Biomarkers in Blood Samples From Young Patients With Newly Diagnosed Brain Tumors Undergoing Standard Radiation Therapy and Chemotherapy



Status:Withdrawn
Conditions:Brain Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:4 - 21
Updated:4/3/2019
Start Date:May 2010
End Date:August 24, 2017

Use our guide to learn which trials are right for you!

Immunologic Profile of Patients With Newly Diagnosed Medulloblastoma at Initial Diagnosis and During Standard Radiation and Chemotherapy

RATIONALE: Studying samples of blood in the laboratory from patients receiving radiation
therapy and chemotherapy may help doctors learn more about the effects of this treatment on
cells. It may also help doctors understand how well patients respond to treatment.

PURPOSE: This research study is studying biomarkers in blood samples from young patients with
newly diagnosed brain tumors undergoing standard radiation therapy and chemotherapy.

OBJECTIVES:

Primary

- Evaluate the fraction of peripherally circulating T-regulatory cells (T_regs) in
pediatric patients with newly diagnosed medulloblastoma and compare it to the levels
found in a control group of patients undergoing craniectomy for Chiari malformation.

- Evaluate the longitudinal effects of standard radiotherapy and chemotherapy regimens on
the overall population of lymphocytes as well as the fraction of T_reg cells in patients
with medulloblastoma.

Secondary

- Determine the baseline fraction of T_reg cells in those with non-medulloblastoma
posterior fossa tumors compared to levels found in patients undergoing decompression for
Chiari malformation.

OUTLINE: This is a multicenter study.

Patients with Chiari malformation and patients with posterior fossa tumor undergo standard
surgery. Patients with posterior fossa tumor also receive standard radiotherapy and
chemotherapy.

Blood samples are collected at baseline and periodically to measure the level of circulating
T-regulatory cells.

DISEASE CHARACTERISTICS:

- Meets 1 of the following criteria:

- Histologically confirmed posterior fossa tumor

- Newly diagnosed disease

- Medulloblastoma OR non-medulloblastoma (pilocytic astrocytoma, ependymoma,
atypical rhabdoid tumor, or others)

- Scheduled to undergo craniotomy and tumor resection

- Chiari malformation

- Requires craniectomy for decompression

- No secondary decompression

PATIENT CHARACTERISTICS:

- No unexplained febrile illness

- No active infection

- No autoimmune disorders such as inflammatory bowel disease, juvenile rheumatoid
arthritis, or systemic lupus erythematosus

- No other immunosuppressive disorders (e.g., HIV infection)

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics
We found this trial at
11
sites
262 Danny Thomas Pl
Memphis, Tennessee 38105
(901) 495-3300
St. Jude Children's Research Hospital St. Jude is unlike any other pediatric treatment and research...
?
mi
from
Memphis, TN
Click here to add this to my saved trials
3333 Burnet Avenue # Mlc3008
Cincinnati, Ohio 45229
 1-513-636-4200 
Cincinnati Children's Hospital Medical Center Patients and families from across the region and around the...
?
mi
from
Cincinnati, OH
Click here to add this to my saved trials
4650 Sunset Blvd
Los Angeles, California 90027
 (323) 660-2450
Childrens Hospital Los Angeles Children's Hospital Los Angeles is a 501(c)(3) nonprofit hospital for pediatric...
?
mi
from
Los Angeles, CA
Click here to add this to my saved trials
4401 Penn Avenue
Pittsburgh, Pennsylvania 15224
412-692-5325
Children's Hospital of Pittsburgh of UPMC UPMC is one of the leading nonprofit health systems...
?
mi
from
Pittsburgh, PA
Click here to add this to my saved trials
Bethesda, Maryland 20892
?
mi
from
Bethesda, MD
Click here to add this to my saved trials
2515 N Clark St
Chicago, Illinois 60614
(312) 227-6060
Children's Memorial Hospital, Chicago Ann & Robert H. Lurie Children
?
mi
from
Chicago, IL
Click here to add this to my saved trials
20 Duke Clinic Cir
Durham, North Carolina 27710
(888) 275-3853
Duke Cancer Institute Leading-edge cancer care and research have been a hallmark of Duke Medicine...
?
mi
from
Durham, NC
Click here to add this to my saved trials
?
mi
from
Houston, TX
Click here to add this to my saved trials
1275 York Ave
New York, New York 10021
(212) 639-2000
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
?
mi
from
New York, NY
Click here to add this to my saved trials
?
mi
from
Palo Alto, CA
Click here to add this to my saved trials
111 Michigan Ave NW
Washington, District of Columbia
(202) 476-5000
Childrens National Medical Center As the nation’s children’s hospital, the mission of Children’s National Medical...
?
mi
from
Washington,
Click here to add this to my saved trials