Neuroblastoma Biology Study



Status:Recruiting
Conditions:Brain Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any - 99
Updated:1/21/2018
Start Date:July 2011
End Date:June 2019
Contact:Araz Marachelian, MD
Email:amarachelian@chla.usc.edu
Phone:323-361-5687

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N2004-05: Neuroblastoma Biology Study

Medical scientists want to find better ways to treat neuroblastoma and to find ways to
prevent the tumor from growing back. To do this, they need more information about the
characteristics of neuroblastoma cells. Therefore, they want to study samples of
neuroblastoma tissues and neuroblastoma and normal cells in the blood and bone marrow that
may be related to the growth of neuroblastoma cells. Doctors and other medical scientists
also want to find better ways to detect and measure neuroblastoma to improve the ability to
follow the response of tumor cells to therapy.

The purposes of this study are:

To establish a storage place or bank of samples of blood, bone marrow, and/or tumor, and
molecular components isolated from these samples from children with neuroblastoma. The stored
specimens will be shared with laboratory researchers studying high risk neuroblastoma.

To evaluate a new test of blood and bone marrow specimens to find tumor cells. The results of
this new test, called 5-gene TaqMan® Low Density Array or TLDA, will be compared between
blood and bone marrow and imaging (radiology) studies. Radiology studies (CT scans, MRI
scans, and MIBG scans) and the TLDA test will be compared for their ability to measure the
amount of tumor present and how this changes with therapy.

To collect clinical data (such as treatments received, date of diagnosis, tumor stage, etc)
and radiology scans to provide this information as needed for the laboratory studies to be
done on the specimens.

To obtain neuroblastoma tumor cells from tumor tissue, bone marrow, and/or blood to use to
start cell lines, or tumor cells that will keep growing in the laboratory. These cell lines
will be shared with laboratory researchers studying high risk neuroblastoma.

Inclusion Criteria:

- Patients must be greater than or 31 days of age.

- Patients must have had a diagnosis of high risk neuroblastoma either by histological
verification of neuroblastoma and/or demonstration of tumor cells in the bone marrow
with increased urinary catecholamines.

- All patients with refractory or recurrent high risk neuroblastoma at NANT institutions
are eligible regardless of disease status (including no measurable or evaluable tumor)
as long as they undergo a disease evaluation and appropriate samples are submitted.

- Additionally, all patients with high risk neuroblastoma without relapse treated at a
NANT institution are eligible if undergoing a disease evaluation, as long as
Children's Oncology Group specimens are prioritized.

Exclusion Criteria:

- There are no exclusion criteria on this study.
We found this trial at
14
sites
5721 S. Maryland Avenue
Chicago, Illinois 60637
Phone: 773-843-3943
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Ann Arbor, MI 48109Bus: -
Ann Arbor, Michigan 48109
Phone: 734-936-8785
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1405 Clifton Road Northeast
Atlanta, Georgia 30322
(404) 785-6000
Phone: 404-785-0853
AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Egleston Campus...
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3333 Burnet Avenue # Mlc3008
Cincinnati, Ohio 45229
 1-513-636-4200 
Phone: 513-636-9863
Cincinnati Children's Hospital Medical Center Patients and families from across the region and around the...
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4650 Sunset Blvd
Los Angeles, California 90027
 (323) 660-2450
Phone: 323-361-5687
Childrens Hospital Los Angeles Children's Hospital Los Angeles is a 501(c)(3) nonprofit hospital for pediatric...
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South 34th Street
Philadelphia, Pennsylvania 19104
 215-590-1000
Phone: 215-590-0965
Children's Hospital of Philadelphia Since its start in 1855 as the nation's first hospital devoted...
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1600 Divisadero Street
San Francisco, California 94115
888.689.8273
Phone: 415-476-3831
UCSF Helen Diller Family Comprehensive Cancer Center UCSF’s long tradition of excellence in cancer research...
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Aurora, Colorado 80045
Phone: 720-777-8856
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Boston, Massachusetts 02115
Phone: 617-632-4901
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Chapel Hill, North Carolina 27599
(919) 962-2211
Univ of North Carolina Carolina’s vibrant people and programs attest to the University’s long-standing place...
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Fort Worth, Texas 76104
Phone: 682-885-2580
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Palo Alto, California 94305
Phone: 650-723-5535
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4800 Sand Point Way NE
Seattle, Washington 98105
(206) 987-2000
Phone: 206-987-5783
Seattle Children's Hospital Seattle Children’s Hospital specializes in meeting the unique physical, emotional and developmental...
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555 University Avenue
Toronto, Ontario M5G 1X8
Phone: 416-813-7654
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