers and facilities including Southeast Hospital...
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Cape Girardeau, MO
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Carbondale, Illinois 62902
Principal Investigator: Bryan A. Faller
Phone: 618-457-5200
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Carbondale, IL
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401 North Hooper Street
Caro, Michigan 48723
Principal Investigator: Tareq Al Baghdadi
Phone: 734-712-3671
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Caro, MI
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Carson City, Nevada 89703
Principal Investigator: John A. Ellerton
Phone: 702-384-0013
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Carson City, NV
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Carterville, Illinois 62918
Principal Investigator: Bryan A. Faller
Phone: 618-985-3333
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160 S Adams St
Carthage, Illinois 62321
(217) 357-6877
Principal Investigator: Bryan A. Faller
Phone: 309-243-3605
Illinois CancerCare - Carthage Illinois CancerCare, P.C. is a comprehensive practice treating patients withcancer andblood...
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Carthage, IL
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Castro Valley, California 94546
Principal Investigator: Ari D. Baron
Phone: 415-209-2686
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Castro Valley, CA
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Centerville, Ohio 45459
Principal Investigator: Howard M. Gross
Phone: 937-775-1350
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Centerville, OH
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Centerville, Ohio 45459
Principal Investigator: Howard M. Gross
Phone: 937-775-1350
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Centerville, OH
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Centralia, Illinois 62801
Principal Investigator: Bryan A. Faller
Phone: 217-876-4740
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Centralia, IL
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Centralia, Washington 98531
Principal Investigator: Gary E. Goodman
Phone: 360-412-8958
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505 S Plummer Ave
Chanute, Kansas 66720
(620) 431-7580
Principal Investigator: Shaker R. Dakhil
Phone: 316-268-5374
Cancer Center of Kansas, PA - Chanute Dr. H.E. Hynes founded Cancer Center of Kansas,...
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171 Ashley Avenue
Charleston, South Carolina 29425
843-792-1414
Principal Investigator: Michael B. Lilly
Phone: 843-792-9321
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
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775 South Main Street
Chelsea, Michigan 48118
Principal Investigator: Tareq Al Baghdadi
Phone: 734-712-3671
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Chelsea, MI
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