Safety and Efficacy Study of a Protease Activated Receptor-4 Antagonist Being Tested to Reduce the Chances of Having Additional Strokes or "Mini Strokes"



Status:Completed
Conditions:Cardiology
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - Any
Updated:12/16/2018
Start Date:April 25, 2016
End Date:March 31, 2017

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A Phase 2, Placebo Controlled, Randomized, Double-Blind, Parallel-Arm Study to Evaluate Efficacy and Safety of BMS- 986141 For the Prevention of Recurrent Brain Infarction in Subjects Receiving Acetylsalicylic Acid (ASA) Following Acute Ischemic Stroke or Transient Ischemic Attack

The purpose of this study is to determine whether BMS-986141 is effective in reducing the
recurrence of stroke in people who recently had a stroke, or a transient ischemic attack
(known as a TIA or "mini stroke") and are receiving acetylsalicylic acid (also known as
aspirin or ASA) to treat the stroke or TIA.


For more information regarding BMS clinical trial participation, please visit
www.BMSStudyConnect.com

Inclusion Criteria:

- Male or female, age 18 or older

- Must have had a very recent stroke or transient ischemic attack ("mini stroke") that
can be confirmed by the study doctor

- Able to be assigned to a study group no later than 48 hours after the stroke occurred

- Has an image of the brain that confirms that the stroke was not caused by hemorrhage
or other reason that could explain symptoms

Exclusion Criteria:

- A suspicion by the study doctor that the transient ischemic attack or stroke was
caused by a blood clot that formed in the heart; examples of this include history of
an abnormal heart rhythm known as atrial fibrillation or a ventricular aneurysm or
defect of the heart.

- Any condition requiring treatment with an anticoagulant

- History of intracranial hemorrhage ("bleeding in the brain")

- Gastrointestinal ("stomach or intestinal") bleeding in the last 3 months that required
treatment

- Planned or anticipated invasive surgery or procedure during the study

- Unable to tolerate MRI procedures.
We found this trial at
28
sites
Newark, Delaware 19713
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800 Washington St
Boston, Massachusetts 02111
(617) 636-5000
Tufts Medical Center Tufts Medical Center is an internationally-respected academic medical center – a teaching...
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Gainesville, Florida 32610
(352) 392-3261
Phone: 352-273-6448
University of Florida The University of Florida (UF) is a major, public, comprehensive, land-grant, research...
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Gainesville, FL
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3400 Spruce St
Philadelphia, Pennsylvania 19104
 (215) 662-4000
Hospital of the University of Pennsylvania The Hospital of the University of Pennsylvania (HUP) is...
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4805 Northeast Glisan Street
Portland, Oregon 97213
(503) 215-1111
Providence Portland Medical Center We strive to give those we serve exceptional, compassionate health care...
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Portland, OR
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3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
Phone: 503-494-6865
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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Portland, OR
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Sarasota, Florida 34232
Phone: 941-330-1864
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Sarasota, FL
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Baltimore, Maryland 21237
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Boston, Massachusetts 02118
Phone: 617-414-1171
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Chapel Hill, North Carolina 27599
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Chapel Hill, NC
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171 Ashley Avenue
Charleston, South Carolina 29425
843-792-1414
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
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2301 Erwin Rd
Durham, North Carolina 27710
919-684-8111
Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
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Edison, New Jersey
Phone: 732-321-7000
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Great Falls, Montana 59405
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Greensboro, North Carolina 27405
Phone: 336-478-2484
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Jacksonville, Florida 32209
Phone: 904-244-9814
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Joliet, Illinois 60435
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Kansas City, Missouri 64111
Phone: 816-932-7985
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500 S Preston St
Louisville, Kentucky
(502) 852-5555
University of Louisville The University of Louisville is a state supported research university located in...
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Memphis, Tennessee 38103
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Morgantown, West Virginia 26506
(304) 293-0111
Phone: 304-598-4000
West Virginia University West Virginia University, founded in 1867, has a long and rich history...
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Nagoya, Aichi 46000
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Newport Beach, California 92663
Phone: 949-764-8190
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Omaha, Nebraska 68114
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601 E Rollins St
Orlando, Florida 32803
(407) 303-5600
Florida Hospital Florida Hospital is one of the country
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Phoenix, Arizona 85006
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9205 SW Barnes Rd
Portland, Oregon 97225
(503) 216-1234
Providence St. Vincent Medical Center Providence St. Vincent is renowned for its many centers of...
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York, Pennsylvania 17315
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