A Registry for Patients With Chronic Hypoparathyroidism
| Status: | Recruiting | 
|---|---|
| Conditions: | Endocrine | 
| Therapuetic Areas: | Endocrinology | 
| Healthy: | No | 
| Age Range: | Any | 
| Updated: | 4/6/2019 | 
| Start Date: | July 1, 2013 | 
| End Date: | November 30, 2034 | 
| Contact: | Shire Contact | 
| Email: | clinicaltransparency@shire.com | 
PARADIGHM (Physicians Advancing Disease Knowledge in Hypoparathyroidism): A Registry for Patients With Chronic Hypoparathyroidism
This is a prospective, observational disease and drug registry designed to evaluate the
safety and effectiveness profile of rhPTH(1-84) under conditions of routine clinical practice
and to observe the clinical course of chronic hypoparathyrodism. No treatment is provided as
a result of participating in this registry and all decisions on the participant's treatment
are determined by his or her physician.
			safety and effectiveness profile of rhPTH(1-84) under conditions of routine clinical practice
and to observe the clinical course of chronic hypoparathyrodism. No treatment is provided as
a result of participating in this registry and all decisions on the participant's treatment
are determined by his or her physician.
Inclusion Criteria:
1. Participants diagnosed with chronic hypoparathyroidism, ie, hypoparathyroidism with a
duration of longer than 6 months, including:
1. Adult participants (greater than or equal to [>=] 18 years of age) who are receiving
for chronic hypoparathyroidism any of the following options: standard therapy,
standard therapy plus rhPTH(1-84), or rhPTH(1-84) therapy alone.
2. Pediatric participants (less than [<] 18 years of age) who are receiving for chronic
hypoparathyroidism any of the following options: standard therapy, standard therapy
plus rhPTH(1-84), or rhPTH(1-84) therapy alone.
Exclusion Criteria:
1. Participants or legally acceptable representatives unable to provide informed consent.
2. Participants using rhPTH(1-34) or used rhPTH(1-34) for more than 2 years and in the
last 3 months.
3. Participants currently enrolled in an interventional clinical study (whether or not
the study is related to hypoparathyroidism). Note that this does not include
participants enrolled in other observational registries.
4. History of hypoparathyroidism resulting from a known activating mutation in the CaSR
gene.
5. History of hypoparathyroidism resulting from impaired responsiveness to PTH
(pseudohypoparathyroidism).
We found this trial at
    51
    sites
	
								East Providence, Rhode Island 02914			
	
			
					Principal Investigator: Geetha Gopalakrishnan, MD
			
						
										Phone: 401-444-3420
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									1720 2nd Ave S
Birmingham, Alabama 35233
	
			Birmingham, Alabama 35233
(205) 934-4011  
							 
					Principal Investigator: Amy Warriner, MD
			
						
										Phone: 205-975-9308
					
		University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...  
  
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									185 Cambridge Street
Boston, Massachusetts 02114
	
			Boston, Massachusetts 02114
617-724-5200
							 
					Principal Investigator: Michael Mannstadt, MD
			
						
										Phone: 617-726-3966
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									75 Francis street
Boston, Massachusetts 02115
	
			Boston, Massachusetts 02115
(617) 732-5500 
							 
					Principal Investigator: Anil Chandraker, MD
			
						
										Phone: 617-525-8003
					
		Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...  
  
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		Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...  
  
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									9500 Euclid Avenue
Cleveland, Ohio 44106
	
			Cleveland, Ohio 44106
216.444.2200
							 
					Principal Investigator: Roy Kim, MD
			
						
										Phone: 216-445-4944
					
		Cleveland Clinic Cleveland Clinic is committed to principles as presented in the United Nations Global...  
  
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									550 University Boulevard
Indianapolis, Indiana 46202
	
			
					Indianapolis, Indiana 46202
Principal Investigator: Munro Peacock, MD
			
						
										Phone: 317-948-8346
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									4650 Sunset Blvd
Los Angeles, California 90027
	
			Los Angeles, California 90027
 (323) 660-2450 
							 
					Principal Investigator: Anna Ryabets-Lienhard, MD
			
						
										Phone: 323-361-6478
					
		Childrens Hospital Los Angeles Children's Hospital Los Angeles is a 501(c)(3) nonprofit hospital for pediatric...  
  
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									8700 Beverly Blvd # 8211
Los Angeles, California 90048
	
			Los Angeles, California 90048
(1-800-233-2771) 
							 
					Principal Investigator: Wendy Sacks, MD
			
						
										Phone: 310-423-8321
					
		Cedars Sinai Med Ctr Cedars-Sinai is known for providing the highest quality patient care. Our...  
  
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								Minneapolis, Minnesota 55455			
	
			(612) 625-5000 
							 
					Principal Investigator: Tasma Harindhanavudhi, MD
			
						
								
		Univ of Minnesota With a flagship campus in the heart of the Twin Cities, and...  
  
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									South 34th Street
Philadelphia, Pennsylvania 19104
	
			Philadelphia, Pennsylvania 19104
 215-590-1000 
							 
					Principal Investigator: Michael Levine, MD
			
						
										Phone: 267-426-7482
					
		Children's Hospital of Philadelphia Since its start in 1855 as the nation's first hospital devoted...  
  
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								Albany, New York 12206			
	
			
					Principal Investigator: Robert Busch
			
						
										Phone: 518-264-4723
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								Arlington Heights, Illinois 60005			
	
			
					Principal Investigator: Mario Chan, MD
			
						
										Phone: 847-981-0560
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									12605 East 16th Avenue
Aurora, Colorado 80045
	
			Aurora, Colorado 80045
720-848-0000
							 
					Principal Investigator: Michael McDermott, MD
			
						
										Phone: 720-848-5146
					
		University of Colorado Hospital, Site Top medical professionals, superior medicine and progressive change make University...  
  
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								Austin, Texas 78731			
	
			
					Principal Investigator: Valerie Espinosa, MD
			
						
										Phone: 512-334-3505
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								Baltimore, Maryland 21204			
	
			
					Principal Investigator: Philip Levin, MD
			
						
										Phone: 443-524-1789
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								Baltimore, Maryland 21218			
	
			
					Principal Investigator: Paul Sack, MD
			
						
										Phone: 410-554-2486
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								Boston, Massachusetts 02118			
	
			
					Principal Investigator: Michael Holick, MD
			
						
										Phone: 617-638-4546
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								Brooklyn, New York 11223			
	
			
					Principal Investigator: Matvey Brokhin, MD
			
						
										Phone: 347-462-9292
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								Charlotte, North Carolina 28204			
	
			
					Principal Investigator: Gary Rolband, MD
			
						
										Phone: 704-302-8218
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									 5841 S Maryland Ave
Chicago, Illinois 60637
	
			Chicago, Illinois 60637
(773) 702-1000
							 
					Principal Investigator: Tamara Vokes, MD
			
						
										Phone: 773-702-1197
					
		University of Chicago Medical Center The University of Chicago Medicine has been at the forefront...  
  
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								Columbia, Missouri 65211			
	
			(573) 882-2121
							 
					Principal Investigator: Robert Zitsch, MD
			
						
										Phone: 573-882-2549
					
		University of Missouri T he University of Missouri was founded in 1839 in Columbia, Mo.,...  
  
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								Columbia, South Carolina 29208			
	
			
					Principal Investigator: Ali Rizvi, MD
			
						
										Phone: 803-545-5430
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									410 W 10th Ave
Columbus, Ohio 43210
	
			Columbus, Ohio 43210
(614) 293-8652
							 
					Principal Investigator: Steven Ing, MD
			
						
										Phone: 614-688-6257
					
		The Ohio State University, Wexner Medical Center Located in Columbus, The Ohio State University Wexner...  
  
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								Columbus, Ohio 43214			
	
			
					Principal Investigator: Michelle Kovalaske, MD
			
						
										Phone: 614-566-1250
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									10525 Vista Del Sol Drive
El Paso, Texas 79935
	
			
					El Paso, Texas 79935
Principal Investigator: Sergio Rovner
			
						
										Phone: 915-633-9387
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								Evanston, Illinois 60201			
	
			
					Principal Investigator: Stuart Sprague, MD
			
						
										Phone: 847-570-1761
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								Fort Worth, Texas 76132			
	
			
					Principal Investigator: Chris Bajaj, MD
			
						
										Phone: 817-644-3807
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									3 Universitätsplatz
Graz, 8010
	
			
					Graz, 8010
Principal Investigator: Karin Amrein
			
						
										Phone: 43.316.385.80798
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								Greenville, North Carolina 27834			
	
			
					Principal Investigator: Mark Warren, MD
			
						
										Phone: 252-413-6299
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								Honolulu, Hawaii 96814			
	
			
					Principal Investigator: David Fitz-Patrick, MD
			
						
										Phone: 808-440-4466
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								Indiana, Pennsylvania 15701			
	
			
					Principal Investigator: Mushtaq Syed, MD
			
						
										Phone: 928-550-3103
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								Las Vegas, Nevada 89102			
	
			
					Principal Investigator: SAMER NAKHLE
			
						
										Phone: 702-826-2795
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								Madison, Wisconsin 53792			
	
			(608) 263-2400
							 
					Principal Investigator: Becky Sippel, MD
			
						
										Phone: 608-262-9799
					
		University of Wisconsin In achievement and prestige, the University of Wisconsin–Madison has long been recognized...  
  
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								Marrero, Louisiana 70072			
	
			
					Principal Investigator: Tilak Mallik, MD
			
						
										Phone: 504-349-6520
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									2160 South 1st Avenue
Maywood, Illinois 60153
	
			Maywood, Illinois 60153
(888) 584-7888
							 
					Principal Investigator: Pauline Camacho
			
						
										Phone: 708-216-2058
					
		Loyola University Medical Center Loyola University Health System is committed to excellence in patient care...  
  
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								New Brunswick, New Jersey 08903			
	
			
					Principal Investigator: Ian Marshall, MD
			
						
										Phone: 732-235-7570
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									630 W 168th St
New York, New York
	
			New York, New York
212-305-2862 
							 
					Principal Investigator: John Bilezikian, MD
			
						
										Phone: 212-305-7364
					
		Columbia University Medical Center Situated on a 20-acre campus in Northern Manhattan and accounting for...  
  
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								Omaha, Nebraska 68114			
	
			
					Principal Investigator: Claire Baker
			
						
										Phone: 402-561-2662
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									1020 Walnut St
Philadelphia, Pennsylvania 19107
	
			Philadelphia, Pennsylvania 19107
(215) 955-6000
							 
					Principal Investigator: Intekhab Ahmed, MD
			
						
										Phone: 215-955-8405
					
		Thomas Jefferson University We are dedicated to the health sciences and committed to educating professionals,...  
  
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								Port Charlotte, Florida 33952			
	
			
					Principal Investigator: Lenita Hanson, MD
			
						
										Phone: 941-764-9110
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								Reno, Nevada 89511			
	
			
					Principal Investigator: Lisa Abbott, MD
			
						
										Phone: 775-786-6770
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									200 First Street SW
Rochester, Minnesota 55905
	
			Rochester, Minnesota 55905
507-284-2511 
							 
					Principal Investigator: Bart Clarke, MD
			
						
										Phone: 507-255-8621
					
		Mayo Clinic Rochester Mayo Clinic is a nonprofit worldwide leader in medical care, research and...  
  
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								San Jose, California 95148			
	
			
					Principal Investigator: Joselito Cabaccan
			
						
										Phone: 757-679-1660
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								Sarasota, Florida 34239			
	
			
					Principal Investigator: Mark Lupo, MD
			
						
										Phone: 941-342-9750
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								Smithtown, New York 11787			
	
			
					Principal Investigator: Michael Shanik, MD
			
						
										Phone: 631-265-5501
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								South Burlington, Vermont 			
	
			
					Principal Investigator: Jennifer Kelly
			
						
										Phone: JENNIFER.KELLY@UVMHEALTH.ORG
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								Staten Island, New York 10301			
	
			
					Principal Investigator: Jeffrey Rothman, MD
			
						
										Phone: 718-442-0300
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								Syracuse, New York 13214			
	
			
					Principal Investigator: Ruban Dhaliwal, MD
			
						
										Phone: 315-464-9008
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								Tucson, Arizona 85724			
	
			
					Principal Investigator: Craig Stump, MD
			
						
										Phone: 520-626-3709
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