Cabozantinib or Paclitaxel in Treating Patients With Persistent or Recurrent Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cavity Cancer



Status:Active, not recruiting
Conditions:Ovarian Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:9/30/2018
Start Date:November 6, 2012

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A Randomized Phase II Study of NCI Supplied Cabozantinib (NSC #761968) Versus Weekly Paclitaxel (NSC #673089) in the Treatment of Persistent or Recurrent Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer

This randomized phase II trial studies how well giving cabozantinib-s-malate or paclitaxel
works in treating patients with persistent or recurrent epithelial ovarian, fallopian tube,
or primary peritoneal cavity cancer. Cabozantinib-s-malate may stop the growth of tumor cells
by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as
paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the
cells or by stopping them from dividing. It is not yet known whether cabozantinib-s-malate or
paclitaxel is more effective at treating patients with persistent or recurrent epithelial
ovarian, fallopian tube, or primary peritoneal cavity cancer.

PRIMARY OBJECTIVES:

I. To assess the activity of cabozantinib (cabozantinib-s-malate) relative to weekly
paclitaxel in patients with persistent or recurrent ovarian, fallopian tube, or primary
peritoneal cancer with a log-rank test assessing progression-free survival (PFS) at 3.68
months (approximately pre-cycle 5) and 7.36 months (approximately pre-cycle 9).

SECONDARY OBJECTIVES:

I. To determine the frequency and severity of adverse events as assessed by Common
Terminology Criteria for Adverse Events (CTCAE).

II. To estimate and compare the proportion of patients responding to therapy by Response
Evaluation Criteria for Solid Tumors (RECIST), cancer antigen 125 (CA125) response, the
overall survival (OS), and the duration of response in each arm.

TERTIARY OBJECTIVES:

I. To retrospectively correlate c-met proto-oncogene (MET) expression with overall outcome.

II. To retrospectively correlate c-MET copy number with overall outcome.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive cabozantinib-s-malate orally (PO) once daily (QD) on days 1-28.

ARM II: Patients receive paclitaxel intravenously (IV) over 1 hour on days 1, 8, and 15.

In both arms, courses repeat every 28 days in the absence of disease progression or
unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for 2 years and
then every 6 months for 3 years.

Inclusion Criteria:

- Patients must have recurrent or persistent epithelial ovarian, fallopian tube or
primary peritoneal carcinoma; histologic documentation of the original primary tumor
is required via the pathology report

- Patients must have measurable disease or non-measurable (detectable) disease:

- Measurable disease is defined as at least one lesion that can be accurately
measured in at least one dimension (longest diameter to be recorded); each lesion
must be greater than or equal to 10 mm when measured by computed tomography (CT),
magnetic resonance imaging (MRI) or caliper measurement by clinical exam; or
greater than or equal to 20 mm when measured by chest x-ray; lymph nodes must be
greater than or equal to 15 mm in short axis when measured by CT or MRI

- Non-measurable (detectable) disease is defined in this protocol as the absence of
measurable disease but at least one of the following conditions:

- Ascites and/or pleural effusion attributed to tumor

- Solid and/or cystic abnormalities on radiographic imaging that do not meet
RECIST 1.1 definitions for target lesions

- Patients with measurable disease must have at least one "target lesion" to be used to
assess response on this protocol as defined by RECIST 1.1; tumors within a previously
irradiated field will be designated as "non-target" lesions unless progression is
documented or a biopsy is obtained to confirm persistence at least 90 days following
completion of radiation therapy

- Patients must not be eligible for a higher priority Gynecologic Oncology Group (GOG)
protocol, if one exists; in general, this would refer to any active GOG phase III or
rare tumor protocol for the same patient population; in addition, patients must not be
eligible for the currently active phase II cytotoxic protocol in platinum resistant
disease

- Patients must have a GOG performance status of 0, 1, or 2

- Recovery from effects of recent surgery, radiotherapy, or chemotherapy to baseline or
CTCAE =< grade 1 toxicity from all prior therapies except alopecia and other
non-clinically significant adverse events (AE's):

- Patients should be free of active infection requiring antibiotics (with the
exception of uncomplicated urinary tract infection [UTI])

- Any hormonal therapy directed at the malignant tumor must be discontinued at
least one week prior to treatment

- Any other prior therapy directed at the malignant tumor, including chemotherapy,
biological/targeted (non-cytotoxic) agents and immunologic agents, must be
discontinued at least three weeks prior to treatment

- Chimeric or human or humanized monoclonal antibodies (including bevacizumab) or
vascular endothelial growth factor (VEGF) receptor fusion proteins (including
VEGF TRAP/aflibercept) must be discontinued for at least 12 weeks prior to
treatment

- Investigational agents must be discontinued for at least 28 days prior to
treatment

- Any prior radiation therapy must be discontinued at least four weeks prior to
treatment

- Prior therapy

- Patients must have had one prior platinum-based chemotherapeutic regimen for
management of primary disease containing carboplatin, cisplatin, or another
organoplatinum compound; this initial treatment may have included intraperitoneal
therapy, consolidation, biologic/targeted (non-cytotoxic) agents (e.g.,
bevacizumab) or extended therapy administered after surgical or non-surgical
assessment; if patients were treated with paclitaxel for their primary disease,
this could have been given weekly or every 3 weeks

- Patients are allowed to receive, but are not required to receive, two additional
cytotoxic regimens for management of recurrent or persistent disease, with no
more than 1 non-platinum, non-taxane regimen; treatment with weekly paclitaxel
for recurrent or persistent disease is NOT allowed

- Patients are allowed to receive, but are not required to receive,
biologic/targeted (non-cytotoxic) therapy as part of their primary treatment
regimen

- Patients must have NOT received any biologic/targeted (non-cytotoxic) therapy
targeting the VEGF and/or MET pathways for management of recurrent or persistent
disease

- For the purposes of this study, poly (adenosine diphosphate [ADP]-ribose)
polymerase (PARP) inhibitors will be considered "cytotoxic"; patients are allowed
to receive, but are not required to receive, PARP inhibitors for management of
primary or recurrent/persistent disease (either alone or in combination with
cytotoxic chemotherapy); PARP inhibitors will NOT count as a prior regimen when
given alone

- Absolute neutrophil count (ANC) greater than or equal to 1,500/mcl

- Platelets greater than or equal to 100,000/mcl

- Hemoglobin greater than or equal to 9 g/dL

- Prothrombin time (PT) such that international normalized ratio (INR) is less than or
equal to 1.3 x institutional upper limit of normal (ULN)

- Partial thromboplastin time (PTT) less than or equal to 1.3 x ULN

- Creatinine less than or equal to 1.5 x ULN

- Phosphorus, corrected calcium, magnesium and potassium greater than or equal to
institutional lower limit of normal (LLN)

- Urine protein creatinine (UPC) ratio must be < 1.0 gm; if UPC ratio >= 1, collection
of 24-hour urine measurement of urine protein is recommended

- Bilirubin less than or equal to 1.5 x ULN

- Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) less than or equal
to 3 x ULN

- Alkaline phosphatase less than or equal to 2.5 x ULN

- Albumin greater than or equal to 2.8 g/dL

- Lipase less than or equal to 2 x ULN

- No radiologic or clinical evidence of pancreatitis

- Patients must have a normal baseline thyroid stimulating hormone (TSH); a history of
hypothyroidism and/or hyperthyroidism is allowed

- Neuropathy (sensory and motor) less than or equal to grade 1

- Patients of childbearing potential must have a negative pregnancy test prior to the
study entry and be practicing an effective form of contraception; sexually active
subjects must agree to use medically accepted barrier methods of contraception (e.g.,
male or female condom) during the course of the study and for 4 months after the last
dose of study drug, even if oral contraceptives are also used; all subjects of
reproductive potential must agree to use both a barrier method and a second method of
birth control during the course of the study and for 4 months after the last dose of
study drug; pregnant women are excluded from this study

- Patients must have signed an approved informed consent and authorization permitting
the release of personal health information

- Patients must meet pre-entry requirements

Exclusion Criteria:

- Patients who have had previous treatment with cabozantinib; patients who have received
previous treatment with weekly paclitaxel for recurrent or persistent disease

- Patients with a history of other invasive malignancies, with the exception of
non-melanoma skin cancer and other specific malignancies, are excluded if there is any
evidence of other malignancy being present within the last three years; patients are
also excluded if their previous cancer treatment contraindicates this protocol therapy

- Patients who have received prior radiotherapy to any portion of the abdominal cavity
or pelvis or thoracic cavity within the last three years are excluded; prior radiation
for localized cancer of the breast, head and neck, or skin is permitted, provided that
it was completed more than three years prior to registration, and the patient remains
free of recurrent or metastatic disease

- Patients who have received prior chemotherapy for any abdominal or pelvic tumor OTHER
THAN for the treatment of ovarian, fallopian tube, or primary peritoneal cancer within
the last three years are excluded; patients may have received prior adjuvant
chemotherapy for localized breast cancer, provided that it was completed more than
three years prior to registration, and the patient remains free of recurrent or
metastatic disease

- Uncontrolled hypertension, defined as systolic greater than 140 mm Hg or diastolic
greater than 90 mm Hg despite antihypertensive medications

- Myocardial infarction or unstable angina within 6 months prior to registration

- New York Heart Association (NYHA) class II or greater congestive heart failure

- History of serious ventricular arrhythmia (i.e., ventricular tachycardia or
ventricular fibrillation) or serious cardiac arrhythmia requiring medication; this
does not include asymptomatic atrial fibrillation with controlled ventricular rate

- Any history of congenital long QT syndrome

- The subject has a corrected QT interval calculated by the Fridericia formula (QTcF) >
500 ms within 28 days before randomization; note: if initial QTcF is found to be > 500
ms, two additional electrocardiogram (EKGs) separated by at least 3 minutes should be
performed; if the average of these three consecutive results for QTcF is =< 500 ms,
the subject meets eligibility in this regard

- Patients with serious non-healing wound, ulcer, or bone fracture within 28 days before
treatment

- Patients with history of organ transplant

- Patients with active bleeding or pathologic conditions that carry high risk of
bleeding, such as known bleeding disorder, coagulopathy, or tumor involving (in
contact with, invading or encasing) major vessels

- Patients who have experienced any of the following:

- Clinically-significant gastrointestinal bleeding within 6 months before the first
dose of study treatment

- Hemoptysis of >= 0.5 teaspoon (2.5 mL) of red blood within 3 months before the
first dose of study treatment

- Any other signs indicative of pulmonary hemorrhage within 3 months before the
first dose of study treatment

- Patients who have radiographic evidence of cavitating pulmonary lesion(s)

- Patients who have tumor invading the gastrointestinal (GI) tract (esophagus, stomach,
small or large bowel, rectum or anus), or any evidence of endotracheal or
endobronchial tumor within 28 days before treatment

- Gastrointestinal disorders, particularly those with potential risk of perforation or
fistula formation including:

- Any of the following within 28 days of registration

- Intra-abdominal tumor/metastases invading GI mucosa

- Active peptic ulcer disease

- Inflammatory bowel disease (including ulcerative colitis and Crohn's
disease), diverticulitis, cholecystitis, symptomatic cholangitis or
appendicitis

- Malabsorption syndrome

- Any of the following within 6 months of registration

- Abdominal fistula

- Gastrointestinal perforation

- Bowel obstruction or gastric outlet obstruction; note: patients requiring
drainage gastrostomy (e.g., percutaneous endoscopic gastrostomy [PEG] tube)
and/or parenteral hydration and/or nutrition are not eligible

- Intra-abdominal abscess; note: complete resolution of an intra-abdominal
abscess must be confirmed prior to registration even if the abscess occurred
more than 6 months prior to registration

- Patients with history or evidence upon physical examination of central nervous system
(CNS) disease, including primary brain tumor, seizures which are not controlled with
non-enzyme inducing anticonvulsants, any brain metastases and/or epidural disease, or
history of cerebrovascular accident (CVA, stroke), transient ischemic attack (TIA) or
subarachnoid hemorrhage within six months prior to the first date of study treatment

- The subject requires chronic concomitant treatment of strong cytochrome P450, family
3, subfamily A, polypeptide 4 (CYP3A4) inducers (e.g., dexamethasone, phenytoin,
carbamazepine, rifampin, rifabutin, rifapentine, phenobarbital, and St. John's wort)

- Patients who are unable or unwilling to swallow tablets

- Patients who are pregnant or nursing

- The subject requires concomitant treatment, in therapeutic doses, with anti-coagulants
such as warfarin or warfarin-related agents, heparin, thrombin or factor Xa inhibitors
or antiplatelet agents (i.e. clopidogrel); low dose aspirin (=< 81 mg/day) low-dose
warfarin (=< 1 mg/day) and prophylactic low molecular weight heparin are permitted

- Major surgery within 3 months of the first dose of cabozantinib if there were no wound
healing complications or within 6 months of the first dose of cabozantinib if there
were wound complications

- Minor surgery within 1 month of the first dose of cabozantinib if there were no wound
healing complications or within 3 months of the first dose of cabozantinib if there
were wound complications

- Patients with concurrent uncompensated hypothyroidism or thyroid dysfunction within 7
days before the first dose of study treatment
We found this trial at
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Bremerton, Washington 98310
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Jacksonville, Florida 32224
(904) 953-2000
Mayo Clinic Florida Thousands of people come to Mayo Clinic in Jacksonville, Fla., annually for...
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Jefferson, Iowa 50129
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1102 W 32nd St
Joplin, Missouri 64804
(417) 347-1111
Freeman Health System Freeman in Joplin, Missouri, is a 485-bed, three-hospital system providing comprehensive healthcare...
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1521 Gull Rd
Kalamazoo, Michigan 49048
269) 226-7000
Borgess Medical Center At Borgess, healing is our calling. This is the place where people...
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Kalamazoo, MI
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750 Avenue D West
Kingman, Kansas 67068
(620) 532-3147
Cancer Center of Kansas, PA - Kingman Dr. H.E. Hynes founded Cancer Center of Kansas,...
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Lancaster, Ohio 43130
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401 N Ewing St
Lancaster, Ohio 43130
(740) 687-8000
Fairfield Medical Center We are people you know offering care you trust. Serving more than...
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3131 La Canada St # 241
Las Vegas, Nevada 89169
(702) 693-6870
Women's Cancer Center of Nevada The Women's Cancer Center is a recognized leader in the...
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325 Maine Street
Lawrence, Kansas 66044
(785) 505-5000
Lawrence Memorial Hospital Lawrence Memorial Hospital (LMH), in collaboration with its medical staff, is dedicated...
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1 Medical Center Dr
Lebanon, New Hampshire 03756
 (603) 650-5000
Dartmouth Hitchcock Medical Center Dartmouth-Hitchcock is a national leader in patient-centered health care and building...
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424 Savannah Rd
Lewes, Delaware 19958
(302) 645-3300
Beebe Medical Center Located in beautiful historic Lewes, Delaware, near Rehoboth Beach, Beebe Healthcare offers...
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315 W. 15th St.
Liberal, Kansas 67905
(620) 629-6727
Cancer Center of Kansas, PA - Liberal Dr. H.E. Hynes founded Cancer Center of Kansas,...
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Liberal, KS
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1983 Marengo St
Los Angeles, California 90033
(323) 226-2622
Los Angeles County-USC Medical Center The origins of LAC+USC Medical Center date back to 1878,...
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1441 Eastlake Ave
Los Angeles, California 90033
(323) 865-3000
U.S.C./Norris Comprehensive Cancer Center The USC Norris Comprehensive Cancer Center, located in Los Angeles, is...
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600 Highland Ave
Madison, Wisconsin 53792
(608) 263-6400
University of Wisconsin Hospital and Clinics UW Health strives to meet the health needs of...
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Manhattan, Kansas 66502
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Manhattan, KS
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401 Matthew St
Marietta, Ohio 45750
(740) 374-1455
Marietta Memorial Hospital We are 2,600 strong and the county
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Marietta, OH
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Marshalltown, Iowa 50158
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Marshalltown, IA
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Marshfield, Wisconsin 54449
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1000 North Oak Avenue
Marshfield, Wisconsin 54449
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Mayfield Heights, Ohio 44124
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