Ibrutinib and Rituximab Compared With Fludarabine Phosphate, Cyclophosphamide, and Rituximab in Treating Patients With Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma



Status:Active, not recruiting
Conditions:Hot Flash, Other Indications, Blood Cancer, Lymphoma, Anemia, Endocrine, Hematology
Therapuetic Areas:Endocrinology, Hematology, Oncology, Other, Reproductive
Healthy:No
Age Range:18 - 70
Updated:9/16/2017
Start Date:February 20, 2014

Use our guide to learn which trials are right for you!

A Randomized Phase III Study of Ibrutinib (PCI-32765)-Based Therapy vs Standard Fludarabine, Cyclophosphamide, and Rituximab (FCR) Chemoimmunotherapy in Untreated Younger Patients With Chronic Lymphocytic Leukemia (CLL)

This randomized phase III trial studies ibrutinib and rituximab to see how well they work
compared to fludarabine phosphate, cyclophosphamide, and rituximab in treating patients with
untreated chronic lymphocytic leukemia or small lymphocytic lymphoma. Ibrutinib may stop the
growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in
chemotherapy, such as fludarabine phosphate and cyclophosphamide, work in different ways to
stop the growth of cancer cells, either by killing the cells, by stopping them from dividing,
or by stopping them from spreading. Monoclonal antibodies, such as rituximab, interfere with
the ability of cancer cells to grow and spread. It is not yet known whether fludarabine
phosphate, cyclophosphamide, and rituximab may work better than ibrutinib and rituximab in
treating patients with untreated chronic lymphocytic leukemia or small lymphocytic lymphoma.

PRIMARY OBJECTIVES:

I. To evaluate the ability of Ibrutinib-based induction therapy to prolong progression free
survival (PFS) compared to standard fludarabine phosphate, cyclophosphamide, and rituximab
(FCR) chemoimmunotherapy for younger patients with chronic lymphocytic leukemia (CLL).

SECONDARY OBJECTIVES:

I. Evaluate overall survival (OS) of patients based on treatment arm. II. Monitor and assess
toxicity of treatment with Ibrutinib-based induction relative to standard FCR chemotherapy.

III. To compare quality of life (QOL) in CLL patients during the first 6 months of treatment
among patients receiving Ibrutinib-based induction therapy relative to standard FCR
chemoimmunotherapy.

IV. To compare QOL over the long-term in CLL patients receiving continuous therapy using
Ibrutinib to that of CLL patients who completed FCR therapy.

V. Determine the effect of pretreatment clinical and biological characteristics (e.g. disease
stage, immunoglobulin heavy chain variable region gene [IGHV] mutation status, fluorescent in
situ hybridization [FISH]) on clinical outcomes (e.g. complete response, PFS) of the
different arms.

VI. Determine if the minimal residual disease (MRD) status as assessed by flow cytometry at
different time points during and after treatment is an effective surrogate marker for
prolonged PFS and overall survival.

VII. Compare the genetic abnormalities and dynamics of intra-clonal architecture of CLL
patients before and after treatment with chemoimmunotherapy (CIT) and non-CIT approaches and
explore relationships with treatment resistance.

VIII. Explore the effects of FCR and Ibrutinib-based therapy on T-cell immune function.

IX. Conduct confirmatory validation genotyping of single nucleotide polymorphisms (SNPs)
associated with the efficacy and toxicity of fludarabine-based therapy as in a prior Eastern
Cooperative Oncology Group (ECOG) genome-wide association study (GWAS) analysis in the E2997
trial.

X. Evaluate the ability of prognostic model that incorporates clinical and biologic
characters to predict a response to therapy and clinical outcome (PFS, OS).

XI. Evaluate signaling networks downstream of the B-cell receptor in patients receiving
Ibrutinib-based therapy.

XII. Collect relapse samples to study mechanisms of resistance to both FCR and
Ibrutinib-based therapy.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM A: Patients receive ibrutinib orally (PO) once daily (QD) on days 1-28. Beginning course
2, patients also receive rituximab intravenously (IV) over 4 hours on day 1 (days 1 and 2 of
course 2 only). Treatment repeats every 28 days for 7 courses. In the absence of disease
progression, patients may continue ibrutinib PO QD.

ARM B: Patients receive rituximab as seen in Arm A and fludarabine phosphate IV over 30
minutes and cyclophosphamide IV over 30 minutes on days 1-3. Treatment repeats every 28 days
for 6 courses.

After completion of study treatment, patients are followed up for 10 years.

Inclusion Criteria:

- Diagnosis of CLL according to the National Cancer Institute (NCI)/Internal Workshop on
Chronic Lymphocytic Leukemia (IWCLL) criteria or small lymphocytic lymphoma (SLL)
according to the World Health Organization (WHO) criteria; this includes previous
documentation of:

- Biopsy-proven small lymphocytic lymphoma or

- Diagnosis of CLL according to the NCI/IWCLL criteria as evidenced by all of the
following:

- Peripheral blood lymphocyte count of greater than 5 x 10^9/L

- Immunophenotype consistent with CLL defined as:

- The predominant population of lymphocytes share both B-cell antigens
(cluster of differentiation [CD]19, CD20 [typically dim expression], or
CD23) as well as CD5 in the absence of other pan-T-cell markers (CD3,
CD2, etc)

- Clonality as evidenced by kappa or lambda light chain restriction
(typically dim immunoglobulin expression)

- Negative FISH analysis for t(11;14)(immunoglobulin heavy locus [IgH]/cyclin D1
[CCND1]) on peripheral blood or tissue biopsy (e.g. marrow aspirate) or negative
immunohistochemical stains for cyclin D1 staining on involved tissue biopsy (e.g.
marrow aspirate or lymph node biopsy)

- No prior chemotherapy, Bruton's tyrosine kinase (BTK) inhibitor therapy, or monoclonal
anti-body therapy for treatment of CLL or SLL

- Has met at least one of the following indications for treatment:

- Evidence of progressive marrow failure as manifested by the development of
worsening anemia (hemoglobin [Hg] < 11 g/dl) and/or thrombocytopenia (platelets <
100 x 10^9/L)

- Symptomatic or progressive lymphadenopathy, splenomegaly, or hepatomegaly

- One or more of the following disease-related symptoms:

- Weight loss >= 10% within the previous 6 months

- Grade 2 or 3 fatigue attributed to CLL

- Fevers > 100.5 Fahrenheit (F) for 2 weeks without evidence of infection

- Clinically significant night sweats without evidence of infection

- Progressive lymphocytosis (not due to the effects of corticosteroids) with an
increase of > 50% over a two-month period or an anticipated doubling time of less
than six months

- ECOG performance status between 0-2

- Life expectancy of >= 12 months

- Ability to tolerate FCR based therapy

- No deletion of 17p13 on cytogenetic analysis by FISH

- Glomerular filtration rate (GFR) > 40 mL/minute as calculated by the Cockcroft-Gault
formula

- Total bilirubin =< 2.5 x upper limit of normal (ULN) unless due to Gilbert's disease;
for those with a total bilirubin > 2.5 x ULN, a direct bilirubin should be performed
and must be < 1.5 mg/dL for Gilbert's to be diagnosed; if value is higher due to
hepatic involvement by CLL, patient is eligible

- Serum glutamic oxaloacetic transaminase (SGOT) aspartate transaminase (AST)/serum
glutamate-pyruvate transaminase (SGPT) alanine transaminase (ALT) =< 3.0 x the
institutional ULN; if value is higher due to hepatic involvement by CLL, patient is
eligible

- Prothrombin time (PT)/international normalized ratio (INR) < 1.5 ULN and partial
thromboplastin time (PTT) activated partial thromboplastin time (aPTT) < 1.5 X ULN; if
value is higher due to hepatic involvement by CLL, patient is eligible

- No active hemolytic anemia requiring immunosuppressive therapy or other pharmacologic
treatment; patients who have a positive Coombs test but no evidence of hemolysis are
NOT excluded from participation

- No current use of corticosteroids; EXCEPTION: low doses of steroids (< 10 mg of
prednisone or equivalent dose of other steroid) used for treatment of non-hematologic
medical condition (e.g. chronic adrenal insufficiency) is permitted

- No previous use of corticosteroids for autoimmune complications that have developed
since the initial diagnosis of CLL; prior use of corticosteroids for reasons other
than treatment of autoimmune complications is allowed

- No other active primary malignancy (other than non-melanomatous skin cancer or
carcinoma in situ of the cervix) requiring treatment or limiting expected survival to
=< 2 years; NOTE: if there is a history of prior malignancy, they must not be
receiving other specific treatment (other than hormonal therapy for their cancer)

- Able to adhere to the study visit schedule and other protocol requirements

- No major surgery within the last 4 weeks (28 days) of first dose of study drug or
minor surgery within 3 days of first dose of study drug

- No radiation therapy =< 4 weeks prior to registration

- Patients with human immunodeficiency virus (HIV) infection may be eligible provided
they meet the following criteria:

- CD4-positive cell count >= lower limit of institutional normal

- HIV viral load < 10,000 copies HIV ribonucleic acid (RNA)/mL (if not on anti-HIV
therapy) OR < 50 copies HIV RNA/mL (if on anti-HIV therapy)

- No evidence of hepatitis B or C infection

- No evidence of resistant strains of HIV

- No history of acquired immune deficiency syndrome (AIDS)-defining condition

- Patients must not have any of the following conditions:

- Congestive heart failure or New York Heart Association Functional Classification
III or IV congestive heart failure

- History of myocardial infarction, unstable angina, or acute coronary syndrome
within 6 months prior to registration

- Recent infections requiring systemic treatment; need to have completed
anti-biotic therapy > 14 days before the first dose of study drug

- Cerebral vascular accident or intracranial bleed within the last 6 months

- Infection with known chronic, active hepatitis C

- Serologic status reflecting active hepatitis B or C infection; patients that are
positive for hepatitis B core antibody, hepatitis B surface antigen (HBsAg), or
hepatitis C antibody must have a negative polymerase chain reaction (PCR) prior
to enrollment (PCR positive patients will be excluded)

- Patients are not eligible if they require treatment with a strong cytochrome P450
(CYP) family 3, subfamily A (3A) inhibitor

- Patients may not be on any other investigational agents

- Patients may not have received warfarin or another vitamin K antagonist in the
preceding 30 days

- Women must not be pregnant or breast-feeding; female patients of childbearing
potential must have a negative serum pregnancy test within 2 weeks prior to
registration to rule out pregnancy; female patients who are of non-reproductive
potential are those who are post-menopausal by history (i.e. no menses for >= 1 year);
OR history of hysterectomy; OR history of bilateral tubal ligation; OR history of
bilateral oophorectomy

- Women of childbearing potential and sexually active males must be strongly advised to
use an accepted and effective method of contraception or to abstain from sexual
intercourse for 90 days after the last dose of study drug

- Patient must be able to swallow capsules and not have the following conditions:

- Disease significantly affecting gastrointestinal function

- Resection of the stomach or small bowel

- Symptomatic inflammatory bowel disease

- Ulcerative colitis

- Partial or complete bowel obstruction

- Patient must not be on any other systemic immunosuppressant therapy other than
corticosteroids within 28 days of the first dose of study drug

- Patient must not be vaccinated with live, attenuated vaccines within 4 weeks of first
dose of study drug

- Patient must not have any known bleeding disorders (e.g., von Willebrand's disease) or
hemophilia

- Patient must not have currently active, clinically significant hepatic impairment (>=
moderate hepatic impairment according to the NCI/Child Pugh)
We found this trial at
781
sites
Anaheim, California 92806
Principal Investigator: Jonathan A. Polikoff
Phone: 626-564-3455
?
mi
from
Anaheim, CA
Click here to add this to my saved trials
1201 Camino de Salud Northeast
Albuquerque, New Mexico 87131
(505) 272-4946
Principal Investigator: Cecilia Y. Arana Yi
Phone: 505-925-0274
University of New Mexico Cancer Center It’s been 40 years since the New Mexico State...
?
mi
from
Albuquerque, NM
Click here to add this to my saved trials
361 Old Belgrade Road
Augusta, Maine 04330
(207) 621-6100
Principal Investigator: Thomas H. Openshaw
Phone: 207-973-7807
Harold Alfond Center for Cancer Care MaineGeneral's Harold Alfond Center for Cancer Care (HACCC) is...
?
mi
from
Augusta, ME
Click here to add this to my saved trials
2545 Schoenersville Rd
Bethlehem, Pennsylvania 18017
(484) 884-2200
Principal Investigator: Eliot L. Friedman
Phone: 610-402-2273
Lehigh Valley Hospital - Muhlenberg At Lehigh Valley Health Network, we continually go the extra...
?
mi
from
Bethlehem, PA
Click here to add this to my saved trials
800 Washington St
Boston, Massachusetts 02111
(617) 636-5000
Principal Investigator: Andreas K. Klein
Phone: 617-636-5000
Tufts Medical Center Tufts Medical Center is an internationally-respected academic medical center – a teaching...
?
mi
from
Boston, MA
Click here to add this to my saved trials
Bremerton, Washington 98310
Principal Investigator: Mehmet S. Copur
Phone: 800-998-2119
?
mi
from
Bremerton, WA
Click here to add this to my saved trials
666 Elm Street
Buffalo, New York 14263
(716) 845-2300
Principal Investigator: Seema A. Bhat
Phone: 716-845-3894
Roswell Park Cancer Institute Welcome to Roswell Park Cancer Institute (RPCI), America's first cancer center...
?
mi
from
Buffalo, NY
Click here to add this to my saved trials
1 South Prospect Street
Burlington, Vermont 05401
802-656-8990
Principal Investigator: George F. Atweh
?
mi
from
Burlington, VT
Click here to add this to my saved trials
1 Hurley Plaza
Flint, Michigan 48503
(810) 262-9000
Principal Investigator: Christopher M. Reynolds
Phone: 734-712-4673
Hurley Medical Center From its founding in 1908, Hurley Medical Center has devoted itself to...
?
mi
from
Flint, MI
Click here to add this to my saved trials
200 North Park Street
Kalamazoo, Michigan 49007
(269) 382-2500
Principal Investigator: Sunil Nagpal
Phone: 269-373-7458
West Michigan Cancer Center In 1994, Borgess Health Alliance and Bronson Healthcare Group opened the...
?
mi
from
Kalamazoo, MI
Click here to add this to my saved trials
701 Doctors Dr
Kinston, North Carolina 28504
(252) 559-2200
Principal Investigator: Peter R. Watson
Phone: 252-559-2200
Kinston Medical Specialists offers comprehensive medical services for all ages. Whether it’s a case of...
?
mi
from
Kinston, NC
Click here to add this to my saved trials
529 West Markham Street
Little Rock, Arkansas 72205
(501) 686-7000
Principal Investigator: Pooja Motwani
Phone: 501-686-8274
University of Arkansas for Medical Sciences The University of Arkansas for Medical Sciences (UAMS) in...
?
mi
from
Little Rock, AR
Click here to add this to my saved trials
777 Hemlock Street
Macon, Georgia 31201
(478) 633-1000
Principal Investigator: Frederick M. Schnell
Phone: 404-501-3279
Medical Center of Central Georgia Navicent Health is a designated Level I Trauma Center and...
?
mi
from
Macon, GA
Click here to add this to my saved trials
300 Community Drive
Manhasset, New York 11030
(516) 562-0100
Principal Investigator: Jacqueline C. Barrientos
Phone: 516-734-8954
North Shore University Hospital North Shore-LIJ Health System includes 16 award-winning hospitals and nearly 400...
?
mi
from
Manhasset, NY
Click here to add this to my saved trials
4805 Northeast Glisan Street
Portland, Oregon 97213
(503) 215-1111
Principal Investigator: Keith S. Lanier
Phone: 503-215-6412
Providence Portland Medical Center We strive to give those we serve exceptional, compassionate health care...
?
mi
from
Portland, OR
Click here to add this to my saved trials
401 College Street
Richmond, Virginia 23298
(804) 828-0450
Principal Investigator: Beata Holkova
Phone: 804-628-1939
Virginia Commonwealth University Massey Cancer Center Founded in 1974, VCU Massey Cancer Center is a...
?
mi
from
Richmond, VA
Click here to add this to my saved trials
60 Crittenden Blvd # 70
Rochester, New York 14642
(585) 275-2121
Principal Investigator: Jonathan W. Friedberg
Phone: 585-275-5830
University of Rochester The University of Rochester is one of the country's top-tier research universities....
?
mi
from
Rochester, NY
Click here to add this to my saved trials
4502 Medical Drive
San Antonio, Texas 78284
(210) 567-7000
University of Texas Health Science Center at San Antonio The University of Texas Health Science...
?
mi
from
San Antonio, TX
Click here to add this to my saved trials
Seattle, Washington 98104
Principal Investigator: Keith S. Lanier
Phone: 503-215-6412
?
mi
from
Seattle, WA
Click here to add this to my saved trials
1100 Fairview Avenue North
Seattle, Washington 98109
(206) 667-5000
Principal Investigator: Mazyar Shadman
Phone: 800-422-6237
Fred Hutchinson Cancer Research Center At Fred Hutchinson Cancer Research Center, our interdisciplinary teams of...
?
mi
from
Seattle, WA
Click here to add this to my saved trials
825 Eastlake Ave E
Seattle, Washington 98109
(206) 288-7222
Principal Investigator: Mazyar Shadman
Phone: 800-422-6237
Seattle Cancer Care Alliance Seattle Cancer Care Alliance (SCCA) is a cancer treatment center that...
?
mi
from
Seattle, WA
Click here to add this to my saved trials
3900 W Avera Drive
Sioux Falls, South Dakota 57108
(605) 322-4700
Principal Investigator: Amy K. Krie
Phone: 605-322-6901
Avera Cancer Institute Avera, the health ministry of the Benedictine and Presentation Sisters, is a...
?
mi
from
Sioux Falls, SD
Click here to add this to my saved trials
808 North 39th Avenue
Yakima, Washington 98902
Principal Investigator: Keith S. Lanier
Phone: 503-215-6412
?
mi
from
Yakima, WA
Click here to add this to my saved trials
Aberdeen, Washington 98520
Principal Investigator: Keith S. Lanier
Phone: 503-215-6412
?
mi
from
Aberdeen, WA
Click here to add this to my saved trials
Adrian, Michigan 49221
Principal Investigator: Rex B. Mowat
Phone: 800-444-3561
?
mi
from
Adrian, MI
Click here to add this to my saved trials
1 Akron General Ave
Akron, Ohio 44307
(330) 344-6000
Principal Investigator: Esther H. Rehmus
Phone: 330-344-6348
Akron General Medical Center It
?
mi
from
Akron, OH
Click here to add this to my saved trials
Albany, Georgia 31701
Principal Investigator: Jose M. Tongol
Phone: 229-312-2251
?
mi
from
Albany, GA
Click here to add this to my saved trials
Albany, New York 12208
Principal Investigator: Charles H. Weissman
Phone: 518-489-3612
?
mi
from
Albany, NY
Click here to add this to my saved trials
Allentown, Pennsylvania 18103
Principal Investigator: Eliot L. Friedman
Phone: 610-402-2273
?
mi
from
Allentown, PA
Click here to add this to my saved trials
Amarillo, Texas 79106
Principal Investigator: Stewart A. Sharp
Phone: 806-359-4673
?
mi
from
Amarillo, TX
Click here to add this to my saved trials
Ames, Iowa 50010
Principal Investigator: Joseph J. Merchant
Phone: 515-239-2621
?
mi
from
Ames, IA
Click here to add this to my saved trials
1111 Duff Ave
Ames, Iowa 50010
(866) 972-5477
Principal Investigator: Joseph J. Merchant
Phone: 515-239-2621
McFarland Clinic PC-William R Bliss Cancer Center The William R. Bliss Cancer Center at Mary...
?
mi
from
Ames, IA
Click here to add this to my saved trials
Anaconda, Montana 59711
Principal Investigator: Benjamin T. Marchello
Phone: 800-648-6274
?
mi
from
Anaconda, MT
Click here to add this to my saved trials
Anacortes, Washington 98221
Principal Investigator: Keith S. Lanier
Phone: 503-215-6412
?
mi
from
Anacortes, WA
Click here to add this to my saved trials
Anchorage, Alaska 99508
Principal Investigator: Keith S. Lanier
Phone: 503-215-6412
?
mi
from
Anchorage, AK
Click here to add this to my saved trials
Anchorage, Alaska 99508
Principal Investigator: Keith S. Lanier
Phone: 503-215-6412
?
mi
from
Anchorage, AK
Click here to add this to my saved trials
Anchorage, Alaska 99508
Principal Investigator: Keith S. Lanier
Phone: 503-215-6412
?
mi
from
Anchorage, AK
Click here to add this to my saved trials
Anchorage, Alaska 99508
Principal Investigator: Keith S. Lanier
Phone: 503-215-6412
?
mi
from
Anchorage, AK
Click here to add this to my saved trials
Anchorage, Alaska 99508
Principal Investigator: Keith S. Lanier
Phone: 503-215-6412
?
mi
from
Anchorage, AK
Click here to add this to my saved trials
Anchorage, Alaska 99508
Principal Investigator: Keith S. Lanier
Phone: 503-215-6412
?
mi
from
Anchorage, AK
Click here to add this to my saved trials
Anchorage, Alaska 99508
Principal Investigator: Keith S. Lanier
Phone: 503-215-6412
?
mi
from
Anchorage, AK
Click here to add this to my saved trials
Anchorage, Alaska 99504
Principal Investigator: Keith S. Lanier
Phone: 503-215-6412
?
mi
from
Anchorage, AK
Click here to add this to my saved trials
Anchorage, Alaska 98508
Principal Investigator: Keith S. Lanier
Phone: 503-215-6412
?
mi
from
Anchorage, AK
Click here to add this to my saved trials
Anderson, Indiana 46016
Principal Investigator: Ubaidullah Sharief
Phone: 765-646-8413
?
mi
from
Anderson, IN
Click here to add this to my saved trials
5301 McAuley Drive
Ann Arbor, Michigan 48197
734-712-3456
Principal Investigator: Christopher M. Reynolds
Phone: 734-712-4673
Saint Joseph Mercy Hospital St. Joseph Mercy Ann Arbor Hospital is a 537-bed teaching hospital...
?
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
Ann Arbor, Michigan 48106
?
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
Antigo, Wisconsin 54409
Principal Investigator: Hamied R. Rezazadeh
Phone: 877-405-6866
?
mi
from
Antigo, WI
Click here to add this to my saved trials
Antioch, California 94531
Principal Investigator: Tatjana Kolevska
Phone: 626-564-3455
?
mi
from
Antioch, CA
Click here to add this to my saved trials
Asheville, North Carolina 28801
Principal Investigator: Christopher H. Chay
Phone: 828-418-0932
?
mi
from
Asheville, NC
Click here to add this to my saved trials
Asheville, North Carolina 28801
Principal Investigator: Christopher H. Chay
Phone: 828-418-0932
?
mi
from
Asheville, NC
Click here to add this to my saved trials
Asheville, North Carolina 28803
Principal Investigator: Raymond Thertulien
Phone: 855-774-5433
?
mi
from
Asheville, NC
Click here to add this to my saved trials
Atlanta, Georgia 30322
Principal Investigator: Leonard T. Heffner
Phone: 404-778-1868
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
Auburn, California 95602
Principal Investigator: Jorge A. Garcia-Young
Phone: 209-526-5280
?
mi
from
Auburn, CA
Click here to add this to my saved trials
Auburn, California 95603
Principal Investigator: Jorge A. Garcia-Young
Phone: 209-526-5280
?
mi
from
Auburn, CA
Click here to add this to my saved trials
Auburn, Washington 98001
Principal Investigator: John A. Keech
Phone: 253-403-2394
?
mi
from
Auburn, WA
Click here to add this to my saved trials
Aurora, Colorado 80012
Principal Investigator: Keren Sturtz
Phone: 303-777-2642
?
mi
from
Aurora, CO
Click here to add this to my saved trials
1501 S Potomac St
Aurora, Colorado 80012
(303) 695-2600
Principal Investigator: Keren Sturtz
Phone: 303-777-2642
Medical Center of Aurora At The Medical Center of Aurora and Centennial Medical Plaza patients...
?
mi
from
Aurora, CO
Click here to add this to my saved trials
2000 Ogden Ave
Aurora, Illinois 60504
(630) 978-6200
Principal Investigator: Maria T. Grosse-Perdekamp
Phone: 800-446-5532
Rush - Copley Medical Center Rush-Copley is proud to be the leading provider of health...
?
mi
from
Aurora, IL
Click here to add this to my saved trials
Bainbridge Island, Washington 98110
Principal Investigator: John A. Keech
Phone: 253-403-2394
?
mi
from
Bainbridge Island, WA
Click here to add this to my saved trials
Baldwin Park, California 91706
Principal Investigator: Jonathan A. Polikoff
Phone: 626-564-3455
?
mi
from
Baldwin Park, CA
Click here to add this to my saved trials
Baltimore, Maryland 21229
Principal Investigator: Carole B. Miller
Phone: 410-368-2910
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
22 South Greene Street
Baltimore, Maryland 21201
410-328-7904
Principal Investigator: Seung-Tae Lee
Phone: 410-328-6896
University of Maryland Greenebaum Cancer Center The University of Maryland Marlene and Stewart Greenebaum Cancer...
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
489 State St
Bangor, Maine 04401
(207) 973-7000
Principal Investigator: Thomas H. Openshaw
Phone: 207-973-7807
Eastern Maine Medical Center Located in Bangor, Eastern Maine Medical Center (EMMC) serves communities throughout...
?
mi
from
Bangor, ME
Click here to add this to my saved trials
4305 New Shepherdsville Road
Bardstown, Kentucky 40004
Principal Investigator: Mehmet S. Copur
Phone: 800-998-2119
?
mi
from
Bardstown, KY
Click here to add this to my saved trials
Baton Rouge, Louisiana 70809
Principal Investigator: Robert V. Emmons
Phone: 888-562-4763
?
mi
from
Baton Rouge, LA
Click here to add this to my saved trials
Beachwood, Ohio 44122
Principal Investigator: Hillard M. Lazarus
Phone: 800-641-2422
?
mi
from
Beachwood, OH
Click here to add this to my saved trials
Beaver, Pennsylvania 15009
Principal Investigator: Alison R. Sehgal
Phone: 412-647-8073
?
mi
from
Beaver, PA
Click here to add this to my saved trials
Bellevue, Washington 98004
Principal Investigator: John A. Keech
Phone: 253-403-2394
?
mi
from
Bellevue, WA
Click here to add this to my saved trials
Bellevue, Washington 98005
Principal Investigator: Keith S. Lanier
Phone: 503-215-6412
?
mi
from
Bellevue, WA
Click here to add this to my saved trials
Bellflower, California 90706
Principal Investigator: Jonathan A. Polikoff
Phone: 626-564-3455
?
mi
from
Bellflower, CA
Click here to add this to my saved trials
Bellingham, Washington 98225
Principal Investigator: Michael A. Taylor
Phone: 360-788-8223
?
mi
from
Bellingham, WA
Click here to add this to my saved trials
800 Farson Street
Belpre, Ohio 45714
(740) 401-0417
Principal Investigator: John P. Kuebler
Phone: 614-488-2745
Strecker Cancer Center-Belpre The Memorial Health System's Strecker Cancer Center, Belpre combines the clinical expertise...
?
mi
from
Belpre, OH
Click here to add this to my saved trials
1300 Anne Street NW
Bemidji, Minnesota 56601
(218) 751-5430
Principal Investigator: Preston D. Steen
Phone: 701-234-6161
Sanford Clinic North-Bemidgi Sanford Health is a voluntary, not-for-profit health care organization. Through its entities,...
?
mi
from
Bemidji, MN
Click here to add this to my saved trials
Bend, Oregon 97701
?
mi
from
Bend, OR
Click here to add this to my saved trials
Berkeley, California 94704
Principal Investigator: Jorge A. Garcia-Young
Phone: 209-526-5280
?
mi
from
Berkeley, CA
Click here to add this to my saved trials
1311 Barre-Montpelier Road
Berlin Corners, Vermont 05602
?
mi
from
Berlin Corners, VT
Click here to add this to my saved trials
Beverly, Massachusetts 01915
Principal Investigator: Angus P. McIntyre
Phone: 978-283-4000
?
mi
from
Beverly, MA
Click here to add this to my saved trials
Billings, Montana 59101
Principal Investigator: Benjamin T. Marchello
Phone: 800-648-6274
?
mi
from
Billings, MT
Click here to add this to my saved trials
1233 North 30th Street
Billings, Montana 59101
406-237-7000
Principal Investigator: Benjamin T. Marchello
Phone: 800-648-6274
Saint Vincent Healthcare The Sisters of Charity of Leavenworth, Kansas, founded St. Vincent Healthcare in...
?
mi
from
Billings, MT
Click here to add this to my saved trials
Billings, Montana 59101
Principal Investigator: Benjamin T. Marchello
Phone: 800-648-6274
?
mi
from
Billings, MT
Click here to add this to my saved trials
Birmingham, Alabama 35233
Principal Investigator: Harry P. Erba
Phone: 205-934-0309
?
mi
from
Birmingham, AL
Click here to add this to my saved trials
300 N. Seventh St.
Bismarck, North Dakota 58501
(701) 323-6000
Principal Investigator: Preston D. Steen
Phone: 701-234-6161
Sanford Bismarck Medical Center Whether your stay in our hospital is one day for same...
?
mi
from
Bismarck, ND
Click here to add this to my saved trials
1505 Eastland Drive
Bloomington, Illinois 61701
309-662-2102
Principal Investigator: James L. Wade
Phone: 217-876-4740
Illinois CancerCare-Bloomington Illinois CancerCare, P.C. is a comprehensive practice treating patients withcancer andblood diseases. Our...
?
mi
from
Bloomington, IL
Click here to add this to my saved trials
Bloomington, Illinois 61701
Principal Investigator: James L. Wade
Phone: 217-876-4740
?
mi
from
Bloomington, IL
Click here to add this to my saved trials
100 E Idaho St
Boise, Idaho 83712
(208) 381-2711
Principal Investigator: Keith S. Lanier
Phone: 503-215-6412
Saint Luke's Mountain States Tumor Institute For more than 100 years, St. Luke
?
mi
from
Boise, ID
Click here to add this to my saved trials
Boise, Idaho 83706
Principal Investigator: Christopher M. Reynolds
Phone: 734-712-4673
?
mi
from
Boise, ID
Click here to add this to my saved trials
1501 North Oakland Drive
Bolivar, Missouri 65613
417-326-7200
Principal Investigator: Jay W. Carlson
Phone: 800-821-7532
Central Care Cancer Center at Carrie J. Babb Cancer Center Cancer treatment often requires a...
?
mi
from
Bolivar, MO
Click here to add this to my saved trials
Bonne Terre, Missouri 63628
Principal Investigator: James L. Wade
Phone: 217-876-4740
?
mi
from
Bonne Terre, MO
Click here to add this to my saved trials
Boone, Iowa 50036
Principal Investigator: Joseph J. Merchant
Phone: 515-239-2621
?
mi
from
Boone, IA
Click here to add this to my saved trials
Boston, Massachusetts 02215
Principal Investigator: Tait D. Shanafelt
Phone: 507-284-2358
?
mi
from
Boston, MA
Click here to add this to my saved trials
1100 Balsam Ave
Boulder, Colorado 80304
(303) 440-2273
Principal Investigator: Keren Sturtz
Phone: 303-777-2642
Boulder Community Hospital Founded in 1922 as a community-owned and operated not-for-profit hospital, Boulder Community...
?
mi
from
Boulder, CO
Click here to add this to my saved trials
Boulder, Colorado 80303
Principal Investigator: Keren Sturtz
Phone: 303-777-2642
?
mi
from
Boulder, CO
Click here to add this to my saved trials
915 Highland Blvd
Bozeman, Montana 59715
(406) 414-5000
Principal Investigator: Benjamin T. Marchello
Phone: 800-648-6274
Bozeman Deaconess Hospital Bozeman Deaconess Hospital is a Joint Commission certified, licensed Level III trauma...
?
mi
from
Bozeman, MT
Click here to add this to my saved trials
Brainerd, Minnesota 56401
Principal Investigator: Bret E. Friday
Phone: 888-203-7267
?
mi
from
Brainerd, MN
Click here to add this to my saved trials
Branson, Missouri 65616
Principal Investigator: Jay W. Carlson
Phone: 800-821-7532
?
mi
from
Branson, MO
Click here to add this to my saved trials
Bremerton, Washington 98310
Principal Investigator: Mehmet S. Copur
Phone: 800-998-2119
?
mi
from
Bremerton, WA
Click here to add this to my saved trials
Brewer, Maine 04412
Principal Investigator: Thomas H. Openshaw
Phone: 207-973-7807
?
mi
from
Brewer, ME
Click here to add this to my saved trials
Bridgeport, West Virginia 26330
Principal Investigator: Abraham S. Kanate
Phone: 304-293-2745
?
mi
from
Bridgeport, WV
Click here to add this to my saved trials
Bristol, Tennessee 37620
Principal Investigator: Asheesh Shipstone
Phone: 423-578-8538
?
mi
from
Bristol, TN
Click here to add this to my saved trials
Brownstown Charter Township, Michigan 48183
?
mi
from
Brownstown Charter Township, MI
Click here to add this to my saved trials
130 S Bryn Mawr Ave
Bryn Mawr, Pennsylvania 19010
(484) 337-3000
Principal Investigator: Albert S. DeNittis
Phone: 484-476-2649
Bryn Mawr Hospital Bryn Mawr Hospital, a nationally recognized community teaching hospital, is conveniently located...
?
mi
from
Bryn Mawr, PA
Click here to add this to my saved trials