Memantine Hydrochloride and Whole-Brain Radiotherapy With or Without Hippocampal Avoidance in Reducing Neurocognitive Decline in Patients With Brain Metastases



Status:Active, not recruiting
Conditions:Cognitive Studies, Cognitive Studies, Brain Cancer
Therapuetic Areas:Oncology, Psychiatry / Psychology
Healthy:No
Age Range:18 - Any
Updated:1/16/2019
Start Date:July 2015
End Date:April 30, 2023

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A Randomized Phase III Trial of Memantine and Whole-Brain Radiotherapy With or Without Hippocampal Avoidance in Patients With Brain Metastases

This randomized phase III trial compares memantine hydrochloride and whole-brain radiotherapy
with or without hippocampal avoidance in reducing neurocognitive decline in patients with
cancer that has spread from the primary site (place where it started) to the brain. Whole
brain radiotherapy (WBRT) is the most common treatment for brain metastasis. Unfortunately,
the majority of patients with brain metastases experience cognitive (such as learning and
memory) deterioration after WBRT. Memantine hydrochloride may enhance cognitive function by
binding to and inhibiting channels of receptors located in the central nervous system.
Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Using
radiation techniques, such as intensity modulated radiotherapy to avoid the hippocampal
region during WBRT, may reduce the radiation dose to the hippocampus and help limit the
radiation-induced cognitive decline. It is not yet known whether giving memantine
hydrochloride and WBRT with or without hippocampal avoidance works better in reducing
neurocognitive decline in patients with brain metastases.

PRIMARY OBJECTIVES:

I. Determine whether the addition of whole-brain radiotherapy with hippocampal avoidance
(HA-WBRT) increases time to neurocognitive failure at months 2, 4, 6, and 12 as measured by
neurocognitive decline on a battery of tests: the Hopkins Verbal Learning Test-Revised
(HVLT-R) for Total Recall, Delayed Recall, and Delayed Recognition, Controlled Oral Word
Association (COWA), and the Trail Making Test (TMT) Parts A and B.

SECONDARY OBJECTIVES:

I. Determine whether the addition of HA-WBRT preserves neurocognitive function at months 2,
4, 6, and 12 as separately measured by each test, the HVLT-R for Total Recall, Delayed
Recall, and Delayed Recognition; COWA; and TMT Parts A and B.

II. Evaluate the potential benefit of HA-WBRT in symptom burden, as measured by the M. D.
Anderson Symptom Inventory-Brain Tumor Module (MDASI-BT).

III. Assessment of quality adjusted survival and cost analysis using the five-level version
of the EuroQol five-dimensional (EQ-5D-5L).

IV. Compare cumulative incidence of progression and overall survival after WBRT versus
HA-WBRT.

V. Compare adverse events between the treatment arms according to the Common Terminology
Criteria for Adverse Events (CTCAE) version (v)4.0 criteria.

TERTIARY OBJECTIVES:

I. Collect serum, plasma, and imaging studies for future translational research analyses.

II. Evaluate magnetic resonance (MR) imaging biomarkers of white matter injury and
hippocampal volumetry at baseline and 6 months as potential predictors of neurocognitive
decline and differential benefit from HA-WBRT as compared to WBRT.

III. Association of symptom burden and anxiety/depression with neurocognitive function.

IV. Evaluate the potential correlation between the prognostic scoring systems Radiation
Therapy Oncology Group (RTOG) recursive partitioning analysis (RPA) and the
diagnosis-specific graded prognostic assessment (DS-GPA) and neurocognitive function at
baseline and overtime.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive memantine hydrochloride orally (PO) twice daily (BID) for 24 weeks.
Patients undergo WBRT daily over approximately 2 weeks (10 fractions).

ARM II: Patients receive memantine hydrochloride as in Arm I. Patients undergo HA-WBRT using
intensity modulated radiation therapy (IMRT) daily over approximately 2 weeks (10 fractions).

After completion of study treatment, patients are followed up at 12 months.

Inclusion Criteria:

- PRIOR TO STEP 1 REGISTRATION:

- Brain metastases outside a 5-mm margin around either hippocampus must be visible on
contrast-enhanced magnetic resonance imaging (MRI) performed =< 21 days prior to Step
1 registration; an allowed exception, regarding ability to image brain metastases,
would be that patients who had undergone radiosurgery or surgical resection and are
planning adjuvant WBRT do not have to have visible disease but do need a pre-surgery
MRI or computed tomography (CT) scan demonstrating brain metastases; however, the
brain metastases could not have been within 5 mm of either hippocampus

- Patients must have a gadolinium contrast-enhanced three-dimensional spoiled gradient
(SPGR), magnetization-prepared rapid gradient echo (MP-RAGE), or turbo field echo
(TFE) axial MRI scan with standard axial and coronal gadolinium contrast-enhanced
T1-weighted sequence and axial T2/FLAIR sequence acquisitions; to yield acceptable
image quality, the gadolinium contrast-enhanced three-dimensional SPGR, MP-RAGE, or
TFE axial MRI scan should use the smallest possible axial slice thickness not
exceeding 1.5 mm; the associated coronal and sagittal contrast-enhanced T1 sequences
can be up to 2.5 mm in slice thickness; this MRI must be obtained =< 21 days prior to
step 1 registration; the vendor specific MRI protocols are available for download from
the Alzheimer's Disease Neuroimaging Initiative (ADNI)

- Patients must provide study-specific informed consent prior to registration

- PRIOR TO STEP 2 REGISTRATION:

- The following baseline neurocognitive assessments must be completed prior to Step 2
registration: HVLT-R, TMT, and COWA; the neurocognitive assessment will be uploaded
into the NRG RAVE System for evaluation by Dr. Wefel; once the upload is complete, a
notification will be sent to proceed to Step 2; NOTE: completed baseline
neurocognitive assessments can be uploaded at the time of Step 1 registration

- Pathologically (histologically or cytologically) proven diagnosis of solid tumor
malignancy within 5 years prior to Step 2 registration

- History and physical examination within 28 days prior to Step 2 registration

- Karnofsky performance status of >= 70 within 28 days prior to Step 2 registration

- Serum creatinine =< 3 mg/dL (265 umol/L) and creatinine clearance >= 30 ml/min

- Blood urea nitrogen (BUN) within institutional upper limit of normal (e.g. < 20 mg/dL)

- Total bilirubin =< 2.5 mg/dL (43 umol/L)

- Patients may have had prior therapy for brain metastasis, including radiosurgery and
surgical resection; patients must have completed prior therapy by at least 14 days
prior to Step 2 for surgical resection and 7 days for radiosurgery

- Negative serum pregnancy test (in women of childbearing potential) =< 14 days prior to
Step 2; women of childbearing potential and men who are sexually active must practice
adequate contraception while on study

- Patients who are primary English or French speakers are eligible

Exclusion Criteria:

- Prior external beam radiation therapy to the brain or whole brain radiation therapy

- Planned cytotoxic chemotherapy during the WBRT only; patients may have had prior
chemotherapy

- Radiographic evidence of hydrocephalus or other architectural distortion of the
ventricular system, including placement of external ventricular drain or
ventriculoperitoneal shunt

- Severe, active co-morbidity defined as follows:

- Unstable angina and/or congestive heart failure requiring hospitalization within
the last 6 months

- Transmural myocardial infarction within the last 6 months

- Acute bacterial or fungal infection requiring intravenous antibiotics at the time
of registration

- Chronic obstructive pulmonary disease exacerbation or other acute respiratory
illness precluding study therapy at the time of registration

- Severe hepatic disease defined as a diagnosis of Child-Pugh class B or C hepatic
disease

- Renal tubular acidosis or metabolic acidosis

- Human immunodeficiency virus (HIV) positive with cluster of differentiation (CD)4
count < 200 cells/microliter; note that patients who are HIV positive are
eligible, provided they are under treatment with highly active antiretroviral
therapy (HAART) and have a CD4 count >= 200 cells/microliter within 30 days prior
to registration; Note also that HIV testing is not required for eligibility for
this protocol

- Pregnant or lactating women, or women of childbearing potential and men who are
sexually active and not willing/able to use medically acceptable forms of
contraception

- Prior allergic reaction to memantine (memantine hydrochloride)

- Current alcohol or drug abuse (may exacerbate lethargy/dizziness with memantine)

- Intractable seizures while on adequate anticonvulsant therapy—more than 1 seizure per
month for the past 2 months

- Patients with definitive leptomeningeal metastases

- Patients with brain metastases from primary germ cell tumors, small cell carcinoma,
unknown primary, or lymphoma

- Contraindication to magnetic resonance (MR) imaging such as implanted metal devices or
foreign bodies

- Contraindication to gadolinium contrast administration during MR imaging, such as
allergy or insufficient renal function

- Current use of (other N-methyl D-aspartate [NMDA] antagonists) amantadine, ketamine,
or dextromethorphan
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Greenville, South Carolina 29605
Principal Investigator: David L. Grisell
Phone: 864-241-6251
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Greenville, SC
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Greenville, South Carolina 29615
Principal Investigator: David L. Grisell
Phone: 864-679-3966
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Greenville, SC
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Greenwood, South Carolina 29646
Principal Investigator: Joseph M. Jenrette
Phone: 864-725-4771
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Greenwood, SC
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24800 SE Stark St
Gresham, Oregon 97030
(503) 674-1122
Principal Investigator: Andrew Y. Kee
Phone: 855-776-0015
Legacy Mount Hood Medical Center Legacy Mount Hood Medical Center, East County's full-service community hospital,...
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Gresham, OR
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Hilton Head Island, South Carolina 29926
Principal Investigator: Howard A. Zaren
Phone: 912-819-5704
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Hilton Head Island, SC
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from
Hines, IL
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Houston, Texas 77030
Principal Investigator: Jing Li
Phone: 713-792-3245
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Houston, TX
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Independence, Ohio 44131
Principal Investigator: Erin S. Murphy
Phone: 800-544-6333
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Independence, OH
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Indianapolis, Indiana 46256
Principal Investigator: Daniel W. Weed
Phone: 317-497-2823
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Indianapolis, IN
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Indianapolis, Indiana 46227
Principal Investigator: Daniel W. Weed
Phone: 317-497-2823
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Indianapolis, IN
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1400 North Ritter Avenue
Indianapolis, Indiana 46219
Principal Investigator: Daniel W. Weed
Phone: 317-497-2823
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Indianapolis, IN
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250 Doctors Ct
Johnson Creek, Wisconsin 53038
(920) 699-3500
Principal Investigator: Steven P. Howard
Phone: 920-699-3500
UW Cancer Center Johnson Creek UW Cancer Center Johnson Creek is a collaboration between Fort...
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Johnson Creek, WI
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Kansas City, Kansas 66160
Principal Investigator: Joshua M. Mammen
Phone: 913-945-7552
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Kansas City, KS
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2800 Clay Edwards Dr
Kansas City, Missouri 64116
(816) 691-2000
Principal Investigator: Joshua M. Mammen
Phone: 816-691-1599
North Kansas City Hospital Generations of Northlanders have considered North Kansas City Hospital as their...
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Kansas City, MO
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Kenosha, Wisconsin 53142
Principal Investigator: Ellen L. Ziaja
Phone: 888-709-2080
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Kenosha, WI
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La Crosse, Wisconsin 54601
Principal Investigator: Nadia N. Laack
Phone: 855-776-0015
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La Crosse, WI
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La Crosse, Wisconsin
Principal Investigator: Collin D. Driscoll
Phone: 608-775-2385
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La Crosse, WI
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3855 Health Sciences Dr,
La Jolla, California 92093
(858) 822-6100
UC San Diego Moores Cancer Center Established in 1978, UC San Diego Moores Cancer Center...
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La Jolla, CA
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