A Registry for Patients With Chronic Hypoparathyroidism



Status:Recruiting
Conditions:Endocrine
Therapuetic Areas:Endocrinology
Healthy:No
Age Range:Any
Updated:2/14/2019
Start Date:July 1, 2013
End Date:November 30, 2034
Contact:Shire Contact
Email:clinicaltransparency@shire.com

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PARADIGHM (Physicians Advancing Disease Knowledge in Hypoparathyroidism): A Registry for Patients With Chronic Hypoparathyroidism

This is a prospective, observational disease and drug registry designed to evaluate the
safety and effectiveness profile of rhPTH(1-84) under conditions of routine clinical practice
and to observe the clinical course of chronic hypoparathyrodism. No treatment is provided as
a result of participating in this registry and all decisions on the participant's treatment
are determined by his or her physician.


Inclusion Criteria:

1. Participants diagnosed with chronic hypoparathyroidism, ie, hypoparathyroidism with a
duration of longer than 6 months, including:

1. Adult participants (greater than or equal to [>=] 18 years of age) who are receiving
for chronic hypoparathyroidism any of the following options: standard therapy,
standard therapy plus rhPTH(1-84), or rhPTH(1-84) therapy alone.

2. Pediatric participants (less than [<] 18 years of age) who are receiving for chronic
hypoparathyroidism any of the following options: standard therapy, standard therapy
plus rhPTH(1-84), or rhPTH(1-84) therapy alone.

Exclusion Criteria:

1. Participants or legally acceptable representatives unable to provide informed consent.

2. Participants using rhPTH(1-34) or used rhPTH(1-34) for more than 2 years and in the
last 3 months.

3. Participants currently enrolled in an interventional clinical study (whether or not
the study is related to hypoparathyroidism). Note that this does not include
participants enrolled in other observational registries.

4. History of hypoparathyroidism resulting from a known activating mutation in the CaSR
gene.

5. History of hypoparathyroidism resulting from impaired responsiveness to PTH
(pseudohypoparathyroidism).
We found this trial at
51
sites
185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
Principal Investigator: Michael Mannstadt, MD
Phone: 617-726-3966
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1720 2nd Ave S
Birmingham, Alabama 35233
(205) 934-4011 
Principal Investigator: Amy Warriner, MD
Phone: 205-975-9308
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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75 Francis street
Boston, Massachusetts 02115
(617) 732-5500
Principal Investigator: Anil Chandraker, MD
Phone: 617-525-8003
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
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75 Francis street
Boston, Massachusetts 02115
(617) 732-5500
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
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9500 Euclid Avenue
Cleveland, Ohio 44106
216.444.2200
Principal Investigator: Roy Kim, MD
Phone: 216-445-4944
Cleveland Clinic Cleveland Clinic is committed to principles as presented in the United Nations Global...
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550 University Boulevard
Indianapolis, Indiana 46202
Principal Investigator: Munro Peacock, MD
Phone: 317-948-8346
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Indianapolis, IN
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4650 Sunset Blvd
Los Angeles, California 90027
 (323) 660-2450
Principal Investigator: Anna Ryabets-Lienhard, MD
Phone: 323-361-6478
Childrens Hospital Los Angeles Children's Hospital Los Angeles is a 501(c)(3) nonprofit hospital for pediatric...
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8700 Beverly Blvd # 8211
Los Angeles, California 90048
(1-800-233-2771)
Principal Investigator: Wendy Sacks, MD
Phone: 310-423-8321
Cedars Sinai Med Ctr Cedars-Sinai is known for providing the highest quality patient care. Our...
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Minneapolis, Minnesota 55455
(612) 625-5000
Principal Investigator: Tasma Harindhanavudhi, MD
Univ of Minnesota With a flagship campus in the heart of the Twin Cities, and...
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South 34th Street
Philadelphia, Pennsylvania 19104
 215-590-1000
Principal Investigator: Michael Levine, MD
Phone: 267-426-7482
Children's Hospital of Philadelphia Since its start in 1855 as the nation's first hospital devoted...
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Albany, New York 12206
Principal Investigator: Robert Busch
Phone: 518-264-4723
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Arlington Heights, Illinois 60005
Principal Investigator: Mario Chan, MD
Phone: 847-981-0560
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12605 East 16th Avenue
Aurora, Colorado 80045
720-848-0000
Principal Investigator: Michael McDermott, MD
Phone: 720-848-5146
University of Colorado Hospital, Site Top medical professionals, superior medicine and progressive change make University...
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Austin, Texas 78731
Principal Investigator: Valerie Espinosa, MD
Phone: 512-334-3505
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Baltimore, Maryland 21204
Principal Investigator: Philip Levin, MD
Phone: 443-524-1789
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Baltimore, Maryland 21218
Principal Investigator: Paul Sack, MD
Phone: 410-554-2486
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Boston, Massachusetts 02118
Principal Investigator: Michael Holick, MD
Phone: 617-638-4546
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Brooklyn, New York 11223
Principal Investigator: Matvey Brokhin, MD
Phone: 347-462-9292
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Charlotte, North Carolina 28204
Principal Investigator: Gary Rolband, MD
Phone: 704-302-8218
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5841 S Maryland Ave
Chicago, Illinois 60637
(773) 702-1000
Principal Investigator: Tamara Vokes, MD
Phone: 773-702-1197
University of Chicago Medical Center The University of Chicago Medicine has been at the forefront...
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Columbia, Missouri 65211
(573) 882-2121
Principal Investigator: Robert Zitsch, MD
Phone: 573-882-2549
University of Missouri T he University of Missouri was founded in 1839 in Columbia, Mo.,...
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Columbia, South Carolina 29208
Principal Investigator: Ali Rizvi, MD
Phone: 803-545-5430
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410 W 10th Ave
Columbus, Ohio 43210
(614) 293-8652
Principal Investigator: Steven Ing, MD
Phone: 614-688-6257
The Ohio State University, Wexner Medical Center Located in Columbus, The Ohio State University Wexner...
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Columbus, Ohio 43214
Principal Investigator: Michelle Kovalaske, MD
Phone: 614-566-1255
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East Providence, Rhode Island 02914
Principal Investigator: Geetha Gopalakrishnan, MD
Phone: 401-444-3420
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10525 Vista Del Sol Drive
El Paso, Texas 79935
Principal Investigator: Sergio Rovner
Phone: 915-633-9387
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Evanston, Illinois 60201
Principal Investigator: Stuart Sprague, MD
Phone: 847-570-1761
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Fort Worth, Texas 76132
Principal Investigator: Chris Bajaj, MD
Phone: 817-644-3807
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3 Universitätsplatz
Graz, 8010
Principal Investigator: Karin Amrein
Phone: 43.316.385.80798
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Greenville, North Carolina 27834
Principal Investigator: Mark Warren, MD
Phone: 252-413-6299
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Honolulu, Hawaii 96814
Principal Investigator: David Fitz-Patrick, MD
Phone: 808-440-4466
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Indiana, Pennsylvania 15701
Principal Investigator: Mushtaq Syed, MD
Phone: 928-550-3103
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Las Vegas, Nevada 89102
Principal Investigator: SAMER NAKHLE
Phone: 702-826-2795
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Madison, Wisconsin 53792
(608) 263-2400
Principal Investigator: Becky Sippel, MD
Phone: 608-262-9799
University of Wisconsin In achievement and prestige, the University of Wisconsin–Madison has long been recognized...
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Marrero, Louisiana 70072
Principal Investigator: Tilak Mallik, MD
Phone: 504-349-6520
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2160 South 1st Avenue
Maywood, Illinois 60153
(888) 584-7888
Principal Investigator: Pauline Camacho
Phone: 708-216-2058
Loyola University Medical Center Loyola University Health System is committed to excellence in patient care...
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New Brunswick, New Jersey 08903
Principal Investigator: Ian Marshall, MD
Phone: 732-235-7570
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New Brunswick, New Jersey 08903
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630 W 168th St
New York, New York
212-305-2862
Principal Investigator: John Bilezikian, MD
Phone: 212-305-7364
Columbia University Medical Center Situated on a 20-acre campus in Northern Manhattan and accounting for...
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Omaha, Nebraska 68114
Principal Investigator: Claire Baker
Phone: 402-561-2662
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1020 Walnut St
Philadelphia, Pennsylvania 19107
(215) 955-6000
Principal Investigator: Intekhab Ahmed, MD
Phone: 215-955-8405
Thomas Jefferson University We are dedicated to the health sciences and committed to educating professionals,...
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Port Charlotte, Florida 33952
Principal Investigator: Lenita Hanson, MD
Phone: 941-764-9110
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Reno, Nevada 89511
Principal Investigator: Lisa Abbott, MD
Phone: 775-786-6770
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200 First Street SW
Rochester, Minnesota 55905
507-284-2511
Principal Investigator: Bart Clarke, MD
Phone: 507-255-8621
Mayo Clinic Rochester Mayo Clinic is a nonprofit worldwide leader in medical care, research and...
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San Jose, California 95148
Principal Investigator: Joselito Cabaccan
Phone: 757-679-1660
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Sarasota, Florida 34239
Principal Investigator: Mark Lupo, MD
Phone: 941-342-9750
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Smithtown, New York 11787
Principal Investigator: Michael Shanik, MD
Phone: 631-265-5501
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South Burlington, Vermont
Principal Investigator: Jennifer Kelly
Phone: JENNIFER.KELLY@UVMHEALTH.ORG
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Staten Island, New York 10301
Principal Investigator: Jeffrey Rothman, MD
Phone: 718-442-0300
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Syracuse, New York 13214
Principal Investigator: Ruban Dhaliwal, MD
Phone: 315-464-9008
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Tucson, Arizona 85724
Principal Investigator: Craig Stump, MD
Phone: 520-626-3709
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