Paclitaxel With or Without Pazopanib Hydrochloride in Treating Patients With Persistent or Recurrent Ovarian Epithelial, Fallopian Tube, or Peritoneal Cavity Cancer



Status:Completed
Conditions:Ovarian Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:6/3/2018
Start Date:December 12, 2011
End Date:January 27, 2018

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A Randomized Phase IIB Evaluation of Weekly Paclitaxel (NSC #673089) Plus Pazopanib (NSC #737754) Versus Weekly Paclitaxel Plus Placebo in the Treatment of Persistent or Recurrent Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Carcinoma

This randomized phase II trial studies how well paclitaxel when given together with or
without pazopanib hydrochloride works in treating patients with ovarian epithelial, fallopian
tube, or peritoneal cavity cancer that is persistent or has come back. Drugs used in
chemotherapy, such as paclitaxel work in different ways to stop the growth of tumor cells,
either by killing the cells, by stopping them from dividing, or by stopping them from
spreading. Pazopanib hydrochloride may stop the growth of tumor cells by blocking blood flow
to the tumor or by blocking some of the enzymes needed for cell growth. It is not yet known
whether paclitaxel is more effective when given with or without pazopanib hydrochloride in
treating ovarian epithelial, fallopian tube, and peritoneal cavity cancer.

PRIMARY OBJECTIVES:

I. To estimate the progression-free survival hazard ratio of the combination of weekly
paclitaxel and pazopanib (pazopanib hydrochloride) compared to weekly paclitaxel and placebo
in patients with persistent or recurrent ovarian, fallopian tube, or primary peritoneal
cancer.

SECONDARY OBJECTIVES:

I. To determine the frequency and severity of adverse events as assessed by Common
Terminology Criteria for Adverse Events (CTCAE).

II. To estimate and compare the proportion of patients responding to therapy by Response
Evaluation Criteria in Solid Tumors (RECIST), cancer antigen 125 (CA125) response, the
overall survival (OS), and the duration of response in each arm.

TERTIARY OBJECTIVES:

I. To explore the association between plasma cytokines and angiogenic markers and
progression-free and overall survival.

II. To explore the association between single-nucleotide polymorphisms (SNPs) and
progression-free and overall survival.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I: Patients receive paclitaxel intravenously (IV) over 1 hour on days 1, 8, and 15 and
placebo orally (PO) daily on days 1-28.

ARM II: Patients receive paclitaxel as in Arm I and pazopanib hydrochloride PO daily on days
1-28.

In both arms, courses repeat every 28 days in the absence of disease progression or
unacceptable toxicity.

After completion of study therapy, patients are followed up every 3 months for 2 years and
then every 6 months for 3 years.

Inclusion Criteria:

- Patients must have recurrent or persistent epithelial ovarian, fallopian tube, or
primary peritoneal carcinoma; histologic documentation of the original primary tumor
is required via the pathology report

- Patients must have measurable disease or non-measurable (detectable) disease

- Measurable disease is defined as at least one lesion that can be accurately
measured in at least one dimension (longest diameter to be recorded); each lesion
must be greater than or equal to 10 mm when measured by computed tomography (CT),
magnetic resonance imaging (MRI), or caliper measurement by clinical exam; or
greater than or equal to 20 mm when measured by chest x-ray; lymph nodes must be
greater than or equal to 15 mm in short axis when measured by CT or MRI

- Non-measurable (detectable) disease in a patient is defined in this protocol as
one who does not have measurable disease but has at least one of the following
conditions:

- Ascites and/or pleural effusion attributed to tumor

- Solid and/or cystic abnormalities on radiographic imaging that do not meet
RECIST 1.1 definitions for target lesions

- Patients with measurable disease must have at least one "target lesion" to be used to
assess response on this protocol as defined by RECIST 1.1; tumors within a previously
irradiated field will be designated as "non-target" lesions unless progression is
documented or a biopsy is obtained to confirm persistence at least 90 days following
completion of radiation therapy

- Patients must not be eligible for a higher priority Gynecology Oncology Group (GOG)
protocol, if one exists; in general, this would refer to any active GOG phase III or
Rare Tumor protocol for the same patient population; in addition, patients must not be
eligible for the currently active phase II cytotoxic protocol in platinum resistant
disease

- Patients who have received one prior regimen must have a GOG performance status of 0,
1, or 2

- Patients who have received two or three prior regimens must have a GOG performance
status of 0 or 1

- Recovery from effects of recent surgery, radiotherapy, or chemotherapy

- Patients should be free of active infection requiring antibiotics (with the exception
of uncomplicated urinary tract infection [UTI])

- Any hormonal therapy directed at the malignant tumor must be discontinued at least one
week prior to registration

- Any other prior therapy directed at the malignant tumor, including chemotherapy,
biological/targeted (non-cytotoxic) agents, and immunologic agents, must be
discontinued at least three weeks prior to registration; chimeric or human or
humanized monoclonal antibodies (including bevacizumab) or vascular endothelial growth
factor (VEGF) receptor fusion proteins (including VEGF TRAP/aflibercept) must be
discontinued for at least 12 weeks prior to registration

- At least 4 weeks must have elapsed since the patient underwent any major surgery
(e.g., major: laparotomy, laparoscopy, thoracotomy, video-assisted thorascopic surgery
[VATS]); there is no restriction on minor procedures (e.g., minor: central venous
access catheter placement, ureteral stent placement or exchange, paracentesis,
thoracentesis)

- Patients must have had one prior platinum-based chemotherapeutic regimen for
management of primary disease containing carboplatin, cisplatin, or another
organoplatinum compound; this initial treatment may have included intraperitoneal
therapy, consolidation, biologic/targeted (non-cytotoxic) agents (e.g., bevacizumab),
or extended therapy administered after surgical or non-surgical assessment; if
patients were treated with paclitaxel for their primary disease, this can have been
given weekly or every 3 weeks

- Patients are allowed to receive, but are not required to receive, two additional
cytotoxic regimens for management of recurrent or persistent disease, with no more
than 1 non-platinum, non-taxane regimen; treatment with weekly paclitaxel for
recurrent or persistent disease is NOT allowed

- Patients are allowed to receive, but are not required to receive, biologic/targeted
(non-cytotoxic) therapy as part of their primary treatment regimen

- Patients must have NOT received any biologic/targeted (non-cytotoxic) therapy
targeting the VEGF and/or platelet-derived growth factor (PDGF) pathways for
management of recurrent or persistent disease

- For the purposes of this study, poly (ADP-ribose) polymerase (PARP) inhibitors will be
considered "cytotoxic"; patients are allowed to receive, but are not required to
receive, PARP inhibitors for management of primary or recurrent/persistent disease
(either alone or in combination with cytotoxic chemotherapy); PARP inhibitors will NOT
count as a prior regimen when given alone

- Absolute neutrophil count (ANC) greater than or equal to 1,500/mcL

- Platelets greater than or equal to 100,000/mcL

- Hemoglobin greater than or equal to 9 g/dL

- Prothrombin time (PT) such that international normalized ratio (INR) is less than or
equal to 1.5 x upper limit of normal (ULN) (or an in-range INR, usually between 2 and
3, if a patient is on a stable dose of therapeutic warfarin)

- Partial thromboplastin time (PTT) less than or equal to 1.5 x ULN

- Creatinine less than or equal to 1.5 x institutional ULN

- Urine protein should be screened by urinalysis; if urine protein is 2+ or higher,
24-hour urine protein should be obtained and the level must be < 1000 mg (< 1.0 g/24
hours [hrs]) for patient enrollment

- Bilirubin less than or equal to 1.5 x ULN

- Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) less than or equal
to 2.5 x ULN

- Subjects who have BOTH bilirubin greater than ULN and AST/ALT greater than ULN are not
eligible

- Alkaline phosphatase less than or equal to 2.5 x ULN

- Patients must have normal baseline thyroid function tests (thyroid-stimulating hormone
[TSH], T3, T4); a history of hypothyroidism and/or hyperthyroidism is allowed, as long
as the patient has stable well-controlled thyroid function for a minimum of 2 months

- Neuropathy (sensory and motor) less than or equal to grade 1

- Patients of childbearing potential must have a negative pregnancy test prior to the
study entry and be practicing an effective form of contraception; pregnant women are
excluded from this study

- Patients must have signed an approved informed consent and authorization permitting
the release of personal health information

- Patients must be capable of taking and absorbing oral medications; a patient must be
clear of the following:

- Any lesion, whether induced by tumor, radiation, or other conditions, which makes
it difficult to swallow tablets

- Prior surgical procedures affecting absorption including, but not limited to
major resection of stomach or small bowel

- Active peptic ulcer disease

- Malabsorption syndrome

- Any concomitant medications that are associated with a risk of corrected QT (QTc)
prolongation and/or Torsades de Pointes should be discontinued or replaced with drugs
that do not carry these risks, if possible; patients who must take medication with a
risk of possible risk of Torsades de Pointes should be watched carefully for symptoms
of QTc prolongation, such as syncope

- Patients with personal or family history of congenital long QTc syndrome are NOT
eligible

- Strong inhibitors of cytochrome P-450 system (CYP)3A4 are prohibited

- Strong inducers of CYP3A4 are prohibited

- Concomitant use of agents with narrow therapeutic windows that are metabolized by
CYP3A4, CYP2D6, or CYP2C8 is not recommended

Exclusion Criteria:

- Patients who have had previous treatment with pazopanib; patients who have had
previous treatment with weekly paclitaxel for recurrent or persistent disease

- Patients with a history of other invasive malignancies, with the exception of
non-melanoma skin cancer and other specific malignancies are excluded if there is any
evidence of other malignancy being present within the last three years; patients are
also excluded if their previous cancer treatment contraindicates this protocol therapy

- Patients who have received prior radiotherapy to any portion of the abdominal cavity
or pelvis within the last three years are excluded; prior radiation for localized
cancer of the breast, head and neck, or skin is permitted, provided that it was
completed more than three years prior to registration, and the patient remains free of
recurrent or metastatic disease

- Patients who have received prior chemotherapy for any abdominal or pelvic tumor OTHER
THAN for the treatment of ovarian, fallopian tube, or primary peritoneal cancer within
the last three years; patients may have received prior adjuvant chemotherapy for
localized breast cancer, provided that it was completed more than three years prior to
registration, and the patient remains free of recurrent or metastatic disease

- Patients with clinically significant cardiovascular disease; this includes:

- Uncontrolled hypertension, defined as systolic greater than 140 mm Hg or
diastolic greater than 90 mm Hg despite antihypertensive medications

- Congenital long QT syndrome or baseline QTc greater than 480 milliseconds

- Myocardial infarction or unstable angina within 6 months prior to registration

- New York Heart Association (NYHA) class II or greater congestive heart failure

- History of serious ventricular arrhythmia (i.e., ventricular tachycardia or
ventricular fibrillation) or serious cardiac arrhythmia requiring medication

- This does not include asymptomatic atrial fibrillation with controlled
ventricular rate

- Patients who have received prior treatment with an anthracycline (including
doxorubicin and/or liposomal doxorubicin) must have an echocardiogram assessment
and are excluded if they have an ejection fraction less than 50%

- CTCAE grade 2 or greater peripheral vascular disease (at least brief [less than
24 hours] episodes of ischemia managed non-surgically and without permanent
deficit)

- History of cardiac angioplasty or stenting within 6 months prior to registration

- History of coronary artery bypass graft surgery within 6 months prior to
registration

- Arterial thrombosis within 6 months prior to registration

- Patients with serious non-healing wound, ulcer, or bone fracture; this includes
history of abdominal fistula, gastrointestinal perforation or intra-abdominal abscess
within 28 days prior to the first date of study treatment

- Patients with active bleeding or pathologic conditions that carry high risk of
bleeding, such as known bleeding disorder, coagulopathy, or tumor involving major
vessels

- Patients with history or evidence upon physical examination of central nervous system
(CNS) disease, including primary brain tumor, seizures which are not controlled with
non-enzyme inducing anticonvulsants, any brain metastases, or history of
cerebrovascular accident (CVA, stroke), transient ischemic attack (TIA) or
subarachnoid hemorrhage within six months prior to the first date of study treatment

- History of allergic reactions attributed to compounds of similar chemical or biologic
composition to pazopanib

- Known human immunodeficiency virus (HIV)-positive subjects on combination
antiretroviral therapy

- Patients with any condition that may increase the risk of gastrointestinal bleeding or
gastrointestinal perforation, including:

- Active peptic ulcer disease

- Known gastrointestinal intraluminal metastatic lesions (gastrointestinal serosa
metastatic lesions are permitted)

- Inflammatory bowel disease (e.g., ulcerative colitis, Crohn's disease)

- Patients with clinical symptoms or signs of gastrointestinal obstruction

- Patients who require parenteral hydration and/or nutrition

- Patients who are pregnant or nursing

- History of hemoptysis in excess of 2.5 mL (½ teaspoon) within 8 weeks prior to first
dose of pazopanib

- Uncontrolled intercurrent illness including, but not limited to, psychiatric
illness/social situations that would limit compliance with study requirements
We found this trial at
142
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Bremerton, Washington 98310
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1660 Springhill Avenue
Mobile, Alabama 36604
(251) 665-8000
University of South Alabama Mitchell Cancer Institute USA Mitchell Cancer Institute (MCI) is located in...
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Mobile, AL
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Mount Vernon, WA
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Muskegon, Michigan 49444
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Muskegon, MI
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100 Grand St
New Britain, Connecticut 06050
(860) 224-5011
The Hospital of Central Connecticut The Hospital of Central Connecticut is dedicated to fostering, sustaining...
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New Britain, CT
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4755 Ogletown-Stanton Road
Newark, Delaware 19718
302-733-1000
Christiana Care Health System - Christiana Hospital A 913-bed, 1.3-million-square-foot, modern facility in Newark, Delaware,...
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Newark, DE
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Newport Beach, California 92663
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Newport Beach, CA
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720 Medical Center Drive
Newton, Kansas 67114
(316) 282-0888
Cancer Center of Kansas, PA - Newton Dr. H.E. Hynes founded Cancer Center of Kansas,...
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Newton, KS
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940 NE 13th St
Oklahoma City, Oklahoma 73190
(405) 271-6458
University of Oklahoma Health Sciences Center The OU Health Sciences Center is composed of seven...
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Oklahoma City, OK
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8303 Dodge Street
Omaha, Nebraska 68114
(402) 354–4000
Nebraska Methodist Hospital Methodist Hospital is a general medical and surgical hospital in Omaha, NE....
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Omaha, NE
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Orlando, Florida 32803
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Orlando, FL
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1902 S. US Hwy 59
Parsons, Kansas 67357
(620) 421-2855
Cancer Center of Kansas, PA - Parsons Dr. H.E. Hynes founded Cancer Center of Kansas,...
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Parsons, KS
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Philadelphia, Pennsylvania 19104
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Philadelphia, PA
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Phoenix, Arizona 85012
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Phoenix, AZ
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Pontiac, Michigan 48341
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Pontiac, MI
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Port Huron, Michigan 48060
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Port Huron, MI
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