Evaluation of Galcanezumab in the Prevention of Episodic Migraine- the EVOLVE-1 Study
| Status: | Completed |
|---|---|
| Conditions: | Migraine Headaches |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 12/1/2018 |
| Start Date: | November 30, 2015 |
| End Date: | August 9, 2018 |
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of LY2951742 in Patients With Episodic Migraine - the EVOLVE-1 Study
The main purpose of this study is to evaluate the efficacy of the study drug known as
galcanezumab in participants with episodic migraine.
galcanezumab in participants with episodic migraine.
Inclusion Criteria:
- Have a diagnosis of episodic migraine as defined by International Headache Society
(IHS) International Classification of Headache Disorders (ICHD)-3 beta guidelines (1.1
or 1.2) (ICHD-3 2013), with a history of migraine headaches of at least 1 year prior
to screening, migraine onset prior to age 50 and MONTHLY frequency of 4-14 Migraine
Headache Days (MHD).
Exclusion Criteria:
- Are currently enrolled in or have participated within the last 30 days or within 5
half-lives (whichever is longer) in a clinical trial involving an investigational
product.
- Current use or prior exposure to Galcanezumab or another CGRP antibody.
- Known hypersensitivity to multiple drugs, monoclonal antibodies or other therapeutic
proteins, or to Galcanezumab.
- History of persistent daily headache, cluster headache or migraine subtypes including
hemiplegic (sporadic or familial) migraine, ophthalmoplegic migraine, and migraine
with brainstem aura (basilar-type migraine) defined by IHS ICHD-3 beta.
We found this trial at
82
sites
Gainesville, Florida 32607
Principal Investigator: Michael Johnson
Phone: 352-333-0094
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3635 S. Clyde Morris Blvd
Port Orange, Florida 32129
Port Orange, Florida 32129
386-760-3862
Principal Investigator: Craig Dean
About Us Accord Clinical Research is a privately owned research facility, founded in Port Orange,...
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1000 Alpine
Boulder, Colorado 80304
Boulder, Colorado 80304
303-443-7229
Principal Investigator: Paul Brownstone
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2417 Marshall Ave.
Imperial, California 92251
Imperial, California 92251
760-355-0176
Principal Investigator: Bernardo Ng
Phone: 760-545-0123
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400 Gresham Dr
Norfolk, Virginia 23507
Norfolk, Virginia 23507
757-627-7446
Principal Investigator: Duane Wombolt
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104 SE 1st Avenue
Ocala, Florida 34471
Ocala, Florida 34471
352-629-5800
Principal Investigator: Sidney Clevinger
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7940 Floyd Curl Dr.
San Antonio, Texas 78229
San Antonio, Texas 78229
210-949-0122
Principal Investigator: Douglas Denham
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8122 Datapoint Drive
San Antonio, Texas 78229
San Antonio, Texas 78229
210-614-7483
Principal Investigator: William Jennings
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400 Bald Hill Road
Warwick, Rhode Island 02886
Warwick, Rhode Island 02886
401-739-9350
Principal Investigator: David Fried
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500 Chase Parkway
Waterbury, Connecticut 06708
Waterbury, Connecticut 06708
203-419-4420
Principal Investigator: Joseph Soufer
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Albuquerque, New Mexico
Principal Investigator: Marigene Salazar Sharma
Phone: 505-224-7407
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Allentown, Pennsylvania 18104
Principal Investigator: Paul Gross
Phone: 610-820-0342
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Amherst, New York 14226
Principal Investigator: Laszlo Mechtler
Phone: 716-558-5670
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Anderson, Indiana 46011
Principal Investigator: Larry Blankenship
Phone: 765-298-2040
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Ann Arbor, Michigan 48104
Principal Investigator: Joel Saper
Phone: 734-677-6000
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Baltimore, Maryland 21208
Principal Investigator: Alan Jonas
Phone: 410-602-1440
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Blue Island, Illinois 60406
Principal Investigator: Charles Campbell
Phone: 312-731-6128
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Boston, Massachusetts 02135
Principal Investigator: Arkadiy Stolyar Stolyar
Phone: 617-447-4868
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Carmichael, California 95608
Principal Investigator: Nancy Coburn
Phone: 916-514-0163
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Charleston, South Carolina 29406
Principal Investigator: David Stickler
Phone: 843-725-5067
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Charlotte, North Carolina 28210
Principal Investigator: Mark Porter
Phone: 704-542-6698
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Charlottesville, Virginia 22911
Principal Investigator: James Clark
Phone: 434-817-2442
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Chattanooga, Tennessee 37421
Principal Investigator: Richard Krause Krause
Phone: 423-698-4584
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Cleveland, Ohio 44122
Principal Investigator: Mary Manning
Phone: 216-682-0320
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Colorado Springs, Colorado 80910
Principal Investigator: Joel Dickerman
Phone: 719-634-6576
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Columbia, South Carolina 29203
Principal Investigator: Xiao Androulakis
Phone: 803-545-6089
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Denver, Colorado 80218
Principal Investigator: Jack Klapper
Phone: 303-839-9900
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Edgewood, Kentucky 41017
Principal Investigator: Pragya Gupta
Phone: 859-757-1359
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Elwood, Indiana 46036
Principal Investigator: Robert Helm
Phone: 765-557-8076
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Encino, California 91316
Principal Investigator: Daniel Grosz
Phone: 818-705-7451
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Encino, California 91436
Principal Investigator: Tooraj Raoof
Phone: 818-788-5060
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Englewood, Colorado
Principal Investigator: Cori Millen
Phone: 720-336-4300
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Fort Collins, Colorado 80528
Principal Investigator: Tamara Miller
Phone: 970-226-6111
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Fullerton, California 92835
Principal Investigator: Jack Florin
Phone: 714-738-3845
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Greensboro, North Carolina 27405
Principal Investigator: Marshall Freeman
Phone: 336-574-8000
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Hurst, Texas 76054
Principal Investigator: Robert Strzinek
Phone: 817-281-4156
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Indianapolis, Indiana 46260
Principal Investigator: Phillip Toth
Phone: 317-705-7050
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Irvine, California 92618
Principal Investigator: Elly Lee
Phone: 949-753-1663
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Kenosha, Wisconsin 53142
Principal Investigator: John Agaiby
Phone: 262-925-1280
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Knoxville, Tennessee 37920
Principal Investigator: William Smith
Phone: 865-305-9100
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Little Rock, Arkansas 72205
Principal Investigator: Kevin Roberts
Phone: 501-907-9169
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Los Alamitos, California 90720
Principal Investigator: Nader Oskooilar
Phone: 714-827-3667
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Louisville, Kentucky 40213
Principal Investigator: Harold Bays
Phone: 502-515-5672
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Manlius, New York 13104
Principal Investigator: Jon Stringer
Phone: 315-682-3263
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Meridian, Idaho 83642
Principal Investigator: Mark Turner
Phone: 208-377-8653
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Minneapolis, Minnesota 55402
Principal Investigator: Gary Berman
Phone: 612-333-2200
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Nashua, New Hampshire 03060
Principal Investigator: Hisham Hafez
Phone: 603-880-9880
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Nashville, Tennessee 37203
Principal Investigator: Stephan Sharp
Phone: 615-329-0197
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New Port Richey, Florida 34652
Principal Investigator: Lisa Cohen
Phone: 727-849-4131
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New York, New York 10168
Principal Investigator: Craig McCarthy
Phone: 212-772-3570
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Newport Beach, California 92660
Principal Investigator: Don De Francisco
Phone: 949-752-7910
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Orlando, Florida 32801
Principal Investigator: Linda Harper
Phone: 407-425-5100
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Pittsburgh, Pennsylvania 15243
Principal Investigator: Nathan Bennett
Phone: 412-650-5623
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Portland, Oregon 97210
Principal Investigator: MaryAnn Colvard-Conrad
Phone: 503-279-8252
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Prairie Village, Kansas 66206
Principal Investigator: Haydn Thomas
Phone: 913-381-7180
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Rancho Mirage, California 92270
Principal Investigator: Dennis Anderson
Phone: 760-464-0470
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Redlands, California 92374
Principal Investigator: Donald Anderson
Phone: 909-792-9007
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Richmond, Virginia 23294
Principal Investigator: John Scott
Phone: 804-672-2133
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Rochester, New York 14609
Principal Investigator: Matthew Davis
Phone: 585-288-0890
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San Diego, California 92123
Principal Investigator: Vishaal Mehra
Phone: 858-278-3647
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San Diego, California 92108
Principal Investigator: William Koltun
Phone: 619-521-2830
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Spokane, Washington 99204
Principal Investigator: David Greeley
Phone: 509-343-3710
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Sunrise, Florida 33351
Principal Investigator: Barry Cutler
Phone: 954-475-4811
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Toledo, Ohio 43614
Principal Investigator: Gretchen Tietjen
Phone: 419-383-6187
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Tucson, Arizona 85741
Principal Investigator: Kevin Pounds
Phone: 520-333-4515
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Vancouver, Washington 98664
Principal Investigator: Melissa Freeman
Phone: 360-253-3294
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West Des Moines, Iowa 50265
Principal Investigator: Kenneth Pollack
Phone: 515-327-4782
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West Jordan, Utah 84088
Principal Investigator: J Kirsten
Phone: 801-542-8190
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West Palm Beach, Florida 33407
Principal Investigator: Paul Winner
Phone: 561-845-0500
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Willow Grove, Pennsylvania 19090
Principal Investigator: Brad Klein
Phone: 215-957-9250
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