S1207 Hormone Therapy With or Without Everolimus in Treating Patients With Breast Cancer
Status: | Recruiting |
---|---|
Conditions: | Breast Cancer, Cancer |
Therapuetic Areas: | Oncology |
Healthy: | No |
Age Range: | 18 - Any |
Updated: | 3/13/2019 |
Start Date: | April 2013 |
End Date: | January 2030 |
Contact: | Cara Laubach, MIIM |
Email: | claubach@swog.org |
Phone: | 2106148808 |
Phase III Randomized, Placebo-Controlled Clinical Trial Evaluating the Use of Adjuvant Endocrine Therapy +/- One Year of Everolimus in Patients With High-Risk, Hormone Receptor-Positive and HER2/Neu Negative Breast Cancer
RATIONALE: Estrogen can cause the growth of breast cancer cells. Hormone therapy using
tamoxifen citrate, goserelin acetate, leuprolide acetate, anastrozole, letrozole, or
exemestane, may fight breast cancer by lowering the amount of estrogen the body makes.
Everolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell
growth. It is not yet know whether hormone therapy is more effective when given with or
without everolimus in treating breast cancer.
PURPOSE: This randomized phase III trial studies how well giving hormone therapy together
with or without everolimus work in treating patients with breast cancer.
tamoxifen citrate, goserelin acetate, leuprolide acetate, anastrozole, letrozole, or
exemestane, may fight breast cancer by lowering the amount of estrogen the body makes.
Everolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell
growth. It is not yet know whether hormone therapy is more effective when given with or
without everolimus in treating breast cancer.
PURPOSE: This randomized phase III trial studies how well giving hormone therapy together
with or without everolimus work in treating patients with breast cancer.
OBJECTIVES:
Primary
- To compare whether the addition of one year of everolimus (10 mg daily) to standard
adjuvant endocrine therapy improves invasive disease-free survival (IDFS) in patients
with high-risk, hormone-receptor (HR)-positive, and human epidermal growth factor
receptor (HER)2-negative breast cancer.
Secondary
- To compare whether the addition of one year of everolimus to standard adjuvant endocrine
therapy improves overall survival (OS) and distant recurrence-free survival (DRFS) in
this patient population.
- To evaluate the safety, toxicities, and tolerability of one year of everolimus in
combination with standard adjuvant endocrine therapy and to compare it with standard
adjuvant endocrine therapy plus placebo in this patient population.
- To determine whether the benefit of one year of everolimus use in addition to standard
adjuvant endocrine therapy varies by recurrence score (RS), nodal status, or other
commonly used prognostic factors.
- To evaluate adherence to 1-year treatment of everolimus in comparison to placebo in
addition to standard adjuvant endocrine therapy in this patient population.
- To collect specimens in order to evaluate biomarkers of therapeutic efficacy.
(exploratory)
OUTLINE: This is a multicenter study. Patients are stratified according to risk level
(node-negative and recurrence score [RS] > 25 in the primary tumor, and a tumor measuring ≥ 2
cm in greatest diameter treated with adjuvant therapy vs 1-3 positive lymph nodes and RS > 25
treated with adjuvant therapy vs ≥ 4 positive lymph nodes [any RS value] treated with
adjuvant therapy vs ≥ 4 positive lymph nodes [any RS value] prior to or after neoadjuvant
chemotherapy). Patients are randomized to 1 of 2 treatment arms.
- Arm I: Patients receive an approved endocrine therapy comprising tamoxifen citrate*,
goserelin acetate** or leuprolide acetate**, or aromatase inhibitor (anastrozole,
letrozole, or exemestane) for 2-5 years. Patients also receive a placebo orally (PO)
daily for 1 year in the absence of disease progression or unacceptable toxicity.
- Arm II: Patients receive an approved endocrine therapy regimen as in arm I. Patients
also receive everolimus PO daily for 1 year in the absence of disease progression or
unacceptable toxicity.
NOTE: *Men receive tamoxifen citrate PO for 5 years.
NOTE: **Goserelin acetate or leuprolide acetate is given if patient is or becomes
postmenopausal.
Blood and tissue samples are collected for biomarker studies.
After completion of study treatment, patients are followed up every 6 months for 2 years and
then yearly thereafter for 10 years.
Primary
- To compare whether the addition of one year of everolimus (10 mg daily) to standard
adjuvant endocrine therapy improves invasive disease-free survival (IDFS) in patients
with high-risk, hormone-receptor (HR)-positive, and human epidermal growth factor
receptor (HER)2-negative breast cancer.
Secondary
- To compare whether the addition of one year of everolimus to standard adjuvant endocrine
therapy improves overall survival (OS) and distant recurrence-free survival (DRFS) in
this patient population.
- To evaluate the safety, toxicities, and tolerability of one year of everolimus in
combination with standard adjuvant endocrine therapy and to compare it with standard
adjuvant endocrine therapy plus placebo in this patient population.
- To determine whether the benefit of one year of everolimus use in addition to standard
adjuvant endocrine therapy varies by recurrence score (RS), nodal status, or other
commonly used prognostic factors.
- To evaluate adherence to 1-year treatment of everolimus in comparison to placebo in
addition to standard adjuvant endocrine therapy in this patient population.
- To collect specimens in order to evaluate biomarkers of therapeutic efficacy.
(exploratory)
OUTLINE: This is a multicenter study. Patients are stratified according to risk level
(node-negative and recurrence score [RS] > 25 in the primary tumor, and a tumor measuring ≥ 2
cm in greatest diameter treated with adjuvant therapy vs 1-3 positive lymph nodes and RS > 25
treated with adjuvant therapy vs ≥ 4 positive lymph nodes [any RS value] treated with
adjuvant therapy vs ≥ 4 positive lymph nodes [any RS value] prior to or after neoadjuvant
chemotherapy). Patients are randomized to 1 of 2 treatment arms.
- Arm I: Patients receive an approved endocrine therapy comprising tamoxifen citrate*,
goserelin acetate** or leuprolide acetate**, or aromatase inhibitor (anastrozole,
letrozole, or exemestane) for 2-5 years. Patients also receive a placebo orally (PO)
daily for 1 year in the absence of disease progression or unacceptable toxicity.
- Arm II: Patients receive an approved endocrine therapy regimen as in arm I. Patients
also receive everolimus PO daily for 1 year in the absence of disease progression or
unacceptable toxicity.
NOTE: *Men receive tamoxifen citrate PO for 5 years.
NOTE: **Goserelin acetate or leuprolide acetate is given if patient is or becomes
postmenopausal.
Blood and tissue samples are collected for biomarker studies.
After completion of study treatment, patients are followed up every 6 months for 2 years and
then yearly thereafter for 10 years.
DISEASE CHARACTERISTICS:
- Patients must have a histologically confirmed diagnosis of invasive breast carcinoma
with positive estrogen (ER)- and/or progesterone-receptor (PR) status, and negative
human epidermal growth factor receptor (HER)2, for whom standard adjuvant endocrine
therapy is planned
- ER and PR positivity must be assessed according to American Society of Clinical
Oncology (ASCO)/College of American Pathologists (CAP) guidelines as either ER or
PR ≥ 1% positive nuclear staining
- HER2 test result negativity must be assessed as per ASCO/CAP 2013 guidelines
using IHC, ISH or both.
HER2 is negative if a single test (or all tests) performed in a tumor specimen show:
1. IHC negative (0 or 1+)
2. ISH negative using single probe or dual probe. If IHC is 2+, evaluation for gene
amplification (ISH) must be performed and the ISH must be negative; ISH is not
required if IHC is 0 or 1+.
HER2 equivocal is not eligible.
- Patients must not have metastatic breast cancer (stage IV disease); patients with
multifocal, multicentric, and synchronous bilateral, and primary inflammatory breast
cancers are allowed
- Multifocal disease is defined as more than one invasive cancer < 2 cm from the
largest lesion within the same breast quadrant
- Multicentric disease is defined as more than one invasive cancer ≥ 2 cm from the
largest lesion within the same breast quadrant or more than one lesion in
different quadrants
- Synchronous bilateral disease is defined as invasive breast cancer with positive
lymph nodes (axillary or intramammary) in at least one breast, diagnosed within
30 days of each other
- Patients must be high risk by belonging to one of the following risk groups:
- Completion of adjuvant chemotherapy and pathologically negative axillary nodes,
and a tumor measuring ≥ 2 cm in greatest diameter, and an Oncotype DX® recurrence
score (RS) > 25 (completed as standard of care). Patients with micrometastases as
the only nodal involvement (pN1mi) are eligible, and will be categorized as
node-negative.
- Completion of adjuvant chemotherapy, and pathologically 1-3 positive lymph nodes,
and either an Oncotype DX® RS > 25 (screened via S1007 or otherwise) or tumor
tissue with pathological Grade III following local practice. If Oncotype DX is
done, then RS must be > 25. If the test is not done, but the patient has Grade
III disease then the patient is eligible and Oncotype DX does not need to be
performed.
- Completion of adjuvant chemotherapy and pathologically 4 or more positive lymph
nodes.
- Completion of neoadjuvant chemotherapy and 1 or more positive nodes
pathologically determined prior to or after chemotherapy
- Patients must have completed either breast-conserving surgery or total mastectomy,
with negative margins and appropriate axillary staging; a negative margin is defined
as no evidence of tumor or ductal carcinoma in situ (DCIS) at the line of resection;
additional operative procedures may be performed to obtain clear margins
- Patients who had breast-conserving surgery must have completed whole-breast
radiation; use of regional nodal-basin radiation will be at the discretion of the
investigator according to institutional guidelines
- Patients with ≥ 4 positive lymph nodes must have completed breast/chest wall and
nodal-basin radiation therapy according to standard-of-care guidelines before
randomization; omission of radiation therapy is not allowed in this high-risk
population of patients
- Patients must be registered no sooner than 21 days after completion of radiation
therapy and must have recovered (≤ grade 1) from any of the effects of radiation
- Patients must have undergone axillary staging by sentinel-node biopsy or axillary
lymph node dissection (ALND)
- For patients with 1-3 positive lymph nodes, sentinel-node biopsy alone is allowed
provided that the patient completed either whole-breast or chest-wall radiation
and the primary tumor is < 5 cm
- All patients with ≥ 4 positive lymph nodes must have completed ALND (with or
without prior sentinel-node biopsy)
PATIENT CHARACTERISTICS:
- Absolute Neutrophil Count ≥ 1,500/mL
- Hemoglobin ≥ 9 g/dL
- Platelet count ≥ 100,000/mL
- Bilirubin ≤ 1.5 mg/dL (≤ 3.0 mg/dL if due to Gilbert syndrome)
- Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 1.5 times
institutional upper limit of normal (IULN)
- Alkaline phosphatase ≤ 1.5 times IULN
- Serum creatinine level ≤ IULN
- Fasting cholesterol ≤ 300 mg/dL and triglycerides ≤ 2.5 times IULN; patients may be on
lipid-lowering agents to reach these values
- Patients must have a performance status of 0-2 by Zubrod criteria
- Patients must not have any grade III/IV cardiac disease as defined by the New York
Heart Association Criteria (i.e., patients with cardiac disease resulting in marked
limitation of physical activity or resulting in inability to carry on any physical
activity without discomfort), unstable angina pectoris, myocardial infarction within 6
months, or serious uncontrolled cardiac arrhythmia
- Patients previously diagnosed with diabetes must not have uncontrolled diabetes
(defined as a hemoglobin [Hg] A1C > 7% within 28 days prior to registration)
- Patients known to be human immunodeficiency virus (HIV) positive may be enrolled if
baseline CD4 count is > 500 cells/mm³ and they are not taking anti-retroviral therapy
- Patients with known hepatitis are not eligible
- Patients must not have any known uncontrolled, underlying pulmonary disease
- Patients must be able to take oral medications
- Patients may not have any impairment of gastrointestinal function or gastrointestinal
disease that may significantly alter the absorption of blinded drug (e.g., ulcerative
disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome, or small
bowel resection)
- Patients must not be pregnant or nursing
- Women/men of reproductive potential must have agreed to use an effective non-hormonal
contraceptive method during and for 8 weeks after completion of study therapy
- In addition to routine contraceptive methods, "effective contraception" also
includes heterosexual celibacy and surgery intended to prevent pregnancy (or with
a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral
oophorectomy, or bilateral tubal ligation; corresponding procedures for men
include castration, vasectomy, and barrier-contractive devices
- If at any point a previously celibate patient chooses to become heterosexually
active during the protocol therapy, he/she is responsible for beginning
contraceptive measures
- No other prior malignancy is allowed except for adequately treated basal cell or
squamous cell skin cancer, in situ cervical cancer, or other cancer for which the
patient has been disease-free for 5 years
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
- Patients must have completed standard neoadjuvant or adjuvant chemotherapy prior to
randomization; completion of chemotherapy will be determined by the treating
oncologist, but should include a minimum of 4 cycles (a cycle of weekly paclitaxel is
considered 3 doses); patients must be registered within 42 weeks after the last dose
of chemotherapy; patients may have started endocrine therapy at any time after the
diagnosis of the current breast cancer
- Patients must not be receiving or planning to receive trastuzumab
- Concurrent bisphosphonate therapy is allowed
- Patients must not have prior exposure to mTOR inhibitors (rapamycin, everolimus,
temsirolimus, deforolimus)
- Patients must not have prior treatment with any investigational drug within the
preceding 28 days and must not be planning to receive any other investigational drug
for the duration of the study
- Patients must not be planning to receive any other anticancer drug for the duration of
the study
- Patients must not have an organ allograft or other history of immune compromise;
patients must not be receiving chronic, systemic treatment with corticosteroids or
other immunosuppressive agent; topical or inhaled corticosteroids are allowed
- Patients must not have received immunization with an attenuated live vaccine (e.g.,
intranasal influenza, measles, mumps, and rubella [MMR], oral polio, varicella,
zoster, yellow fever, and Bacillus Calmette-Guérin [BCG] vaccines) within seven days
prior to registration nor have plans to receive such vaccination while on protocol
treatment
- Patients must not have taken within 14 days prior to registration, be taking, nor plan
to take while on protocol treatment, strong cytochrome P450 3A4 (CYP3A4) inhibitors
and/or CYP3A4 inducers
We found this trial at
1457
sites
601 South Sherman Street
Spokane, Washington 99202
Spokane, Washington 99202
(509) 228-1000
Principal Investigator: Julie R. Gralow
Phone: 509-228-1680
Cancer Care Northwest - Spokane South Cancer Care Northwest is the Inland Northwest’s premier cancer...
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1201 Camino de Salud Northeast
Albuquerque, New Mexico 87131
Albuquerque, New Mexico 87131
(505) 272-4946
Principal Investigator: Ursa A. Brown-Glaberman
Phone: 505-925-0366
University of New Mexico Cancer Center It’s been 40 years since the New Mexico State...
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361 Old Belgrade Road
Augusta, Maine 04330
Augusta, Maine 04330
(207) 621-6100
Principal Investigator: Peter Rubin
Phone: 207-626-4855
Harold Alfond Center for Cancer Care MaineGeneral's Harold Alfond Center for Cancer Care (HACCC) is...
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8600 Old Georgetown Road
Bethesda, Maryland 20814
Bethesda, Maryland 20814
301-896-3100
Principal Investigator: Antonio C. Wolff
Phone: 301-896-2719
Suburban Hospital Suburban Hospital is a community-based, not-for-profit hospital serving Montgomery County and the surrounding...
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2545 Schoenersville Rd
Bethlehem, Pennsylvania 18017
Bethlehem, Pennsylvania 18017
(484) 884-2200
Principal Investigator: Philip J. Stella
Phone: 734-712-3671
Lehigh Valley Hospital - Muhlenberg At Lehigh Valley Health Network, we continually go the extra...
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Bremerton, Washington 98310
Principal Investigator: Richard L. Deming
Phone: 308-398-6518
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Roswell Park Cancer Institute Welcome to Roswell Park Cancer Institute (RPCI), America's first cancer center...
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1 South Prospect Street
Burlington, Vermont 05401
Burlington, Vermont 05401
802-656-8990
Principal Investigator: Marie E. Wood
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1300 Jefferson Park Avenue
Charlottesville, Virginia 22908
Charlottesville, Virginia 22908
434-243-6784
Principal Investigator: Patrick M. Dillon
Phone: 434-243-6303
University of Virginia Cancer Center We are fortunate in having state of the art clinical...
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3500 Gaston Avenue
Dallas, Texas 75246
Dallas, Texas 75246
1.800.422.9567
Principal Investigator: Joanne L. Blum
Phone: 800-422-9567
Baylor University Medical Center Baylor University Medical Center in Dallas, TX is ranked nationally in...
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1500 E Duarte Rd
Duarte, California 91010
Duarte, California 91010
(626) 256-4673
Principal Investigator: James R. Waisman
Phone: 800-826-4673
City of Hope Comprehensive Cancer Center City of Hope is a leading research and treatment...
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1 Hurley Plaza
Flint, Michigan 48503
Flint, Michigan 48503
(810) 262-9000
Principal Investigator: Philip J. Stella
Phone: 734-712-3671
Hurley Medical Center From its founding in 1908, Hurley Medical Center has devoted itself to...
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4725 North Federal Highway
Fort Lauderdale, Florida 33308
Fort Lauderdale, Florida 33308
(954) 771-8000
Principal Investigator: Michael A. Schwartz
Phone: 954-267-7750
Holy Cross Hospital While spirituality plays an essential role in the way that we minister...
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2500 N State St
Jackson, Mississippi 39216
Jackson, Mississippi 39216
(601) 984-1000
Principal Investigator: Barbara S. Craft
Phone: 601-815-6700
University of Mississippi Medical Center The University of Mississippi Medical Center, located in Jackson, is...
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524 South Park Street
Kalamazoo, Michigan 49007
Kalamazoo, Michigan 49007
(269) 341-7654
Principal Investigator: Kathleen J. Yost
Phone: 616-391-1230
Bronson Methodist Hospital Our healthcare system serves patients and families throughout southwest Michigan and northern...
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200 North Park Street
Kalamazoo, Michigan 49007
Kalamazoo, Michigan 49007
(269) 382-2500
Principal Investigator: Kathleen J. Yost
Phone: 616-391-1230
West Michigan Cancer Center In 1994, Borgess Health Alliance and Bronson Healthcare Group opened the...
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1800 West Charleston Boulevard
Las Vegas, Nevada 89102
Las Vegas, Nevada 89102
(702) 383-2000
Principal Investigator: John A. Ellerton
Phone: 702-384-0013
University Medical Center of Southern Nevada University Medical Center is dedicated to providing the highest...
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529 West Markham Street
Little Rock, Arkansas 72205
Little Rock, Arkansas 72205
(501) 686-7000
Principal Investigator: Issam Makhoul
Phone: 501-686-8274
University of Arkansas for Medical Sciences The University of Arkansas for Medical Sciences (UAMS) in...
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8700 Beverly Blvd # 8211
Los Angeles, California 90048
Los Angeles, California 90048
(1-800-233-2771)
Principal Investigator: Monica M. Mita
Phone: 310-423-8965
Cedars Sinai Med Ctr Cedars-Sinai is known for providing the highest quality patient care. Our...
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300 Community Drive
Manhasset, New York 11030
Manhasset, New York 11030
(516) 562-0100
Principal Investigator: Lora R. Weiselberg
Phone: 516-562-3467
North Shore University Hospital North Shore-LIJ Health System includes 16 award-winning hospitals and nearly 400...
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4805 Northeast Glisan Street
Portland, Oregon 97213
Portland, Oregon 97213
(503) 215-1111
Principal Investigator: Gary E. Goodman
Phone: 503-215-2614
Providence Portland Medical Center We strive to give those we serve exceptional, compassionate health care...
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401 College Street
Richmond, Virginia 23298
Richmond, Virginia 23298
(804) 828-0450
Principal Investigator: Harry D. Bear
Phone: 888-823-5923
Virginia Commonwealth University Massey Cancer Center Founded in 1974, VCU Massey Cancer Center is a...
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60 Crittenden Blvd # 70
Rochester, New York 14642
Rochester, New York 14642
(585) 275-2121
Principal Investigator: Paul M. Barr
Phone: 585-275-5830
University of Rochester The University of Rochester is one of the country's top-tier research universities....
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4502 Medical Drive
San Antonio, Texas 78284
San Antonio, Texas 78284
(210) 567-7000
Principal Investigator: Kate I. Lathrop
Phone: 210-450-3800
University of Texas Health Science Center at San Antonio The University of Texas Health Science...
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Sarasota, Florida 34236
Principal Investigator: Fadi Kayali
Phone: 941-957-1000
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825 Eastlake Ave E
Seattle, Washington 98109
Seattle, Washington 98109
(206) 288-7222
Principal Investigator: Julie R. Gralow
Phone: 800-804-8824
Seattle Cancer Care Alliance Seattle Cancer Care Alliance (SCCA) is a cancer treatment center that...
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Seattle, Washington 98104
Principal Investigator: Gary E. Goodman
Phone: 206-215-3086
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1100 Fairview Avenue North
Seattle, Washington 98109
Seattle, Washington 98109
(206) 667-5000
Principal Investigator: Julie R. Gralow
Phone: 800-804-8824
Fred Hutchinson Cancer Research Center At Fred Hutchinson Cancer Research Center, our interdisciplinary teams of...
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Avera Cancer Institute Avera, the health ministry of the Benedictine and Presentation Sisters, is a...
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808 North 39th Avenue
Yakima, Washington 98902
Yakima, Washington 98902
Principal Investigator: John A. Keech
Phone: 509-574-3535
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'Aiea, Hawaii 96701
Principal Investigator: Jeffrey L. Berenberg
Phone: 808-487-7447
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98-1079 Moanalua Road
'Aiea, Hawaii 96701
'Aiea, Hawaii 96701
Principal Investigator: Jeffrey L. Berenberg
Phone: 808-486-6000
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2226 Liliha Street
'Aiea, Hawaii 96701
'Aiea, Hawaii 96701
Principal Investigator: Jeffrey L. Berenberg
Phone: 808-678-9000
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'Aiea, Hawaii 96701
Principal Investigator: Jeffrey L. Berenberg
Phone: 808-539-2273
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Aberdeen, Washington 98520
Principal Investigator: Gary E. Goodman
Phone: 360-412-8958
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1200 Old York Road
Abington, Pennsylvania 19001
Abington, Pennsylvania 19001
(215) 481–2000
Principal Investigator: Willard G. Andrews
Phone: 215-481-2402
Abington Memorial Hospital Abington Memorial Hospital (AMH) is a 665-bed, regional referral center and teaching...
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Bixby Medical Center ProMedica's Mission is to improve your health and well-being. Which is why,...
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1 Akron General Avenue
Akron, Ohio 44307
Akron, Ohio 44307
Principal Investigator: Esther H. Rehmus
Phone: 866-223-8100
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Albany, Georgia 31701
Principal Investigator: Sharad A. Ghamande
Phone: 229-312-0405
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Albuquerque, New Mexico 87102
Principal Investigator: Ursa A. Brown-Glaberman
Phone: 505-272-0530
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Albuquerque, New Mexico 87106
Principal Investigator: Ursa A. Brown-Glaberman
Phone: 505-938-5858
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Albuquerque, New Mexico 87109
Principal Investigator: Ursa A. Brown-Glaberman
Phone: 505-272-0530
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Albuquerque, New Mexico 87102
Principal Investigator: Ursa A. Brown-Glaberman
Phone: 505-272-0530
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Alexandria, Louisiana 71301
Principal Investigator: John T. Cole
Phone: 318-448-6976
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Allentown, Pennsylvania 18103
Principal Investigator: Philip J. Stella
Phone: 734-712-3671
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Altamonte Springs, Florida 32701
Principal Investigator: Carlos A. Alemany
Phone: 888-823-5923
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Amarillo, Texas 79106
Principal Investigator: Brian T. Pruitt
Phone: 806-212-1985
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170 North 1100 East
American Fork, Utah 84003
American Fork, Utah 84003
Principal Investigator: Xylina T. Gregg
Phone: 801-408-1347
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Ames, Iowa 50010
Principal Investigator: Joseph J. Merchant
Phone: 515-956-4132
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Ames, Iowa 50010
Principal Investigator: Joseph J. Merchant
Phone: 515-956-4132
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Anaconda, Montana 59711
Principal Investigator: Benjamin T. Marchello
Phone: 406-969-6060
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Anacortes, Washington 98221
Principal Investigator: Gary E. Goodman
Phone: 206-386-2323
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Anaheim, California 92806
Principal Investigator: Han A. Koh
Phone: 800-398-3996
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Anchorage, Alaska 99508
Principal Investigator: Gary E. Goodman
Phone: 907-212-6871
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Anchorage, Alaska 99508
Principal Investigator: Gary E. Goodman
Phone: 907-212-6871
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Anchorage, Alaska 99508
Principal Investigator: Gary E. Goodman
Phone: 907-212-6871
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Anchorage, Alaska 99508
Principal Investigator: Gary E. Goodman
Phone: 907-212-6871
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Anchorage, Alaska 99508
Principal Investigator: Gary E. Goodman
Phone: 907-212-6871
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Anchorage, Alaska 98508
Principal Investigator: Gary E. Goodman
Phone: 907-212-6871
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Anchorage, Alaska 99504
Principal Investigator: Gary E. Goodman
Phone: 907-212-6871
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Anchorage, Alaska 99508
Principal Investigator: Gary E. Goodman
Phone: 907-212-6871
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2000 E Greenville St
Anderson, South Carolina 29621
Anderson, South Carolina 29621
(864) 512-4640
Principal Investigator: James D. Bearden
Phone: 800-486-5941
AnMedical Health Cancer Center Cancer is the general term for a group of more than...
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5301 McAuley Drive
Ann Arbor, Michigan 48197
Ann Arbor, Michigan 48197
734-712-3456
Principal Investigator: Philip J. Stella
Phone: 734-712-3671
Saint Joseph Mercy Hospital St. Joseph Mercy Ann Arbor Hospital is a 537-bed teaching hospital...
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1500 East Medical Center Drive
Ann Arbor, Michigan 48109
Ann Arbor, Michigan 48109
800-865-1125
Principal Investigator: Anne F. Schott
University of Michigan Comprehensive Cancer Center The U-M Comprehensive Cancer Center's mission is the conquest...
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Annapolis, Maryland 21401
Principal Investigator: Carol K. Tweed
Phone: 443-481-1320
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Antigo, Wisconsin 54409
Principal Investigator: Harish G. Ahuja
Phone: 715-623-9869
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Antioch, California 94531
Principal Investigator: Jennifer M. Suga
Phone: 877-642-4691
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Ardmore, Oklahoma 73401
Principal Investigator: Soley Bayraktar
Phone: 405-751-4343
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921 North Oak Park Boulevard
Arroyo Grande, California 93420
Arroyo Grande, California 93420
Principal Investigator: John A. Ellerton
Phone: 702-384-0013
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364 White Oak St
Asheboro, North Carolina 27203
Asheboro, North Carolina 27203
(336) 625-5151
Principal Investigator: James M. Granfortuna
Phone: 336-832-0821
Randolph Hospital Since 1932, Randolph Hospital has been fortunate to employ dedicated and loyal personnel...
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Asheville, North Carolina 28801
Principal Investigator: Cameron B. Harkness
Phone: 800-506-2550
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Asheville, North Carolina 28801
Principal Investigator: Cameron B. Harkness
Phone: 828-213-4150
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Asheville, North Carolina 28801
Principal Investigator: Cameron B. Harkness
Phone: 828-213-4150
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Asheville, North Carolina 28816
Principal Investigator: Cameron B. Harkness
Phone: 828-213-4150
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Asheville, North Carolina 28803
Principal Investigator: Raymond Thertulien
Phone: 828-650-8037
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Ashland, Kentucky 41101
Principal Investigator: David K. Goebel
Phone: 888-823-5923
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1625 Maple Lane
Ashland, Wisconsin 54806
Ashland, Wisconsin 54806
Principal Investigator: Bret E. Friday
Phone: 218-786-3308
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Ashland, Wisconsin 54806
Principal Investigator: Bret E. Friday
Phone: 218-786-3308
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Athens, Georgia 30607
Principal Investigator: Sharad A. Ghamande
Phone: 706-353-5006
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Attleboro, Massachusetts 02703
Principal Investigator: Asma Latif
Phone: 508-236-7059
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Auburn, California 95602
Principal Investigator: Ari D. Baron
Phone: 415-209-2686
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Auburn, California 95603
Principal Investigator: Ari D. Baron
Phone: 415-209-2686
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Auburn, New York 13021
Principal Investigator: Jeffrey J. Kirshner
Phone: 315-472-7504
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Auburn, Washington 98001
Principal Investigator: John A. Keech
Phone: 253-887-9333
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Augusta, Georgia 30912
Principal Investigator: Sharad A. Ghamande
Phone: 706-721-2388
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1303 D'Antignac Street
Augusta, Georgia 30901
Augusta, Georgia 30901
Principal Investigator: Sharad A. Ghamande
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Augusta, Georgia 30909
Principal Investigator: Sharad A. Ghamande
Phone: 706-736-1830
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Aurora, Colorado 80012
Principal Investigator: Keren Sturtz
Phone: 303-777-2663
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1501 S Potomac St
Aurora, Colorado 80012
Aurora, Colorado 80012
(303) 695-2600
Principal Investigator: Keren Sturtz
Phone: 888-785-6789
Medical Center of Aurora At The Medical Center of Aurora and Centennial Medical Plaza patients...
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12605 East 16th Avenue
Aurora, Colorado 80045
Aurora, Colorado 80045
720-848-0000
Principal Investigator: Anthony D. Elias
Phone: 720-848-0650
University of Colorado Hospital, Site Top medical professionals, superior medicine and progressive change make University...
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2000 Ogden Ave
Aurora, Illinois 60504
Aurora, Illinois 60504
(630) 978-6200
Principal Investigator: Maria T. Grosse-Perdekamp
Phone: 630-978-6212
Rush - Copley Medical Center Rush-Copley is proud to be the leading provider of health...
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1500 Red River Street
Austin, Texas 78701
Austin, Texas 78701
Principal Investigator: Om N. Pandey
Phone: 512-324-7991
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Aventura, Florida 33180
Principal Investigator: Michael A. Schwartz
Phone: 305-674-2625
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Bainbridge Island, Washington 98110
Principal Investigator: John A. Keech
Phone: 206-342-6954
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